HOMEWORK PATHOLOGY SET A A. Factor IX C.

Factor VII
B. Factor VIII D. von Willebrand factor
NAME:
C__13. A skin biopsy from a 20-year-old man with eczematous dermatitis is
B__1. The Pap smear from a 38-year-old woman showed cohesive flat sheets submitted for histopathological examination. Which of the following changes
of cells with large nuclei, pale chromatin, would be most consistent with a diagnosis of acute spongiotic dermatitis?
abundant cytoplasm and prominent nucleoli. Occasional mitoses were seen. A. Acanthosis D. Papillomatosis
These features are characteristic of which of the following? B. Epidermotropism E. Parakeratosis
A. Atrophy C. Intraepidermal edema
B. Repair
C. Atypical endocervical cells, not otherwise specified A__14. A skin biopsy reveals spongiotic changes associated with acanthosis
D. Endocervical adenocarcinoma and parakeratosis. Neutrophils are found in the stratum corneum. The
E. Squamous cell carcinoma granular layer is of normal thickness. Which of the following diagnoses is
most likely?
E__2. HPV infection is established in which layer of the squamous A. Dermatophytosis D. Pustular psoriasis
epithelium? B. Irritant contact dermatitis E. Stasis dermatitis
A. Anucleated surface keratin layer C. Pityriasis rosea
B. Parakeratotic surface squamous cells
C. Superficial squamous cells E__15. Which of the following bullous diseases is pathogenetically related to
D. Intermediate squamous cells autoantibodies against antigens of epidermal intercellular junctions?
E. Basal squamous cells A. Bullous pemphigoid D. Erythema multiforme
B. Dermatitis herpetiformis E. Pemphigus vulgaris
B__3. What is the most common anatomic location of cervical squamous C. Epidermolysis bullosa
intraepithelial neoplastic (CIN) lesions?
A. Lateral side of ectocervix D__16. Which of the following elements in fibrocystic change is related to
B. The transformation zone/squamocolumnar junction increased risk of breast cancer?
C. Lower end of the endocervical canal A. Adenosis D. Epithelial hyperplasia
D. Upper end of the endocervical canal B. Apocrine metaplasia E. Papillomatous growth
E. Vaginal fornix C. Cyst formation

C__4. Gandy gamma body is typically seen in chronic venous congestion of B__17. Which of the following breast lesions lacks a myoepithelial lining in
which of the following: spite of its benign nature?
A. Lung C. Spleen A. Intraductal papilloma D. Sclerosing adenosis
B. Kidney D. Liver B. Microglandular adenosis E. Tubular adenoma
C. Radial scar
A___5. An autopsy, the spleen of a patient is noted to have a thickened
capsule and many small, scarred areas. Scarred reveals fibrosis fibrosis with B__18. The medullary variant of breast carcinoma is characterized by:
hemosiderin and calcium deposition. This type of spleen is usually seen in A. Expression of hormone receptors
conjunction with which of the following disorders: B. Frequent association with BRCA-1 gene mutations
A. Hepatic cirrhosis C. Theumatoid arthritis C. Low mitotic activity
B. Hodgkin’s disease D. Sickle cell anemia D. Marked desmoplastic reaction
E. Worse prognosis than invasive ductal carcinoma
D__6. Which one of the listed receptors is the type of receptor on leukocytes
that binds to pathogen-associated molecular patterns (PAMPs) and mediates A__19. Which of the following histological features or patterns are
immune response to bacterial lipopolysaccharide: associated with increased risk of malignancy in fibroadenomas?
A. Cytokine receptor C. Mannose receptor A. Cysts greater than 3 mm, sclerosing adenosis, epithelial
B. G-protein-coupled receptor D. Toll-like receptor calcification
B. Infarction
B__7. A 14yo girl on exposure to cold has pallor of extremities followed by C. Multinucleated giant cells
pain and cyanosis. In later ages of life, she is prone to develop what: D. Myxoid hyaline stroma
A. SLE C. Rheumatoid arthritis E. Presence of heterologous stromal components
B. Scleroderma D. Sickle cell disease
D__20. A breast angioma is usually an incidental microscopic finding. Its
A__8. Regarding severe combined immunodeficiency disease, which of the most typical histologic feature is:
following statement is true: A. Anastomosing vascular channels D. Perilobular arrangement
A. Adenosine deaminase deficiency C. NADPH oxidase deficiency B. Frequent cellular atypia and mitoses E. Subcutaneous location
B. Decreased circulating lymphocytes D. C1 esterase deficiency C. Intralobular invasion

D__9. Heerfordt’s syndrome consists of fever, parotid enlargement, facial E__21. Rosenthal fibers are eosinophilic, corkscrew-shaped structures that
palsy, and: are pathognomonic of:
A. Arthralgia C. Erythema nodosum A. Alexander disease D. Reactive astrocytosis around tumors
B. Bilateral hilar adenopathy D. Anterior uveitis B. Pilocytic astrocytoma E. None of the above
C. Reactive astrocytosis around infarcts
B__10. A newborn baby presented with profuse bleeding from the umbilical
stump after birth. PT, aPTT are within normal limits. Most likely diagnosis is: C__22. Which of the following is the most frequent primary malignant tumor
A. Factor X deficiency C. von Willebrand disease of the central nervous system?
B. Glanzmann’s thrombathenia D. Bernard Soulier disease A. Anaplastic oligodendroglioma D. Lymphoma
B. Ependymoma E. Medulloblastoma
A__11. Best blood product to be given in a patient of multiple clotting factor C. Glioblastoma multiforme
deficiency with active bleeding:
A. FFP C. PRBC B__23. Histological examination of a well-circumscribed mass involving the
B. Whole blood D. Cryoprecipitate cerebellum and fourth ventricle of an 18-y0 male reveals a tumor. Which of
the following is the most likely diagnosis?
D__12. A 7yo girl presents with bleeding in joints. She has prolonged aPTT, A. Cerebellar liponeurocytoma D. Medulloblastoma
normal PT, and platelet counts, What could be the deficiency: B. Ependymoma E. Pilocytic astrocytoma
C. Hemangioblastoma A. Circumferential involvement of the esophagus
B. Distal invasion of the gastric wall
B__24. Which of the following is correct about sacrococcygeal germ cell C. Growth confined to submucosa, regardless of nodal status
tumors? D. Infiltration limited to lamina propria
A. Associated with spina bifida E. Invasion limited to mucosa and submucosa, with negative nodes
B. Mature teratoma is the most common type
C. Seminoma is the most common type D__34. Which of the following statements applies to esophageal
D. Up to 90% occur in males adenocarcinoma?
E. Usually malignant if present at birth A. The “inlet patch” is the most frequent location
B. Has a better prognosis than squamous cell carcinoma
C__25. A 46-yo male presents with an ulcer of the hard palate. A biopsy C. Incidence is steadily decreasing in the United States
reveals necrosis, chronic inflammation, and squamous foci. The lesion D. Majority of cases develop from Barrett esophagus
exhibits a prominent lobular architecture. Which of the following is the most E. Minority of cases arise from the gastroesophageal junction
probable diagnosis?
A. Leukoplakia D. Oral submucosal fibrosis A__35. A gastric biopsy of the antral/pyloric region shows replacement
B. Mucocele E. Squamous cell carcinoma of the normal gastric epithelium by intestinal-type epithelium. Gastric
C. Necrotizing sialometaplasia columnar cells are replaced by absorptive cells and goblet cells producing
acid sulfomucin. These findings are consistent with:
E__26. Which of the following is a prominent feature of adenoid A. Intestinal metaplasia, large bowel type, complete
cystic carcinoma? B. Intestinal metaplasia, large bowel type, incomplete
A. Association with Mikulicz syndrome C. Intestinal metaplasia, small bowel type, complete
B. Cytoplasm packed with mitochondria D. Intestinal metaplasia, small bowel type, incomplete
C. Good long-term prognosis E. Pyloric metaplasia
D. Most frequent in parotid gland
E. Perineurial invasion is common B__36. Which of the following histopathologic changes of the
antral mucosa is most frequently associated withHelicobacter pylori
B__27. A biopsy of a mass located in the left ethmoid sinus reveals gastritis?
a carcinoma characterized by a glandular architecture. Knowing that the A. Erosions
patient is a 65-year-old retired woodworker, which of the following is the B. Lymphoid follicles with germinal centers of deep mucosa
most likely diagnosis? C. Neutrophilic infiltration of surface epithelium
A. Adenoid cystic carcinoma D. Pit abscesses
B. Intestinal-type adenocarcinoma E. Severe atrophic gastritis
C. Low-grade sinonasal adenocarcinoma
D. Mucoepidermoid carcinoma A__37. A patient undergoes surgery for resection of a gastric neoplasm
E. Undifferentiated nasopharyngeal carcinoma previously diagnosed as gastrointestinal stromal tumor (GIST) on biopsy. This
class of tumors is presumably derived from:
C__28. A transglottic cancer of the larynx is a tumor that: A. Interstitial cells of Cajal D. Smooth muscle cells
A. Arises from the true cord D. Involves the false cord B. Myofibroblasts E. Undifferentiated mesenchymal cells
B. Arises in the pyriform sinus E. Lies below the true cord C. Schwann cells
C. Crosses the ventricle vertically
B__38. The pancreas of a 50-year-old patient shows extensive hemorrhagic
E__29. Which of the following laryngeal tumors has the lowest and fat necrosis. Chalky-white deposits are observed in the omentum.
metastatic potential? Besides alcoholism, the most common etiologic factor associated with this
A. Basaloid squamous carcinoma condition is:
B. Carcinomas with neuroendocrine differentiation A. Acute ischemia D. Hyperlipoproteinemia
C. Salivary glandlike tumors B. Bile stones E. Infections
D. Squamous cell carcinoma C. Drugs
E. Verrucous carcinoma
D__39. In the differential diagnosis between pancreatic adenocarcinoma
E__30. An endomyocardial biopsy performed 2 weeks after cardiac and chronic pancreatitis, which of the following changes favors
transplantation shows a single well-demarcated focus of endocardial adenocarcinoma?
lymphocytic infiltrate composed of B and T lymphocytes, macrophages, and A. Chronic inflammation D. Loss of lobular architecture
plasma cells. This change is probably a consequence of: B. Ductal dilatation E. Parenchymal atrophy
A. Acute rejection D. Prior biopsy C. Fibrosis
B. Cyclosporin A toxicity E. None of the above
C. EBV infection D__40. Which of the following pancreatic conditions is described
by the designation of nesidioblastosis?
B__31. Which of the following is the most common pattern of so-called renal A. Atypical changes of islet cells
artery dysplasia? B. Extensive pancreatic heterotopia
A. Intimal fibroplasia—hyperplasia of intima C. Islet hyperplasia in chronic pancreatitis
B. Medial fibroplasia—fibrosis of media alternating with aneurysms D. Islets in connection with ductules
C. Medial hyperplasia—fibrosis of media without aneurysms E. Squamous metaplasia of interlobular ducts
D. Periarterial fibroplasia—adventitial and periadventitial fibrosis
E. Perimedial fibroplasia—hyperplasia of smooth muscle layer B__41. A 20-year-old male with chronic liver disease, increased copper in the
urine, and Kayser-Fleisher rings on slit-lamp examination will most likely
D__32. A histologic change that definitively supports a diagnosis have which of the following associated alterations?
of Barrett esophagus within an esophageal biopsy is: A. Antinuclear, anti–smooth muscle and antimitochondrial antibodies
A. Cardiac-type glands B. Degeneration of putamen in the brain
B. Columnar cells with PAS-positive secretion C. Glucose intolerance
C. Endocrine cells D. Increased serum levels of ceruloplasmin
D. Goblet cells with acid mucin E. Panacinar emphysema
E. Villous surface of the mucosa

C__33. Superficial squamous cell carcinoma of the esophagus is

a carcinoma characterized by: