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Traumatic Aortic Injury Does The Anatomy of The Aortic Arch Influence Aortic Trauma Severity PDF
Traumatic Aortic Injury Does The Anatomy of The Aortic Arch Influence Aortic Trauma Severity PDF
DOI 10.1007/s00595-016-1443-0
ORIGINAL ARTICLE
Received: 17 June 2015 / Accepted: 14 June 2016 / Published online: 17 November 2016
© The Author(s) 2016. This article is published with open access at Springerlink.com
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Materials and methods The aortic arch index was obtained by measuring the
distance from the outer wall of the ascending aorta to the
Patients outer wall of the descending aorta on the lesser curvature in
the horizontal plane, at the height of the mid-left bronchus.
The study was conducted retrospectively by analyzing the In cases involving large aortic lesions and aneurysmal dila-
results of endovascular treatment in patients with TAI due tation of the descending aorta at the level of measurement,
to blunt chest trauma who were treated in our department the outer wall of the descending aorta was determined by
between 2009 and June 2014. Twenty-nine patients with drawing a line between two unaffected points (above and
aortic lesions were treated using TEVAR. We excluded 7 below the lesion), which were placed on unaffected seg-
patients from the group who were treated for false aneu- ments of the aorta.
rysms of the aortic isthmus in which the injury had The aortic arch angle was obtained by measuring the
occurred 2–20 years earlier. The remaining 22 patients with angle created by connecting three points: (1) the outer wall
acute TAI were included in the analysis. of ascending aorta on the level of mid-left bronchus; (2) the
The study population included 17 men (77.3%) and 5 highest point on the outer wall of the aortic arch (greater
women of 21–66 (38.8 ± 13.54) years of age. Twenty-one curvature); (3) the outer wall of the descending aorta at the
of the patients were treated in an emergency setting, and level of the mid-left bronchus. In cases involving aneurys-
one patient was treated in an elective setting. The severity mal dilatation of descending aorta, the measurement was
of injury was evaluated according to the Injury Severity performed using the above-mentioned method (Fig. 1a–c).
Score (ISS) [8] of each patient. To compare our new parameters to conventional param-
Each of the patients with suspected blunt chest trauma eters, we also measured the aortic diameter at specified
underwent an ECG-gated CT scan, which was performed levels. The measurements were performed from centerline
in the emergency department of our hospital or in the refer- models at the levels of the ascending aorta (above the sinus
ring hospital. Seven patients were diagnosed with an aor- of Valsalva), the aortic arch (before origin of left carotid
tic injury at the referring hospital. The time from injury artery), and the descending aorta (behind the origin of the
to TEVAR was approximately 24 h in 5 cases, 5–6 h in 6 LSA, at the level of pulmonary artery division and at the
cases; the procedure was performed within 3 h after the level of diaphragm).
injury in the remaining cases. In all of the acute cases, The degree of trauma to the aorta was evaluated based
the delay was no more than 2 h after admission to our on the scale proposed by Azizzadeh et al. in accordance
hospital. In one case, the treatment was carried out after with the SVS recommendations [9, 10].
2 months. The case involved a patient with a type I aortic A Zenith TX2 (Cook Inc., Bloomington, USA) stent-
injury, where the injury met the criteria for a “minimal aor- graft was used in 21 (95.4%) cases; in the remaining case
tic injury.” After two months, a follow-up CT scan of aorta (4.6%), an E-vita THORACIC (JOTEC GmBH, Hechin-
revealed progression into a pseudoaneurysm. The treatment gen, Germany) stent-graft was used. The ostium of the LSA
strategy was, therefore, changed from watchful waiting to was covered in cases in which the seal zone of the healthy
TEVAR. aorta was <1 cm.
In cases in which a diagnosis of aortic isthmus damage
was confirmed, the patient was scheduled for endovascu- Statistical analysis
lar treatment in either the interventional radiology suite
(Siemens Artis Zee, Erlanger, Germany), or the operating All calculations were performed using the SAS System
room using a C-arm (Siemens Arcadis Avantic, Erlanger, software program (v.9.4; SAS Institute, Cary, USA). Con-
Germany). tinuous variables were expressed as the mean and standard
deviation (SD). Categorical variables were expressed as
Evaluation of the aortic arch percentages. Fisher’s exact test (categorical values) and the
U Mann–Whitney test (continuous variables) were used to
The measurement of aortic arch was made based on analyze simple associations. Two-tailed p values of <0.05
DICOM picture reconstruction using the OsiriX DICOM were considered to indicate statistical significance. A mul-
Viewer software program (version 3.9.4; Pixmeo Sàrl, tivariate analysis was performed with a stepwise logistic
Bernex, Switzerland). Aortic arch reconstruction in 3D regression model (odds ratio and 95% confidence limit).
MPR was performed for all of the cases. To allow the esti- The distribution of age, angle and distance were tested
mated parameters to be easily applied in the emergency set- with the Shapiro–Wilk and Kolmogorov–Smirnov tests. An
ting, we decided not to use the centerline model. Recon- ROC curve analysis was performed to evaluate sensitivity
structions were used for the evaluation of two parameters: and specificity of the aortic arch angle for predicting the
the aortic arch index and the aortic arch angle. occurrence of type III and IV injuries.
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Because of the small sample size, it was only possible Table 3 Assessment of the aortic arch according to the aortic index
to analyze the patients with type III and type IV injuries. and aortic arch angle
The ages of the patients with type III and type IV inju- Type of injury Aortic arch index (cm) Aortic arch angle
ries ranged from 25 to 60 years (39.7 ± 12.08) and 22 to (degrees)
33 years (27.2 ± 4.6), respectively (p = 0.039). The two
I (n = 2) 6.83 ± 0.23 (6.59–7.08) 58.3 ± 2.7 (55.2–61.40)
groups did not differ in terms of gender; the type III injury
III (n = 15) 4.37 ± 0.64 (3.38–5.48) 45.51 ± 5.7 (35.18–53.35)
group included 11 males and the type IV injury group
IV (n = 5) 3.12 ± 0.64 (2.3–3.59) 36.29 ± 3.39 (33.07–44.8)
included 4 males (p = 0.56).
Anatomical considerations
The aortic arch angle in the type III injury group ranged
The univariate analysis revealed a significant difference from 35.18° to 53.35° (45.51° ± 5.7°), while that in the type
in the aortic diameter of the patients with type III and IV group ranged from 33.07° to 44.8° (36.29° ± 3.39°). This
type IV injuries. The aortas at the level of the aortic arch difference was statistically significant (p = 0.002) (Table 3).
in the patients with type III damage were significantly All of the variables that were identified as significant on
larger in comparison to the patients with type IV inju- the univariate analysis were included in a logistic regres-
ries. There were also significant differences in the diam- sion analysis. Due to the low number of cases in each of the
eter of the descending aorta at the level of LSA and pul- injury groups, each regression model could only include
monary division, but not so at the level of a diaphragm three variables. We, therefore, built several models. All of
(Table 1). the models accounted for sex, age and one of the variables
The aortic arch index and aortic arch angle were 6.59– listed in Table 4. The aortic arch angle was the only vari-
7.08 cm (average 6.83 cm) and 55.2°–61.4° (average able that was found to be an independent risk factor for the
58.3°), respectively, in the patients with type I injuries. occurrence of a specific type of injury in the logistic regres-
The aortic arch index values of the patients in the sion analysis (logistic regression, OR 1.5; 95% CI 1.03–
type III injury group ranged from 3.38 to 5.48 cm 2.2; p = 0.03 for the occurrence of a type III injury). The
(4.37 ± 0.64 cm); in the type IV injury group they ranged ROC curve analysis revealed that the critical aortic angle
from 2.3 to 3.59 cm (3.12 ± 0.64 cm). The difference was for the occurrence of a type IV injury was ≤36.5°. The area
statistically significant (p = 0.007). under the ROC curve was 0.92 (Fig. 2).
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LSA left subclavian artery, PA pulmonary artery, ISS injury severity score
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artery, and the highest point of the aortic arch. Measure- different CT scanners, and the potentially arbitrary place-
ments made in aortography—particularly assessments ment of the measurement points on the CT scans (selection of
based on lateral projections—may be inaccurate when mid-left bronchus level may produce inter-observer inconsist-
reconstructions are not created using the modern software ency). The low number of patients is also a serious limitation
programs that are used in the evaluation of angio-CT pic- and the data should be further validated in larger cohorts.
tures. In the present study, we used an evolution of this There is an apparent need to extend the understanding of
parameter, but it was based on vascular computed tomogra- the biomechanics of the aortic arch in the current surgical
phy reconstruction. We named the parameter the aortic arch era, in which endovascular devices are increasingly used to
angle. We measured the angle of the arch between the two treat pathological conditions in this area of aorta. The shape
aforementioned points and the highest point of the aortic of the aortic arch has an unquestionable influence on the
arch in oblique MPR reconstruction. occurrence of endoleak, bird-beaking, and even on the col-
The study population only included 2 patients with type lapse of stent-grafts in TEVAR [7, 25, 26].
I aortic injuries; thus, it was not possible to include them in
the statistical analysis. However, both of the patients with
this minor type of injury—in which conservative treatment Conclusions
may be considered—had a mild aortic arch angle. We had
no patients with type II injuries. This observation is in line The low number of complications in the endovascular treat-
with the observations of other authors. Many authors ques- ment of injuries of the aortic isthmus indicates that it is
tion the inclusion of intramural hematoma injury in aortic safe and effective. The severity of TAI is influenced by the
injury scales, and alternative aortic injury scales, in which sharpness of the aortic arch. There is an inverse relationship
this type of injury is omitted, have been suggested [22, 23]. between severity of aortic injury and the aortic arch index.
The univariate analysis revealed significant differences in
the age of the patients, the aortic diameter, and the sever-
Compliance with ethical standards
ity of injury (according to the ISS) between the patients
with type III and IV injuries. The univariate analysis also Conflict of interest The authors declare no conflicts of interest in
revealed a significant difference in the aortic arch index association with the present study.
values and in aortic arch angles of the type III and type IV
cases. However, the aortic arch angle was the only inde- Open Access This article is distributed under the terms of the Crea-
pendent risk factor that influenced the severity of aortic tive Commons Attribution 4.0 International License (http://crea-
injury in the logistic regression analysis. tivecommons.org/licenses/by/4.0/), which permits unrestricted use,
distribution, and reproduction in any medium, provided you give
Several authors who investigated the results of TEVAR appropriate credit to the original author(s) and the source, provide a
for TAI have mentioned problems in the treatment of link to the Creative Commons license, and indicate if changes were
patients with a small aortic diameter or an acute aortic made.
arch angle. The problem is especially common in young
patients. This problem may be overcome by selecting stent-
grafts that allow for the perfect conformability of the proxi- References
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