Professional Documents
Culture Documents
Issue: BCMJ, vol. 44 , No. 8 , October 2002 , [1] Pages 415-419 Clinical Articles
By: J. Ellen Anderson, MD [2] Erin E. Michalak, PhD [3] Raymond W. Lam, MD, FRCPC [4]
Here are some screening and diagnostic tools you can easily incorporate into your
repertoire to improve the diagnosis and management of depression.
[5]
[6]
[7]
[8]
A+ [9] A- [9]
Introduction
How many times have physicians wished they could measure a serum sadness level, and show
the report to their skeptical patients, thus convincing them that they have a medically treatable
disorder? After all, this is the model we use for diabetes, thyroid disease, elevated cholesterol,
and many other chronic illnesses. Even when we reach that moment where there is widespread
public acceptance that clinical depression, despite its multifactorial causes, is a treatable illness,
we will need to use diagnostic tools to confirm our clinical suspicions, inform our patients, and
monitor their treatment outcomes.
Symptom-based psychiatric rating scales were developed more than 40 years ago to assign
numerical values to a complex range of patient behaviors, affects, and feelings. They have since
proliferated into a bewildering array of tools designed for a variety of purposes, some very
general in their scope, and some quite narrowly focused. This article is not intended to be a
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comprehensive review; rather it is an attempt to identify and describe a few such tools that can
be easily incorporated into a busy clinician’s repertoire to improve diagnosis and management of
depression.
Although we routinely rely on clinical data, most explanations of how to interpret diagnostic data
are confined to laboratory and X-ray reports. Yet symptoms and signs usually produce far more
powerful support of diagnostic hypotheses than we can ever derive from the laboratory. Rating
scales are not intended to provide a substitute for good clinical judgment. Once we have a
clinical suspicion that depression plays a role in a particular patient’s problems, we want reliable,
accurate ways of confirming the diagnosis and monitoring the patient’s progress over time. We
need psychometrically sound, user-friendly tools that give us clinically useful information, and
that are reliable, valid, and consistent for a variety of patients and settings when administered by
different clinicians.
To choose the correct tools we need to determine the goals of our assessment. Screening tools,
which give us a quick indication of whether further assessment is warranted, need to have high
sensitivity (few false-negatives). Diagnostic tools need good content validity (do they measure
what we think they do?), test-retest reliability (reliability over time), good inter-rater reliability
(agreement between clinicians), and high specificity (fewer false-positives). When we use scales
to evaluate treatment outcomes we need good test-retest reliability and the scale needs to be
sensitive enough to detect clinically significant changes in a variety of domains. The gold
standard for comparison of all these tools is always a focused, in-depth interview by an
experienced mental health clinician. For busy physicians, an ideal test would be short,
straightforward, and reliable for screening, diagnosis, and outcome assessment.
In most clinical settings we are likely to have multiple goals of assessment and a minimum of
time, so careful choice of tools is crucial. Any assessment must be individualized to
acknowledge language/cultural differences, intellectual or cognitive impairments, age-specific
issues (children, teens, the elderly), co-morbid psychiatric or other illness (anxiety, bipolar
disorder), or concurrent substance abuse (e.g., the CAGE questionnaire is useful). Risk of
suicide must always be evaluated.
Both self-report inventories and clinician-rated scales are available.[1] Some are in the public
domain, while others are protected by copyright and require payment of a fee for their use.
Ultimately, a clinically useful diagnostic test must do three things: provide an accurate diagnosis,
support application of an efficacious therapy, and ideally, lead to a better outcome for the patient.
The complete evaluation process is impractical for an individual physician to apply to each test
he or she uses, so this article will summarize some of the most useful validated tools in
depression. As a busy doctor you can choose and become familiar with these few, thereby
improving the quality of your patient assessments. Most of the frequently used instruments show
robust correlations among themselves, although the self-rating scales show better correlation
among themselves than with the clinician-rated scales. Tempting though it may be to use a cut-
off score on a self-report inventory as a single means of deriving a diagnosis, it is inadequate
and unreliable and should be avoided.
Screening
Two quick questions from Primary Care Evaluation of Mental Disorders (PRIME-MD)[2] can
provide us with a highly sensitive (94%) but not very specific (35%) screening test for
depression:[3]
2. Have you been feeling down, depressed, or hopeless in the last month?
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If a patient responds positively to these two questions, only four follow-up questions—on sleep
disturbance, appetite change, low self-esteem, and anhedonia—are needed to confirm a
diagnosis of depression. If a patient has a positive response on at least two of these four
questions (Table 1), the specificity of a positive test increases to 94%.[3]
Self-rated screening tools are also available.[1] The Hospital Anxiety and Depression scale is the
most widely investigated and validated scale for screening; however, it is too long and difficult to
score, making it less useful in clinical practice. The 20-item Zung Depression Self-Rating Scale
is less commonly used but it is in the public domain. It does not have adequate sensitivity to
detect change over time, so it is not considered useful for following response to treatment.
The Geriatric Depression Scale (GDS) is a self-report measure designed to minimize the impact
of somatic symptoms associated with aging and illness.[4] It has a yes/no format, and the 15-
item version, using a cutoff of five, has good sensitivity and positive predictive values for
diagnosis of major depression (Table 2). If a clinician is concerned about cognitive impairment,
the Mini Mental State Exam (MMSE), which takes 5 minutes to administer and score, is a useful
addition.[5]
Diagnosis
The full version of the PRIME-MD clinician-rated scale, available in the public domain, contains
26 yes/no questions concerning symptoms experienced in the past month, and incorporates
observed and reported behavior.[2] On average, it takes 8.4 minutes to perform. If we have a
clinical suspicion that a patient is depressed, the pre-test probability is close to 50%, and the
post-test probability after a positive test (using a cut-off value of 5/9) becomes 94%. This is
better than most of the routine laboratory tests we use daily in practice. If the score is 4/9 or less,
then we need to consider other depressive disorders such as dysthymia, complicated
bereavement, adjustment disorder, mixed anxiety/depression, minor depressive disorder, or
premenstrual dysphoric disorder. PRIME-MD has been validated in adults and adolescents over
age 13; its applicability to seniors and children is limited.
More recently, a streamlined patient self-report version of the PRIME-MD, called the Patient
Health Questionnaire (PHQ) has been made available.[6] The PHQ is 3 pages long and covers
the five most common psychiatric issues in primary care (depression, anxiety, alcohol,
somatoform, and eating disorders). An abbreviated PHQ (the PHQ-9) for depression has been
developed that reduces physician time to less than 3 minutes (Table 3).[7] The PHQ-9 also offers
a severity score for each symptom, and hence can also be used to follow outcome. The PHQ-9
and other depression tools can be downloaded from the MacArthur Foundation web site
(www.depression-primarycare.org [10]).
Measuring outcomes
The Hamilton Depression Rating Scale (HAM-D), the oldest, most widely used and validated
instrument, has numerous versions, both clinician-rated and self-reported, as well as a
computer-administered version.[8] Some versions are currently available in the public domain
while others are still copyright protected. The clinician-administered versions are widely used in
clinical trials for evaluating response to treatment but they require training to use, take 20 to 30
minutes to administer, and so are less useful for busy family physicians.
Many clinicians prefer to use a patient self-rated scale such as the Beck Depression Inventory
(BDI, protected by copyright and requiring permission and payment of a fee to reproduce). The
BDI-II is a 21-item self-report measure of the severity of depressive symptoms. It has high
sensitivity and specificity and is valid and reliable in assessing the severity of depressive
symptoms.[9] Among its shortcomings are its high item difficulty (requires the patient to be able
to read and understand the questions) and poor discriminant validity against anxiety.
Currently, the HAM-D and the BDI are probably the best-validated scales to quantitatively assess
response to treatment. Response has been defined as a 50% reduction in baseline score on the
HAM-D or BDI in most clinical trials—in practice we ideally want to see our patients in remission
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(e.g., scores within the normal range) rather than just a 50% symptom reduction. There are
shorter six- to seven-item versions of the HAM-D and the BDI, but they are not yet widely
validated or used in clinical practice, and do not include some important clinical items such as
sleep disturbance.
On a day-to-day basis, use of the two PRIME-MD screening questions followed by either the rest
of the clinician-administered PRIME-MD or the self-report PHQ-9, with evaluation of both
alcohol/drug consumption and anxiety by screening questions, remains the briefest, simplest,
most accurate way to diagnose major depression in an adult population. Using the self-report
BDI or the PHQ-9 to follow scores at baseline and designated follow-up intervals is an accurate
and reliable strategy that allows us to identify those individuals who are unresponsive to
treatment and/or who require further intervention or consultation. Patients can complete and
score the questionnaires themselves in the waiting room prior to seeing their doctor.
Consistent use of this systematic approach to depression management can improve our
diagnostic accuracy, save time, help us choose appropriate treatment interventions, and
effectively monitor outcomes. This approach should also allow us to further reduce the significant
burden associated with depression in primary care.
Competing interests
A. Evaluation questions
B. Symptom questions
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9. Suicidal thoughts (bored with life): Have you thought that you or
your family would be better off if you were dead? Have you thought
of killing yourself? Have you tried to hurt/kill yourself before? When?
How many times? What did you do? Are you thinking of killing
yourself? Do you have a plan? How will you do it? What stops you
from acting on your thoughts?
Scoring
Choose the best answer for how you have felt over the past
week:
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12. Do you feel pretty worthless the way you are now? Yes No
15. Do you think that most people are better off than you? Yes No
Scoring
Score: ____/15
Normal is 0–5; scores above 5 suggest depression
Patient
name: _________________________________ Date:________________________
Over the last 2 weeks, how often have you been bothered by any of the
following problems?
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If you checked off any problem on this questionnaire so far, how difficult have
these problems made it for you to do your work, take care of things at home, or
get along with other people?
Scoring
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Score Action
www.depression-
primarycare.org/ap1.html [11]. Patient
Health Questionnaire (PHQ-9), screening
questions, and PRIME-MD questions.
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www.stanford.edu/~yesavage/GDS.html
[12]. Geriatric Depression Scale–GDS,
Short Form
References
1. Nezu AM, Ronan GF, Meadows EA, et al. (eds). A Practitioner’s Guide to Empirically Based
Measures of Depression. New York, NY: Kluwer Academic/Plenum Publishers, 2000:3-7, 9-16,
27-122.
2. Spitzer RL, Williams JB, Kroenke K, et al. Utility of a new procedure for diagnosing mental
disorders in primary care. The PRIME-MD 1000 study. JAMA 1994;272:1749-1756. PubMed
Abstract [13]
3. Brody DS, Hahn SR, Spitzer RL, et al. Identifying patients with depression in the primary care
setting: A more efficient method. Arch Intern Med 1998;158:2469-2475. PubMed Abstract [14]
4. Montorio I, Izal M. The Geriatric Depression Scale: A review of its development and utility. Int
Psychogeriatr 1996;8:103-112. PubMed Abstract [15]
5. Cockrell JR, Folstein MF. Mini-Mental State Examination (MMSE). Psychopharmacol Bull
1988;24:689-692. PubMed Citation [16]
6. Spitzer RL, Kroenke K, Williams JB. Validation and utility of a self-report version of PRIME-
MD: The PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health
Questionnaire. JAMA 1999;282:1737-1744. PubMed Abstract [17]
7. Kroenke K, Spitzer RL, Williams JB. The PHQ-9: Validity of a brief depression severity
measure. J Gen Intern Med 2001;16:606-613. PubMed Abstract [18]
8. Bech P, Hamilton M, Zung WWK. The Bech, Hamilton, and Zung Scales for Mood Disorders:
Screening and Listening 2nd ed. New York, NY: Springer-Verlag, 1996. 63 pp.
9. Arnau RC, Meagher MW, Norris MP, et al. Psychometric evaluation of the Beck Depression
Inventory-II with primary care medical patients. Health Psychol 2001;20:112-119. PubMed
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Links
[1] https://www.bcmj.org/node/1327
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[4] https://www.bcmj.org/author/raymond-w-lam-md-frcpc
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