Artie Safety Assessment of Alkyl Esters as Used in Cosmetics ei ‘eam SSAGE Monice M. Fiume', Bart A. Heldreth?, Wilma F. Bergfeld?, Donald V. Belsito’, Ronald A. Hil?, Curtis D. Klaassen’, Abstract C. Liebler’, James G. Marks Jr’, Ronald C. Shanie, ‘Thomas J. Slaga’, Paul W. Snyder’, and F. Alan Andersen’ ‘The Coxmesicngrediont Review Expert Panel Pan! assesed the sfty of 37 ay epter fr ute n cosmetic. The ali esters Included inthis assssmenchave variety of reported factions in cosmets, with sn-condtsoning agent tig the mo carmen fonction. The Panel reviewed salable anil and ceil data in making determination of ety on thse ingredients and here there were da aps. sir in structure, properties, functions and uses of these ingredints owed or exapelaon ‘tthe avaible rovcologes ane to ast ne sey ef te entire group. Ie Fane! cncled tha thse ingens ae eae osmeti formulations inthe presen practices of ure and concenzason when formulated tobe nonrlanng, Keywords allt esters, safer, cosmetes Introduction Cety esters is indicated inthe Itrnational Cosmetic Ingre- det Dictionary and Handbook a 2 sytetic wax composed ‘of a mixture of esters of saturated fy aids and ay aloo With eatan chai lengths between 18 and 18! The Cosmetic Ingredient Review (CIR) Expere Paz! (Pal) reviewed thi ingredient in 1997 and coneled tat cep eters safest ‘ed in cosmetics” ‘Cty esters ia constituent of «broader group of cosmetic Ingredients, the alkyl ets, which ort ofthe reaction prog: ucts of fity acids and alcoho. The 237 allyl ester Being reviewed in hs sty aesument are presented alphabetically fn Table I. Although 57 ofthese allyl esters have been reviewed previously by the Pane, they are ince beens thee sractral and fictional similares alow or he prop ing fal alkyl exer, thereby creating a compete fey. “The conclusions reached for the previously reviewed ing: ions (nclading ety estes), alongwith summaries of the st included in those existing Safety assessments, re provided in Table2 Only new dus availabe for these yl eer ae Include inthe teat of ds suetyemensment 1 rapport safey of this elas of eames ingreiet, Inadditon the Pane! previusl concluded that many ofthe Individual constituents tat rake the alkyl ester (i, the Alcohol andor te aid), ar sate as used in cosmetics Beene the safety ofthe individ consents may be relevant othe safety of theses, Table indicates wheter al, one, ornon of ‘he individual costituens of each ay exes have ben found ‘safe for us in cosmetics, and Table provides the covelsions previously reported for those individual compo- ents. Duo the indo contituente are salable inthe exiting CUR eafery assesment ana not Summarized har; however, the reported manimim corenta- tow of ee provided o reflect contexal const. Chemistry Defriton and Structure ‘The ingredient inthis evew ae aly ets. The core o> Sioship between these ingredients i earbony eter fine tinal group flanked on bth sides by extended ally ean, Some of these lk] chains ae surat and se ae unt ‘ted, and some ofthe chains are staigt and some branched Formal definitions for the ingredient nln inthis ase ‘ment are provide in Table 5" “Comat bye ew Ser Scan aa, Wash Se Wa ue Comets beter Reve Chan Wing. 2 UA 2caimete bye Reve Eero Mes’ Wasp 0. USA ‘Famer Ove Cnet nar Retn ngan BEER itt" Coineae yee: Ree, M01 Su NW, Soe 1% Ena arise ear,Algae Group raved Apt ‘aig eh Cooter ‘ec ena ict esis open Sint erare Beothoncare Shey ceae eiecane concerts Scere Eoseitaene rites eoaceae soccer Seolanone Sonor Eeteacant Soap cee Sr ar Boreyoorarftaeex Bestop Personen Sesleget Ciotnowars Soi seae Smee Foster Sonata Dependant cernte Sign exanchane Segoe orn Ssgtenene eyo cane Eee Soyo emelie Synalar! Boyoc cance i Boece se Egon 1040 ol sedce Beet pore Engen cco ieee ecg ocyodecs yen! ernst — Eyer sonoma 1450 a beeae Eoyhenh somes leds aly sare Eyes! coment ede ah bexemae ener! rte lean yl chests ewer Epa mea? (2040 ag bate Edyheny mopemnost hoae eee fete ee {080 shy bee hen oa S050 mae shea arnt’ (Cie eet are yen pargeet {C0 a emer Eyer ar eset com epg dence Gant bere ipgiancey somreete Ge are ‘on bern Se tonne es once sea See ea henna (tay endtine eo exer stay sonoma Henle ir rary soanene™ explo sae ‘ear ce ee ae leary pate Har sar {Gear pa Henpoteocyéegt ‘Cea fee bate ‘eronntarate Cert ter dregeana hn Scoromacae — coy bem repented ar aap Ceol = Esaieorace trogen cto of sant eal secmocnante P Estero rset een ae Eee sonnet eared een! sate cet rce Freseated ioc see Eat terested apap obs etme Herne sonente Hraronecouy ‘eomarae bowel oe. ‘irc CR Come byte Reon ‘Theoden na romed rao eC Neyer ae epoopaac pep et apron sear open tere (Seay oa svar tree Wena ercne ‘Seer ermrterte ‘omar sono ‘oar ooewste ‘sear rate Vesa! ete hove mse eta mopencaet enter pe owe nononnosn? ‘owe tate ove met own see (Sir beterFume etl ss “Table 2 Conon (Yarn) and Da Sure Previously Reid Aly Eters Nien CCncion (ear) Soran ‘erence Fal roprt onthe soley asenmene of cio propre "heh ‘Swear sed (990, Thence rl LD ine was 20 gh sp 2500 meligaconcenraons 34 Tropone "reamed 200, of sn como tnt ns Eyal ap Nota prinary trae to rabi skn whan tad undnte. 2 formation nang Pas nat raing na hor SOP and Islan a ener a unaid nsace mah tag amare Ion enor s enter when ced rdf acs a es roc eomeopenc whan ned undhed ~Unatte ert atria formuaten cnaing were 0 ‘al rapr onthe amended fry tamer of mic dit and rare wed oss (2010 Fra repr neh slay se of bre (199) Dien do yen ney pte erpleted nd abo aed ne detranton of sly (1990 pon) Buy mest Sates ued (199, 2010) ~ War served to ean deel perineal Theor Dana 8p = Ainge apcatin of gg ws rao an oniraiginabie ~Arthourscse spleen rt mes pratced modes tretaion = 208) aie acer sant at ht seen ‘Rs pigs wen jc acermaly —Nanerentag be ye! Ceol myrinaca Stead 2010) “Novara e's lable, Dey myrtare Suet ued 010) "No aa were se yen myiace Safes wed (2010) Ns a were nla Iebuod mate" Ses wed (2010) No a were ble Icey myrate Safes wed 2010) No hn ware eable Noaecy mate Seas wed 2010) Ne ha ware ble Nopropy myisate Safe wee (98 2010) ~ tna syn whch mee were expe for § seconds a arse ‘iperpratconaing an srspeces conerraton of ("Chapooy Irate aatbaan hte sled snd svel mer eed ny 025% of prayed ve war sborbdne tout trend The scat ol [Dy war 16 Lg nt an 49.7 mga ce The eat dermal UD tes me pkg coal psn of? ge ‘ermaason conning 64 20% n bbe 26 dy GD aplesont) d ot rosie sin of ott bt i ese sere een and mest ‘fora an ihr dnl fet nd crecpcny rari tos Scott ana hyperarst and med irre ca ers pletion of? mul florian cntating AICATS ra fr 4 tots 21 aplasons) rosndeyehems ema rng kr nd srg br meroscope ec were ony sen th npcason Se "hour laon expire to fornstone concn 166208 03-4 mg) tnd 47% (87 mg no produce ny dae or tence ef ee ‘onc intr avec alton sin olan cong 6%, rs ast toto ganesi lymean enerton 063-24 mg flor tre chur expnral) ut chapter cough wheean Irony Macrophage carlson whet shes nd encase ‘als wore see rth igs i det propre donge ofthe seat G3arargin nar) A 5m catenin ojopaleha sian sclera he crchogei sty of 015% belsprne on ten ec: no amar ware Frodutezn mee yapicton of eslaan for [8 mest ops of Toxo wo te bet of Sets mice ok ent rsa te read ercnogui tine ~InDraze et etd et mater a 56585 frm wt a ‘simi tag eS frat Romer aplatin of Satie et ater oes was mara oar tay frodiced comer cy fase ee Beewwee (ented)8s Inert Juri of Tso 3(Soplement 2) “Table2 (conta) Higher ‘Conon ee) Surary eterno on ign atria was no rating (IS wee and ‘he phe Pl wh formato conaring 1550 es 1 SON) rary stato sadn imate acon se, nchaed es, ‘ter bj) ae frmucon conan 13S O13 secs) ‘fee in renog no tne wa stn mcm sae [cn gec or 129% formato: 25 jee) or RPT (IS and SP Senn 00suhjec)aformaaconconaing 29% want hotene {10sec oa sotalergen (25 secs) Undid ri os mira riating to a yes a Formuton, mating ISICSEN wre nore told frang Nor anotave mth Somalis es ed es ware sen read erm penetration enc Tidy in wch monte were epord fas seconds tan rte dpenprancconasing tt maura be dbton mt ele a a inser coe hcnted ony 0288 of the spre dose ma sorbed a "ha 10 ofeach the ona pry ce. No ater dts were srble owidact Seeseuseé (oi, “No auwere sabe . verses Lampe Sf and 2010 pte myenace Sle ed (982 2010) leona myristate Safes wed 2010, No en were bie ‘Tracts ou LD rats was 44 ge “Th ate dermal Byp mer wa22 he ive ce mcr as st most ray ening ais produced comecogsescviy brs Inher si, forulcon vas no an rian QD secs) or ei (196 90). Unltd art 158 50% com oa formation coming [S805 wer on t9 mim eriting i Ccyioieed —Sessaed 2010) — No en varemeaibe : Ob mpieae — Seaswnd 2010) — No dn ware sabe : Feeadojocaies) Stesiwed Q010) Ne dn ware alte : verte “Tidcpmpricee Sle ed 2010) —No de ware atte ‘ Fea rparon te salty stein uy eke, a nbn wa hace art grap nei, Ini seated ot nee inl seorate Sveasuned (1985, —Thescuttord LOwinratewar>32ghg ina Dyeerfeedngsudyncas wih 78 refined 2005, upto 60) glo tes aril aad tw wa cere -Bhcaryneouscon f 629800 ale dole for Owes pre ‘rang na ery, aro, horas navi ba grow at Acute pre: ad pontwening — Urata mao tot odes ning (none) ce ‘btn (aged Yom Oto 279} 0 in pyooge slne wa hoa ‘erin pen pi when este ig nears coos ‘ner of wey comedogene in rasan owe ty -Inhurasaring ned Aho civ pc eng th 29 {emul ethene of003 and, spectre fb of wb ‘ox paced 50% rier ol war se moses bd ra ahd ws ee Sraern an RPT (I secs 1% mormon was Noon ane Sri (4 mb or hr (2 bec) Ceymrate Sens ad 1985. Sn rll seo a ld ranean war not seer nan ‘extined1005) APT TT maj hoops seetaton was apo I dhenpstnras Seated 985, Theses rly rat nn 28 lag ” (Creal oy retlomac 205) —Undintere atartnssmost iy ing orabi kin kan sy [aahinatedy care nso oy. i eater ae 3 ‘Melo 67 and wpa trad a 0k 3g ston Fass Mo Oi wae etna wel ert —Nene Conaison yen) —__Sarmary ~nhuan sri + orl onang 76% wa nota rior ‘Seua (86 lect nex poss (1 sca). noes Dhotrenzer (17 jc) ough somes recs were eporind [nthe phroeeaan ty = Unies ws mater nt provoke ary sigan in ib eyes (ac P487100 | Bow ease tne Parl ote ht the ero oy of. sare! wa reed ft sty peor on ety ‘Spates mgd Gt he sony epee fr mie ‘Soy ssc owt se ecency aa tpn he exer of “Lathes aterpuon a eon at wl be expected eter ‘Sehepecreeon he pte or ty besa nse’ ‘product only war not sah obs tte Uns ese acrwa dyeing bi oP 062) na esfned 208) how ecu ay -lehunan ang irae adn seer when texted ised in SRP (19 ibjoaSOK m neo warner > ‘bu eure ieccconete scotmrn tegen fortirttt cams | wae “te Emme SSSA wants ae “Eo cyte enn eee rg raked cea ee ee ys arte Safe ase (1985, — anu pore concent supe rs aveonormution i Emaar Unidata wasnt at sl (= 00) thar asig ormulsrs conning 39% 98% produced non ‘aon nope and clove patch ee 2-10 wba) Una et rar proses sgh vse njconmelvng oy fenjncive tM hour andnoreation wat obarved on Sgt 2? ral epcton the sly aaemen of person na narnia he nora ee auc te Bacasze ofthe sn ponetrton entancean ropery of searenic nln the presence Pamnoberoie scr ond et |S tormutcing prose consigned conan wit sny [reers whore sty mabe on Ser opto or whet ‘rma! steorpeon wart concern bce sel suse ve boon ‘pore, hn mi be io eects pathogen wes oF Ineceaus goes cert ‘Slee zed 010) ~The ol Lg nice wa >5 gg in a rl sty in which ats wre ded ‘france wth 10,908 or 1000 gh, verse Sy skeracare ware adn che Ther feral mi on rd esd fe hh dove a and he NOAEL wes 100 metal Nota roped nae dy whieh 100000 mph wat disarray eo gv rs on oy 15 of pstion sd he NOAEL ferrteralan eyo fatsxey as 100 mpg —Necimzagenn a oes coer pt S00 pit who iho Signy erasing othe sn of tle ce and noting obi kn ots era mga ys (5% jected raceway neon ad Eng OL be nef cometngente ne or“Tale 2 (conte) Bier exe nontons Ceo uonorncnie Een Etybont esr Sobel mtr sera ose soweeot eee nsratinl Jounal of Toxcolgy 24(Suppemert 2) oneton ger) Sorry ea ‘aul 28our SOP (2 secs» oon comaring | swarnorsconac laren 3 masiinon (25 uj) a uncted [hectare eran Franc a sear prone RT (0 ec Ther Layne wae 3h ~The scata dermal Dig wae >2 hg andre wan era ian chee ~Unained st maar (7% pur) was nonin 0 abst nota Sere rs GPT (104 or racaneous nation SOX Tor topes Induction 10% calrgs, sesame of was te wei) = Nerina na roe ee a doses op 510 ppt we 2 wot treiotestaon mn eng nd at acr (7% pare) wat moan eka n= ‘Show SOFT (82 ubjecsyunded tat mara ws hot an tanto Sevier naa RPT (06 sje) ‘Uns ext rar! wa ial eng © a pe Safes wed (2010) die were ae Ses 01) “Nowa Ane ds pt SD ae who wa lama ar nde es mater dir ato for alerge ‘ont weston nan PT (1 ec) Safes we 2010) Ssfe se ured 2010) oa Safes ure 2010) ‘Sie muned 201) —Inhmanesing a araton conning 51256 was nota rt or eer iT (0 sje ander coving 26 No ‘Conse strpr in macnn (26sec) Sse as used 2010) ~The nner LD rac wat 25 gi, 50 an 000 ghd ced moral nal dese (10D 1000mgh nde ver anche toxic Seek ortynrte ~ 300 ah wes) 060 mah ( anced rer a aren hind ny Sera sy Roc embrotoue or toe nats domed by page wth 300 my on Sis 17 psc Neiman han ese a oss pt 500 ye weh owed Imeiboke scan Sighting to bbe sn (ty dei orprovee) “nha ay oro anya 0 ec) 5112 (7 nae) were nor rn or sears RPT an ‘Srmaton coining 466% was not canteen in» enon soe(aesates) Noting to abit ee (concen ested was ot sed) Sofe sewed 2010) — Nedra were site ‘sfc sr ured 2010) Inhuman extg a formlaon cong vas noc aconac aren int Imoxmanton at (9 eee) ‘Sfesrwed 010) Rega weresmtte arpa anh ly ascent of cen etre Cen etes hie ued (1997) (Sonya weh shee parce: wa coment can etre Frtyradonconpia ts sare of neo nore fhe lowing et ‘opp yrange prey racy ya ae oar ere = Theol LD mice orton onan 6O%-5% wa 20 gh = Norman conaing 668% miro ring o abn Sesour SOP onan)Niger “Concsion er) Summary ata eee ‘Besson ter carom he fy est nce peat My esac sare ad mp strate mere raped rm sey Fa report onthe ley seen of pata, ey pit. and open paiate ‘Ce pmiace Sle ae ned (962, ~ War quanenaly neat nth cof aerate when aa 20K the 8 resirmesin 2005) See ese oa LD was > 44 gh rs nto in yay ty fn =o moray was ohierved when 2S sur wa pled ai sin Ader a ote pth =a mos ly erating ner when ape undated ob ‘ermacon(25%27) unser season I penton prods s ‘nso nd was not anes Ina je es ones ~Ethumans formas conaing 27% wa nt prim i, (lO sabeca manson sud orutuon seeing 25% wat {lied ar: weak pen rte ht as daly to presen rk of omact semton una cnaos of normal ie (0 sees) ard one omaring 27% ws cased ay wee poten sear fh eae {Fie (5 secs ormston conning 27% na not porto (1D ‘tbe or potosergene (8 sate aw eraton per a ‘hrerved fre tds 2-5 ys 30-10 steers) Minealy rng 9 ate ee: lege Far 03 eo 6 for anes tee traland 80 or 4 fw) daproon yen pmite Saved (1962, The we el LD wat >A mg (Gry, oy retired 2005) ~The sae derma Dy wea >94 mn abs (nly 2 abi n ech paint) rsp eral ony wnt Oban na Sek eal) wth ‘halted me anced ws mal wpa erated a Oday uy th “onesie carats” 03 rie War ml rian tated rite a SOP in bb 0.1% epesone ‘wer not eet th andre’ aco tet gare we lnhaman st, 3 frmtons conan 5% snd one onan 4% 50% teed oat cca ts th 100 ues m3 fords fenan 5.72%4652% teed nan dy occa PT wth Tnnete rere notion adh ny ache RIT ers conan ‘Tioe ceuted spa of raton 04 uc dey mae Gi oruncandet matarlrigeé for 0334173 Oris, Insaang tat ec or re spflen nr o rabbi oes Isopropyl pasate Sites used (1962; ~The sete ol LD was 264 Ug st ested io 205) ~The sera (Dy war ®2.0 megs No alonconay nats exposes to 200 gf fr | hour = Urlied ster was noir to sigh renga sn “inhuman sgn 3 ute with our ccs pces with ute ester perormed a toa 160 set hare wee aon Serr of 0S ant reine na a Oday gee ison Sa oalon coven 68 arn renga TOs ot ermine hen attuned an IT with 10D cer fermion a 46% ms anon est th 25ers rmation Sonn pn (se) Pree Strange fom 0010 65in$ Oris sade denen ta not aise spare ryt ab pes ‘al rapor on te fastest of es onan (osu ol yeep tro pee erate, yen enolase, "ell to pomssum rinls sum raat sn elt, ce rant, sy Aol, geal sare, ope ‘ele mei ecole a cp rile ‘ecstatic cnn (st) sd i hich oneness a rch resided) meee Succi rapon we ean say arenebs remover jour of Te “able 2 (conned igiener ‘Condon Ger) Sorry a rt 2 etree ‘of sencation rections to rtnlec ai in pales wih eczewatou | ‘Shoots were ered ob epee n Sa pase pra a nthe eur poplton an cd one Paes xpretn npaone he Irene f pave racist fenloe se was very ow Cen enolate Ssfearusd Q007) The see ol [Dy mie was”? Bh = Noe ein oben et coneanendon nt se) prop ‘Sfesewsed 2007) Ne wpectie yd were ale "enolate COtgldodey! —Saleac sed 007] —No space af aa were male Fal porto te sty seen of Cc me (coco) ol nd rated nent Daca ems nue thers reson oem he ttt from “oat of econo, acon sod, eroganate coon Iyozaned coer al and hrsfore te ta wae on ete Ines ne sppordve oly: acess procedure noe be ‘ime ye Cosmas nyt i pus estos 2 Py Deo cose feared (B11) Nord ware wba Elgheytcorome Searund GOI} Nodes ware sae Mullen” Slesrwes(ll!) No ea weresle (pion Stearuna Gat} “No ds worse Scpkieot” —Stestund Gott} “Noda wae sae edhe ects fest GO) Neo dt were site Fol repr te aay sort dof ada las DepheeSMesrued (98, The seca La mas> 40 gard gh ats eaten 2003) ins primary aural ration ng rab te Pos 10% slash ‘corral soluson mmr nue ast rte were 08, 105, sd 020. pec and im amos Dre tn SY seluson polyethylene soran sara (0) pone (8 ahd mate ah Sale aremserl were oni nan Ben yn ab ly ‘Spletn a e 15% soon produced some ape ovens bt at [erry wel nated nde nated mar eed nan ang, In rab (oa ered no ated) nd vescas mI rab was pom (Slated 5X ston ncn al wat net sentar abe Lande! cob ee pies pet Inhuman srg osetia was eporcdinan RIP in 13sec ‘ormaluson nang 13% orn 402 ec wah Afomalatons ‘Remose vey ig iar ob ee when dias "ate [Dn wat > 40 keine Unde tat marl ads Pf 0 3 bs, bt beg astng ‘ports Pf 018 and adios es wae 19 eon Pyoneyene sorian sara (3) preverate 28) and ater Fade mater was nrg (Pl core f 0 ad 1 forthe ‘rcted aera snd or IS olon nan Best nae ‘iy aplaion ofthe 58 soon prodved eno macle pope, Sn vec but ae res wel ler andthe unt mae Dooly tesee th congerte demir cfectsaSscaen star s {erates oe anne alesis nen bjce and nay cane taney tin eect wih nate ‘marl be iraon core wat 1.5756 — etme vr igi set Boyes when teed ued Fea par one ly ase of hep onto eopony ‘ese aed (992. —Unalvted we matrl wat ronerian (Pl ~ 042) nab sn 24a 2 ‘Cemiase enfin 011) hows aspen. and nan Beak Sy» 10% 4 soon mar ‘eat waren IMP 200) bathe hd car as poory (onsFume eo ‘able 2. (Connon) as. ieee (Conon er) Srary da ‘led QP 330 i cn fr Sn od 10% ag ad ed ast rar ere gt car kre in ie ye Dan ten cnet oneal a (ea ren. et Iran nd comecopercy a) were sible te Pel aed non Siu opropy eters ta hed sendy bean reviewed sound ‘erin ey Fal rporcon the malay assent of opp noite Ueopropltsete unto suppor ~The are LD of IOR corn was > rg “ay (9) 10K aga nce ees natal wae cased se cd frre sige when ety weep ‘ih pre salsa arora sn ran so 10% neon ‘Sant prosict ay entacn eto alba rates TOR bantu ast aur ware sgh ear eras whl 10% Denn tn: man acon md seen tad eats at Fra report onthe sey sesmant of Hosta neoperaate ‘comma Sf ar ured (1985. ~The seat Dae mts 40 mig in sn 99 dys, ‘eopenancite reamed in 2054) agravaon of one et ater In was se nar of ‘enantve steer = Unted wx mace spd der 2 24hou patch was 0 tag so speech re erucd swe) adn svar ender i cob a Inguespt omuscon conning wars pon son ian swe oc poco SOK iar ws may emeogen nd “ralued was roncomedopn nb hana ering wa ana ins 4a SOPT whenteedundsed on formulcare coneaning 33% 10 100 sujeca) Sk fora (Goes) wat mney rtag (P= 0 and ID nerminon wat ‘evwring 20 uajeca) in 2404" SPT» ran consning ‘rs iy tatgin est 5 3c) ieee ater ed (ratios conning 32% were noe esas PT sae (52.210, tues per sat) abiegh ome eason was oper eration eming 605% as noe phottnt ors phtalergen #27 ce tated rematral a may renting ara peri oman oairg {230% were sms may ng eaten tebe ofthe hn peetrsonenareansnpopary of pearonicssin he peserce of pamiober td retno be ken "tormalsrg padi con hau ncoreon with ry ‘yredans whore sey war bare on Ro el apn Sh Seal sborpson wart coca al report on sey heptane and red ar abarsta St tdin cosas Fal raport on he ey seeumee of ary heponse ‘pplatece determine fey, lung etapa dn on ay aha taneparie Steaytbenante —sueasuses 010) — Noa ere Sele Seal cpryite Seat ued (010) No da were arable Scaythepavoate Sessused (995, Theol Dyin mas 16 nig Teafered 2019) ~Arimare isu comand ary cape was et mugen nan Aes texofth or thos mabe acne cape ‘vo meronaear etn whch mic were t's ge Su one 30" Ts00 mene erm“6 leverasna jonal of Tesesogy 34(Soplemex 2) “Table 2. come Rigener ‘Cencvon jee) Siar a Fleene Undead et ater war mi erate to aban (I~ 1 ormaiton conning 1S was soytsarn ges ipeformaon enraing 5 rode ipo moder areca abe ee = infuran wsong comes formations crn OF (98 ec) rd 153 (56194 ad 02 sao) were por sete I PTs = Und sacra sn exagry 3 our Wann rabies and 2 fermion coming | was oe pry oc tne ics: ough rato sing ware! 0D seta ‘esto son pafored wa sora conan of 5% ere tere sno nation at ringer wold ear Imld recon nee obtvedin cea ain sa wih unas (mara and ns iaion oh frmuatn corntg 15 certre he Final wat fhe opr nt norman mre woul Not rosea cite nracor bec rev ed iran rs, aon say echo rd hepa acd mere seeped to erin atey No dea wore sabe Ne da were aah ‘ieee GT gine prion rasmus een ml Da masa lente reson Ppa rion (SER pst ph SOP ge a ac ch geo moe “Table 3. Ab Ee Grove” Ingres fave Sen reviewed by ie CIR and ound” ‘Arch ropa {hyn oneranoxe leopropesente Oude ocote tet mya syngas Ieopreny mysate, —Gepdoeel myiate ‘Bu ance Ebon pte Ioprooouminte Ocoee nemaate ‘Cater sonomnte ESyhenytpereoate Ieprom Senate ‘Serer! rnanosee nyheny eae opr sterte ‘Cen cas ‘but mrs tar onan ‘Ce romano ou pertegeace Ivey myst sSimene sok ar esr ‘Comp Rewoie ‘ear sate Ieee mre ‘Cony erate Node eocote (ey eoroue Deol coon ose sonranoste ta ete Deeg mtte ode mate Sl mete Deep one Node le yn seace yon coc Inner! woncrancate othe soon the slecha hve ten fund se by she OR op! wore (Ceusar serie sta meron Bag seevate Set te ctl ‘onaeg! onan [cheng are ‘ore! reosrarte cry ete prop ree Bont owen Faragersted ear of bebe! oprop! late Soom oe oto compre er ae Siptgered tr otcagtemer: Ronny tonne ‘Seca ate droped cnr ol ay ory ree (Ceca faace sere Iowan pace ‘Crea tee bra ‘spray! ergata ‘Seorer| wate opropy oeFume ee Iss. “Table 3. (conn) Sly eee Oley inotre Stem Seema ‘Sten ercte Stenylinste Teerieeyaco stearate ‘Tevadecoctne searato Uitntiorearste) Toe lauate ytrogete ace ofiate Tee stearate (Coco corynlapmte Feroreated oprepy cate Fyeronce iotearate Hyscomecaconn ydronysteorate COR ot conc on fry of th oe seal esc ahaa Seen uae ruc rvs lesen pryacprae ‘chy even lent eae Hopnisc unecyerate Laur bvente Bylo asx sel eevee Henley besarte Ugece eet yoy baherate Deol etre lett one Peta copra yoy ansiane Dest tae occ bene Feandagioccee Soon CES ay ees Eytany C1040 soy acon thse hoceanoste Tendo e-3 any beee Eyer eopamiee Coieylecopenarente " heylccrene (0.0 eee Eyton ecpenarete lohesepnine — Terseoyprepinces (040 at ahr Eytan) bate totam neapenanente Trey borane Clase ayiaesndeser Expat toto Dacre Trae vee “Tee capone {ica wnt tl cove an rd ‘Newt tee ar eoned pty bx as conden tr co mgr ey “Thee conpone srt hy, cman peso pac ars toh hhh be red Ocal nlalassayaneselaoe i Se oa os Sora ‘en 0 ny > ce SER ana me Sires ee : ieee Feber peters fata ane SSGseecsm. f Solgar eal teed meee eect Frit rte a : a, SebSege oe econ tam noes : cet BEL eet 3 ae Sreess {iernvondoural of Taesiogy 34 2 Table 4 comin) Conscie ‘Cohn jer dl asim ue concentraon rape) "fgets akahl Sess ed 008 inne a OS% rivet) Syne sesh Safe urd (1988 retired 206 125m are-osTin se ) o Seales Sele a urd (1985, renmed 2006 85 n leone 208 Hraoeo) nn Supacral She. ured (1985 ret fied 206 S508 nlemeons 25% raseot) od Seay scoot Sal a td (985; refined 206 56% leneon 25% hh mas ewe ape nt 000001% in aver 5 nef) » ibe ai norepored ue Coco d Stes wed (201: nero in eveor: 14% in eee.) Fydomptcare soit Seed (197 108 leven ns soared forrest) (orc cd Seles wed (196): retired i 20051 n avec, 8) Core ee Seles used (967 renirmed i 2006 In avec 25% re) Sela used (201 15% mae on SOX neh) Saud (1987 reir i 2006 5% 9 wave: SU ec) $f wsed (201: pc rporte In evens: in ae) a Site awed (58 ried 2006 15% nave 38 ec) 1 Sues wed (201: no reported ne) 2 Ree Bean acs Seen 01: no ropectd es) " Sed (207 concemeson no reper) : Sse ued (0: no reported ue) ” Snare Sites wed (987, retired 2006: SOK a aetna) we Sot wt Sse ued (2008 nc reparta nlorons #2 eect) ; ‘Rare CR Cama rg ew “Table 5, Detson ane unser IngreintCAS nm [Deion Ged te genented by CR) Fanon ‘esi baorte 167 “Th noice soho and babe acd Th str Ski-cond agne—0 vc Fer rete econ fom lah ge Arch eueneB01-96-7 “The er ofc sea and acs The er Ski-cond agente ‘green ren fou tho Arc proponnat1 “The er ofeach sleaho and mpropioniaeThe Ski-cond agen ‘ser bared fom reaion of odio Frepane oa ey sonar 70754208 Aer of aloha ower cd The mite Skincond ene fo tard fom eco ch serena ‘Anstey cobain star ai The ar Sdncond agente ‘ted fete econo ban kb! wi sare eer Desens “Ther ofan! skal nd heevan acid The Shncond agente Iti of tes ated fam he rect of ony Skt wk mine of raghchan fey oe ‘orang 03 coon ny ch gh eae od. Beta othe 701.274 “The eer ofshane ald and bebe aleho The ety Skincond agent ‘stoned fm oan of hen od wath Oh Bete arceBI2328 “Ther ofthe acho and rae a he eh con eat ‘Stoned fw cco of eter kaa ith enceFue e ‘Table 5. cine) nye ma Bevan omar 01496253 Behan ri Seen Behe obrze Buy aocadne Sug basa Ba eoteance Bue myst 1036-1 uy cen. 778 gt ser 120.95-5 uocy| bua S161.982 2uocy etre oc cden2699403-2 uocy emar0127.08:1 uocy lace Bloc panne 14.30 ey tesw207228401 Ws ‘Deon (aed wn enero by CR) Futon “heer often schol and eonaar nd tat Sn cond gene ‘colors toto Thema afer aed Frente retzon of Ete kal i) brocedcha owe ase ‘Teer ofa mbcire of btu sleha a ese! incon gen—oe "cohol ih Berwoe sa The mica of er ‘Stand fone recto of eer aon 2 ree se oa i ome ah ha fy ant onan 20 aon ay dan leg amar od “Teeter cool nd oe ai tat_—_— Skin agente eae: ‘vforns perl o ermal Te mite of fin omer pier: ner ‘tr some’ fo the sco of ae aa wth genoa {he yas ded fom be “Teer of tulle and he rae dred Scand agente ftom Perse rns octal The mare of ‘ser cae foe econ of ll i th Fay ets dee om Poa tsa fc) a ‘Te aro bryan he yas dered ip agene—nonsut en ab Iromtabasu ot Temaref te edt con gel trib tone ah ot en Tiga theaahnd tomer Sco ate from be mason of leat wth brocade ome se ‘Theatr of by sleho and myri alé The eer Sanco, genteel ‘htaed fom te ein of Bh ae wi yrs sea ‘The eter of by aha an ec ac. Te ew hincon, gente gnc gr "toned fm rein oft he wh ‘hetero byl akoha and see wd The exer kincond. gente “eae fom the mate of yal and eae rape ge ‘Thecse of uplocaral and been ai The mare incon gent—oe ‘fetes abet fone race ac oh Sima of sri fy aad omg 2096 on ca gs ben 3. “Te orpml compos oa conform othe formula. Skncond sgent—emat ‘heer eben forte acon of xeon th eho ‘The et’ of -bayocao and he ac drive fom Since geo “Exe cnt (anes ax Tere ee ‘Stared fete econ of bhai ‘eh aed fem Ephrem nese theca andy) Snead geen ‘The maar ene abel fr hereon of 2 ‘ojos tae fy ae eine Peon pte od and see as ‘Wewrcftuylocmaland cee rod Teeter Stincond agene—oe ‘head fem te eaion of 2 tfc wth ea ‘The ar of upland pari el. Te eer Sun cond agent ‘ited fe ben yen pc ‘Thecntr of mire of yah conning 1410 Sco gene—oe Warton nth ali ch wth era The re of ee stan fame enon of tre forte)“able 5. (comin) IagederscAS vo [C18 aly weewan23 7017-9 20.0 aly beeen 207-18.5. 20.0 absence (Cal C054 an er 16-36 aly serate 20-4 aly nerve 30-50 ali serae 040 aig nerne Chen tara 0384 Coon aprye306 80.9 opr desea ear tere era anatine meatal Jounal of Te re 2 ‘Datos (cued wc gennd by OR) Fencton fy aks anton 146 30 cars ne ih ‘om who mare of sean ay a, ‘Seay 240 26 cron ay chan eno dh “Thee afamizar oft sol conan 181 Ski-cond agence ‘8 earon sas ne aca aed wesw ‘The mie of exes cee! fo recn of rare fey ao, esti 18 38 cs in ‘et ca th mur wach ya ‘oroig 2410 36ers ay chan oe) “The er {©2050 sok tn ees sca TheSkin-cond gece Trae fet eared fore enc of mae ffs, cannng 350 cater ne a ‘eo mre of ron fay act erg 241036 carer ch eva ce) Tre of ce tare fore reco of moe ‘ff aes caning 20210 can ne i ‘on ba bene sd “Thganerof minaret fy cohol conning 1810 Vi ner genoa "cron som ads near of ys ‘eotiing 49 Starbon sae Terre of te Shred Yom he aie of mtr fay tbe. ‘Graney 3030 can aca oth 9 Irae of rota fay ad cman 24 $4 ‘Stee lh “Theor of C1636 oblast aed he Skncond agene—oe| Tra fees ettared forte ean of mre tye, canning T4698 caer he ag Ce ere se “The nar of C040 skool and steric. The Skncond ago Te fest tare fore aco fo mare cine sere (fy se, canang 20160 cata oe a Ce ea wo “These of CH0SU seohlsan arsed The Scand agente Ts fe tare fore eo of mae {ff aesacantang 3 650 saan ne orb ea “Ther of C1060 seohlsan sar 24 The Scone agente Inu of sur tare fone recon of me ‘ff aks cantaing A 6 6 car ah ‘om eo “These of cael wih by acd hat conforms. Shi-condagne—mise: grace ‘oie forma Thee fom acne mgreaent ean wahbg a. “Theorpn compound hat crams othe fords. Skicond agente The ster ote fn he mine ant th one “Theorprie compound at conerns to he forms,Shincond agente The eter bated fom he eon of man sera a “The eer of eatery! eael nd bea The Shand age ite of aed fom Be ec of a re {Ye sie i 8 cobs ct “The eer of cata sleoho sd ey ace dered Sin-condasre—oc “fom spot crf (ndls) we Tere of ‘ics chard fa onsen fo ma of ‘Shae canning Ie 18 ans mh sy Oa ‘eh fy odo fum up ee Pea atte tet tt eee eet bebiattttttttttttt itt ownedFume et 19s “Table 5. (continued) Cesarnnoranate Crea morsel 8027.10 Cer hace Cezar palee504-793 {Cen ce bate eum sete3620974 (Ceo tent 9236404 ct beta Cen expe Cen eapten971031-4 eof inehylocnonte Ceo ere Cen isonomneeel84878331 etrion iid wn gered by CR) ova “The ear ef ten sab anda brandwd chan Sincond general cond Teranoe se The mute fet sae fo heap (Seeman dea mere ‘The orgie compound a conforms ote formula.Skncond gear "he mae of es inane fo he ctr of nue fay ass casoney Ie 8 cab {hey ota anno oo ‘The eneofetu sol nd aie dried Hancond apne ‘fom ave ot The mare ese oted fm be ‘maton of mir of fy a con 1618 ‘Steen oy chan ee “The re cca aco an pln a The mie Sind geet a ab texas btaned frst en me oy stoi, conaney 16018 coos he yt cn ‘te 03 dered fam at st ‘Thee of cay edo and gan cd The Sinondagen—amcthlncond near of ee chtoes fn co of mie ge {Ff ato cng To actors at Sh tn prc oo ‘The eter feta kool andre ba ad. The_ Sino agente ua fee eared fo then of ane {ey seahacamaog 1618 core ah yo hed fa ee reno ‘These feran cholate Tere Skin agen—oe fee toned fey ec mae oo ‘toto conaneg Tso 1c te ay cn roo cd ‘Timmer of esse rd he ya derived Shinn agente wc er irom Oreos) Te ioe of gens ‘eset fe econ of ey a ee {ey ct ced fom Otel ata Theceeroftarcontarms fe formas Te ete Stivondaene—oe ond fom ero of oa th ben “hee of en akohl and capri wid. The er Stncond sentra ceed fm eof a wh ‘These’ of er aol nd apical he esr Skincond agente ceed fm ren of ah wh eae me. “The er ofa skool an reac sé The Skincnd gener ier aed fa ec of ey ce th Siren [Asse wx ane o be niga from Sond age ral terrence wx wt regs craton {proper cones ota mare sensor 4 {2 etn ys snd Ac The re of ‘ius suaned fon Be aon ee mce of y ‘Sek ocaing 140 Tera se ogo, Shamctaragen ent “Te ener ofce soho was bce hin Skncand agent Tomo sla Te mtr of eon aed Pa he ‘con of al wh ocean (cnet)‘Table 5. cones) narra Jura of Toioy 34(Supplemert 2) ‘efron faced text generate by CR) Faneion ered “Thee ofc aloha and wre a dar color Sincord geneva Cenlnaaertencea ceo myees9.01:1 ot myst ny eaar2383 368 Ceo pmiars40-103, Cen ntl 001585 Cen tare 190832 cep atone Co tomar Cn seal 1952180 (1040 toa si coca ree ‘CAS oat come (2226 ea sart20-229 Cococapyataprate Cosorapeedie “eth om The et’ bane ore etn ef ‘yf atl i eae ‘The cster of etal and mye cd The er Skin condgen—oe shad for the rent of rf kt od mpc ‘The eter of cn alehal and myriad Shancond agente Conforms tothe ora: Thee ted fo he roche ea and msec oo ‘heen ofc sechaand dee sd Teer Sincond agente boned ra he acne ka i ot ‘Te stro cay sea snd pie ace These Skincondagent—oe France ing tones fae rein of tl hp “We mtr of ce ahol andrei ab The eer Shin cond geno raed fom the racine al th ron oa ‘Thon of cn salad sari The eer Skinz agent—oe nro he mec atl ee “Thea of a scboland alow 6 "he mie of Scone gem "at ead fom cn of ey tl we ay cs deve for lon. ‘Theeste of cin ool adioxar nel The Skincond gener nite of ten ote Frome enn of een eer mth once oe “Tees af cn scold sere Teeter Sincond gear sad fom te reson of ey gener wo [Amst of ears of xydodcanal witsbranchad-Sincond gemini er Gu sods conning [Dt Dears The agon—norag Ire of es Sine! fer te ren of 2 ith ahd fy a ong {ae crn ne ce, Thee Satna ay ta) hn roraot 0. eta earelael39 ‘Trt facut sleshl a sere 6 The eer Stincond gente tard fom cn fb ae! ware rt eowae8526S0-1 ‘Tecate fob akc ada a Theme Shrcond agente \faten taeda een fa ae th {he foy as ee or alow et ey bohereaA247 286 “The entrofteocn seal nd beer ad The Stncond geo tare of eos aban form te een of bce ‘han a aa wth Been soto vodecnont/29500052 Themicur of eters abe rom the reacton of Skncond agen "eon sectel witha rane ty ac concng IDeartona mh sy can Te mica of te ‘ie fone ncn ft cet tote 2006-45-8 ‘inerercftecytaksal sed conan wd The Sdncond gnarl Insts fee bared an herein of tone ‘han eos wes anced sane a ce uae 957-24 ‘hesstr of oc ae aad fe acd Theme Stncnd pete fete oon fae moan f rand chae {ay ea nth co acon myrael708.61 ‘Teco hag kool nd mye se The Skbncond apne tire of ters bed for actin of aed ‘hn eat wth mye ce paletal1277027.8 ‘Tecate of woe ool pln acl The __Stincond geen ture of xt ed ferme reac of bowed ‘hon eae wah pao cag enra2539.007 “Teatro Selon steric Th mitre Shincond geno {eter ean forthe rato f arch acai wh ere ood ode cocone ‘Tecra ranched cin dec shot nd coon Strcond gett "eit The mature of ser etaed ame eas [Sanches dn la th fay ac dered fem corto oie hyeonpnrne9360-275, Theater of ranhed cle dec aehaland 2: Sin cond agent—anel ‘yalides Ipdronrteare so Themiar fer tare For Be eacan of ence dot ate wh 12 hose ede tonoraretelAB95095; SDI. Testo branes chi dc acooleands__ Sond agent—enel se "ean chan rosa ee Te mar of ee shtaed fo te ace of brooch ‘oh wh bones chan ron oe ede urn 4779932 9047-16 Theater of brand chai dcp kool a ure Skn-ondaene—enel se. The mitre of eos sted fom be razon tronic Se! aos i) ae soley mprat!!76709-& SI4TE246 The eter bron eh So sled and mye Skr-and area i. Theme of ee saed fa Be eo of Ironic Sey lal mse oe tac oeopearenls002.7 The ester cfc din eel aleao and Sincond agement eopenanci sa The mar fess aed fomFume e ‘Table 5. (coined) 2s, ngedensCAS ro, leaden lntS923 1.4 rode pall 479.95-4 5900-933 ode suara3568368 ohn erate een! urates219-727 lesan nopeneonte 3111-7035 Vohon placs8 9491-7; 89219.726 lary tebe oor eapryatalaprae oocyte ‘opcplracide2671890-1 leoprop! eatna90990059 lesprop abana sopopy|bbana6718 95.6 soporte ‘Delon (and wat gered by CR) Fancion ‘he ein of orc daa wth open ee “The ero trance hn dey ash an ae Skincond ager lt. The re of ees sed fm he etn of ey aes wah ate ™ arched can day! Seo pale Skane aster "es: The cre of eter cand fon he maton of branche ey cea hp ce ‘Tester ofsrantet dey acobls an arc aclé_ Skin agar ane ‘he mare of ten Shanes fm he mao of ches ey aah ete Theater ofepe sd ands bcd an arbon Scand geal {evo The mur of ese eta fr re eo {ftonchedcha ey se st coo “Te rw ofabranced can hen! weal nd laseSkncond agora ‘ld. The rae of ees ated fm he eon of Brecht es. ‘Theest’ of iohenilesholand eopenarsc si hut Skcondaer-—ena confor tthe emul The rise of ee ced {fom te acon of ache hah wh reste 24 ‘Theatr oftranched ca hl seal anpalne Skincare ar “eid The mare of ese siaed fom te azo of ened hen lal wb pa ct Tracrtr fered cla dose alcoho and—Sincond gece {eben aed The ve of eset bared fore ‘cio of anche fue wh ae me “Tie ear of branche chin nen aebos wh Skncond agen Tranced chan nono se Mee of es Shiaed fa te reo of rhea en ‘oan wo ben ar non te ‘The ur of trance! incest wth Skncond agement onde Irate of pr nd cape ais. The mae of {hes ciated fa he acon of rani hc who mia of ep nd cape at ‘Te orn compound dur conforms of formula. Svan gehen pice The me ofenon ated fo ion of she Ibehehan cy aie wh fy ec hed font “Te eof koro acho and wei al hae Second agonal nfo ou arma The aed fo reocon f pry kel wh ech “TWeeste’ of Sopropy aol! the ay ac dered Skicond serena Irom necadoa Te mre of tes are fom erator a te fy cc ened Frm owen ot ‘Tees olsopropyaeceland ely ace ered Skncond gunmen inde dap Irom Oe cfr (abs) al The mare of agene—nonte ral sa {hr etd fm than of prey wth te yo dete fn Oty Oe a ‘Theeste of sopecpy alco andbahenc act The ear Sod agonal "tained foe macs of poy el ih ‘The eter apr aool nd I2ysrooptarie Ser cond gee 1. The et boned Foe acto of ee ce wah 12 nso oc eons)