Sibur-Khimprom CJSC Safety Data Sheet: According To 1907/2006/EC (REACH), 1272/2008 (CLP) & 453/2010

VERSION: 2.
2
DATE CREATED: 21/03/2012
SIBUR-KHIMPROM CJSC
SAFETY DATA SHEET

According to 1907/2006/EC (REACH), 1272/2008 (CLP) & 453/2010
TERT-BUTYL METHYL ETHER
VERSION: 2.2
DATE CREATED:21/03/2012
Regulation: EC No 1272/2008
SECTION 1. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND
COMPANY/UNDERTAKING
1.1 Product identifier
NAME OF SUBSTANCE: Tert-butyl methyl ether

SYNONYMS: Methyl tertiary butyl ether; MTBE; Methyl t-Butyl Ether;
2-Methoxy-2-Methylpropane; propane, 2-methoxy-2-methyl-;
TRADE NAMES: MTBE
Index No (CLP) 603-181-00-X
CAS #: 1634-04-4
EC #: 216-653-1
REGISTRATION #: 01-2119452786-27-0020
Most common technical function of substance: Fuels and fuel additives. MTBE acts as an octane
enhancer.
Uses advised against: None.
For the detailed identified uses of the product see Annex 1.
The use of the substance should be limited to those specified in Annex 1.
1.3. Details of the supplier of the safety data sheet

SUPPLIER:
Company name: Sibur-Khimprom CJSC
Address: 98, Promishlennaya str., Perm, Perm region,
614055, Russian Federation
Contact phone: +7 3422 90-83-72; 90-84-84; 90-82-82
Fax: +7 3422 90-81-61; 90-86-60
Email Address: mail@siburperm.ru
Emergency phone: +7 3422 90-87-05 (round the clock)
+7 3422 90-86-79, 290-87-18 (English, German,
5 AM to 1 PM CET, leave the message)
Emergency phone in 112 (Please note that emergency numbers may vary depending
the country of delivery: upon the country of delivery though 112 remains valid as
universal number
Page 1 of 32
VERSION: 2.2
ONLY REPRESENTATIVE:
Company name: Gazprom Marketing and Trading France
Address: 68 avenue des Champs-Elysées, Paris, 75008, France
Contact phone: +33 1 42 99 73 50
Fax: +33 1 42 99 73 99
Email address: yury.severinchik@gazprom-mt.com
SECTION 2. HAZARDS IDENTIFICATION
2.1 CLASSIFICATION
Tert-butyl methyl ether
ANNEX I OF DIRECTIVE 67/548/EEC:
Physical/Chemical Hazards:
F; R11 Highly flammable; Highly flammable.
Health Hazards:
Xi:R38. Irritant; Irritant; Irritating to skin.
Environmental hazards:
None.
EU CLP 2008:
H225: Flammable Liquid Cat. 2. Highly flammable liquid.
Health Hazards:
H315: Skin irritation Cat. 2. Causes skin irritation.
None.
Classification according to Globally Harmonized System of Classification and Labelling of

Chemicals (UN-GHS):
Health Hazards:
H303: Acute toxicity Category 5. May be harmful if swallowed.
H305: Aspiration hazard Category 2. May be harmful if swallowed and enters airways.
H316: Skin corrosion/irritation Cat. 3. Causes mild skin irritation.
None.
Page 2 of 32
VERSION: 2.2
2.2 LABELLING
EU LABELLING
Indication of danger:
F - highly flammable
Xi - irritant
Symbol: F+, Xi
CLP LABELLING
Signal word: Danger
Hazard pictogram:
GHS02: flame GHS07: exclamation mark
UN-GHS LABELLING
Chemical name: Methyl Tertiary Butyl Ether
Signal word: Danger
Hazard pictogram:
GHS02: flame GHS08: health hazard
Other hazards:
Assessment PBT / vPvB:
According to Annex XIII of Regulation (EC) No.1907/2006 concerning the Registration,
Evaluation, Authorisation and Restriction of Chemicals (REACH):
- not fulfilling PBT (persistent/bioaccumulative/toxic) criteria;
- not fulfilling vPvB (very persistent/very bioaccummulative) criteria.
The full text for all S, P-Phrases is given in Section 16.
Page 3 of 32
VERSION: 2.2
SECTION 3. COMPOSITION/INFORMATION ON INGREDIENTS
Name EC No EC No CAS No Content Classification Regulation (EC) No

(w/w) % 67/548 and (EC) No 1272/2008 (CLP)
methyl tert-butyl 216-653-1 1634-04-4 97.0-99.8 F: R11; Xi: R38
ether H225; H315
Index No(CLP):
603-181-00-X
methanol 200-659-6 67-56-1 ≤1.0 none
Index No(CLP):
603-001-00-X
The product does not contain impurities or additives that could affect product’s labelling and
classification according to Regulation (EC) No 67/548/ЕЕС and Regulation (EC) No 1272/2008
(CLP).
Specific Conc. Limits (СLP): none.

M-factor: none.
SECTION 4. FIRST-AID MEASURES
Product-specific hazards and other issues:

Low acute toxicity.
May be moderately irritating to skin and slightly irritating to eyes and respiratory system.
Harmful: may cause lung damage if swallowed (Aspiration).
At high doses, effects on the CNS are possible.
General advice:
Always observe self protection methods.
Move out of dangerous area.
Remove contaminated shoes and clothing.
Consult a physician.
Show this material safety data sheet to the doctor in attendance.
Inhalation:
Remove to fresh air and keep at rest in a position comfortable for breathing.
Do not leave the victim unattended.
Keep patient warm and at rest.
Immediately seek medical attention.
If breathing is difficult, give oxygen.
If unconscious place in recovery position and seek medical advice.
In the event of unconsciousness, apnea or cardiac arrest (no Pulse) apply cardiopulmonary
resuscitation.
Contact:
Immediately flush affected area with plenty of soap and water for at least 15 minutes while
removing contaminated clothing and shoe.
If irritation persists get medical advice/attention.
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VERSION: 2.2
Eye contact:
Flush eyes with water thoroughly and continuously for 15 minutes.
Remove contact lenses, if present and easy to do. Continue rinsing.
If irritation persists get medical attention. The patient should be seen by an ophthalmologist.
Ingestion:
Clean mouth with water and drink afterwards plenty of water.
Do NOT induce vomiting.
Do not give milk or alcoholic beverages.
Never give anything by mouth to an unconscious person.
If vomiting does occur, have victim lean forward to reduce risk of aspiration.
Get medical attention immediately.
Advice to physician:
If inhalation of high concentrations occur signs and symptoms may include coughing, choking,
wheezing, difficulty in - breathing, chest congestion, shortness of breath and/or fever. The onset of
respiratory symptoms may be delayed.
Absorption by Inhalation or Ingestion of high doses may cause CNS symptoms like headache,
dizziness, fatigue, muscular, weakness, drowsiness and lack of coordination.
In case of ingestion the stomach should be emptied by gastric lavage under qualified medical
supervision.
SECTION 5. FIRE-FIGHTING MEASURES
Suitable extinguishing media:

SMALL FIRE: Use dry chemicals, CO2, water spray or alcohol-resistant foam.
LARGE FIRE: Use water spray, water fog or alcohol-resistant foam.
Unsuitable extinguishing media:

Do not use solid water stream.
Specific hazards during fire fighting:

Releases flammable vapors below normal ambient temperatures.
Flammable vapors may be heavier than air.
May travel long distances along the ground before igniting and flashing back to vapor source.
When mixed with air and exposed to ignition source, vapors can burn in open or explode if
confined.
Move containers from fire area if you can do it without risk.
Fight fire from maximum distance or use unmanned hose holders or monitor nozzles.
Cool containers with flooding quantities of water until well after fire is out.
Do not use straight streams.
Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.
Always stay away from tanks engulfed in fire.
For massive fire, use unmanned hose holders or monitor nozzles; if this is impossible, withdraw
from area and let fire burn.
Further information:
Collect contaminated fire extinguishing water separately. This must not be discharged into drains.
Fire residues and contaminated fire extinguishing water must be disposed of in accordance with
local regulations.
Page 5 of 32
VERSION: 2.2
Special protective equipment for fire-fighters:

Wear positive pressure self-contained breathing apparatus (SCBA).
Structural firefighters protective clothing will only provide limited protection.
SECTION 6. ACCIDENTAL RELEASE MEASURES
Personal precautions:
Use personal protective equipment.
Ensure adequate ventilation.
Evacuate personnel to safe areas.
Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low
areas.
Environmental precautions:
MTBE is highly volatile, partially water soluble and has only a minimal tendency to adhere to soil
particles.
Even small volumes can pose a threat to the environment and nearby water resources.
Surface spills can reach groundwater through porous soil or cracked surfaces.
All efforts should be made to prevent any leaks or spills, and to protect water resources.
Where spills are possible, a comprehensive spill response plan should be developed and
implemented.
If a leak or spill reaches the groundwater, the groundwater may become contaminated.
If the groundwater is a source of drinking water, the associated drinking water well(s) could become
contaminated.
MTBE can impart an unpleasant taste and odor to water at very low concentrations.
Methods for cleaning up:

Extremely flammable liquid.
Release can cause fire or explosion.
Eliminate all sources of ignition.
All equipment used when handling this product must be grounded.
Do not touch or walk through spilled material.
Stop leak if you can do it without risk.
Prevent entry into waterways, sewers, basements or confined areas.
A vapor suppressing foam may be used to reduce vapors.
Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers.
Use clean non-sparking tools to collect absorbed material.
Water spray may reduce vapor; but may not prevent ignition in closed spaces.
Dike large spills and place materials in salvage containers.
SECTION 7. HANDLING AND STORAGE
Handling:
Advice on protection against fire and explosion:
Keep container tightly closed when not in use.
Extinguish all ignition sources.
Wear recommended personal protective equipment.
Ground/bond container and receiving equipment.
All electrical equipment should be grounded and conform to applicable electric codes and
regulatory requirements.
Page 6 of 32
VERSION: 2.2
Check atmosphere for explosiveness and oxygen deficiencies.

Ensure adequate ventilation.
Observe precautions pertaining to confined space entry.
Use only non-sparking tools.
Carefully vent any internal pressure before removing closure.
Isolate, vent, drain, wash and purge systems or equipment before maintenance or repair.
Handle empty containers with care; vapor/residue may be flammable.
Avoid contact with incompatible agents.
Keep away from sources of ignition - No smoking.
Take measures to prevent the build up of electrostatic charge.
Storage:
Requirements for storage areas and containers:Store only in tightly closed, properly vented
containers away from heat, sparks, open flame and strong oxidizing agents.
Carbon steel; avoid most plastics, Viton and Flourel.
Store closed drums with bung in up position.
Vapor space above stored liquid may be flammable/explosive unless blanketed with inert gas.
Store in a well-ventilated place.
Electrical installations / working materials must comply with the technological safety standards.
No smoking.
Store in cool place.
Do not pressurize, cut, weld, braze solder, drill, or grind on containers.
Do not puncture or incinerate containers.
Empty pressure vessels should be returned to the supplier.
Container advice:
Carbon steel; avoid most plastics, Viton and Flourel.
For more information please see the relevant exposure scenario in Appendix II of this SDS.
SECTION 8. EXPOSURE CONTROLS/PERSONAL PROTECTION
8.1 Control parameters

8.1.1 Occupational Exposure Limits
1)
International Limit Values
SUBSTANCE LTEL LTEL STEL STEL Note

Butyl acrylate 8 hr 8 hr ppm mg/m3
CAS #141-32-2 TWA ppm TWA mg/m3
Austria 50 180 100 360
Belgium 40 146
Denmark 40 144 80 288
European Union 50 183,5 100 (1) 367 (1) Occupational Exposure Limit
Values
(1) 15 minutes average value
France
Germany (AGS) 50 180 75 (1) 270 (1) (1) 15 minutes average value
Page 7 of 32
VERSION: 2.2
SUBSTANCE LTEL LTEL STEL STEL Note

Butyl acrylate 8 hr 8 hr ppm mg/m3
CAS #141-32-2 TWA ppm TWA mg/m3
Germany (DFG) 50 180 75 270 STV 15 minutes average value
Hungary
Italy
Poland 180 270
Spain 40 147
Sweden 30 110 60 220
Switzerland 50 180 75 270
The Netherlands
USA - NIOSH
USA - OSHA
United Kingdom 25 92 75 275
1)
GESTIS International Limit values:
http://bgia-online.hvbg.de/LIMITVALUE/WebForm_ueliste.aspx
8.1.2 DNEL/ PNEC values

DN(M)ELs for workers
Exposure Route Descriptor DNEL/DMEL Remarks/Justification
pattern
Acute - Dermal No-threshold - The DNELacute needs only be derived if an
systemic effect and/or acute toxicity hazard (leading to
effects no dose- classification and labelling) has been
response identified and peak exposures are likely to
occur. The available data do not trigger
information
classification for acute systemic dermal
available toxicity.
Acute - Inhalation No-threshold - The DNELacute needs only be derived if an
systemic effect and/or acute toxicity hazard (leading to
effects no dose- classification and labelling) has been
response identified and peak exposures are likely to
information
classification for acute systemic inhalation
available toxicity.
Acute - local Dermal No-threshold - The data support classification of MTBE
effects Most sensitive effect and/or for skin irritation, however, it is not
endpoint: no dose- possible to derive a DNEL on the basis of
irritation / response the available data. It is necessary to
implement risk management measures that
corrosion information
prevent dermal exposure that will cause
(eye and skin) available skin irritation.
Acute - local Inhalation DNEL 357 mg/m³ The DNELacute needs only be derived if an
effects Most sensitive Corrected acute toxicity hazard (leading to
endpoint: Dose classification and labelling) has been
irritation descriptor: identified and peak exposures are likely to
(respiratory based on
classification for acute local inhalation
tract) IOELV toxicity. Nevertheless, there is a published
Page 8 of 32
VERSION: 2.2

pattern
IOELV STEL (derived by the SCOEL) of
100 ppm (357 mg/m3) for MTBE based on
respiratory tract irritation.
Long-term - Dermal DNEL 5100 Regarding dermal exposure, no dermal
systemic Most sensitive mg/kg bw/day repeated dose toxicity studies are available.
effects endpoint: To arrive at a long-term value for workers,
repeated dose route to route extrapolation will be applied
starting with the inhalation long-term value
toxicity
of the SCOEL
Long-term - Inhalation DNEL 178.5 mg/m³ The15-min STEL of 100 ppm (357 mg/m3)
systemic Most sensitive and the 8-h TWA of 50 ppm (178.5 mg/m3)
effects endpoint: as recommended by the SCOEL will be
repeated dose used as DNEL for acute and long-term for
inhalation exposure.
toxicity
Long-term - Dermal No-threshold - Due to the effective lipid extraction
local effects effect and/or properties of MTBE, it can be presumed
no dose- that repeated skin exposure may result in
response skin fatigue (and consequent risk of toxic
eczema), an effect common to a variety of
information
organic solvents. No quantitative data on
available this effect are available. Therefore a
qualitative risk characterisation will be
performed.
Long-term - Inhalation No-threshold - No local effects were reported after
local effects effect and/or repeated inhalation exposure.
no dose-
response
information
available
DN(M)ELs for the general population

pattern
Acute - Dermal No-threshold effect The DNELacute needs only be
systemic and/or no dose- derived if an acute toxicity hazard
effects response (leading to classification and
information labelling) has been identified and
peak exposures are likely to occur.
available
The available data do not trigger
classification for acute systemic
dermal toxicity.
Acute - Inhalation No-threshold effect The DNELacute needs only be
available
classification for acute systemic
inhalation toxicity.
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pattern
Acute - Oral No-threshold effect The DNELacute needs only be
available
classification for acute systemic oral
toxicity.
Acute - local Dermal No-threshold effect The data support classification of
effects Most sensitive and/or no dose- MTBE for skin irritation, however, it
endpoint: response is not possible to derive a DNEL on
irritation / information the basis of the available data. It is
necessary to stipulate risk
corrosion (eye available
management measures that prevent
and skin) dermal exposure that will cause skin
irritation.
Acute - local Inhalation DNEL 214 mg/m³ The DNELacute needs only be
effects Most sensitive Corrected derived if an acute toxicity hazard
endpoint: Dose (leading to classification and
irritation descriptor: labelling) has been identified and
(respiratory 363.8 mg/m³
tract) (based on AF classification for acute local
of 1.7) inhalation toxicity. Nevertheless,
there is a published IOELV STEL
(derived by the SCOEL) of 100 ppm
for MTBE.
Long-term - Dermal DNEL 3570 mg/kg The SCOEL has established an 8-h
systemic Most sensitive bw/day TWA of 50 ppm (178.5 mg/m3). The
effects endpoint: SCOEL value is derived for workers.
repeated dose To arrive at a long-term value for the
dermal route for the general
toxicity
population, route to route
extrapolation will be applied starting
with the inhalation long-term value
calculated for the general population
Long-term - Inhalation DNEL 53.6 mg/m³ Regarding long-term exposure, the
systemic Most sensitive Corrected SCOEL has established an 8-h TWA
effects endpoint: Dose of 50 ppm (178.5 mg/m3). The
repeated dose descriptor: SCOEL value is derived for workers.
To arrive at a long-term value for the
toxicity 91.1 mg/m³
general population, a factor for
(based on AF exposure modification and
of 1.7) intraspecies differences will be
applied to the 8-h TWA.
Long-term - Oral DNEL 7.1 mg/kg The SCOEL has established an 8-h
systemic Most sensitive bw/day TWA of 50 ppm (178.5 mg/m3) for
effects endpoint: workers. To arrive at a long-term
repeated dose value for the oral route for the
toxicity general population, route to route
extrapolation will be applied starting
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pattern
with the inhalation long-term value
calculated for the general
population.
Long-term - Dermal No-threshold effect Due to the effective lipid extraction
local effects and/or no dose- properties of MTBE, it can be
response presumed that repeated skin
information exposure may result in skin fatigue
(and consequent risk of toxic
available
eczema), an effect common to a
variety of organic solvents. No
quantitative data on this effect are
available. Therefore a qualitative
risk characterisation will be
performed.
Long-term - Inhalation No-threshold effect No local effects were reported after
local effects and/or no dose- repeated inhalation exposure.
response
information
available
PNEC water
PNEC Assessment Remarks/Justification
factor
PNEC aqua (freshwater): 10 Extrapolation method: assessment factor.
5.1 mg/L Long-term results (e.g. EC10 or NOECs) from at least three species
representing three trophic levels are available.
PNEC aqua 100 Extrapolation method: assessment factor.
(marine water): Long-term results (e.g. EC10 or NOEC) from three freshwater or
0.26 mg/L saltwater species representing three trophic levels are available.
PNEC aqua (intermittent 10 Extrapolation method: assessment factor.
releases): Short-term toxicity test results indicate that MTBE has not any
47.2 mg/L specific mode of toxic action in aquatic species. Variability between
species and trophic levels is not high. Therefore, for intermittent
release an assessment factor of 10 is used.
PNEC sediment
factor
PNEC sediment - Extrapolation method: statistical extrapolation.
(freshwater): The equilibrium partitioning method was used using a Koc value of
23 mg/kg sediment dw 9.1 l/kg.
PNEC sediment (marine - Extrapolation method: statistical extrapolation.
water):
1.17 mg/kg sediment dw
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VERSION: 2.2
PNEC soil
factor
PNEC soil: - Extrapolation method: statistical extrapolation.
1.43 mg/kg soil ww The equilibrium partitioning method was used using a Koc value of
9.1 l/kg and a Henry's Law constant of 33.3 Pa.m3/mol (at 20 oC).
PNEC sewage treatment plant

Value Assessment Remarks/Justification
factor
PNEC STP: 71 mg/L 10 Extrapolation method: assessment factor.
From the key study an EC10 is available and therefore an AF of 10
(instead of 1) will be applied to this value.
PNEC oral (secondary poisoning)

factor
Not applicable - Not applicable; there are no indications of accumulation in the
food chain as the substance has a log Kow of 1.06.
8.2 Exposure Controls

Engineering measures:
Provide adequate ventilation. Use process enclosures, local exhaust ventilation, or other engineering
controls to keep airborne levels below recommended exposure limits.
Respiratory protection:
In case of dusts/vapours/aerosols being formed or if the limit values like TLV are exceeded: wear
respirator conforming to EN140 with type A filter or better.
Hand protection:
Chemical-resistant protective gloves (EN 374).
The selected protective gloves have to satisfy the standard EN 374 derived from it.
Glove material for example, Glove (multi-layer) – PE/EVAL/PE (PE=Polyethylene;
EVAL=Ethylene-vinyl-alcohol-copolymer); Break through time >= 480 min.
Source: GESTIS substance database (hazardous substance information system of commercial
professional associations).
Suitability for specific workplaces should be clarified with protective glove manufacturers. Gloves
should be discarded and replaced if there is any indication of degradation or chemical breakthrough.
Eye protection:
Wear safety glasses as minimum eye protection.
Conditions may warrant the use of tightly fitting chemical goggles and possibly a face shield.
Skin and body protection:

Choose body protection according to the amount and concentration of the dangerous substance at
the work place.
Use PPE that is chemical resistant to the product and prevents skin contact.
Fire retardant clothing is appropriate for routine occupational use.
Page 12 of 32
VERSION: 2.2
Hygiene measures:
Selection of appropriate personal protective equipment should be based on an evaluation of the
performance characteristics of the protective equipment relative to the task(s) to be performed,
conditions present, duration of use, and the hazards and/or potential hazards that may be
encountered during use.
Emergency eye wash fountains and safety showers should be available in the immediate vicinity of
any potential exposure.
Take off contaminated clothing and wash before reuse.
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.
For more information please see the relevant exposure scenario in Appendix II of this SDS.
SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES
Property Value Remarks/Justification

Physical state at 20°C liquid
and 101.3 kPa Colour: Colourless
Odour: characteristic terpene-like
Melting / freezing point -108.6 ˚C Value published in a peer-reviewed
handbook. Scholz et al., 1990
Boiling point 55.3 ˚C Value published in a peer-reviewed
Relative density 0.74 at 20 ˚C Value published in a peer-reviewed
handbook. Budavari, 1989
Vapour pressure 33000 Pa at 25 ˚C Value obtained in GLP-compliant
guideline (OECD 104) study.
Harlan Laboratories Ltd, 2009
Surface tension 72.5 mN/m at 21.5 °C Value obtained in GLP-compliant
(at concentration 1.07 g/l in guideline (OECD 104) study.
water) SafePharm Laboratories, 2008
19.3 mN/m at 25 °C (neat liquid)
18.1 mN/m at 40 °C (neat liquid)
Water solubility 41850 mg/l at 20 ˚C Value reported in a near-guideline study.
Oil Products Research, 1997
Partition coefficient n- 1.06 at 20 °C The value of 1.06 was chosen for the risk
octanol/water (log value) assessment, in agreement with the value
used by the European authorities in the
European Risk Assessment Report
(2002).
Hüls, 1989
Flash point -28 °C (closed cup) Value published in a peer-reviewed
Flammability highly flammable. In accordance with section 1 of REACH
Annex XI testing does not appear
scientifically necessary. The flammability
of liquids is determined on basis of their
flashpoint (in combination with their
boiling point), their ability to emit
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VERSION: 2.2

flammable gases upon contact with water
and their pyrophoricity. The molecular
structure of MTBE does not contain
groups that indicate potential reactivity
with water or pyrophoric properties. It
has a boiling point of 55.3˚C. The
flashpoint of -28˚C indicates that MTBE
is a highly flammable liquid.
Explosive properties not explosive. In accordance with column 2 of REACH
Annex VII, the study does not need to be
conducted. Potential explosive properties
are indicated by the presence of certain
reactive groups in the molecule and/or by
the oxygen balance. Since MTBE is an
ether, the molecular structure shows
potential reactivity. However, the oxygen
balance of MTBE is -272, where only an
oxygen balance higher than -200
indicates the potential presence of
explosive properties. Therefore, explosive
properties are not expected.
Self-ignition temperature 460 °C Value published in a peer-reviewed
Oxidising properties The substance is not oxidising. No oxidising properties are expected
based on low oxygen balance (<-200) and
an absence of highly electronegative
centres, the oxygen atoms being bonded
only to C and/or H atoms. Furthermore,
in accordance with column 2 of REACH
Annex VII, the study does not need to be
conducted as the substance is highly
flammable.
Viscosity 0.464 mm²/s (static) at 20 °C Value obtained in a GLP-compliant
0.409 mm²/s (static) at 40 °C guideline study OECD 114.
SafePharm Laboratories, 2008
Granulometry Not applicable In accordance with column 2 of REACH
. Annex VII, a granulometry study does
not need to be conducted as MTBE is
manufactured and used in a non solid
(liquid) form
Stability in organic Not applicable In accordance with section 1 of REACH
solvents and identity of Annex XI testing does not appear
relevant degradation scientifically necessary as MTBE is a
products stable chemical and is not expected to
show instability when mixed with typical
organic solvents.
Dissociation constant Not applicable In accordance with section 1 of REACH
Annex XI testing does not appear
scientifically necessary as MTBE does
not contain functional groups which can
undergo dissociation.
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VERSION: 2.2
SECTION 10. STABILITY AND REACTIVITY
Conditions to avoid:
Heat, sparks, open flame, other ignition sources, and oxidizing conditions.
May accumulate static electrical charges, and may cause ignition of the vapors.
Materials to avoid:
Contact with strong acids can decompose this material and generate extremely flammable
isobutylene.
Thermal decomposition:
Thermal decomposition may produce carbon monoxide and other toxic vapors.
Hazardous reactions:
Not expected to occur.
Note: this material is stable when properly handled and stored.
SECTION 11. TOXICOLOGICAL INFORMATION
Property Results Remarks/Justification

Acute toxicity:
Oral LD50: > 2000 mg/kg bw key study, experimental result.
rats/ male/ female OECD Guideline 401 (Acute Oral
Toxicity). RBM (1996b).
Inhalation LC50: 85 mg/L (85000 mg/m³ air) key study, experimental result.
rats/ male/ female OECD Guideline 403 (Acute
Inhalation Toxicity). Industrial Bio-
test Laboratories, Inc. (1969a).
Dermal LD50: > 2000 mg/kg bw key study, experimental result.
rats / occlusive OECD Guideline 402 (Acute Dermal
Toxicity). RBM (1996c).
Irritation/Corrosivity:
Tert-butyl methyl ether is irritating to skin. The substance is not corrosive.
EU classification according to Annex I of Directive 67/548/EEC: irritating to skin (Xi, R38).
EU-CLP: Skin irritation: Category 2.
Eye irritant Rabbit: not irritating key study, experimental result.
OECD Guideline 405 (Acute Eye
Irritation / Corrosion). Hüls (1985b).
Skin irritant rabbit (occlusive): irritating key study, experimental result.
OECD Guideline 404 (Acute Dermal
Erythema score: Irritation / Corrosion). Hüls (1985a).
2.9 of max. 4 (mean);
Time point: 24+48+72;
fully reversible within: 8 days.
Respiratory tract mouse (inhalation, vapour): supporting study, experimental result
not irritating. Tepper JS, Jackson MC, McGee JK,
Costa DL & Graham JA (1994).
Sensitisation:
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Skin sensitization guinea pig (intradermal): not key study, experimental result.
sensitizing equivalent or similar to OECD
Guideline 406 (Skin Sensitisation).
Inveresk Research International
(1979b).
Respiratory system No information available Respiratory tract sensitisation is not
expected since MTBE is not a skin
sensitiser and no human data
indicative of an effect are known. In
addition, no evidence of inflammatory
changes indicative of respiratory tract
sensitisation were reported in repeated
exposure inhalation studies in animals.
Repeated dose In accordance to Directive 67/548/EEC and EU CLP Regulation (EC) No.
toxicity: 1272/2008: classification is not necessary for repeated dose toxicity.
Oral NOAEL = 209 mg/kg bw/d key study, experimental result.
Rat (male/female) OECD TG 408 (Repeated Dose 90-
subchronic (oral: drinking water) Day Oral Toxicity in Rodents).
Inhalation NOAEC (systemic) = 800 ppm key study, experimental result.

(2856 mg/m3) EPA OTS 798.2450 (90-Day
Inhalation Toxicity).
Rat (male/female) EPA OTS 798.6050 (functional
subchronic (inhalation: vapour; whole observation battery testing).
body) EPA OTS 798.6200 (motor activity).
EPA OTS 798.6400 (neuropathology)
Bushy Run Research Center (1989a).
Dermal In accordance with column 2 of

Not applicable REACH Annex IX, testing shall be
performed using the most appropriate
route of administration. Testing by the
inhalation route is appropriate if
exposure of humans is likely to occur
via inhalation; this is the main route of
exposure to MTBE. Subchronic studies
are available for the inhalation route.
Mutagenicity: Negative
MTBE is considered to be not mutagenic. In accordance to Directive
67/548/EEC and EU Regulation (EC) No. 1272/2008, classification as a
mutagen is not necessary.
In vitro data genotoxicity: negative key study, experimental result.
bacterial reverse mutation assay e.g. EU Method B.13/14 (Mutagenicity -

Ames test, gene mutation; (S. typhi- Reverse Mutation Test Using Bacteria)
murium TA); OECD Guideline 471 (Bacterial
Reverse Mutation Assay).
mammalian cell gene mutation assay OECD Guideline 476 (In vitro
Chinese hamster lung fibroblasts Mammalian Cell Gene Mutation Test)
In vivo data genotoxicity: negative key study, experimental result.
Equivalent or similar to OECD
Page 16 of 32
VERSION: 2.2

mouse (male/female) Guideline 486. Test with Mammalian
inhalation: vapour Liver Cells in vivo.
Equivalent or similar to EPA OPPTS
870.5385. In Vivo Mammalian
Cytogenetic Tests.
Bushy Run Research Center (1993;94)
Carcinogenicity: No carcinogenic effects
In accordance to Directive 67/548/EEC and EU Classification, Labelling and
Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008,
classification is not necessary for carcinogenicity.
Inhalation Neoplastic effects: yes key study, supporting study.
NOAEC (carcinogenicity) ≥ 3000 EPA OPPTS 870.4200
ppm (10710 mg/m3) (Carcinogenicity)
Bushy Run Research Center (1992b).
There is no evidence of a direct

mouse (male/female);
genotoxic mode of action as MTBE is
inhalation: vapour (whole body);
not genotoxic in vitro or in vivo.
Exposure: 18 months (6 hours/day, 5
Furthermore, the treatment relation of
days/week).
the occurred tumours is equivocal in
some cases, other types are not
relevant for humans and for some the
human relevance was questionable.
Moreover, the tumours appear mostly
at high and systemically toxic
concentrations.
Toxicity for No effect on reproductive organs
reproduction:
Effects on fertility NOAEC (effects on fertility): 28560 key study, experimental result.
mg/m3 (8000 ppm) Bushy Run Research Center (1991)
No significant changes in the No specific guideline was reported
reproduction parameters (however, the study was generally well
conducted).
rat (male/female); Based on the available data, MTBE is

inhalation: vapour (whole body); not considered toxic to fertility in rats
Exposure: 10 weeks (6 hours/day). and mice. Therefore, no DNEL has to
be derived for this endpoint.
Developmental toxicity Based on the available data key study, experimental result.
classification for developmental
toxicity is not warranted. The long-term
DNEL (repeated dose toxicity) will also
protect against the occurrence of
developmental toxic effects.
NOAEC (rat, developmental OECD Guideline 414 (Prenatal

toxicity): 2500 ppm (1428 mg/m³) Developmental Toxicity Study).
No adverse developmental effects Conaway CC, Schroeder RE & Snyder
NK (1985).
were observed)
inhalation: vapour (whole body)
Exposure: gestation days 6-15 (6 hours
Page 17 of 32
VERSION: 2.2

per day)
NOAEC (mouse, developmental EPA OTS 798.4350 (Inhalation

toxicity): 1000 ppm (3570 mg/m³) Developmental Toxicity Screen).
inhalation: vapour (whole body) Bushy Run Research Center
Exposure: during gestation days 6-15 (6 (1989d)
hours/day)
Toxicokinetics (absorption, metabolism, distribution and elimination)

MTBE is efficiently absorbed orally and via inhalation. Apart from specific binding to
Absorption and male rat kidney protein, the extensive tissue distribution of MTBE appears to be
distribution determined by solubility: concentrations in soft tissues are approximately the same as in
blood with the exception of fat that may reach a ten-fold higher concentration. Hepatic
first-pass metabolism was not observed.
The human data on toxicokinetics show a respiratory uptake of MTBE of 42-49% and a
respiratory net uptake of 32-42%. The key study showed an oral absorption of over 80%
for MTBE in humans.
The oral, inhalation and dermal absorption percentages used for DNEL derivation (in
case of route-to-route extrapolation) are 100%, 40% and 0.2%, respectively.
MTBE is metabolised to formaldehyde and tert-butyl alcohol (TBA). Formaldehyde is
Metabolism believed to be metabolised extremely rapidly to formate (which is largely incorporated in
the one-carbon pool) and to CO2 (the metabolism of formaldehyde is much quicker than
it is formed from MTBE), and TBA is further metabolised to 2-hydroxyisobutyrate, 2-
methyl-1,2-propanediol, TBA conjugates and acetone.
Saturation of metabolism indicated in the rat during 6-hour inhalation exposure to 8000
ppm MTBE. In human inhalation exposures up to 75 ppm for four hours, no signs of
saturation were found.
The metabolic pathway of MTBE is identical after ingestion and inhalation exposure.
In most experimental conditions the major part of MTBE in the body was excreted as
Elimination urinary metabolites, and less than a half was exhaled unchanged, however, if the uptake
rate was high the opposite was true. The main metabolite of MTBE in human urine is 2-
hydroxyisobutyric acid. The elimination half-time for MTBE in blood was about 0.5 hour
in the rat and about ten times longer in humans.
The kinetics of excretion of MTBE were identical after ingestion and inhalation
exposure.
After exposure to MTBE, TBA is found in the blood circulation for a longer period and at
higher concentrations than MTBE. TBA is highly water-soluble and distributed in total
body water. Apart from lower levels found in fat, soft tissues are expected to show
approximately the same concentrations as the blood. The elimination half-times for the
different urinary MTBE metabolites varied between 2.9 and 5 hours in rats and between
7.8 and 17 hours in humans. These data allow concluding that MTBE or its metabolites
will not accumulate in the human body significantly.
Other effects: none
Page 18 of 32
VERSION: 2.2
SECTION 12. ECOLOGICAL INFORMATION

AQUATIC TOXICITY
Fish:
Short-term toxicity LC50 (96 h): 672 mg/L test mat. key study, experimental result.
Pimephales promelas/ freshwater US EPA 1981.
Geiger DL, Call DJ & Brooke LT
(1988).
LC50 (96 h): 574 mg/L mg/L test mat.
OECD Guideline 203 (Fish,
Menidia beryllina/ saltwater Acute Toxicity Test).
BenKinney MT, Barbieri JF,
Gross JS & Naro PA (1994).
long-term toxicity NOEC (31 d): 299 mg/L test mat. key study, experimental result.
based on: growth rate ASTM E1241-92
Pimephales promelas / freshwater ENSR (1999b)
Aquatic invertebrates:
Short-term toxicity Freshwater: key study, experimental result.
EC50 (48 h): 472 mg/L EPA OPPTS 850.1010 (Aquatic
test mat. based on mobility Invertebrate Acute Toxicity Test,
(Daphnia Magna) Freshwater Daphnids).
Wildlife International Ltd.
(1999c).
saltwater
EC50 (96 h): 106mg/L ((meas. (geom. The results were harmonised by a
mean)) geometric mean.
(Americamysis bahia)
Long-term toxicity Freshwater: key study, experimental result.
NOEC (21 d): 51 mg/L test mat. EPA OPPTS 850.1300 (Daphnid
based on: reproduction Chronic Toxicity Test).
(Daphnia Magna) Wildlife International Ltd.
(1999g).
saltwater EPA OPPTS 850.1350 (Mysid

NOEC (28 d): 26 mg/L test mat. Chronic Toxicity Test).
based on: reproduction Wildlife International Ltd.
(1999h).
(Americamysis bahia)
Algae and aquatic plants EC50/LC50 (96 h): 491 mg/L test mat. key study, experimental result.
EC10/LC10 or NOEC for freshwater ASTM E1218-90
algae: 103 mg/L ENSR (1999g)
Freshwater/ algae - Selenastrum
capricornutum (new name:
Pseudokirchnerella subcapitata)
Sediment organisms: Not applicable
In accordance with column 2 of REACH Annex X, the study on sediment organisms does not need to be
conducted as direct and indirect exposure of the sediment compartment is unlikely. In the absence of any
data for sediment organisms the PNEC sediment is calculated using the equilibrium partitioning method.
According to the physico-chemical properties, there is no indication that MTBE accumulates in sediment.
Therefore a quantitative risk assessment seems not to be necessary for this compartment. As the results of
Page 19 of 32
VERSION: 2.2

the CSA do not indicate the need to investigate further the effects of the substance and/or relevant
degradation products on sediment organisms, according to REACH Annex X, column 2, long-term toxicity
testing on sediment organisms shall not be proposed.
Terrestrial compartment: Not applicable
Toxicity to soil macro-organisms: Not applicable
In accordance with column 2 of REACH Annexes IX and X, the study on soil macro-organisms does not
need to be conducted as direct and indirect exposure of the soil compartment is unlikely. In the absence of
any data for terrestrial organisms the PNEC soil is calculated using the equilibrium partitioning method.
According to the physico-chemical properties, there is no indication that MTBE accumulates in soil.
degradation products on terrestrial organisms, according to REACH Annexes IX and X, column 2, toxicity
testing on terrestrial organisms shall not be proposed.
Toxicity to terrestrial plants: Not applicable
In accordance with column 2 of REACH Annexes IX and X, the study on terrestrial plants does not need to
be conducted as direct and indirect exposure of the soil compartment is unlikely. In the absence of any data
for terrestrial organisms the PNEC soil is calculated using the equilibrium partitioning method. According to
the physico-chemical properties, there is no indication that MTBE accumulates in soil. Therefore a
quantitative risk assessment seems not to be necessary for this compartment. As the results of the CSA do
not indicate the need to investigate further the effects of the substance and/or relevant degradation products
on terrestrial organisms, according to REACH Aёnnexes IX and X, column 2, toxicity testing on terrestrial
organisms shall not be proposed.
Toxicity to soil micro-organisms: Not applicable
In accordance with column 2 of REACH Annex IX, the study on soil micro-organisms does not need to be
conducted as direct and indirect exposure of the sediment compartment is unlikely. In the absence of any
data for terrestrial organisms the PNEC soil is calculated using the equilibrium partitioning method.
According to the physico-chemical properties, there is no indication that MTBE accumulates in soil.
degradation products on terrestrial organisms, according to REACH Annexes IX and X, column 2, toxicity
testing on terrestrial organisms shall not be proposed.
Toxicity to aquatic EC10 (18 h): 710 mg/L (estimated) key study, experimental result.
micro-organisms based on: growth inhibition Bacteria toxicity test according
to the principles of Bringmann,
Pseudomonas putida G. and Kühn, R.: Journal for
freshwater Wasser- and Abwasser-
Forschung 10 (1977) S. 87-98.
Toxicity to birds: Not applicable
In accordance with column 2 of REACH Annex X, no tests are needed taking into account the large
mammalian dataset that is available.
DEGRADATION
Abiotic degradation rates
Degradation for hydrolysis 0 d-1
Degradation for photolysis 0 d-1
Degradation rate in air 0.123 d-1
Biotic degradation rates
Degradation in a non-adapted STP 0 d-1
Degradation in an adapted STP Monod kinetics (default values)
Degradation rate in surface water 4.62·10-3 d-1
Degradation rate in aerated sediment 2.31·10-3 d-1
Degradation rate in soil 1.00·10-3 d-1
Page 20 of 32
VERSION: 2.2

Abiotic degradation:
Hydrolysis Not applicable MTBE is resistant to hydrolysis
processes within environmentally
relevant pH ranges. Strong acids
can contribute to the hydrolysis
of MTBE, but the pH range in
which this would occur is below
typical ranges found in natural
soil and water.
Phototransformation in Half-life: 5.65 days (calculated); key study, supporting result.
air Degradation rate constant: Schumann HP & Sonntag CV
2.84E-12 cm3/molecule/s; (1973).
OH –radical concentration: 5E05 Method: Not specified.
Howard PH (1990)
radicals/cm3
US EPA (1994)
Phototransformation in Not applicable Direct photolysis will not be an
water important removal process of
MTBE in water because aliphatic
ethers do not absorb light at
wavelengths, >290 nm, that are
responsible for this process. The
MTBE UV-spectrum, max t 289
nm, indicates that there is a low
potential for direct photolysis in
water.
Biodegradation:
Biodegradation in water In anaerobic, static sediment/water experimental result.
anaerobic microcosms, MTBE does not
biodegrade. Under mixed
aerobic/anaerobic conditions
biodegradation may be a significant
removal process of MTBE in aerobic
sediment:
% Degradation of test substance (non Mormile MR, Liu S and Suflita

standard aerobic/anaerobic, static JA (1994)4;
sediment/water): Suflita JM and Mormile MR
0 after 152 d (pure culture study); (1993);
73 after 105 d (CO2 evolution); Bradley P, Landmeyer J &
0 after 249 d Chapelle F (1999)
Biodegradation in water: inherently biodegradable
MTBE is characterised as “inherently biodegradable, not fulfilling criteria” for non-adapted sewage sludge,
for adapted sludge MTBE can be characterised as "readily biodegradable".
The percentage of biodegradation ranged from 0 to 9.24 (closed bottle tests/ OECD 301D). Therefore,
MTBE is not considered readily biodegradable in the aquatic environment according to the standardised
aerobic ready-biodegradation tests. However, certain adapted micro-organisms are capable of degrading
MTBE. Thus, a well adapted industrial sewage treatment plant (STP) is able to degrade the substance. It
may be concluded that MTBE is inherently biodegradable under certain conditions in aquatic aerobic
environment. Therefore, in the further assessment the substance is assumed to be “inherently biodegradable,
not fulfilling criteria” for professional and consumer releases and on the regional scale.
There is good evidence for ready biodegradability when sewage sludge has become adapted to the substance.
Page 21 of 32
VERSION: 2.2

Such conditions will apply where there are continuous releases of MTBE to a STP, such as for large
production and processing sites. Thus, the substance can be assumed to be readily biodegradable in such
cases.
Biodegradation in soil Half-life (DT50): 101.6 d key study, experimental result.
Aerobic degradation of MTBE
by micro organisms present in
soil was followed using GC and
GC-MS for up to 151 days.
Yuan H (2006).
ENVIRONMENTAL DISTRIBUTION
Adsorption/desorption Adsorption coefficient: The organic carbon-water
partitioning coefficient (Koc)
Koc at 20°C: 9.1
calculated from the octanol-water
partition coefficient (log Kow =
1.06) using the equation from the
TGD (predominantly
hydrophobics) is 9.1 l/kg (log
value = 0.93).
Volatilization Henry's Law constant H: estimated by calculation.
69.8 Pa m³/mol at 25 °C The Henry's Law constant (H) is
calculated as 69.8 Pa m3/mol (log
H = 1.84), based on a vapour
pressure of 33 kPa at 25 °C and a
water solubility of 42,000 mg/l at
25 °C.
Environmental Percent distribution in media: estimated by calculation:
distribution Air (%): 93.9 fugacity model.
Water (%): 6.04 European Commission (2002)
Soil (%): 0.05
Sediment (%): 0
BIOACCUMULATION:
Aquatic bioaccumulation BCF: 1.5 key study, experimental result.
Cyprinus carpio (whole body w.w.) Details of method: No data

Fujiwara Y, Kinoshita T, Sato H
& Kojima I (1984).
Secondary poisoning Considering the measured log KOW of
MTBE of 1.06, it is not expected that
MTBE would bioconcentrate in high
extent or would accumulate in biota for
long time periods.
PBT/vPvB Properties Regarding all available data on biotic and abiotic degradation,
bioaccumulation and toxicity it can be stated that the substance does not
fulfill the PBT criteria (not PBT) and not the vPvB criteria (not vPvB).
WATER HAZARD According to the German VwVwS: WGK- 1 (low danger for water
CLASSIFICATION pollution).
Page 22 of 32
VERSION: 2.2
SECTION 13. DISPOSAL CONSIDERATIONS
General information:
Contaminated product, soil or water may be hazardous waste due to potentially low flash point.
Dispose of in compliance with respective national and local regulations.
Assure effluent complies with applicable regulations.
Landfill solids at permitted sites.
Use registered transporters.
Burn concentrated liquids in systems designed for low flash point material.
Avoid flame-outs.
Assure emissions comply with applicable regulations.
Avoid overloading/poisoning plant biomass.
Dilute aqueous waste may biodegrade.
SECTION 14. TRANSPORT INFORMATION
Land transport:
ADR/ RID
ID number: UN 2398
Hazard class: 3
Packing group: II
Hazard label: 3
Classification Code: F1
Inland waterway transport:

ADN
ID number: UN 2398
Hazard class: 3
Packing group: II
Hazard label: 3
Classification Code: F1
Sea transport:
IMDG
ID number: UN 2398
Hazard class: 3
Packing group: II
Hazard label: 3
Marine pollutant: NO
Description of the goods: METHYL tert-BUTYL ETHER
Chemical name: tert-butyl methyl ether
EmS Number 1 : F - E
EmS Number 2 : S - D
Air transport:
IATA/ICAO
ID number: UN 2348
Hazard class: 3
Packing group: II
Page 23 of 32
VERSION: 2.2
SECTION 15. REGULATORY INFORMATION
REGULATORY
Chemical Safety Report has been performed for Tert-butyl methyl ether.
APPENDIX II to the e-SDS: Exposure scenarios for Tert-butyl methyl ether.
SECTION 16. OTHER INFORMATION

16.1 Indication of changes
VERSION Date of Section Description of changes

change
Version: 1 17/03/2010 Version was created according to Regulations (EC)
No 1907/2006 (Article 31.1).
Version: 2.1 08/02/2011 Version was created according to Regulation (EC) No
1272/2008 (Regulation CLP) & 453/2010.
Version: 2.2 21/03/2012 1.1; 2.2; Version was created according to recommendations
3; 8; 9; 11; of Guidance on the compilation of safety data sheets
12; 14; 15; (ECHA. Version 1.0 – September 2011) and due to
16; update of CSR by Lead Registrant (31/10/2011):
Appendix I; 1. Phrases “For the detailed identified uses of the
II. product see Annex 1” and “The use of the substance
should be limited to those specified in Annex 1” were
added to Section 1.1.
2. UN-GHS LABELLING was added to Section 2.2.
3. Phrase “Other hazards” was added to Section 2.2.
4. Phrase “The Full Text for all S, P-Phrases is
displayed in Section 16” was added to Section 2.2.
5. Index No (CLP) was added to table of Section 3.
6. Phrase “M-factor: none” was added to Section 3.
7. Section 8 was fully updated.
8. Remarks/Justification was added to table of Section
9. Section 11 was reconfigured and Remarks/
Justification ware added to table.
10. Section 12 was reconfigured and Remarks/
Justification ware added to table.
11. Section 14 was reconfigured.
12. Sections 15, 16 were fully updated.
13. Specific Environmental Release Categories
(SpERC) were added to Appendix I for IU: 1; 2; 3; 4;
5; 6; 7; 8.
14. Appendix II was fully reconfigured.
Page 24 of 32
VERSION: 2.2
16.2 Abbreviations and acronyms

ADR European Agreement concerning the International Carriage of Dangerous Goods by
Road
AGS The German Committee on Hazardous Substances (Ausschuss für Gefahrstoffe – AGS)
BCF Bioconcentration factor
DFG Germany Research Foundation
DNEL Derived No Effect Level
IMDG International Maritime Dangerous Goods
ICAO-TI Technical Instructions for the Safe Transport of Dangerous Goods by Air
Koc Adsorption coefficient
Kow octanol-water partition coefficient
LC50 Lethal Concentration to 50 % of a test population
LD50 Lethal Dose to 50% of a test population (Median Lethal Dose)
LOAEC Lowest Observable Adverse Effect Concentration
LTEL Long Term Exposure Limit
NIOSH National Institute for Occupational Safety and Health (USА CDC)
NOEC No Observed Effect Concentration
NOAEL No Observed Adverse Effect Level
OECD Organization for Economic Co-operation and Development
OSHA Occupational Safety & Health Administration (USА)
PNEC Predicted No Effect Concentration
PBT Persistent, bioaccumulative, toxic chemical
vPvB Very Persistent, Very Bioaccumulative
RID Regulations concerning the International Carriage of Dangerous Goods by Rail
SCOEL Scientific Committee on Occupational Exposure Limits
STEL Short Term Exposure Limit
STP sewage treatment plant
STOT Specific Target Organ Toxicity
(STOT) RE Repeated Exposure
(STOT) SE Single Exposure
TWA Time Weighted Average
UN United Nations
WGK Wassergefährdungsklasse (German: Water Hazard Class)
16.3 Relevant R-phrases, Hazard- and EU Hazard-statements

R-phrases:
R11 Highly flammable; Highly flammable.
R38. Irritant; Irritant; Irritating to skin.
Safety Advice (S-phrases):

S2 - keep out of the reach of children.
S9 - keep container in a well-ventilated place.
S16 - keep away from sources of ignition - No smoking.
S24 - avoid contact with skin.
S33 - Take precautionary measures against static discharges.
EU CLP 2008
Hazard statement:
H315: Skin irritation Cat. 2. Causes skin irritation.
Page 25 of 32
VERSION: 2.2
Precautionary statements:
P210 - Keep away from heat/sparks/open flames/.../hot surfaces. ... No smoking.
P243 - Take precautionary measures against static discharge.
P280 - Wear protective gloves/protective clothing/eye protection/face protection.
P403+P235 - Store in a well-ventilated place. Keep cool.
P302+352 - IF ON SKIN: Wash with plenty of soap and water.
Classification according to Globally Harmonized System of Classification and Labelling of

Chemicals (UN-GHS).
Hazard statement:
H303: Acute toxicity Category 5. May be harmful if swallowed.
H305: Aspiration hazard Category 2. May be harmful if swallowed and enters airways.
H316: Skin corrosion/irritation Cat. 3. Causes mild skin irritation.
Precautionary statements:
P210 - Keep away from heat/sparks/open flames/.../hot surfaces. ... No smoking.
P243 - Take precautionary measures against static discharge.
P280 - Wear protective gloves/protective clothing/eye protection/face protection.
P301+310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P331 Do NOT induce vomiting.
P302+352 - IF ON SKIN: Wash with plenty of soap and water.
P403+P235 - Store in a well-ventilated place. Keep cool.
16.4 List of ES (exposure scenario) given in Appendix I to the extended SDS

ES1 Manufacturing
ES2 Formulation
ES3 Use as intermediate
ES4 Use as process solvent and extraction agent
ES5 Industrial distribution of MTBE and gasoline containing MTBE
ES6 Fuel use – Industrial
ES7 Fuel use – Professional
ES8 Fuel use – Consumer
16.5 KEY LITERATURE REFERENCES AND SOURCES
DOCUMENTS, PROVIDED BY FERC CONSORTIUM: CHEMICAL SAFETY REPORT to

Tert-butyl methyl ether (CAS 1634-04-4).
EU DIRECTIVES
REGULATION (EC) No 1907/2006 OF THE EUROPEAN PARLIAMENT AND OF THE
COUNCIL of 18 December 2006 concerning the Registration, Evaluation, Authorisation and
Restriction of Chemicals (REACH), establishing a European Chemicals Agency, amending
Directive 1999/45/EC and repealing Council Regulation (EEC) No 793/93 and Commission
Regulation (EC) No 1488/94 as well as Council Directive 76/769/EEC and Commission Directives
91/155/EEC, 93/67/EEC, 93/105/EC and 2000/21/EC.
Page 26 of 32
VERSION: 2.2
Regulation (EC) No 1272/2008 REGULATION (EC) No 1272/2008 OF THE EUROPEAN

PARLIAMENT AND OF THE COUNCIL of 16 December 2008 on classification, labelling and
packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and
1999/45/EC, and amending Regulation (EC) No 1907/2006.
Regulations. Commission regulation (EU) no 453/2010 of 20 May 2010 amending Regulation (EC)
No 1907/2006 of the European Parliament and of the Council on the Registration, Evaluation,
Authorization and Restriction of Chemicals (REACH).
DIRECTIVE 1999/45/EC OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL of 31

May 1999 concerning the approximation of the laws, regulations and administrative provisions of
the Member States relating to the classification, packaging and labelling of dangerous preparations
Directive 67/548/EEC on the approximation of the laws, regulations and administrative provisions
relating to the classification, packaging and labeling of dangerous substances.
COMMISSION DECISION of 16 January 2001 amending Decision 2000/532/EC as regards the list
of wastes (notified under document number (2001/118/EC).
UK REGULATORY REFERENCES
Chemicals (Hazard Information & Packaging) Regulations. The Control of Substances Hazardous
to Health Regulations 1988. Health and Safety at Work Act 1974.
ENVIRONMENTAL LISTING
Control of Pollution Act 1974.
STATUTORY INSTRUMENTS
Notification of New Substances Regulations (NONS) 1993. The Export and Import of Dangerous
Chemicals Regulations 2005 number 928.
APPROVED CODE OF PRACTICE
Classification and Labelling of Substances and Preparations Dangerous for Supply (EU
2001/59/EC). Safety Data Sheets for Substances and Preparations (REACH).
GUIDANCE NOTES
Workplace Exposure Limits EH40. Introduction to Local Exhaust Ventilation HS(G)37. CHIP for
everyone HSG(108).
NATIONAL REGULATIONS
The Chemicals (Hazard Information and Packaging for Supply) Regulations 2002. No. 1689.
Workplace Exposure Limits 2005 (EH40).
The Carriage of Dangerous Goods and use of transportable pressure equipment regulations 2004.
Control of Substances hazardous to health regulations 2002 (as amended).
NATIONAL REGULATIONS (GERMANY)
Major Accident Hazard Legislation 82/501/EWG.
DISCLAIMER
This information is based on our current level of knowledge. This information may be subject to
revision as new knowledge and experience becomes available, and SIBUR makes no warranties and
assumes no liability in connection with any use of this information. Since SIBUR cannot be aware
of all aspects of your business and the impact the REACH Regulation has for your company, SIBUR
strongly encourages you to get familiar with the REACH Regulation in order to comply with its
requirements and timelines.
Page 27 of 32
VERSION: 2.2
Annex 1
Relevant identified uses of the substance
Uses by workers in industrial settings

IU number Identified Use Substance Use descriptors
(IU) name supplied to
that use
1 Manufacturing as such Process category (PROC):
(ES1) (substance PROC 1: Use in closed process, no likelihood of exposure
itself) PROC 2: Use in closed, continuous process with occasional
controlled exposure
PROC 3: Use in closed batch process (synthesis or
formulation)
PROC 4: Use in batch and other process (synthesis) where
opportunity for exposure arises
PROC 8a: Transfer of substance or preparation
(charging/discharging) from/to vessels/large containers at
non-dedicated facilities
PROC 8b: Transfer of substance or preparation
dedicated facilities
PROC 15: Use as laboratory reagent
Environmental release category (ERC):
ERC 1: Manufacture of substances
Specific Environmental Release Categories: ESVOC1
SpERC
Sector of end use (SU):
SU 3: Industrial uses: Uses of substances as such or in
preparations at industrial sites
Subsequent service life relevant for that use?: no
2 Formulation as such Process category (PROC):
(ES2) (substance PROC 1: Use in closed process, no likelihood of exposure
itself) PROC 2: Use in closed, continuous process with occasional
controlled exposure
formulation)
PROC 5: Mixing or blending in batch processes for
formulation of preparations and articles (multistage and/or
significant contact)
PROC 9: Transfer of substance or preparation into small
containers (dedicated filling line, including weighing)
Page 28 of 32
VERSION: 2.2

that use
ERC 2: Formulation of preparations
SpERC
3 Use as as such Process category (PROC):
intermediate (substance PROC 1: Use in closed process, no likelihood of exposure
(ES3) itself) PROC 2: Use in closed, continuous process with occasional
controlled exposure
formulation)
ERC 6a: Industrial use resulting in manufacture of another
substance (use of intermediates)
SpERC
4 Use as process as such Process category (PROC):
solvent and (substance PROC 1: Use in closed process, no likelihood of exposure
extraction agent itself) PROC 2: Use in closed, continuous process with occasional
(ES4) controlled exposure
formulation)
Page 29 of 32
VERSION: 2.2

that use
ERC 4: Industrial use of processing aids in processes and
products, not becoming part of articles
SpERC
5 Industrial as such Process category (PROC):
distribution of (substance PROC 1: Use in closed process, no likelihood of exposure
MTBE and itself) PROC 2: Use in closed, continuous process with occasional
gasoline controlled exposure
containing PROC 3: Use in closed batch process (synthesis or
MTBE (ES5) formulation)
ERC 1: Manufacture of substances
ERC 2: Formulation of preparations
SpERC (distribution) and A&B Tables (storage)
6 Fuel use – in a mixture Process category (PROC):
Industrial (ES6) PROC 1: Use in closed process, no likelihood of exposure
PROC 2: Use in closed, continuous process with occasional
controlled exposure
formulation)
Page 30 of 32
VERSION: 2.2

that use
PROC 16: Using material as fuel sources, limited exposure
to unburned product to be expected
ERC 8b: Wide dispersive indoor use of reactive substances
in open systems
SpERC
Uses by professional workers

IU number Identified Substance Use descriptors
Use (IU) supplied to
name that use
7 Fuel use – in a mixture Process category (PROC):
Professional PROC 1: Use in closed process, no likelihood of exposure
(ES7, indoor) PROC 2: Use in closed, continuous process with occasional
controlled exposure
formulation)
PROC 16: Using material as fuel sources, limited exposure to
unburned product to be expected
ERC 8b: Wide dispersive indoor use of reactive substances in
open systems
ERC 8e: Wide dispersive outdoor use of reactive substances
in open systems
SpERC
SU 22: Professional uses: Public domain (administration,
education, entertainment, services, craftsmen)
Page 31 of 32
VERSION: 2.2
Uses by consumers
IU number Identified Use descriptors
Use (IU)
name
8 Fuel use – Chemical product category (PC):
Consumer PC 13: Fuels
(ES8) Environmental release category (ERC):
ERC 8d: Wide dispersive outdoor use of reactive substances in open
systems
Specific Environmental Release Categories: ESVOC30 SpERC
SU 21: Consumer uses: Private households (= general public = consumers)
Most common technical function of substance: Fuels and fuel additives. MTBE acts as an octane
enhancer.
Uses advised against: None.
Page 32 of 32

Sibur-Khimprom CJSC Safety Data Sheet: According To 1907/2006/EC (REACH), 1272/2008 (CLP) & 453/2010

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Sibur-Khimprom CJSC Safety Data Sheet: According To 1907/2006/EC (REACH), 1272/2008 (CLP) & 453/2010

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VERSION: 2.

SAFETY DATA SHEET

TERT-BUTYL METHYL ETHER

1.1 Product identifier

NAME OF SUBSTANCE: Tert-butyl methyl ether

1.3. Details of the supplier of the safety data sheet

SECTION 2. HAZARDS IDENTIFICATION

ANNEX I OF DIRECTIVE 67/548/EEC:

Classification according to Globally Harmonized System of Classification and Labelling of

GHS02: flame GHS07: exclamation mark

GHS02: flame GHS08: health hazard

The full text for all S, P-Phrases is given in Section 16.

SECTION 3. COMPOSITION/INFORMATION ON INGREDIENTS

Name EC No EC No CAS No Content Classification Regulation (EC) No

Specific Conc. Limits (СLP): none.

SECTION 4. FIRST-AID MEASURES

Product-specific hazards and other issues:

SECTION 5. FIRE-FIGHTING MEASURES

Suitable extinguishing media:

Unsuitable extinguishing media:

Specific hazards during fire fighting:

Special protective equipment for fire-fighters:

SECTION 6. ACCIDENTAL RELEASE MEASURES

Methods for cleaning up:

SECTION 7. HANDLING AND STORAGE

Check atmosphere for explosiveness and oxygen deficiencies.

SECTION 8. EXPOSURE CONTROLS/PERSONAL PROTECTION

8.1 Control parameters

SUBSTANCE LTEL LTEL STEL STEL Note

SUBSTANCE LTEL LTEL STEL STEL Note

8.1.2 DNEL/ PNEC values

Exposure Route Descriptor DNEL/DMEL Remarks/Justification

DN(M)ELs for the general population

Exposure Route Descriptor DNEL/DMEL Remarks/Justification

Exposure Route Descriptor DNEL/DMEL Remarks/Justification

PNEC sewage treatment plant

PNEC oral (secondary poisoning)

8.2 Exposure Controls

Skin and body protection:

SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES

Property Value Remarks/Justification

Property Value Remarks/Justification

SECTION 10. STABILITY AND REACTIVITY

SECTION 11. TOXICOLOGICAL INFORMATION

Property Results Remarks/Justification

Property Results Remarks/Justification

Inhalation NOAEC (systemic) = 800 ppm key study, experimental result.

Dermal In accordance with column 2 of

bacterial reverse mutation assay e.g. EU Method B.13/14 (Mutagenicity -

Property Results Remarks/Justification

There is no evidence of a direct

rat (male/female); Based on the available data, MTBE is

NOAEC (rat, developmental OECD Guideline 414 (Prenatal

Property Results Remarks/Justification

NOAEC (mouse, developmental EPA OTS 798.4350 (Inhalation

Toxicokinetics (absorption, metabolism, distribution and elimination)

SECTION 12. ECOLOGICAL INFORMATION

Property Value Remarks/Justification

saltwater EPA OPPTS 850.1350 (Mysid

Property Value Remarks/Justification

Property Value Remarks/Justification

% Degradation of test substance (non Mormile MR, Liu S and Suflita

Property Value Remarks/Justification