| vo\ i"
Pathog 4 Assianmen
Krd ney “1
RP. Sang eedh
Roll no: 74use (a
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| in the oer
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| oligania. and mild te moderate hg poens ian
| raltisystem discascy a8 SC & Mero Seop/e
Nephvitic — ;
+ Glomenulan disexsea proserdin with a hephritic
Syndrome ane often chanacteuiyed a inf leanmslion.
“the nephritic patient usual presokt's with
emalunta , ned cell casts jh urine 1 Ty Te mid. 5
sAedte nephritic Syndrome mag ecluaih
Pally ang tte
Pastatire toc occol Cal omerul &f haitts :
Ths [8 0 poster pica lomerclay —_ |
immthe Complexe etidogy , which tg olecrecyi ascally |
appears | te 4 weeks afte a. $tropto coccak infection.
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phar nx % kip - |
» Poot Theplococeal lomeralo nephritid ecewn A a |
greqoertly in children toto gers J age, buf |
ohldrcn ahd odults ¢ any age ean alee of ce
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Et > paleg enenigs :
Post wtregte coceal lomeralo nephvitis 1s caus eck
| by Ipataone Complex» cents ATreptococeal exrlgony
and apeciic wutibed ica, which anc Jerned incdite
“Wephrife genic one Typo Rig, ] nck rel {ake
fre A P-haemolitic watrepte cocer
* ITrepts coceal infection may be identified b
culture oy may be ingoned frm elevedled titres
4 — against dtyeploceecal antigen &
Thue at + ante- dtreptolysin o (ASe)
‘andi ~ deoxy nibonvclease B (anti-bwasn)
- anti - Sheptrinase (Askao-e)
vandi- nic ctinyl aclenine dinuclectidas e,
* anh? ~hgaleronidase
The inetting andlgens we maneganente planted
prom the cinealition in dubendothelial Loceibony
| in glomeralan capillany walls , Leading te in stu
| formation immon® compolecey , where thes elist
| Er ermarton neaponse Sabsequedly the aut! on enilady
complesc digsociat @, wiyrate across HBM , and ne for
| on the Subepitheial a7ole ¢ BM; @)
Morpholo
The clopate histologic picture is d enlarged hyper -
| cellular gional “The hy porcellalenity 1 Caused by
; Indilfreition by deuko cpt:
* Prolifanettion 4 endothelial and nes ansial cella.
‘En ephe Corey crescent formation.
These ¢s algo Awellin endothelial cells ,
| ond the combinatian prolif eredisn > dwelling , and
Leute gle infiltredion obliterates the Capillary Jamons,
Thane maybe tate stifval edema and. inf lammation |
wh the tubal after Cobain Neel cell casts .
granalan deposits y Iya 1 and C3 and “Aometines IM
lag Meh a oy and ls the &BM.
“The Chanactenistic electron microscopic qindin ane
discrete , amonphoay , electan -clense depertts on Ke
epithelial Alde 4 the membrane , often having
appearance 4 hamps 2 epreacitin the anti en vashbady
Complexes at the Subepithelal * cell danface
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*In Linmone flurry escen ce mic Fo6COPS here arc |
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|Clinical Course -
Typically , The patient 8 a ge child,
Preventing with acate nephiitie 4 ndrome , havin
Aadden and abrust onset gellowin ah tpidod. Ane
throat ov Akh injection I-2 weeks priate FAR
oleu2 lopmest ¢ Symptoms ;
the Acoli include microscope o intermitfed
haemebwnin , red cell casts, mild non-selective
Posteinuyia hypotension jporterbitel oedema and
polly sligunia
+Th adults ,The deoture> ane appeal andk include
sudden hgpriten sinh 1 Gedemd and. apolacmit «
b.Ra id | Progressive Grlomenulenephritis :
“Rapidl frogessiee glomenule nephrti ie a cdg ndvom &
asgodoled with severe olomeruslar Pap ang , bat oloes nat
dencte a Specific & veg ht jd 9 lomenslongohrti
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“dt 1é chanaclenin ed bg. napid ahd Pre gressioe |
loys of nenah danction asgocided with seve olfgeia. |
and Bans 4 nephratic dy ndiorme |
i6)
tiepcllg chedis
A nambder Primany, lomeralan and Sq stoic
diseaty are thanactenited ba fermation of crcaceets.
RPM ane divided ints le
Type.| RBG: AntintnBhdlscade
A nambey of dgstemic discasee Auch or
9 G0 d. pastures agrd rome ; SCE, Vasealit/s , Wegener's
GPanulomateal’ , Henoch -S chenlein porpure and.
ilispadhic mixed ergo glebulinanensa ane adsociakd
with Cresecndic tiv
Tyrew RP6N : T mune Copmploge discase -
tt mall proportion Coed post - ahreococ cal
AN , Pwticulanly th adally and Sometime q Non-
Shepto ac ah origin | dl evelo fs RPE. hranulay depeaits
immer complecer of Lath and eg along tho
g lomanalan Capillary, walls» lewenin { blond
Co mplerrcid Dewel and demon stron 4
a comp lec af )
ty pC ID RAN: Paver immons in :
Theace includ+ caser of wegenu's
granals modoaiy and micro écopic pay othewhit nodosa.
The petegenesy 4 Pauci ~limmont Gb is act not
| pully defined. loweven Prejortty ¥ these potterty
Fone ANCA positire , implying a aefe ed in Aumoval
immunity. Sonam Complement devel k cre noarmel
and artt- BM ands bed 4 1 pegatim .thae ip
LHe ov no glemeralan Fminunt depose t
Morphologic features.
resely ythe kidney e are ugcel lu enlorg ed i
aol o with gmooth oaltn § fee ge!
Showy Pale eorterc and congeat eal medalla
Hero g-copie f irding
Cilomenali Show patho anv VC crescent?’ oh
the indlde 4 Bouman? capsulea- These are colledtonr |
pale “Haining pay onal ella wheln commonly
tend. to be elongated «
* Tabada’ Tibet. epltheliok cell Show hg alae
droplet * Codaine RBC cats + fibrinfy
Trterstitiom: is oecle maload- and may adhow only
| fibrosis Lr fla mmator celle) wsaally Lymphoc yteg
eves in the
and plasma cells, ane ene
antensh biol tid ux -
Clinical features:
Genenall , tle feoturcsef RPAN ane dinilan
to these o) acute an , prevesting am acute penal
gailun The patties i § Goodpastures byndrant
Pray presct aa acute nena farline and/or assoctellel
inte palmonan haem ermhage predaciny necaned
haemo sty iy.
Mephrtic: dgndrome_
Nephrotic dyndrame it caused by a“ olerongmit |
hh 4 lomenulan mapas walls —_ in Increaxdh
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lgiaadar Te plasma proteins, The manifeffation au
* Moosine proteinlur’'n.
“Hy poalbumine mie.
“Gennalined edema
: Hyru lipiderva and [rpidayin@
Causey :
The incidence, of the Sevnal canaca 4 the nephratic
Sgndrome rey merit to age and geography
En childten, Primang glemoule nephritis iy Ths cause
th maf 4 Cases 4 the nephrotic Syn drone. nos frequct bing
Lipa hephrosis
“In adalty dysTenic oliseao (diabeto,cny|eldox k Ste)
nl ment freyer] ctuade nephatfe Sgndrom?
Hembranous Nope pe!
(membranous nepphr» pathey, is chonlerne by ee
hiker 4 Te {emenalan tala, wall due to the
Becumulation q deporte cordsing Ly clon the Subpithe
Side 4 the basement membrane.
Membranouy nephropathy 15 0 fom 4 chron
immune compet - redislal dixeod -In secodaa
Membrancug nephropathy the hneiting arnt chy COR
Sone Timey be idedi ted in He immune Complex ep.
The aura oa may be endegensuy orexe genowy@ —
Thy disorde, uauall prevesde with the ingidiowy
onact 4 the nephretle Ag ndrem e 0% jin Sz
Potties» With Non nephrstic. proteinwia- Hemélunit.
¥ mild hy pentension bre presckt rh 167 40 4
Coch CORRS,
_Hinimel chang digeas.
this nelative! benign dismder ig character
by did duse ed facement dort precedscs o viscod.
epitheltal cells ( Pode cyte), cletecTable only by elechon,
leva kcqy, In glomeruli that appean virtually normal
by Light mricte § Copy
The peak incidence (+ between 2 and cynid
age - The disease Sometimes follow a nerpinale
in} ection 1 noutine Prphylatie Immun it tion