sh ray 198 360-0 Use of ambroxol and bromhexine as mucolytics for enhanced diffusion of furaltadone into tracheobronchial secretions in broilers H. SUMANO, I GRACIA’, A. CAPISTRAN, G, MEADE, A. RIVERO! asp 1 RUI-RAMIREZ! Deparment of Pamaclay, Fay of Viney) Mebiine ond Huta, Dgarineat of Tene Chant, Fay of Christy, Uhvesidad Naval Aina de Me, (ERAN Axe Coy 04510, and "Calbia Tabor of Mai, Cand dH 160, Mesa City 01940, Maxio ee fe pn Dec Abstact 1. Ambon! aod brombexine wore ewaed a8 mucobyie 20d t0 ‘Since the pasage of furshadone ino tracheobronchial teres (TBS) in tuone completed sesintory dteweraetet boters 2 Mica of THS wor paeably ncrened the abroslreted Bird and nly sightyincened the brenexine groups however, he phy (ae of {Tah war spec he ambronteented brs. 271i = ar ne nea of aoe no aches {thera te fama a eae die, INTRODUGTION 1k je perhaps reasonable > sate that chronic respiratony dear associated with Exch cs the ingle mon prvalent nd economically mporant pathologic, onion in bros, Ire eaute oe esten expert nr acti She poultry istry. Therefore any suds have been eared outta evauate Che st Staatbacterl gents under partclar ld conditions aswell as bacterial sesivites to antbiotcs and chemoherapeuts (Bereta and. Cav, 1984), In. addon t fensidering the deseeeivenes telasonsip obtained with a given antbacerial agent, itsecessary to anajse the costhenefit ato ofthe particular therapy, because appears that tere sa dose relationship benween increased efetvenest ofa drug and i higher cos. Neverbeles,fraiadone appears to be les expensive and yet ‘etetve aguinet Eekrwtis nk urthennore, # has been observed iat dhe [Production of some torn hence mining efictnenes ant sme Mpa Species Huber, 1988). However ths ltrfuran has a narrow maria of sf and for ‘he reauon sone clinicians have decided to reise we, pact iit ecesay to increase the dove above tandad therapeutic level, ‘Apart fom the minimum iibtory concentration (MIC) values ofan ansbace-sot MATERIAL AND METHODS One hundred and twenty 1Sbold brie from a farm pase to Mylene ellpicon, as shown by routine concal haemagglutnation tnd ELISA tere! wee ‘hd in hit a The brs etn Neweasle disease and inoculated with two drop of alive sluton 9 pension of apron Exh el (Bld stan) per crop. Ts 4 eld condoms The chicken wee allt to gg body eh 73 mg/kg ody. weigh) pur farladone 263 ng 75 mg/h body weigh) plus furakadone 263 mg/l al Hy (convo! group. the birds were Kile sing a the uache tion of readily vise lump, the reladveviscaty Co wate) ofthe Hid phase ‘Oswald vicouneter, kept at 20°C in water bath and recorded sof fuatadone were measired with a sadfeation ofthe spec- “by Herrett and. Buzard (1960), in whic Table, Gand fe fa eli 1 Prepress cea meme fe pe er sluble. Colour is developed with » phenyLAydeasine ya nd the procedure follows a near tad from 0° a to 504 RESULTS ‘The mean and standard deviation ofthe teaive vscosiy tnacheobronchial serene vere FlSos ln eon nr