SYLLABUS ‘The academic year when the cycle of instruction is 2012-2018 Module/course name: | Analytical Chemistry Module code Faculty: II Faculty of Medicine with English Language Division Major: Medicine Am/Ar/Tw Specialty: Level of study: Ineqrted Master studies N Ht [Doctor sues) Mode of study : full-time X Year of study: IXH om ow Vo VI | Semester : | Rea ee Module/course type: | obligatory X_ elective eet Polish foreign X Form of education Hours Lecture 25 Seminar Laboratory class 60. | E-learning ee Practical class e Internship Students work input ‘Student's hourly workload (ounkipacnin cls. prearon eatin, te) T. Inelass 5 2. Student's own work ae 155 ‘Summary of the student’s workload a 240 ECTS points for module/course 8 Educational objectives: This course aims to enable students to develop and understand the principles of general and analytical chemistry and their application in common life. From general chemisty point of view subject also includes: > understanding physicochemical fundamentals require of further education in the field of medical study ie. biochemistry, drug chemistry, pharmacodynamics, pharmacokinetics. > Learning the methods of determining the selected physicochemical quantities, applicable in medicine, mathematical development of data obtained during experiments, enabling objective evaluation of results. From analytical chemistry point of view the issue includes: > necessary theoretical and practical knowledge of analytical chemistry - classical quantitative analysis and instrumental analysis. > development of manual skills needed to perform analyzes. > familiarization of students with some analytical equipment and to teach them how to use this equipment. ‘The matrix of learning outcomes for module! subject with reference to verification methods of the intended educational outcomes and forms of instruction:: Form of Methods of verifying | Learning | 4 student who has obtained a credit forthe moduletcourse has the | the achievement of || __instruction outcome | Knovledge’sill to: the intended learning | « soyide the code ene provide the symbol Tn terms of knowledge: the student describes acid-base equilibrium Multiple choice test BW2 and buffer action mechanism as well a their significance in systemic | MUMPlechoiee ests | homeostasis; Test exam Tn tera of knowledge dhe udent kaos sad ticleniand de al Multiple choice tests BW3. concepts of solubility, osmotic pressure, isotonia colloidal solutions . eee and Gibbs-Donnan equilibrium; Test exam Tn terms of knowledge: the student knows natural and artificial Multiple choice tess ewe sources of ionizing radiation and its interactions withthe matters | pa cam a Multiple choice tests In terms of knowledge: the student knows the basis of Lect /Lab classes thermodynamics and chemical kinetics Test exam Multiple choice tess In terms of knowledge: the student knows the physicochemistry of Lect /Lab class multiphase systems and surface phenomena, Test exam ‘Multiple choice tests In terms of knowledge: the student knows the influence of physical Lect/Lab classes and chemical factors on the human body Test exam 5 Malliple choice tesis In terms of knowledge: the student knows the mechanisms of ; formation and types of chemical bonds and mechanisms of ae Lec JLeb ears intermolecular interactions Multiple choice tess In terms of knowledge: the student knows the elasscal and Lect instrumental methods of quantitative analysis Test exam In terms of knowledge: the student knows the principles of eae validation ofthe analytical method Pree nee Tin terms of knowledge: the student knows the theoretical and methodological basis as well as the principles of operation of devices | s4uttipte choice tes tool in pertoscopseeruochemiealchromalographic and mess | Mite choice texts Lect spectrometry techniques ne In terms of skills: the student determines solution pH and the est | Ovation by ogee ‘of pH changes on inorganic and organie compounds; teacher Tn terms of skills the student makes the use of basic laboratory BULO, ‘techniques, such as qualitative analysis, titration, calorimetry, pH Locretideal by Lab classes teacher retry, chromatography, protein and nucleic acid electrophoresis aan In terms of skills the student operates simple measuring equipment] Op. ation by coo and assesses accuracy of measurements teacher : In terms of skills: the student is able to measure or determine | Ht ere physical, biophysical and physicochemical quantities using Ghecrainnt appropriate laboratory equipment and perform physical and chemical | Oosemvation by Meaicareea! calculationsIn terms of skills: the student is able to describe and interpret biophysical properties and phenomena and assess the influence of | Observation by Lab classes. physical factors of the environment on living organisms | teacher In terms of skills: the student is able to perform qualitative and ‘quantitative analysis of chemical compounds by some instrumental | Observation by Lab classes ‘methods and to assess the reliability ofthe analysis result teacher Te terns file stadt sabe To cary ot sis on he ‘oneavalton By, Lab classes netics of chemical reactions teacher | In terms of social competences the stent will upgrade his ability | Oyceryation by ‘Laneneed to self-improvement, teacher Interms of social competences: the student has the bility 10 work i8 | Oservation by Tabeles team teacher EXAMPLES OF METHODS VERIFYING THE ACHIEVEMENT OF THE INTENDED LEARNING OUTCOMES: In terms of knowledge: laboratory checking test quizzes, midterm quizzes, exam In terms of skills: teacher observation In terms of social competences: student co-operation during experiment, preparation of laboratory report (teacher observation),[ Cour conan iseKencres eoring to he Gnori o ach das Tlbwing te niended aig oboe): 1 Lectures ties: 1. Practical silin cecal aboratony 2 Molec force: hong ital ogah Int and intamolaula forces (Sspesin eres, hyérogen bonds, hysropobic foes, covlent bon), Eft of intermolecular bonds ‘onthe physieal operas a qu, soli and gaseous stat of mater Monomers ad poles 4 The sate of mater. Laws act gases and quits. Proper gaseous a ai slate mati, Viscosity, sutace tension Mure (gas and quid and sold and gui). Coligatve popes 4 Chemical reactions: ringing maleate We. Various Wpes ofchemialreacions. Enzymatic reacten 5 Equa: now fr do eats go?. Equitrum constants, eacton quotont Le Chatto’ nc how o shit tbe choca equim 8,7, Energy: wat makes reactions go pars, 2. Themadynmics, calmer, system and is surourigs, kinds of systems, heat, work acd eneay, ethaly, enopy, re Gis ena, soortaneous ad non-spoianeus reactors, 8. Kinetic whats the speed ofa reacton. Speedo cemicl reaction. Rate of chanical eacton, ate constant err of teil recon (2, is, secon), Variables hi fete speed of ration, Reacton mechanisms. 8. ElectochomistyOxitaton Reducn, Cxdatonnurbes, ndaton and reduction pccoses, red. tration, acre and noble meiss, galvanic sees, galvanic cal, eduction oni, elecromotve force cathode ard erode potent Noms qua, standard hydrogen clactod. Betty in nae 10, Inoducten to Analyical Chemisty. Quattave and quanta analysis -comgarson, examples. entiation of ctons (gous of ations, ame reactions). Quantiatne arly ~ calbraton cues, valdaton process. Overview of anajical mets. Electo- anayical meds (ptenionety, concuconety, votammety), Eecroceicaly base Besensos. 11 12 Chemical nays pans 1, 2: now do we Koow what is there? Spacal methods (mokcularspecroscopy UNV, IR, some spectroscopy atomic atsor=n Secoscopy. ame enisscn spectroscopy) turner. Node arajicalecnques~ Nigh permance Inuit cromalogapeyHPLC), eapaaryeecvoptcress (CE), specoscopy 1 Nucor chemisty and vadocharical methods in ana. stops, Radloactue decay potucs (lp decay, bets decay, gamma decay, positon emission, econ ‘capur, garma emission. Raiaton ber, posiron ensson irrgtaphy FET), computrtreraohy (CT Laboratory opis |. Inveducton Rules Measurements, Graphs, Tals: hw to pena 2.Thn- layer Chromalorary separatontchriques, compounds and ir prysiccchemical properties (molclrvolunalsze, platy, moleadar interactions), mabe chase, Statonary pase, ud cromatbgrapy, thin-layer chorategapy,clum chomogaphy retardation lca, een, crometogran develpment, uaa ad quantiatve rays wih crotg-aphy lechnques,eluotope aris, on song ‘Coles (sperse syst, yopic an phobic calls, ropes of clots, coaqulston, sedimetsion processes facts inluene on coauai). 4 Gallecrophoresis (sparatin metods,troperies of ompeund (Srucur,chage),migraton in elect, electoporec moby, x, capllay secrophores) 5. Sutace tension (ype of ittce, defrng the interacial gion, ute tron, weting,adsorgton measurement ofsufae tension. adhesion cohesion, surface tension of ure ques, hyropnob - ysrophnc maton suracans, moots), 6 Exacton (soupy, mise stent, artton of sts in wo phase system, dstrbuon constant parton cf neutel compounds, parton faci and bases, facts ‘emperaive), prt in canoiwater system, SAR, SSR), 7. Soectosholomety (spectoscopy ht [a parle and a wave nate), wave properties. how fedaon and mater interacts, electonagnetcspectum, wha do specscl, 5 rmessue, UV‘VIS speciophetamety,absotance,chomanhtes, Bees Law. ety vel days fx moleoues, nstumants x measuteg absorpen 8 Repetto ats 17) 8. Themodyranics (Heat nergy, exthemc & endothe reacto, calorimeter, calrinety, ental of eatton, spac hal, chez & physical change, onhaby of reuralzaton, aw cf conservation of energy fal tempers, ital emperatue tice ene, hyreaton energy, enalyo outon, 10 Equirium autumn, eqlbrum constant, cssocaton constant, elects, non lecroe,weak ard stung acs (bases), dissociation, tat, ber soon. catulaton the pf butler soliton, he Hendersor-fasseba equation, he wig properties of ut soliton afc of ton eect of died acs ard tases, bute capaci) 11. Kes. (Chomaleacton, reactants, products, radon scteme, stochionery, reistbuton of lence eltons, hetero Geave,herlytc ceat, rescon mectanism (ares curyarons ful aro, Fish noo heterotic reactions (nucleophile lech, ex), hemo earns (ee adic, itn, propagator, chain eaten, terrain) ,reacten mechanisms (utsttuon, srg, rule steps, vastin sao ermedte,crkceaton, aéston,hyrataten,elminetion, condensation poymareao, yoy) “Tho rte ofeactn graphsin Kinet (rdiontslope, target). hecalsonheoy of eacion ates (colton, energy ané orerton in clision, number ol eatant elec, effect concontaban and tenperatur) the activation eneay the Anheivs equation calayt enzymes ot ~ based atl, specic acon substrate, cl ct te, Ince ft mestens, Mihaess constant, song and weak beng, denaie of enzymes) *12.Eleochemity (oxidation reducer, anode, cthad, ptetal gala al Nemst equation, come ce), ‘pt measurement (pH, 90H, weak andstong acd anc bases, burs, elecsoes, utr capac). "Conduct (ecccuet, on migratn, esis str, conduct, molar cont, Kahlorausch equation, wate soko fsa, acts, bases and tee conduc, lization. gfe of cnzaton. Sabon, equiaence pri. eecro¥es,noelectayes, constant of erizatn) 4 15, Repatiton (ab. 916)Obligatory / Complementary literature: 1) J.B. Brady, F. Senese: Chemistry ~ Matter and its Changes, 4th ed. Wiley 2003, 2) M. Hein and S. Arena: Introduction to Chemistry, 13" ed, Wiley 2011 3) J. Crowe. T. Bradshaw, P. Monk, Chemistry for the Biosciences. The essential concepts., Oxford University Press, 2006 4) D.A. Skoog, DM. West, F.J. Holler, $.R. Crouch: Analytical Chemistry, An Introduction, 7 ed. 5) P. Monk, Physical Chemistry, Wiley, 2004 6) _D.A. Skoog; F.J. Holle, T.A. Nieman ~ Principles of Instrumental analysis, 5 "ed, Hartcourt 1998 "ed. Wiley 2007 7) F. Rowessac, A. Rouessac, Chemical analysis, moder Instrumentation methods and techniques, Requirements for didactic aids (multimedia projecior, movie camera, et.) Equipment necessary for laboratory classes: test tubes, burettes, pipettes, Erlenmeyer flasks, chemical compounds, spectrophotometer, calorimeter, thin-layer chromatography chambers and chromatographic plates Multimedia projector (for lectures) | corect ansiver. To pass the examination, students should obtain 6 ‘Conditions for obtaining a eredit for the subject: 1. Presence on lab classes, Presence at lab-elasses is obligatory. Students are allowed to have one unexcused lab-olass absence during the whole course. Any: ‘ther absences have to be excused. The excuses must be provided as soon as possible afer being absent, sinee students who have unexcused absences at lab-elasses are not allowed to take partial and final exams, Every absent lab-class material must be passed theaceteally, students have to obtain the eredit fom the professor running the lah-class before the partial tet including the given material is taken, Students are {o participate in lab-classes according to the schedule i.e together with groups to which they have been assigned by the Dean's office, If there are any problems with attending the lab-class according o the curriculum, student has to contact the professor running the given lab- class and ask about the possibilities to come with another group at least ane day before the given lab-class, Labeclases and lectures tart punetually, Students who are late are not allowed to participate in ab-slasses, 2. The importance of obeying safety rules: ‘A clean white lab coat and covers on the shoes must be worn at all times. Active participation in fab class. Students are expected to he prepared to and actively participate in lab-classes, Students are obliged to receive a eredit for each lab «lass which is required to be allowed to take each partial ts. Positive grades from partial tests. After having finished 7 and [4 laboratory classes students are required to take partial tests checking their knowledge in the particular subjects. First partial test includes material from lab 1-7 and lectures 1-4. Second partial test covers material from labs 9-14 and 513 lectures All partial tests take place during the lablasses acconding to the curriculum, Students are obligated to participate in partial tests cording o the schedule, ie. together with their groups. ‘3. Positive grade from laboratories In regard to laboratory classes student has to receive credit at least on satisfactory level (average score from labs.2-14 tests and 180 _midterms should be min. 60%). Student can improve their score by’solving additional quizzes given during some lectures. AL Positive grade trom final exam FINAL EXAM Only students who finished the whole course of General and Analytical Chemistry’ and have average score ftom tests min, 60% all partial ests can take the final examination. Students who have uneNcused absences at lab-lasses oF average score lower than 60% from all Partial tests are not allowed to take final exam and must repeat cours, Final exam test consists of approximately 50 questions (multiple choice questions, multiple step problem, short answer, lab related questions and tasks based on given formulas to be solved) covering all topics ofthe program, Students obcain from 0,5 to 2 points for each fof the maximum amounts of points. The final grade is presented as standard percentile seale 93-100% gives 5.0(A) 92.85% gives 4.5 (B+) 84.7795 gives 4.0(B) 716 -6%o gives 3.5 (C¥) 68-61 “ogives 3.0(C) 6OMoFless gives 20(D)‘The name and address of the department/clinie where the course is taught (module/eourse); contact details (phone number/ email address): Medical University of Lublin Department of Physical Chemistry Lublin, ul. Chodaki 4a, tel: +48 81448 7202 Head of Department: Prof. dr hab. Tadeusz Dzido Contact e-mail address: tadeusz.dzido@umlub.edupl Coordinator of the course: Beata Polak, (DhD) beata.polak@umlub.pl Names of the author/authors of this syllabus: Beata Polak Names of the teacher/teachers conducting classes: Wojciech Markowski, PhD Beata Polak, PhD Anna Klimek- Turek, PhD ‘Adam Chomicki, M Se Signature of the head of the department/clinie Dean’s signature \ noid.