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1416

ARTICLE

Evaluation of total keratometry and its


accuracy for intraocular lens power
calculation in eyes after corneal refractive surgery
Li Wang, MD, PhD, Tatyana Spektor, MD, Rodrigo G. de Souza, MD, Douglas D. Koch, MD

Purpose: To compare the accuracy of total keratometry (TK) D, 0.61 D, 0.54 D, and 0.50 D in the myopic laser in situ
and standard keratometry (K) from a swept-source optical keratomileusis (LASIK)/photorefractive keratectomy (PRK) group,
coherence tomography biometer for intraocular lens (IOL) and 0.74 D, 0.68 D, 0.71 D, and 0.70 D in hyperopic LASIK/PRK
power calculation in eyes with previous corneal refractive group. For the radial keratotomy (RK) eyes, the MAEs were 0.66
surgery. D, 0.71 D, and 0.72 D for the Haigis, Barrett True-K, and Haigis-
TK formulas, respectively. In the myopic LASIK/PRK group, the
Setting: Cullen Eye Institute, Baylor College of Medicine, Houston, Barrett True-K and Haigis-TK produced significantly lower MAEs
Texas, USA. than did Haigis (P < .05). In the hyperopic LASIK/PRK and RK
groups, there were no significant differences between the
Design: Retrospective case series. formulas in MAEs and percentages of eyes within the above
prediction errors.
Methods: The differences between the TK and K and their as-
sociation with K were assessed. For IOL power calculation,
combinations of 1) K with Haigis, Haigis-L, and Barrett True-K,
Conclusions: The performance of the combination of Haigis
and TK in refractive prediction was comparable with Haigis-L
and 2) TK with Haigis (Haigis-TK) were used. The mean
and Barrett True-K in eyes with previous corneal refractive
absolute error (MAE) and the percentages of eyes within
surgery.
prediction errors of G 0.50 diopters (D), G 1.00 D, and G
2.00 D were calculated. J Cataract Refract Surg 2019; 45:1416–1421 Q 2019 The Authors. Pub-
lished by Elsevier Inc. on behalf of ASCRS and ESCRS. This is an open
Results: The study comprised 129 eyes. For Haigis, Haigis-L, access article under the CC BY-NC-ND license (http://
Barrett True-K, and Haigis-TK, respectively, the MAEs were 0.72 creativecommons.org/licenses/by-nc-nd/4.0/)

R
adial keratotomy (RK), photorefractive keratectomy determination of total corneal power calculated based on
(PRK), and laser in situ keratomileusis (LASIK) both anterior and posterior corneal curvatures should
have been used for the correction of myopia, hyper- improve the accuracy in IOL power prediction. Optical
opia, and astigmatism. These procedures create difficulties coherence tomography (OCT) can measure both anterior
in accurately calculating intraocular lens (IOL) power.1,2 and posterior corneal curvatures with high axial resolution.
There are two major causes of error in corneal power esti- Using high-resolution anterior segment OCT (RTVue, Op-
mation in these eyes: 1) because of the large variations in toVue, Inc.), Tang and et al.4 developed an OCT-based IOL
corneal power within the central area of the cornea, it is calculation formula. Promising results for the OCT-based
difficult for the standard keratometers or corneal topogra- IOL formula have been reported in eyes with previous LA-
phers to obtain accurate anterior corneal curvature, and 2) SIK, PRK, or RK.4–7 Scheimpflug camera–Placido topogra-
LASIK/PRK alters the ratio of the anterior to posterior phers, such as the Pentacam (OCULUS, Inc., Germany), the
corneal radius of curvature, and the standard effective Galilei (Ziemer Opthalmic Systems AG), and the Sirius
refractive index of the cornea is no longer valid.3 (Costruzione Strumenti Oftalmici), also offer total corneal
With advances in technology, it is now possible to power values. In unoperated eyes, these values have been
measure the posterior corneal curvature. Theoretically, shown to produce accurate refractive outcomes.8

Submitted: March 21, 2019 | Final revision submitted: April 22, 2019 | Accepted: May 14, 2019
From the Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, USA.
Supported in part by Sid W. Richardson Foundation, Fort Worth, Texas, and an unrestricted grant from Research to Prevent Blindness, New York, New York, USA.
Corresponding author: Douglas D. Koch, MD, Cullen Eye Institute, Baylor College of Medicine, 6565 Fannin, NC205, Houston, TX 77030, USA. Email: dkoch@bcm.edu.

Q 2019 The Authors. Published by Elsevier Inc. on behalf of ASCRS and ESCRS. 0886-3350
This is an open access article under the CC BY-NC-ND license (http:// https://doi.org/10.1016/j.jcrs.2019.05.020
creativecommons.org/licenses/by-nc-nd/4.0/).
TOTAL K IN POST-REFRACTIVE EYES 1417

Savini et al.9 assessed the accuracy of total corneal power Intraocular Lens Power Calculation Methods
values obtained from the Galilei in eyes that had previous For IOL power calculation, a combination of IOL formulas and
myopic corneal excimer laser surgery. corneal power values were used as follows:
Total keratometry (TK) from a swept-source OCT (SS- 1. Haigis C anterior K: the standard Haigis formula10 is proposed
OCT) biometer (IOLMaster 700, Carl Zeiss Meditec AG) for eyes without previous corneal refractive surgery. The Haigis
is a new measurement that combines telecentric keratome- formula was used in this study to serve as a scenario when the
try and SS-OCT technology for the assessment of anterior laser vision correction status of the eye was not identified
and posterior corneal curvatures. According to the manu- correctly by the examiner during the biometry examination;
that is, the laser vision correction was selected by the user as
facturer, TK is lens-constant compatible for User Group “untreated” before the ocular biometry scan.
for Laser Interference Biometry (ULIB),A and the existing 2. Haigis-L C anterior K: the Haigis-L formula was designed for
standard formulas and IOL constants can be applied. Com- eyes with previous myopic11 or hyperopicC LASIK/PRK. With
parison of the TK and the standard K and their accuracy for the Haigis-L formula, the K value measured with the SS- OCT
IOL power calculation have not been investigated and biometer was modified and then used for IOL power
calculation.
reported. 3. Barrett True-K C anterior K: the Barrett True-K formulaD was
This study was designed to compare the TK and standard developed for eyes with previous corneal refractive surgery.
K and their accuracy for IOL power calculation in eyes with The Barrett True-K formula uses measured keratometry and
previous LASIK, PRK, or RK. change in refraction (DMR) induced by the refractive surgery.
The True-K No History formula can be used when data for
DMR are not available. In this study, the standard K was
PATIENTS AND METHODS used with the Barrett True-K No History formula. In RK
eyes, as recommended by Dr. Barrett,E manifest refraction ob-
Patients
tained before the cataract surgery was used as the post-RK
Institutional Review Board approval (Baylor College of Medi-
refraction; and
cine, Houston, Texas) was obtained for this study. Consecutive
4. Haigis C TK (Haigis-TK): the TK was used with the standard
cases that had previous corneal refractive surgery and had un-
Haigis formula.
dergone cataract surgery at the Cullen Eye Institute (Baylor Col-
lege of Medicine, Houston, Texas) between June 2016 and
January 2018 were retrospectively reviewed. Inclusion criteria
were patients with 1) available TK data from the SS-OCT bio- Refractive Prediction Error
meter scans taken before the cataract surgery, 2) no complica- The lens constants from the ULIB websiteA were used for all IOLs.
tions during or after the cataract surgery, 3) manifest With each formula, the predicted refraction for the implanted IOL
refraction performed at 3 weeks or later after the cataract sur- power was recorded. The refractive prediction error (RPE) was
gery, and 4) corrected distance visual acuity of 20/40 or better calculated by subtracting the predicted refraction from the actual
at 3 weeks or later after cataract surgery. postoperative refraction. A negative RPE indicated a postoperative
All cataract surgeries were performed by one surgeon refractive result that was more myopic than predicted by the indi-
(D.D.K.) using a temporal clear corneal incision, phacoemulsifi- vidual formula.
cation, and implantation of IOLs in the capsular bag. Preopera- The mean numerical error, mean absolute error (MAE), and
tively, various methods were used for corneal power estimation, median absolute error (MedAE) were calculated. The percentage
and the American Society of Cataract and Refractive Surgery of eyes with RPEs within G 0.50 D, G1.00 D, and G 2.00 D
post-refractive IOL calculatorB was used for IOL power calcula- were computed for each method.
tion. The IOL power to be implanted was determined by the
surgeon. Eyes were categorized into three groups depending
on their previous corneal refractive surgery: myopic LASIK/ Statistical Analysis
PRK, hyperopic LASIK/PRK, and RK. Sample size was calculated to determine the number of eyes
required to detect a difference of half of the standard deviation
of differences in RPEs between groups. With a significance level
Standard Keratometry and Total Keratometry of 5% and a test power of 80%, 32 eyes are required in each
The SS-OCT biometer has two ways of determining corneal power group. In this study, 32 to 53 eyes were enrolled in the three
as follows: groups.
Data distribution for normality was checked using the
1. Standard keratometry (K): the standard K is calculated based Kolmogorov-Smirnov test. To account for the correlation between
on the anterior corneal curvature from measuring reflections pairs of eyes for each individual, a regression analysis with gener-
of 18 light-emitting diodes, combined with telecentric kera- alized estimating equations was performed to assess the associa-
tometry; and tion between the standard K and the differences between the TK
2. Total keratometry (TK): the TK is calculated based on the ante- and K. To assess whether the mean numerical errors produced
rior corneal curvature, posterior corneal curvature, and corneal by various methods were significantly different from zero, one
thickness derived from combination of telecentric keratometry sample t test or Wilcoxon one-sample signed-rank test was used,
and the OCT technology. The calculated TK values are modi- depending on the data distribution. The Friedman test was used
fied to match the K values, so that existing IOL calculation for- to compare the MAEs using different formulas. The Cochran Q
mulas and IOL constants can be used. test was performed to compare the number of eyes within G0.5
D, G1.0 D, and G2.0 D of RPE. If a significant difference was ob-
For comparison between the TK and K, the corneal curvature tained between formulas, the post hoc analysis with the Wilcoxon
values in millimeters were converted to values in diopters (D) us- test or McNemar test was used for pairwise comparisons. The
ing a corneal refractive index of 1.3315. Differences between the Bonferroni correction was applied for multiple tests. SPSS for
TK and K were calculated in each group. Windows software (version 24.0, IBM Corp.) was used for

Volume 45 Issue 10 October 2019


1418 TOTAL K IN POST-REFRACTIVE EYES

Table 1. Summary of demographic and biometric data obtained from the swept-source optical coherence tomography
biometer.
Myopic LASIK/PRK (53 Eyes) Hyperopic LASIK/PRK (32 Eyes) RK (44 Eyes)

Parameter Mean ± SD Range Mean ± SD Range Mean ± SD Range


Age (y) 64.5 G 7.1 45, 77 68.6 G 4.6 60, 80 65.7 G 6.4 50, 78
Standard keratometry (mm) 8.31 G 0.47 7.69, 9.81 7.52 G 0.28 6.93, 8.24 9.06 G 0.79 7.43, 10.63
Total keratometry (mm) 8.40 G 0.52 7.72, 10.15 7.51 G 0.29 6.94, 8.24 9.02 G 0.78 7.48, 10.50
Anterior chamber depth (mm) 3.40 G 0.43 2.42, 4.38 2.99 G 0.35 2.33, 3.44 3.34 G 0.33 2.76, 4.01
Lens thickness (mm) 4.52 G 0.39 3.60, 5.30 4.66 G 0.35 3.99, 5.33 4.54 G 0.36 3.94, 5.38
Axial length (mm) 25.72 G 1.64 22.76, 30.37 23.09 G 0.96 21.47, 24.68 25.61 G 1.51 22.95, 29.57
Implanted IOL power (D) 20.6 G 3.2 10.5, 33.0 21.5 G 2.8 16.0, 26.5 24.7 G 5.5 8.0, 34.0

IOL Z intraocular lens; LASIK Z laser in situ keratomileusis; PRK Z photorefractive keratectomy; RK Z radial keratotomy

statistical analysis, and a probability of less than 5% (P ! .05) was significantly higher percentage of eyes within G1.0 D
considered statistically significant. of RPE than did Haigis (P ! .05). There were no signif-
icant differences in MAE and the percentage of eyes with
RESULTS RPEs within G0.5 D, G1.0 D, and G2.0 D between the
Table 1 shows the demographic and biometric data. A total other formulas.
of 129 eyes were included: 53 eyes of 37 patients with pre- In eyes with previous hyperopic LASIK/PRK, the MAEs
vious myopic LASK/PRK, 32 eyes of 23 patients with hyper- ranged from 0.68 to 0.74 D. The percentage of eyes with a
opic LASIK/PRK, and 44 eyes of 32 patients with RK. The RPE within G 0.5 D ranged from 43.8% to 56.3%. There
implanted IOL models include: ZCB00, ZCTx, ZXR00, and were no significant differences in MAE and the percentage
ZXTx (Johnson & Johnson Surgical Vision, Inc.), and of eyes with RPEs within G0.5 D, G1.0 D, and G2.0 D be-
SN60WF and SN6ATx (Alcon laboratories, Inc.). tween formulas.
In eyes with previous RK, the range of MAEs was 0.66
Difference Between TK and T
to 0.72 D. The percentage of eyes with an RPE within G
Table 2 and Figure 1 show the differences between TK and 0.5 D ranged from 43.2% to 54.5%. There were no signif-
K. The mean differences were 0.39 D (P ! .05), C0.06 D icant differences in MAE and the percentage of eyes with
(P O .05), and C0.15 D (P ! .05) in eyes with previous RPEs within G0.5 D, G1.0 D, and G2.0 D between
myopic LASIK/PRK, hyperopic LASIK/PRK, and RK, formulas.
respectively. There were moderately positive associations
between the K and the difference between TK and K in DISCUSSION
eyes with previous myopic LASIK/PRK and hyperopic LA- Although corneal refractive surgery produces excellent vi-
SIK/PRK (correlation coefficient r Z 0.51 and 0.45, respec- sual outcomes, it creates difficulties in accurately calcu-
tively, both P ! .05). lating IOL power, primarily because of incorrect
estimation of total corneal power. In this study, we evalu-
Accuracy of TK and K in Refractive Prediction ated the TK from the SS-OCT biometer and its accuracy
Table 3 shows the RPEs. In eyes with previous myopic for IOL power calculation in eyes with previous LASIK,
LASIK/PRK, the Haigis produced hyperopic prediction PRK, or RK. We chose the Haigis formula to evaluate TK
errors, and the Haigis-L produced myopic prediction er- because this formula does not use corneal power to calcu-
rors (both P ! .05). The MAEs ranged from 0.50 to 0.72 late the effective lens position. TK values could therefore
D, and the Barrett True-K and Haigis-TK had signifi- be inserted directly into the formula without any
cantly lower MAEs than did Haigis (both P ! .05). modification.
The percentage of eyes with an RPE within G0.5 D In this study, we found that in eyes with previous myopic
ranged from 35.8% to 58.5%. The Barrett True-K had a LASIK/PRK, the mean TK was significantly lower than

Table 2. Difference between the TK and K.


Parameter Myopic LASIK/PRK Hyperopic LASIK/PRK RK
Mean G SD (D) 0.39 G 0.26* 0.06 G 0.17 0.15 G 0.32*
Range (D) 1.12, 0.20 0.36, 0.47 1.15, 0.66
Correlation with K 0.51† 0.45† 0.09

K Z standard keratometry; LASIK Z laser in situ keratomileusis; PRK Z photorefractive keratectomy; RK Z radial keratotomy; TK Z total keratometry
*Significantly different from zero

Significant correlation between the standard K and the difference between TK and K (P ! .05 with Bonferroni correction)

Volume 45 Issue 10 October 2019


TOTAL K IN POST-REFRACTIVE EYES 1419

modified corneal radius of curvature is entered into the


standard Haigis formula.11,C Results from this study
showed that combination of the TK and standard Haigis
formula produced similar results in refractive prediction
as the Haigis-L and Barrett True-K formulas. The
Haigis-L and Barrett True-K formulas are among the
most accurate approaches for IOL power calculation in
eyes with previous corneal refractive surgery. This indi-
cates that the TK values do not need to be modified
and can be used directly in the standard Haigis formula
in LASIK, PRK, and RK eyes.
In previous studies that investigated the accuracy of IOL
power calculation formulas in eyes with prior myopic or hy-
peropic LASIK/RPK,6,12–14 the Haigis-L formula produced
MedAEs of 0.26 D to 0.62 D, and 40.2% to 69.0% of eyes
within G0.5 D of RPE. In this study, the Haigis-L formula
yielded MedAEs of 0.51 D to 0.53 D, and 45.3% to 46.9% of
eyes within G0.5 D of RPE. Our results with the Haigis-L
formula are consistent with the findings reported in the
literature.
With the Barrett True-K No History formula, in eyes
with previous myopic LASIK/PRK, Abulafia et al.13 and
Wang et al.6 reported MedAEs of 0.41 D and 0.42 D,
and 63.3% and 58.7% of eyes, respectively, within G0.5
D of RPE. In this study, we found a MedAE of 0.37 D
and 52.8% of eyes within G0.5 D of RPE. In eyes with
previous hyperopic LASIK/PRK, Hamill et al.15 reported
a MedAE of 0.60 D and 42.9% of eyes within G0.5 D
of RPE. In this study, we found a MedAE of 0.49 D
and 50% of eyes within G0.5 D of RPE. In eyes with pre-
vious RK, Ma et al.7 reported MedAEs of 0.56 D to 0.71
D, and 29% to 43% of eyes within G0.5 D of RPE. In this
study, we found a MedAE of 0.55 D and 43.2% of eyes
Figure 1. Scatterplot K versus difference between the TK and K in within G0.5 D of RPE.
eyes with previous myopic LASIK/PRK (top, correlation coefficient Limitations of this study include: 1) Because of the low
r Z 0.51, P ! .05), hyperopic LASIK/PRK (middle, correlation coef- number of eyes with previous corneal refractive surgery
ficient r Z 0.45, P ! .05), and RK (bottom, correlation coefficient
and subsequent cataract surgery, we included both eyes
r Z 0.09, P O .05) (K Z standard keratometry; LASIK Z laser
in situ keratomileusis; PRK Z photorefractive keratectomy; of some patients. Regression analysis with generalized
RK Z radial keratotomy; TK Z total keratometry). estimating equations was performed to account for the
correlation between pairs of eyes for each individual.
2) Different IOL types were included. 3) The ULIB-
mean K, and, with decreasing or flattening K, the TK had optimized lens constants were used for IOL power calcu-
increasingly lower values compared with K. In eyes with lation, and lens constant optimization was not per-
previous hyperopic LASIK/PRK, there was no significant formed in each group. This represents the clinical
difference between mean TK and K, and with increasing scenario in that surgeons generally do not optimize their
or steepening K, the TK had increasingly higher values lens constants for eyes with previous corneal refractive
compared with K. In eyes with previous RK, mean TK surgery.
was significantly higher than mean K, and there was no as- In summary, our results showed that the differences be-
sociation between the K and the differences between TK tween TK and K were positively correlated with the K in
and K. eyes with previous myopic LASIK/PRK and hyperopic LA-
The Haigis formula was originally developed based on SIK/PRK. The Barrett True-K and Haigis-TK produced
partial coherence interferometry (PCI) (IOLMaster, Carl significantly lower MAEs than did Haigis in myopic LA-
Zeiss Meditec AG).10 The corneal radius of curvature SIK/PRK group. The accuracy of Haigis-TK in IOL power
measured by the PCI or SS-OCT biometer is used in calculation was comparable to those with Haigis-L and Bar-
the Haigis formula for virgin eyes. In the Haigis-L for- rett True-K in eyes with previous corneal refractive surgery.
mula, which was developed for eyes with previous LA- Further studies are desirable to evaluate the accuracy of TK
SIK/PRK, the corneal radius of curvature measured in IOL power calculation in multicenter studies in a larger
with the PCI or SS-OCT biometer is modified, and this population.

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1420 TOTAL K IN POST-REFRACTIVE EYES

Table 3. Refractive prediction errors using User Group for Laser Interference Biometry lens constantsA and percentage of
eyes within certain ranges of prediction errors.
Parameter Haigis10 Haigis-L11,C Barrett True-KD Haigis-TK
Myopic LASIK/PRK
MNE (D) G SD C0.57 G 0.68* 0.42 G 0.61* 0.02 G 0.73 C0.19 G 0.59
Range (D) 0.81, C2.87 1.66, C0.76 1.48, C3.04 0.83, C1.78
MAE (MedAE) (D) 0.72 (0.65)† 0.61 (0.53) 0.54 (0.37)† 0.50 (0.44)†
G0.5 D (%) 35.8 45.3 52.8 58.5
G1.0 D (%) 73.6† 81.1 92.5† 90.6
G2.0 D (%) 98.1 100.0 98.1 100.0
Hyperopic LASIK/PRK
MNE (D) G SD 0.28 G 1.01 0.04 G 0.99 0.04 G 1.04 0.22 G 1.03
Range (D) 2.74, C3.19 2.43, C3.34 2.48, C3.66 2.83, C3.37
MAE (MedAE) (D) 0.74 (0.54) 0.68 (0.51) 0.71 (0.49) 0.70 (0.44)
G0.5 D (%) 43.8 46.9 50.0 56.3
G1.0 D (%) 75.0 81.3 81.3 81.3
G2.0 D (%) 93.8 93.8 93.8 90.6
RK
MNE (D) G SD C0.27 G 0.87 N/A C0.33 G 0.86 C0.41 G 0.88*
Range (D) 1.98, C2.91 N/A 1.42, C2.72 1.35, C3.14
MAE (MedAE) (D) 0.66 (0.47) N/A 0.71 (0.55) 0.72 (0.57)
G0.5 D (%) 54.5 N/A 43.2 43.2
G1.0 D (%) 75.0 N/A 70.5 72.7
G2.0 D (%) 97.7 N/A 97.7 97.7

K Z standard keratometry; LASIK Z laser in situ keratomileusis; MAE Z mean absolute error; MedAE Z median absolute error; MNE Z mean numerical error;
N/A Z not applicable; PRK Z photorefractive keratectomy; RK Z radial keratotomy; TK Z total keratometry
*Significantly different from zero (P ! .05 with Bonferroni correction)

Significant difference between formulas (P ! .05 with Bonferroni correction)

4. Tang M, Li Y, Huang D. An intraocular lens power calculation formula based


on optical coherence tomography: a pilot study. J Refract Surg 2010;
WHAT WAS KNOWN 26:430–437
 It is difficult to predict accurate intraocular lens (IOL) power 5. Tang M, Wang L, Koch D, Li Y, Huang D. Intraocular lens power calculation
in eyes with previous corneal refract surgery. after previous myopic laser vision correction based on corneal power
 The Barrett True-K and Haigis-L formulas are among the measured by Fourier-domain optical coherence tomography. J Cataract
Refract Surg 2012; 38:589–594
most accurate and popular IOL power calculation formulas
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 Total keratometry (TK) from the swept-source optical omy. Invest Ophthalmol Vis Sci 2016; 57:162–168
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coherence tomography (SS-OCT) biometer (IOLMaster 700,
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Carl Zeiss Meditec AG) was a new measurement of total surements with a new optical biometer. J Cataract Refract Surg 2018;
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 In LASIK, PRK, and RK eyes, the combination of the directly wer calculation using a Placido disk-Scheimpflug tomographer in eyes that
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TOTAL K IN POST-REFRACTIVE EYES 1421

15. Hamill EB, Wang L, Chopra HK, Hill W, Koch DD. Intraocular lens power cal- Disclosures: Dr. Wang is a consultant to Alcon Laboratories, Inc.
culations in eyes with previous hyperopic laser in situ keratomileusis or pho-
Dr. Koch is a consultant to Alcon Laboratories, Inc., Carl Zeiss Meditec
torefractive keratectomy. J Cataract Refract Surg 2017; 43:189–194
AG, and Johnson & Johnson Vision, Inc. None of the other authors has
OTHER CITED MATERIAL a financial or proprietary interest in any material or methods mentioned.
A. User Group for Laser Interference Biometry. Available at: http://ocusoft
.de/ulib/. Accessed June 25, 2019
B. American Society of Cataract and Refractive Surgery. Post-Refractive IOL
Calculator. Available at: http://iolcalc.ascrs.org/. Accessed June 25, 2019
First author:
C. Haigis W, Goes F, “IOL calculation after laser refractive surgery for hyperopia Li Wang, MD, PhD
with current measurements,” presented at the XXVI Congress of the Euro-
pean Society of Cataract and Refractive Surgeons, Berlin, Germany,
Cullen Eye Institute, Baylor College of
September 2008 Medicine, Houston, Texas, USA
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Available at: http://www.apacrs.org/barrett_true_K_universal_2/. Accessed
June 25, 2019
E. Barrett GD, personal communication, November 25, 2016

Volume 45 Issue 10 October 2019

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