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Definition
Etiology and risk factors
Pathophysiology
Clinical Presentation
Classification
Workup
Management
Definition
Diabetic foot ulcer
A non healing or poorly healing, break in the skin, below the ankle in an
individual with diabetes, critical in the natural history of the diabetic
foot.
Risk factors
Peripheral
Abnormal Foot
Neuropathy Vascular Hyperglycaemia
Pressures
Disease
Previous
Limited Joint
Trauma Foot Deformity Ulceration
Mobility
/Amputation
Duration of
Poor Vision Old Age
Diabetes
Etiology
The three pathogenetic mechanisms involved in diabetic foot
complications are
Angiopathy
neuropathy infection
/ischaemia
Pathophysiology
Clinical presentation
History
• Onset and progression of ulcer
• Constitutional symptoms- fever
Physical examination
• Ulcer
• Neuropathic foot
• The neuropathic foot is warm and well perfused with palpable pulses; sweating is
diminished, and the skin may be dry and prone to fissuring.
• Neuroischemic foot
• The neuroischaemic foot is a cool, pulseless foot; the skin is thin, shiny, and without hair.
There is also atrophy of the subcutaneous tissue, and intermittent claudication and rest pain
may be absent because of neuropathy
• Infected
Left: Neuropathic foot with plantar
ulcer surrounded by callus. Right:
Ulcer over medial aspect of first
metatarsophalangeal joint of
neuroischaemic foot
Ulcer examination
• Location, size, depth, margins, colour, odour, base, floor
• type of discharge
• attempts made to express pus
• type of ulcer (neuropathic, ischemic or neuro-ischemic) needs to be
determined.
• probed to look for extension into bone, sinus tract, joint and tendon
sheath. Probe hitting bone signifies possible underlying osteomyelitis.
When bone is exposed, the patient is assumed to have osteomyelitis
until proven otherwise.
Vascular
• Pulses (dorsalis pedis, posterior tibial, popliteal, femoral)
• Capillary return (normal < 2 seconds)
• Colour changes: Cyanosis, erythema
• Changes of ischemia: Skin atrophy; nail atrophy, abnormal wrinkling,
diminished pedal hair
Neurological
• Vibration perception: Tuning fork 128 Hz
• Pressure & Touch: Cotton wool (light), Monofilament (5.07) 10gm
(Semmes Weinstein)
• Pain: Pinprick, using sharp and blunt tool ( e.g. Neurotip)
• Temperature perception: hot and cold
Monofilament test: testing sites and
application. The nine plantar sites are
the distal great toe; third toe; fifth toe;
first, third, and fifth metatarsal heads;
medial foot, lateral foot, and heel; and
one dorsal site
Musculoskeletal deformities
• Attitude and posture of lower extremities and foot
• Orthopedic deformities – Hammertoes / Bunions / Charcot
deformities / amputations / prominent metatarsal heads
• Limited joint mobility – active and passive movements
• Tendo - Achilles contractures
Evaluation of the skin and nails of the foot
• Skin appearance: color, texture, turgor, quality, and dry skin
• Calluses, heel fissures, cracking of skin due to reduced sweating
inautonomic neuropathy
• Nail appearance: Onychomycosis, dystrophic, atrophy,
hypertrophy,paronychia
• Presence of hair
• Ulceration, gangrene, infection
• Interdigital lesions
• Tinea pedis
Classification
University
Wagner’s
of texas
Stages
Stage A: No infection or ischemia
Stage B: Infection present
Stage C: Ischemia present
Stage D: Infection and ischemia
present
Grading
Grade 0: Epithelialized wound
Grade 1: Superficial wound
Grade 2: Wound penetrates to
tendon or capsule
Grade 3: Wound penetrates to
bone or joint
Workup
Biochemical
• Fasting or random blood sugar (FBS, RBS)
• Glycohemoglobin (HbA1C)
• Full blood count (FBC)
• Erythrocyte sedimentation rates (ESR)
• CRP
• Wound and blood cultures(C&S)
Imaging
Vascular investigations
Neurological investigations
Any abnormal results of the above investigations in the presence of a non-healing foot ulcer warrant
a vascular assessment. Determination of distal run-off and perfusion can be assessed by
arteriography, digital subtraction angiography (DSA)or magnetic resonance angiography (MRA)
Left: Hand held Doppler used with sphygmomanometer to
measure ankle systolic pressure. Right: Doppler waveform from
normal foot showing normal triphasic pattern (top) and from
neuroischaemic foot showing damped pattern (bottom)
Assessment of plantar foot pressure