use of a malaria drug to treat COVID-19, India’s government is recommending that front-line workers take the medicine to prevent infection. Researchers say the advice is premature and risky, because there is limited evidence that the drug, hydroxychloroquine, works against the new coronavirus, and there are a growing number of reports that it can trigger serious side effects. There is no vaccine for the new coronavirus, so the prospect of a widely available drug such as hydroxychloroquine — and a similar compound, chloroquine — reducing infection risk is appealing, especially in parts of India where high population density makes social distancing difficult. Many people around the world, including US President Donald Trump, have taken the drug in the hope it might prevent infection. But, at this stage, there is almost no evidence that the drug works in this way, and the results of several randomized and placebo-controlled prophylaxis trials under way in the United States, Europe and South Asia have not been published.