T(min) Via intravenosa Via intramuscular Via subcutánea

0 0 0
5 144.20 59.88 16.07
15 54.78 72.66 39.14
30 67.56 118.67 16.07
60 34.35 54.77 75.04
90 26.68 47.11 34.02
120 13.91 41.99 31.45
Via intravenosa

AUC= (1/2)(144.20+54.78)(15-5)=994.9

AUC= (1/2)(54.78+67.56)(30-15)=917.55

AUC= (1/2)(67.56+34.35)(60-30)=1528.65

AUC= (1/2)(34.35+26.68)(90-60)=915.45

AUC= (1/2)(26.68+13.91)(120-90)=608.85

AUC 0−120=4965.4

Ke= (2.63-3.54)/(120-60)=-0.015

ABC 13.91
120−¿= =927.33 ¿
0.0 15

ABC 0−¿=4965.4 +927.33=5 883.73 ¿

T(min) Log concentración

5 2.16
15 1.74
30 1.83
60 1.54
90 1.43
120 1.14
Ŷ0= 2.03

102.03=107.15
ABC 107.15
0−¿= =5357.5¿
0.02

75 mg −¿ 1 Kg
195000µg
x=195 mg −¿2.6 Kg
Vd=195000/107.15=1819.88mL/1000=1.82 L

Cl=1.82*0.02=0.0364Lmin*1000=36.4 mLmin

ln 0.5
t 1/ 2= =46.20 h
0.015
Via intramuscular

AUC= (1/2)(0+59.88)(5-0)=149.7

AUC= (1/2)(59.88+72.66)(15-5)=662.7

AUC= (1/2)(72.66+118.67)(30-15)=1434.97

AUC= (1/2)(118.67+54.77)(60-30)=2601.6

AUC= (1/2)(54.77+47.11)(90-60)=1528.2

AUC= (1/2)(47.11+41.99)(120-90)=1336.5

AUC 0−120=7713.67

Ke= (3.74-4.78)/(120-30)=-0.004

ABC 41.99
120−¿= =10497.5¿
0.0 04

ABC 0−¿=7713.67+10497.5=1 8211.17 ¿

F
( 158211.17
|¿|=
883.73 )
∗100=309.52% ¿

Via subcutánea

AUC= (1/2)(0+16.07)(5-0)=40.17

AUC= (1/2)(16.07+39.14)(15-5)=276.05

AUC= (1/2)(39.14+16.07)(30-15)=414.07

AUC= (1/2)(16.07+75.04)(60-30)=1366.65

AUC= (1/2)(75.04+34.02)(90-60)=1635.9

AUC= (1/2)(34.02+31.45)(120-90)=982.05

AUC 0−120=4714.8

Ke= (3.45-4.32)/(120-60)=-0.015

ABC 31.45
120−¿= =2096.67 ¿
0.0 15

ABC 0−¿=4714.9+2096.67=6811.57 ¿
F
|¿|=
( 56811.57
88 3.73 )
∗100=115.77 %¿