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Seeley’s
ESSENTIALS OF
Anatomy &
Physiology Chapter 3
Tenth Edition
Cinnamon Vanputte
Cell Structures and Their
Jennifer Regan Functions
Andrew Russo
© 2019 McGraw-Hill Education. All rights reserved. Authorized only for instructor use in the classroom. No reproduction or further distribution permitted without the prior written consent of McGraw-Hill Education. © 2019 McGraw-Hill Education
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Organelles:
• specialized structures in cells that perform
• specific functions
• Example: nucleus, mitochondria, ribosomes
Cytoplasm:
• jelly-like substance that holds organelles
Cell membrane:
• also termed the plasma membrane
• a structure that encloses the cytoplasm
Figure 3.1
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Some substances, like O2 and CO2, can pass Some substances require carrier molecules to
directly through the cell membrane’s transport them across the cell membrane, such
phospholipid bilayer. as glucose.
Some substances must pass through Some substances require a vesicular transport
transmembrane protein channels, such as Na+ across the membrane.
through its channels.
The vesicle must fuse with the cell membrane
The route of transport through the membrane for transport.
depends on the size, shape, and charge of the
substance.
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Active Transport and Passive Transport 1 Active Transport and Passive Transport 2
Passive membrane transport does not require Passive membrane transport mechanisms
the cell to expend energy. include diffusion, osmosis, and facilitated
diffusion.
Active membrane transport does require the
cell to expend energy, usually in the form of ATP. Active membrane transport mechanisms include
active transport, secondary active transport,
endocytosis, and exocytosis.
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Figure 3.3
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Figure 3.4
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Figure 3.5
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Isotonic Hypertonic
A cell immersed in an isotonic solution has the The cytoplasm of a cell in a hypertonic solution
same solute concentrations inside and outside has a lower solute concentration and higher
the cell. water concentration than the surrounding
solution.
The cell will neither shrink nor swell.
Water moves by osmosis from the cell into the
hypertonic solution, resulting in cell shrinkage,
or crenation.
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Red Blood Cell Changes in Differing
Osmosis 2
Solutions
Figure 3.7
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Figure 3.8
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Active transport is a carrier-mediated process, A major example of active transport is the action
requiring ATP, that moves substances across the of the sodium-potassium pump present in cell
cell membrane from regions of lower membranes.
concentration to those of higher concentration
The sodium-potassium pump moves Na+ out of
against a concentration gradient.
cells and K+ into cells.
Active transport processes accumulate
The result is a higher concentration of Na+
necessary substances on one side of the cell
outside cells and a higher concentration of K+
membrane at concentrations many times
inside cells.
greater than those on the other side.
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Figure 3.9
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Figure 3.10
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Exocytosis 1 Exocytosis 2
Figure 3.12
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The nucleus is a large organelle usually located The nuclei of human cells contain 23 pairs of
near the center of the cell. chromosomes which consist of DNA and
proteins.
The nucleus is bounded by a nuclear envelope,
which consists of outer and inner membranes During most of a cell’s life, the chromosomes are
with a narrow space between them. loosely coiled and collectively called chromatin.
The nuclear membrane contains nuclear pores, When a cell prepares to divide, the
through which materials can pass into or out of chromosomes become tightly coiled and are
the nucleus. visible when viewed with a microscope.
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Figure 3.16a
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Mitochondria 1 Mitochondria 2
Mitochondria (singular mitochondrion) are small The material within the inner membrane is the
organelles responsible for producing considerable mitochondrial matrix and contains enzymes and
amounts of ATP by aerobic (with O 2) metabolism. mitochondrial DNA (mtDNA).
They have inner and outer membranes separated Cells with a large energy requirement have more
by a space. mitochondria than cells that require less energy.
The outer membranes have a smooth contour, but
the inner membranes have numerous folds, called
cristae, which project into the interior of the
mitochondria.
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Figure 3.19
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Microtubules Microfilaments
Microtubules are hollow structures formed from Microfilaments are small fibrils formed from
protein subunits. protein subunits that structurally support the
cytoplasm, determining cell shape.
The microtubules perform a variety of roles,
including helping to support the cytoplasm of Some microfilaments are involved with cell
cells, assisting in cell division, and forming movement.
essential components of certain organelles, such
Microfilaments in muscle cells enable the cells to
as cilia and flagella.
shorten, or contract.
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Figure 3.20
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Centrioles Centriole
The centrosome is a specialized area of
cytoplasm close to the nucleus where
microtubule formation occurs.
It contains two centrioles, which are normally
oriented perpendicular to each other.
Each centriole is a small, cylindrical organelle
composed of microtubules.
The centriole is involved in the process of
mitosis.
Figure 3.21
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Cilia Flagella
Cilia project from the surface of certain cells. Flagella have a structure similar to that of cilia
but are much longer, and they usually occur only
They are responsible for the movement of
one per cell.
materials over the top of cells, such as mucus.
Sperm cells each have one flagellum, which
Cilia are cylindrical structures that extend from
propels the sperm cell.
the cell and are composed of microtubules.
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DNA 1 DNA 2
DNA contains the information that directs Each nucleotide on one DNA strand has a specific
protein synthesis; a process called gene bonding pattern to another nucleotide on the
expression. opposite strand.
A DNA molecule consists of nucleotides joined A gene is a sequence of nucleotides that
together to form two nucleotide strands. provides a chemical set of instructions for
making a specific protein.
The two strands are connected and resemble a
ladder that is twisted around its long axis.
Each nucleotide consists of a 5-carbon sugar, a
phosphate group, and a nitrogenous base.
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Gene expression, which is protein synthesis, Transcription takes place in the nucleus of the
involves transcription and translation. cell.
Transcription involves copying DNA into DNA determines the structure of mRNA through
messenger RNA. transcription.
Translation involves messenger RNA being used During transcription, the double strands of a
to produce a protein. DNA segment separate, and DNA nucleotides of
the gene pair with RNA nucleotides that form the
mRNA.
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Transcription 2 Transcription 3
DNA contains one of the following organic bases: DNA nucleotides pair only with specific RNA
thymine, adenine, cytosine, or guanine. nucleotides.
Messenger RNA (mRNA) contains uracil, adenine, DNA’s thymine pairs with RNA’s adenine.
cytosine, or guanine.
DNA’s adenine pairs with RNA’s uracil.
DNA’s cytosine pairs with RNA’s guanine
DNA’s guanine pairs with RNA’s cytosine.
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Transcription 4 Translation 1
Figure 3.23
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Translation of mRNA in Protein
Translation 2
Synthesis
Transfer RNA transports specific amino acids
from the cytoplasm to the ribosome-mRNA
complex and initiates formation of the
polypeptide chain.
The process continues until the entire
polypeptide is completely formed.
Figure 3.24
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Figure 3.22
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A cell spends most of its life cycle in interphase Nucleotides in the DNA of each template strand
performing its normal functions. pair with new nucleotides that are subsequently
joined by enzymes to form a new strand of DNA.
During interphase, the DNA (located in
chromosomes in the cell’s nucleus) is replicated. The sequence of nucleotides in the DNA
template determines the sequence of
The two strands of DNA separate from each
nucleotides in the new strand of DNA.
other, and each strand serves as a template for
the production of a new strand of DNA. Replication of DNA gives two identical
chromatids joined at a centromere; both form
one chromosome.
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Figure 3.25
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Mitosis Prophase
Mitosis involves formation of 2 daughter cells During prophase the chromatin condenses to
from a single parent cell. form visible chromosomes.
Mitosis is divided into four phases: prophase, Microtubules, termed spindle fibers, form to
metaphase, anaphase, and telophase. assist in breaking the centromere between the
chromatids and move the chromosomes to
opposite sides of the cell.
The nuclear membrane dissolves.
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Metaphase Anaphase
During metaphase, the chromosomes align near At the beginning of anaphase, the chromatids
the center of the cell. separate and each chromatid is called a
chromosome.
The movement of the chromosomes is regulated
by the attached spindle fibers. Each of the two sets of 46 chromosomes is
moved by the spindle fibers toward the centriole
at one of the poles of the cell.
At the end of anaphase, each set of
chromosomes has reached an opposite pole of
the cell, and the cytoplasm begins to divide.
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Tumors
Tumors are abnormal proliferations of cells.
They are due to problems occurring in the cell
cycle.
Some tumors are benign and some are
malignant (cancer).
Malignant tumors can spread by a process,
termed metastasis.
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