ma

rcome
di
c
Ofcour
se,ther
ear ecer
tainexactdi
recti
onstof
oll
ow whi
chwi
llhel
pyout
oac
hievet
his
,
andwewillbecoveri
ngallofthem l
ateron.

2.Realpl
ant
sar
eal
waysbet
ter
Pharmaceuti
calc
ompanieshavesucces
sful
lyi
sol
atedandsubsequent
lyarti
ficial
ly
repl
ic
atedthetwomainchemicalcompoundsincannabi
s:t
etr
ahydrocannabinol(
THC)
andcannabidi
ol(CBD)
.

Themai nreas
onwhyi t’
salwaysbett
ertous erealcannabisflowers(andother
whole-pl
antderi
vat
ives)i
sbecauseoftheso-call
ed“ f
ulls
pectrum”,whic
hc anbe
descri
bedasanas s
or t
mentofnumer ouscannabinoidsandt erpenesi
nter
acti
ngwi
th
eachothertomaximizetherapeut
icpotent
ialofthewhol e.

Terpenesareorgani
cmolecul
esres
ponsi
blef
ortheuniquearomaandfragranceof
cannabisst
rai
ns.Besi
desthei
rar
omati
cnature,t
erpenesal
sohaveval
uabletherapeut
ic
propert
ies
.

Thiss
ymbioti
ccooper
ati
onofterpenesandcannabi
noidsi
sals
ocal
led“
theentour
age
effect
”,andbecaus
eeachstr
aincontai
nsoverahundreddiffer
entc
annabi
noidsand
ter
penes,t
hisi
saveryimport
antaspectt
obec onsi
dered.

Mostofthesecompoundsar
eonlyfoundintr
aceamounts(
whencomparedt
oTHCand
CBD),butt
hisdoesnotmeantheydon’
thaveanimpor
tantr
olet
oplay.

Se
ver
alst
udi
eshav
econfirmedthatt
heuseof“
ful
lspe
ctr
um”cannabi
spr
oduct
s
pr
ovi
desamuchmorebenefic
ialeffe
ctc
ompari
ngtotheuseofi
sol
ate
dcompounds
.

Bythemeansofexper imentati
on,apati
entsti
llneedstofindthebes
tpossi
blestr
ainf
or
thei
rindi
vidualcondi
ti
on,whichisacompletel
ydifferentandals
oaveryc
ompl extopi
c,
mostlyduetot hecomplexi
tyofourendocannabinoidsys
tem.

3.Formos
tmedi
calc
ondi
ti
onsus
ingTHCandCBDi
ssuper
ior
Somepat i
ent
swi
llexper
ienceagr
eateral
levi
ationofsymptomswhenus
ings
trai
ns
thathaveahi
ghc
onc ent
rati
onofj
ustoneoft hesetwocannabi
noi
ds.

F
ormos tcannabi
spati
ents
,iti
smuc
hmor ebe
nefic
ialt
ocons
umec
annabi
s
v
ari
eti
esthatcont
ainbothTHCandCBD.
CombiningTHCandCBDisfavorablef
oranumberofreas
ons,andthemainonei
s
theprevi
ousl
ymenti
oned“entourageeffect
”wher
ethesecannabi
noidspl
ayoff
eachotherwhic
hmaximi
zestheirimpact
.
Gett
ingusedtothepsychoact
ivequal
it
iesofTHCs
lowl
ycanbecons
ider
edmi cr
odosi
ng,
andisespec
ial
lyadvi
sedifyouarepredis
posedwi
thahei
ght
enedsensi
ti
vit
ytothi
s
compound.

Usingcannabi
sproduct
swi t
houtsmokingorvapori
zat
ion,andi
ns t
eadc ons
umingthem
orall
ybefor
ebedisals
of ant
asti
cforbegi
nners.bec
ausethepsychoact
iveeffec
tscanbe
avoidedwit
hthist
ypeofadmi ni
str
ati
on.

Thi
smethodal
soinducesr
est
orat
ives
leep,wher
eTHCper
for
msmuc
hbet
terasourbody
andmi
ndar er
est
ing.

Mi
crodos
ingTHC

J
ustl
ikewi
thdos
ingf
orbegi
nner
s,t
hes
amepr
inc
ipl
esappl
y.

Theonlydi
fferenceist
hatwi
thmicrodos
ingyoutakeonepuffofcannabi
sever
y15
minut
es,unti
lyoureac
hthedes
iredeffect—orunti
lyoureac
hthe2.5mgperdayl
imi
t.

Thi
sisanevengent
leri
ntr
oducti
ontotheeffect
sofTHC,andal
lowsyout
ocas
ual
lyget
acc
ustomedtothepsyc
hoact
iveeffect
softhi
samazi
ngcompound.

I
ncr
eas
ingt
hedos
e

Fort
hefir
stt
wodayst
hedai
lydos
eshoul
dbes
omewher
ear
ound2.
5mgofTHC.

I
ftheeffec t
saren’
tsat
isf
ac t
oryyet(andtheymostl
ikel
ywon’
tbe,bec
ausethes
tar
ting
doseisther
etoeaseyoui ntother
apy),i
ncreas
ethedoseby1.
25mgt o2.
5mgofTHCf or
thenexttwodays.

Conti
nuetoinc
reaset
heamountins
uchf
ashi
on(
ever
ytwodays
)unt
ilt
hedes
ired
ther
apeut
iceffect
sareac
hieved.

I
ntheeventt
hatyous
tar
texper
ienc
ingunpl
eas
ants
ideeffec
ts,l
oweryourdai
lydos
eby
1.
25mgt o2.
5mg.

Reac
hingt
hedai
lyaver
agel
imi
t

Dr.Sulakcl
aimsthatthemaj
orit
yofmedicalcannabispati
entsusual
lyfindreli
efwi
th
approximatel
y15mgadayandadvi sesnottogot oofaroverboard— morethan30mgof
THCperdayi susuall
yass
oci
atedwit
hunwant edps ychoac
tiveeffect
sformanynovice
users.

Thequant
it
ieswe’
retalki
ngaboutr
ightnow ar
eonl
yfors
trai
nsandder
ivat
ivest
hatar
e
highi
nTHC,andlow i
nCBD.

Cons
umingl
argerquant
iti
esinasi
ngl
edos e(
10mgormor
e)i
sus
ual
lyc
ons
ider
edabad
i
deafort
hebi
ggestperc
entageofpat
ient
s.
Burni
ngQuest
ions:Whencombi ni
ngT HCandCBD,i
stheappr
opri
atedoseof15mgT HC
als
oappli
ed(f
ormos tpat
ient
s),orshouldt
hecompl
eteamountnowbear ound30mg?
Shoul
dthequanti
tyofTHCincreasebecaus
eCBDdimini
shesi
tsps
ychoac
tivequal
it
ies
?

Dr
.Sul
ak:

Aswemovefr
om s
omet hi
ngthat’
sjus
tTHCtosomet
hingthatcombi
nesTHCandCBD,and
theni
fwewer
etotryt
ogoalltheytothet
reat
mentt
hat’
sjustCBD,wi
thoutanyTHCi
nit
.

Sowehavet
hisent
ires
pec
trum her
e.

OntheTHCsi
deofthespec
trum,t
hatwoul
dbet
hemos
tpot
ent
,sot
hel
owes
tnumberof
mi
ll
igr
ams(mg)i
sneeded.

Aswegettoequalpar
tsTHCandCBD,whic
hal
otofpeopl
ear
edoi
ng,t
het
otalnumberof
mil
li
gramsi
sgoingtogoupsi
gni
ficant
ly.

I
tmightevendoubl
e,thepoi
nti
sifsomeonei
sget
ti
nggoodpai
nrel
iefwi
th5mgofTHC,
t
hisdoesn’
tmeanthattheyc
antake2.
5mgofTHCand2.5mgofCBD.

Mor
elikel
ytheyaregoi
ngtoneed5mgofeach,ormaybeeven6mgor7mgofeac hof
t
hes
etwoc annabi
noids
,becaus
eCBDaddsit
sownanalgesi
a,buti
tcanac
tual
lydec
reas
e
t
heanalgesi
aofTHC.

Ast
her
ati
oofCBDt
oTHCi
ncr
eas
es,t
het
otalnumberofmi
ll
igr
amsi
ncr
eas
es.

Thec ostgoesup,t
henumberofmi l
li
gramsgoesup,buttypi
cal
lyt
hetol
erabi
li
tyalso
i
nc reases
.Sothepati
entsar
espendingmore,t
hey’
realsotaki
ngmoremill
igr
ams ,buti
n
favortheyhaveles
ssideeffect
s.

Ast
arti
ngdoseofar
ound2.5mgCBDpe
rday
,wi
thane
xac
t(ore
vens
mal
ler
)dos
eof
THCcanbri
ngaboutcur
ati
veeffe
cts
.

Experi
mentationwit
hdos i
ngi
smucheas
ierwhenapat
ienti
scombini
ngthesetwo
cannabinoi
ds,bec
aus eourmi
ndsc
antol
erat
eCBDandTHCt oget
herfarbet
tert
hanj
ust
THC.

Thebes
ts c
enari
owouldbetofindastr
ain(
oranyot
herder
ivat
ive)t
hathasaneven
conc
entr
ationofbot
hthes
ecannabi
noi
ds.

Fort
hefir
stt
wodaysc
ons
ume2.
5mgTHCand2.
5mgCBD.

I
ftol
erat
edwel l
,inc
reasethedoseby1.
25mg- 2.
5mgTHCand1.
25mg-
2.5mgCBDever
y
t
wodays ,unt
ilt
hedes i
redeffect
sareachi
eved.

Whenus i
ngonlyTHCthebestdosef ormostpati
entsi
s15mgaday,butbecauseCBD
si
gni
ficantl
yles
sensthepsychoac
tivit
yofTHC,you’l
lmostl
ikel
ybequit
ecomfor
tabl
ewit
h
t
wicethatamount,orappr
oximately30mgofTHCandCBDc ombi
ned.