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Before anesthesia, a group of drugs are used to prepare the patient, administered
from half an hour before the surgery to the night before, known as pre
anesthetic medication.
Aims
1. Relief of anxiety and apprehension
As patient is going for operation, he is apprehensive.
2. Amnesia
To produce amnesia, so that the patient does not remember what he is going
through.
3. Supplement analgesia
Different general anesthetics produce different levels of anesthesia, so used to
supplement or augment analgesia.
4. Decrease secretions
Given to decrease the secretions in the mouth and gastric secretions (as
laryngospasm, problem in metabolism, gastric aspiration might occur)
6. Anti-emetic effect
Used to prevent nausea, vomiting, providing anti-emetic effect pre and post-
operatively.
8. Reduce dose
Overall, decrease the requirement of dose of general anesthetic required (for
muscle relaxation, analgesia).
· Lorazepam
· Midazolam
· Pentobarbital
Characteristics
– Use
They decrease the anxiety, make the person relax and drowsy, providing
amnesia.
– Duration
There is difference in the duration of action
Diazepam 72 hours
Lorazepam 24 hours
Midazolam 4 hours
– Depressant Effect
Barbiturates have more depressant effect on CVS and respiration, so are less
used, but when depressant effects are required, these barbiturates can be given.
2. Opioid Analgesics
– Morphine
– Pethidine
Characteristics
There is a difference in the duration of action. All can be given parentally.
Fentanyl is also available as transdermal patches.
– Use
Given to provide sufficient analgesia during procedure and post operatively.
– Disadvantages
a. Awakening
Patient has delayed awakening after operation and takes longer time to come out
of anesthesia.
b. GIT
Morphine causes contraction of smooth muscles, so may cause constipation
because of constriction of sphincters.
c. Respiratory System
In asthmatics, can precipitate asthma.
d. CVS
Excessive hypotension
e. Urinary
Benign prostatic hypertrophy, leading to urinary retention.
f. Eye
As morphine causes constriction of pupil, so sign of shock (dilated pupil) is
obscured in the patients administered.
3. Antiemetics
– Metoclopramide
– Antihistamines
•Tropisetron
•Granisetron
•Characteristics
– Use
Antiemetics enhance gastric emptying. They are used to prevent nausea,
vomiting in patients. Most commonly used is Metoclopramide. Antihistamines
are also used for this purpose. They are not only antiemetic but also used for:
1. Sedative property
2. Relieving anxiety
3. Anti-cholinergic effect
Patients having cancer chemotherapy have some vomiting. 5HT receptor
blockers are used to protect. Nowadays Ondansetron is also in use in patients as
pre-anesthetic.
Metoclopramide
Acts both centrally and peripherally.
1. Central Action
Acting as dopamine antagonist, acts on medullary vomiting center, producing
anti-emetic effect.
2. Peripheral Action
Enhances gastric emptying so that gastric components are passed earlier,
preventing gastric aspiration.
4. Anticholinergics
Three drugs are in use as preanesthetic
– Atropine
– Hyoscine
– Glycopyrronium
Characteristics
Effects produced in patients:
Combinations
These are the different preanesthetic medications administered before surgery.
In emergency, along with these proton pump inhibitors like Omeprazole and H2
blockers like Cimetidine are advised to decrease gastric secretions.