‘omega raat ae ‘ear INTRODUCERE IN PROBLEMATICA BOLILOR INFECTIOASE Boli infectioase: definitie » Disciplina care se ocupa de studiul bollor ccauzate de agent infectiosi > Agentiinfectosi + Bacteri fas + Fungi + Paraztl + Prion Bolile infectioase- interdisciplinaritate Istoria bolilor infectioase ‘marturi serise, legende >» Epopesa babilonana Gilgamesh (2000 ien) “all moimelor| > Biblia (Vechiut Testament): epidemi de lepra, ‘lum, holera > Legendele Okmpul ciuma in armata Troe > Paprusul egiptean Ebers: boala Aat > Inert Dendarah: tantar -vector si maariel 2117/2020Istoria modema a bolilor infectioase ous Paster (18221898) > Gasca uals Yc et penn {acres a goth Soongecenee > Denenapea noses comp » tyes psa Istoria moderna a bollorinfectioase le Robot Rac 180-1910 L > ies bof ‘Souci spel > Tle hole sa nea laborer ere germenior 1. Alcoa cea deerat ba acu sete rant nap cx singeomel sles 2. Mer alt nla pss Henin 3. oven tines a mina sev pode expel ea nara Limitele teoriei germenilor: ‘un microb- 0 boala > © boala poate fprodusa de microorganisme Aferte: peumonie, meningita, osteomiita > Un mierob poate determina mal mite bol steptocoe B-hemolile~ erie, engine, scalatina > Un microb nu determina inttdeauna o boala > Miroblomullmicrabiota umana ~ noua abocdare concoptuala abolior infoctioasevolta flogenetica, "ARBORELE VIETIF; ReciintectaNaS Microbii si organismul uman > Me paca om de ay po Toa > Mbit Bll 1 + Nr hie ins io mie > Inorgznismal una ese ml de ir de mii Par lo vl ca "mlb di copa man css naa ~ 2K + nmi cer mle x10, celir une + runt ptler micabiene > 15 solo sar + Mito dn cell tno ut ei de bat nr en epee de set ie de 0 eer Funetile microbiotet 1 Mtabotesagestva 2 Aoarare Recnosteescomensallor cae gaa ddsceminrea sini ptoge,daterata PR (ater tecoghitnrosepor) TLR®-8, NLR Pinal verze ertsrotok, cal M, col dndicn ‘Modules mroane a respunauainun sap ‘GALT (gutaseocitedympnois tetue) 43. Funcia stucurle~menanenomecetazia * duc imuncioererta, meth rus imuroge rt 211712020Intestine-Brain-Microbiome Tissue Systems eeSoasmadutnancipttdoni’ Clasificarea agentilor infectiosi Papa rata organo gaia 7. Comma evo is inde mai ge bpd 2. Simbios ea vorbis gzd: sz Vinnie BK, vara aor teste asin, ‘sie melas hss se 5. Paton pr dea er rer ode roland proc, poe de tv tale Operant (condition page vin pops inc ‘ious Patogenia capaci erotitr da produce sla Este posibila eradicarea bolilor infectioase? Chimioterapia atinicrobiane § > Paul Eni (1854-1915) Salvarsanul > Alexander Fleming (1881-1955): Penilina ‘Veccinarea > Edward Jenne (1749-1823): anvil > Louis Pastour (1822-1895): ¥-antiabie LW. Stewart (instr al Sanaa In SUA, 1961: "vom ‘mloacele pentru cain cur tip sa eadicam boil Injetoase”™ 1. aoninere! cestares incidents nor bol nection Jz Patomertozebotorinfectoase Bolle infectioase in prezent Pesto 40% dintre consuttatile medicale sunt ‘solleltate din cauze... Infctilor! 211712020Factor favorzant a crestor incidents boll infectoase 1. Crestorea dati mec do vata 2 Extindoretaricorinvriv de agnostics ‘lament vancpon pretecare 3, Abuzl de atbtce (watt mieebana) 4: Abul ratamenlor parenteral (HIV, VHB, VHC) 5 volta demegraice urbanzarea, ure popuatonae 6. Noten orporameniala(toxicomane, una cis sponte, eat‘ea selon privet sono edie) 7. Nosieasacsagce Progrese in intelegerea mecanismelor Patogenice a bolilor intectioase > Sa are elo nfestonsa nor sincroama a oer ‘toll rivera cnoeowa Kanata Royo ‘Soauton SIDA, SARS > S.a dovedtimpliarea viusuror in oncageneza (intone, HC, cancete de cl ton) > S.a demons capeciate eratogona a uot vist (itv eke hefpete, Wz vote enero, cate eptspie,vepenams pallu, lise) sau protzoareoxopiasmna ara) > S.a.deronsratca une nfect volusezaauicintn, ‘ulmurtate rendu, dr cu perastnts nef 8 evel nace nse torts epesn.cu, Parvovirus VAB, VHC, HV) ‘Schimbari in epidemiologia bolle infectioase > Sauidoniteat agent infects no + Visit hemragieeV fers Lassa. Eboa, Mararg + Mit ste etoura 7, rvV + Veneptie C.D, fav 1 usu Za 1 Bactert Leperate prounephil, Helcobeter pa, Compaen «Pri nesta sponges, b. Athens) Bolile infectioase in prezent -Asezzut morale nor bo ering peut tepiem endocete 2 Avdspeitunele ol caren cma, varia 9. S-aubinutprogressimensein canto nor pier tupols polemels asora oe titceagsnont iis oceans eee Boll inectosseclascesaumodfieat ~ ‘patemoxe to focen > Boe especive ns ular sit doer te a Sl pier is mae cps = BOL ReeheReevTe > Avapanut tl nlc tole saucs era de manestare "BOLI EMERGENTE 21720202197/2020 ‘Serre repays SARS) ase can any aren PERS) Legoomes duos wee-4rc 5 Neon shoe) deren | 8 a 2 parenreenemacre tere2117/2020 "priors fr 2040" 2020 became He)" vasa” ity 3 etectious diasas and improving slabs heath | sare na cacp Controlul bolilor infectioase > Supravegherea si prevenirea infectior > Supraveghere si preverirea infectilor Fezistentei gemenior > Diagnostcu si terapia adecvata a infectilor 1 Distrburea ecitablaaresuseormedcale(n terior ne catego srot-economice) | Fomarea persona careasaingrasca sees pacer! > Cercetarea medical in domeniulbotlor Infectioase