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Although the fifth edition of the Diagnostic and Statistical Manual of Men-
tal Disorders (DSM-5; American Psychiatric Association [APA], 2013) has
continued the tradition of syndrome-based categorical diagnosis of person-
ality disorder, it is widely acknowledged (including in the alternative model
in section III of the DSM-5) that the threshold for distinguishing patients
with and without a personality disorder is arbitrary and that there is no
From Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, Australia (K. N. T.,
M. C., J. B., M. J., A. M. C.); Centre for Youth Mental Health, The University of Melbourne, Melbourne,
Australia (K. N. T., M. C., J. B., M. J., A. M. C.); School of Psychological Sciences, The University of
Melbourne (H. J.); and Orygen Youth Health, Melbourne, Australia (L. M., M. J., A. M. C.)
Address correspondence to Professor Andrew Chanen, Orygen, the National Centre of Excellence in
Youth Mental Health, Locked Bag 10, Parkville VIC 3052, Australia. E-mail: andrew.chanen@orygen.
org.au
1
2 CLINICAL SIGNIFICANCE OF SUBTHRESHOLD BPD FEATURES
strict demarcation between “cases” and “non-cases” (Clark, 2007). This is-
sue is especially salient for the prevention of and early intervention for se-
vere (a.k.a. borderline) personality disorder (BPD) because the absence of a
distinct threshold for “caseness” also means that there is no distinct point of
“onset.” This principle is foundational to the argument that early interven-
tion programs for BPD should have broad inclusion criteria that incorpo-
rate “subthreshold” forms of the disorder (Chanen & McCutcheon, 2013).
However, the clinical significance of subthreshold features has not been in-
vestigated among real-world patients during the clinical emergence of BPD,
which is usually between puberty and emerging adulthood (Newton-Howes,
Clark, & Chanen, 2015).
A series of publications from the Rhode Island Methods to Improve
Diagnostic Assessment and Services (MIDAS) project (Ellison, Rosenstein,
Chelminski, Dalrymple, & Zimmerman, 2016; Zimmerman, Chelminski,
Young, Dalrymple, & Martinez, 2012, 2013) has demonstrated that, in adult
patients (aged 18 years and older), subthreshold BPD features are clinically
important and are significantly correlated with indicators of psychosocial
morbidity, such as a greater number of current mental state (formerly known
as Axis I) disorders, lower global functioning, greater suicidal ideation, more
psychiatric hospitalizations, and more time unemployed (Zimmerman et al.,
2013). When patients with just one BPD feature were compared with pa-
tients with zero features, the former fared significantly worse on each of
these same indicators of psychosocial morbidity, indicating poorer function-
ing and greater mental health problems (Zimmerman et al., 2012, 2013).
Moreover, when the individual diagnostic features of anger, affective insta-
bility, impulsivity, and chronic emptiness were examined, each feature was
associated with aspects of impairment, but only chronic emptiness was found
to be associated with every aspect of psychosocial impairment that was as-
sessed (Ellison et al., 2016). These findings clearly indicate that subthreshold
BPD symptoms are clinically important among adults with features of BPD.
However, the MIDAS sample focuses neither on youth nor on individuals
presenting early in the course of BPD.
There has been a proliferation of evidence establishing that personality
disorder is both common and clinically important among adolescents (aged
12–18 years) and youth (aged 15–25 years) (Newton-Howes et al., 2015).
DSM-5 BPD is as valid and reliable a diagnosis in adolescence as it is in adult-
hood, based on similar prevalence, phenomenology, stability, and risk factors;
marked separation of course and outcome from other disorders; and efficacy
of disorder-specific treatment (Chanen, Sharp, Hoffman, & Global Alliance
for Prevention and Early Intervention for Borderline Personality Disorder,
2017). This knowledge, supported by recent research suggesting that BPD
captures the general “severity” factor of personality disorder (Sharp et al.,
2015), has ushered in the “first wave” of empirically supported treatments
that have focused on BPD in young people (Chanen & Thompson, 2014).
While these studies are often grouped under the rubric of “early inter-
vention,” it is noteworthy that not all treatment that occurs among young
people is necessarily preventive or early intervention in nature (Chanen,
2015; Chanen, Berk, & Thompson, 2016). Some young people can pres-
THOMPSON ET AL. 3
ent prior to age 18 years with severe, enduring, and sometimes treatment-
refractory problems. Those engaged in the research and treatment of young
people with BPD have been inconsistent about defining the theoretical and
practical thresholds for phase and stage of disorder or severity of BPD to be
used when framing the importance of prevention and early intervention for
BPD or inclusion/exclusion criteria for clinical trials (Chanen, 2015).
Among 15–18-year-old outpatients presenting for their first BPD treat-
ment, the BPD diagnosis (i.e., five to nine features) has been associated with
poor psychosocial functioning, as evidenced by school truancy and poor
peer and family relationships (Chanen, Jovev, & Jackson, 2007; Kaess et
al., 2013). Other studies have suggested that adolescents with BPD are more
likely to have a history of sexual trauma and sexual concerns (Venta, Ken-
kel-Mikelonis, & Sharp, 2012), to struggle with issues of sexual orientation
(Reuter, Sharp, Kalpakci, Choi, & Temple, 2016), and to have co-occurring
mood, anxiety, and substance use disorders, self-harm and suicidal ideation,
and poor functioning (Kaess et al., 2013; Winsper et al., 2016). However, to
date there has not been a large-scale study investigating the specific effects
of subthreshold (or one to four) BPD features on indicators of psychosocial
morbidity among youth. It remains unclear whether these indicators of psy-
chosocial morbidity are elevated in early-stage disorder, at first diagnosis of
BPD features, and prior to commencing BPD treatment.
The present study aimed to replicate the MIDAS study (Zimmerman
et al., 2012, 2013) in a sample spanning the age during which BPD typi-
cally emerges clinically, i.e., youth aged 15–25 years. Specifically, the study
aimed to compare psychosocial morbidity indicators among two groups of
patients, one with no BPD features and the other with subthreshold BPD fea-
tures. Psychosocial indicators included the number of mental state disorders,
social and occupational functioning, number of visits to an outpatient men-
tal health service, number of current medications, number of “days out of
[usual] role,” referral due to suicidal ideation, and referral due to disruptive
behavior. It was hypothesized that outpatient youth with subthreshold BPD
features would have more psychosocial morbidity than outpatient youth
with no BPD features.
METHOD
PARTICIPANTS
The sample comprised 499 potential participants from Orygen Youth Health,
a frontline state government–funded psychiatric service for youth in north-
west and western metropolitan Melbourne, Australia. Participants were
help-seeking outpatient youth, aged 15–25 years, with little prior psychiatric
treatment, who had participated in previous research studies. The current
study combined diagnostic, demographic, treatment, and functioning data
across a total of four research studies (Chanen et al., 2004, 2007, 2015;
Chanen, Jackson, et al., 2008). All participants provided written informed
consent to participate in each original study. Permission to combine these ex-
isting data for the current study was granted by Melbourne Health Research
4 CLINICAL SIGNIFICANCE OF SUBTHRESHOLD BPD FEATURES
PROCEDURE
Participants were assessed using the Structured Clinical Interviews for DSM-
IV Axis I and II Disorders (SCID-I/P, First, Gibbon, Spitzer, & Williams,
1996; SCID-II, First, Gibbon, Spitzer, & Benjamin, 1997). Demographic and
psychosocial morbidity information was collected consistent with the aims
of this study, and the Social and Occupational Functioning Assessment Scale
(SOFAS; Goldman, Skodol, & Lave, 1992) was rated. The assessments were
conducted by the principal investigator (A. C.), or one of eight graduate re-
searchers trained by the principal investigator and colleagues (e.g., H. J., J.
B.). The research assistants were supervised by the principal investigator and/
or a senior colleague (e.g., H. J), and where queries arose regarding diagno-
ses, a consensus decision was reached in consultation with senior colleagues
(e.g., A. C., H. J., L. Mc.). Testing of interrater reliability revealed good to
excellent results (e.g., an intraclass correlation [ICC] for individual SCID-II
items ranged from 0.64 to 0.94; Chanen et al., 2004).
MEASURES
Mental state and personality disorder diagnoses were derived from the SCID-
I/P and SCID-II (First et al., 1996, 1997). The SOFAS was used to assess so-
cial and occupational functioning (Goldman et al., 1992). This scale is rated
from 1 to 100, where 1 represents extremely poor functioning, and 100 is
extremely high functioning.
Demographic information included sex, age, marital status, and educa-
tion. Psychosocial morbidity indicators included number of DSM-IV mental
state disorders, number of DSM-IV BPD features, number of mental health
visits in the previous month, number of current medications, number of days
out of role (unable to carry out normal activities) in the past 6 months, and
referral due to suicide attempt/ideation or referral due to disruptive behavior.
DATA ANALYSIS
tures. The two groups (0 BPD features and one to four BPD features) were
compared according to sex, marital status, and education level using chi-
square analyses. Several continuous variables, including age, number of cur-
rent mental state disorders, number of current medications, number of days
out of role in the past 6 months, and number of mental health visits in the
past month were not normally distributed. For these variables, comparisons
were made according to group using Mann-Whitney U tests. The SOFAS
score was normally distributed and comparisons were made using t tests.
RESULTS
health visits in the past month, the number of current psychotropic medica-
tions prescribed, or the number of days out of role in the past 6 months.
DISCUSSION
This study compared two groups of outpatient youth (one with subthreshold
BPD features and the other a mixed patient group with no BPD features)
on a range of psychosocial morbidity indicators. The key finding to emerge
from this study is that subthreshold BPD features in youth were associated
with greater psychosocial morbidity. This was indicated by poorer social and
occupational functioning; a greater likelihood of being referred for mental
health treatment due to suicidal ideation, a suicide attempt, or disruptive be-
haviour; and a higher number of co-occurring mental state (Axis I) disorders.
The current findings demonstrate that subthreshold BPD features are
clinically significant early in the course of BPD, when first presenting for psy-
chiatric care. The presence of subthreshold BPD features was associated with
the co-occurrence of almost two additional mental state disorders. The high-
est prevalence of these disorders among the BPD group included depression,
anxiety, substance abuse or dependence, and impulse control disorders. The
BPD features with highest prevalence were inappropriate anger, recurrent
suicidality and self-harm, affective instability, and unstable and intense in-
terpersonal relationships. This pattern of symptomatology is similar to that
reported in adults with one feature of BPD, who were also reported to have
higher rates of depression, anxiety, and adjustment disorder, together with
the BPD features of chronic emptiness, impulsivity, inappropriate anger, and
affective instability (Ellison et al., 2016; Zimmerman et al., 2012). Greater
THOMPSON ET AL. 7
age and stage. While both the MIDAS study and the current youth sample
included young adults, aged 18–25 years, the present study differs because
it conceptualizes youth as ages 15–25 years and because these “first-pre-
sentation” patients, by definition, have had minimal prior contact with the
psychiatric system, including inpatient care. They are also unlikely to have
entered into the regrettably common pattern of combative engagement with
the mental health system that is often characteristic of the care of people with
either BPD or subthreshold features of BPD and that often leads to repeated
cycles of hospitalization and iatrogenic harm (Chanen, Jovev, et al., 2008).
Community-based epidemiological data from the Children in the Commu-
nity Study (Winograd, Cohen, & Chen, 2008) indicate that BPD features
in adolescence are associated with poor employment outcomes (days out
of role) in adult life, which is consistent with the longitudinal course of em-
ployment and adaptive functioning over the lifespan among adults with BPD
(Chanen, 2015; Sansone & Sansone, 2012; Zanarini, Jacoby, Frankenburg,
Reich, & Fitzmaurice, 2009). It might be that there is a general effect upon
days out of role for acute psychiatric presentations among youth and that the
effect of BPD features is to prolong this disability or to hinder recovery, caus-
ing “scarring” effects that increase the likelihood of future unemployment,
as seen among adults with BPD (Chanen, 2015).
These findings point to the clinical significance of subthreshold BPD fea-
tures in youth and, therefore, the need to provide clinical intervention. This
is termed “indicated prevention” (Mrazek & Haggerty, 1994) and involves
targeting individuals with subthreshold disorder. The current findings suggest
that this should aim to strengthen developmental trajectories with regard to
functioning and psychopathology. Such programs exist and are supported
by controlled clinical trials (Chanen, 2015; Chanen & Thompson, 2014).
For example, evidence from such trials shows reduction of BPD symptoms
and internalizing and externalizing behaviors and improved social and oc-
cupational functioning over a 2-year period (Chanen et al., 2009; Chanen,
Jackson, et al., 2008).
Taken together, the findings of the current study and those of the MIDAS
study (Zimmerman et al., 2012, 2013) suggest that subthreshold BPD fea-
tures are clinically meaningful indicators of psychopathology and poor
THOMPSON ET AL. 9
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