zed “saprized— G “ vitamin © irom cosnoz proven Hayashibara AAZG -HAYASHIBARA NAGASE Groupstabilized Vitamin C from ‘formations is the fact that it can easily lose its biologic activity because of heat, ‘oxidation, and reactions with metal ione and other common cosmetic Ingredients. This ‘causes discoloration in the cosmetic formulations and dramatically decreases the ability ‘of vitamin € to provide the benefits of younger looking healthier skin. To overcome these problems, Hayashibara partnered with a renowned cosmetic chemist fo develop a new suostance consisting vitamin C and glucose using a navel enzyme manufacturing process, This has resulted ina unique stabilized vitamin © called Ascorbic Acid 2-Glucoside. This vitamin © derivative, which fs now being sold under the trade name AAZG™, has superior ‘formation stability that essentially resists discoloration and degradation. while retaining all the biologic activity that provides lightening. UV damage and anti-aging properties. {has been known for many yoars that tho uso of vitamin C (ascorbic acid) can BE est in tire, healer younger loking skin. Science nas cacovered thal is lightening etfect is related to the ably of vitamin C to suppress melanin synthesis and AD reduce existing melanin. The challenge with using vitamin C in health and beauty G) = EE] Structure of t-Ascorbic Acid 2-Glucoside “The hye up ofthe second carbon in vtarin Cs righ reactive ae pays an Inport role in te biologic set, however, ft can also be the site of Inactivation ara decomposion Ascot ‘Acid 2.Glucoside is produced fom vain (© and starch by use of erzymes that reversibly bind glucose 10 the resclve yoo! grown 1 plotect the site tom CHAOH [AA2G™ is highly stable in solution even at high temperatures, low pH and in the presence of metal lons, This results in AA2G™ helping to maintain product quality ibe stably of an aqueaus solution AA2G™ stability and color in the presence ie tae J re / Cr al d I a a ool {ttm comes mere ea fue Sinton ede stash taunt a Satan e 2 de ‘iors wrt at ode 25 hu2 Resistant to discoloration WiColr of AR2G and other vitamin © derivative slusions AA2G™ Is resistant to discoloration during production or storage of cosmetic products. This os vitamin C from .-Ascorbic Aci cellular surface and provides benefits over a sustai 2-Glucoside at the sults in AZG™ helping to maintain product quality sd Irate 10% nou sitions Marat, Reelin see eae Mi Ascotbic Ac 2-Glucosice eects period of time. L-Ascorbic Acid 2-Glucoside is hydrolyzed by a-glucosidase, an enzyme Shincat present in the membrane of skin colls. This process releases vitamin C in its active form, When vitamin C enters cells It results in significant and well-documented biological responses. 1-Ascorbie Acid 2-Glucoside Is hydrolyzed over a prolonged period, resulting in consistent and sustained beneficial physiological etfect on the skin Lightens skin Suppresses melanin synthesis When L-Ascorbic Acid 2-Glucoside is Converted to vitamin © and enters skin cells, it significantly reduces the production of melanin by inhibiting tyrosinase activity. This results in a reduction of dopaquinone. an Intermediate of melanin synthesis. Additionally it converts existing dopaauinone to dopa, Lightens skin Reduces existing melanin When Ascorbic Acid 2-Glucoside is Converted to vitamin C and enters skin cells, it can significantly lighten existing black melanin by a reduction reaction, Prevents melanin syntesis IMskn ightening mechanism by LAscotic Acid 2-Glucoside ite Sean pare (oe (Se) — ee) ~ Ca) Ges Velen sosucion Tieng fla [AAZG Is a trademark of Hayashibara and a registered trademark of Hayashibara In Japan, the U.S. and other countries.Lightens skin Reduces skin hyperpigmentation Creams containing AAZG™ ate effective at Measurement of skin hypernigmentation lgtoring sn hypepignertaion, Sneteen ae il | [ revtieetiars Doi soeston| Protects from UV damage ‘Suppresses damage to cells caused by UV irradiation When L-Ascorbic Acid 2-Glucoside is Ml shits UV damage to skin foblasts converted to vitamin C, it ean dramatically singer tats reduce the {ree radicals that result from UV lnradiation of the skin, thereby significantly voastan armas at pete hea Ase fot Anti-aging irene ae st of sn ei Promotes collagen synthesis c— Collagen is a protein that plays an important role in the structure and frmness of skin. When L-Ascorbic Acid 2-Glucoside is Converted to vitamin C and enters skin cells, It promotes collagen synthesis of skin Abroblasts. L-Ascarbic Acid 2-Glucoside maintains its eects fora sustained period of time, Daye eet ‘agi warns sn win on Anti-aging vane on rand Improves wrinkles and roughness... ; effective at reducing wrinkles and reducing. ~ ° ‘skin roughness. 1] 5BLAA2G™ appearance and packaging I Japanese regulatory approval Quasi-crugs containing ARZG™ as an active ingredient are approved in Japan. The claims are listed as: “Preventing pigmentation in age spots and freckles trom sunlight” or “Suporessing melanin syntnesis and preventing pigmentation in age spots and freckles” Ifyou need further information ar technical support, please ‘eel free to contact @ company representative atthe number listed on the back page. INCI Name: Ascorby! Glucoside ‘AA2G is a trademark of Hayashibara and a registered trademark of Hayashibara in Japan, the U.S., Australia, Brazil, Canada, China, European Union, Hong Keng, india, Malaysia, Moxico, Philippines, Republic of Korea, Aussian Fedoralion, Singapore. South Altica, Tainan, United Arab Emirates and Viet Nam (as of June 30, 2016). II How to use AA2G™ in your formulations: (© Aer preparing an AAZG™ solution, neutralize it by using an alkaline agent before adding ito the formulation, © Ifthe formulation needs heating, coo! it below 40°C before adding neutralized AAZG™ solution. Avoid heating formulations containing AA2G™ above 40°C for prolonged periods. © Adding butlers, chelating agents and antioxidants, and shielding the product from strong lignt are also useful in proventing AA2G™ trom decomposition during formulation. (© The stability of AAZG™ is intuonced by DH. Avoid leaving It under prolonged conditions of strong acidity or alkalinity (pH 2-4 of 8-12), [Compatibility with water-soluble polymers It water-soluble polymers are used with AA2G™, it is recommended that they are either natural or sat-tolerant syntnetc polymers. Further technical assistance can be provided upon requestContact Us Japan HAYASHIBARA CO.,LTD. [Nhor-Seimel Okay Bag. Shinkan 1-1-8 Shinai, Kita, Oxayama 700-0907, Japan (TEL/FAX) +81-86-224-4312/+81-86-222-2268, Please vist ou website at it//www int havachinera.coip! for general information ard inure North and South America Nagase America Corp. ‘546 Fit Avenue Vet Foor, New Yor NY 10036-5000, USA, (TeL/FAx) +9.212-708-1340/+1.212-998.0687 hayashibaratnagasenam.com Europe ‘Nagase (Europa) GmbH Imermarnsrasse 650, 40210 Dusselért, Gormany (TEL/FAX) +49.211-866700/+48-211-3257068 eyashibarauinagacece Asia [Nagase Business Management and Planning (Shanghai) Co. Lie (02. 7 Eco City. 1788 Nanjing Road. ‘Shanghai PA. China 200040 (TEL/F9x) +86.4121)93607851/+86.(21)33607852 hayashibaratnagacecr Nagase (Taiwan) Co. Ltd 16F. No. 248, Soc.3, Nanking Ed, Tape, Taiwan, R.0., (TELEX) +886-2127733668/1886.2)27757288 ‘South East Asia and Oceania ‘Nagase Singapore (Pte) Ltd 1600 Nort Bridge Road #11-01 Parkview Square Shespare 188778 (TEL/FaX) +05-63080088/+65-63080227 hayashiparanagasecom se Nagase India Private Lia £312, Hubiown Solari, N.S, Phoske Marg. Near East West Flyover. Ardheri East, Mumbai 400 068, ia (TEVFAx) +91-22-8681-8586/+91-22.6681-8508 hayashibaraiiagaseco NAGASE & CO, LTD. Personal Cave Products Ov. Life & Healhoate Products Dect. 5-1, NrsashiKobunache, Chuo, Toyo 108-8355, dapan (TEL/FaX) +81-3-9006-9804/+87-9.3605.3191 rpcnbaragase.cojo Nagase do Brasil Comérclo de Produtos Quimicos Ltda. ua Cupatao, 86, 204 e 306, Vila Mariana CEP 04073-000, ‘Sto Paulo, SP (TeL/Pax) +55.11-8251-9511/455.11-9262-9451 contatotnagacetraslcomtr Nagase (Europa) GmbH, London Branch 3 Caversh Saar, Lone, Wi PW, UK (TEL/FAX) +444000)7 182.4948/+48-020)9402-2427 hayashibarasnagase ce Nagase (Hone Keng) Ltd Suites 3801 & 3912-14, Tower 6, The Gateway Haxbou City, 8 Canton Road. Tsim Sha Tu Kouleo, Hang Kong, SAR. P.R. China (TEL/FAX) +852-2302-7607 /+852-2377-2720 rag olerime-websnagase comic Danam Bldg. 23F. 10. Sowol,Jung-eu, Seoul Korea 08527 (TEL/Pax) +824297598589/+82-(297348747 Nagase (Thailand) Go. Lt No 952, Raraland Buln. 14th Poor, Rar V Road, Kwaeng Survawangse, Ket Banga, Sangkok 10500 Trailara (TEL/FAX) +0642)6327253/+66-(210327254 ayashibarasinagace.coth “The infomation provides herein is for customers nthe cosmetic Inausby andr cosmetic related inaustie, None of the infomation is for end consuers of the fal formulations, The cosmetic iy and/or cosmetic related industry customer is responsible for determining wheter products ate compance wih applicable Inward ob governmental enacts Pertomarice ofthe products describes herein should be veri by testing ard cated out ony by {quai experts. Is the sole resporsiilties of the customer to cary out and ararge for such testing Hayashibara assures ro lability for providing such information and advice Inlung the een fo which sch intomaton and ace may relate To existing ti gh party intellect Hens, especialy patents igs INCI name: Ascorbyl Glucoside Fayashibara does net make any warranty or representation. express or implied, with respect tothe utlity 2 completeness of ho infomation povided are specifcaly slams te imoliea wararsios of merchandise-abily aa fess fora particular purpose. Unsuthorzedrepecscton of thi och is probit CARETETS AA2G™ is manufactured by Hayashibara Co,, Ltd. in Japan HAYASHIBARA NAGASE Group