Md.

Arafat Hossain
Brand Executive, SBMD, 01713354512

Product Profile
SKU Brand Therapeutic Dosage Pack Price/Unit
Generic Name Strength
Name Name Class form size (IP+VAT)
Hemojet Vitamin &
Hemojet Ferric Carboxymaltose Injection 100 mg/2 ml 1x1’s 410 tk
100 minerals
Hemojet Vitamin &
Hemojet Ferric Carboxymaltose Injection 500 mg/10 ml 1x1’s 700 tk
500 minerals
Hemojet Vitamin & 1000 mg/ 20
Hemojet Ferric Carboxymaltose Injection 1x1’s 1300 tk
1000 minerals ml

Mode of Action

Ferric Carboxymaltose (Hemojet)

Hemojet enters into blood stream

WBC takes Hemojet through blood

Enzymatic degradation of shell

Outer Carbohydrate shell is removed and the iron is released

Iron is transported by transferrin

Ferritin (Stored iron) Hemoglobin

Mode of action in short: Ferric Carboxymaltose increases hemoglobin level by increasing amount of iron to form
hemoglobin as well as increases ferritin level.
Indication & Dosage Guideline

Indication Patient Category Recommended dose

Adults & Adolescents (17 years & Hemojet 100 mg/2 ml Injection: Patient who are
older) intolerant to oral iron.
Hemojet 500 mg/10 ml Injection & Hemojet 1000 mg/20
Pediatrics (9 months to 17 years) ml Injection: Iron requirement depends on patient body
weight & Hb level.
Iron Deficiency
Anemia (IDA) Hb (g/dL) Patient body weight (Kg)
<35 35 to <70 >70
Pregnant Women <10 500 mg 1,500 mg 2,000 mg
10 to 14 500 mg 1,000 mg 1,500 mg
>14 500 mg 500 mg 500 mg

Indication-wise Target Doctor

Target Doctor Indication

An effective, convenient & safe option to treat iron deficiency anemia during
pregnancy (second & third trimester) & postpartum hemorrhage.
Gyne An effective, convenient & safe option to treat iron deficiency anemia in
women with heavy menstrual bleeding & teen girls during the beginning of
menstruation.
Qualified Medicine/ GP Iron Deficiency Anemia (IDA)
Effective & safe in non-dialysis & dialysis dependent Chronic Kidney Disease
Nephrologist
(CKD) patient with IDA
Effective & safe in patient with GI related problems like Inflammatory Bowel
Gastroenterologist
Disease (IBD) with IDA
Oncologist Improve hemoglobin level in cancer patients with Chemotherapy induced IDA
Non-Qualified RMP/ PC Iron Deficiency Anemia (IDA)

Unique Selling Point (USP)

 Providing type -1 plus glass vial which ensures no interaction between sensitive drug
product with vial
 Convenient IV infusion set with Y injection Port
Premium  Latex free safe IV Infusion set
(Must cover)  Convenient complementary pouch pack with syringe, iv infusion set, alcohol pad & first aid
bandage to ensure dust free auxiliaries & hazardless administration
 Ensures best quality normal saline manufactured by aseptic Blow-Fill-Seal technology,
Germany
 Novel IV iron preparation which ensures rapid correction of IDA
 Can be administered at large dose (1000 mg) in a very short time (15 minutes)
Regular  Ensures controlled slow release of iron due to highly stabilized Carbohydrate shell
(Opportunistic  More safe iv iron formulation
)  More effectively reload iron storage
 No test dose required before administration
 USFDA approved medicine in IDA & widely used in UK & Europe
Disease Profile
Anemia: It is defined as pale coloration of skin, sclera & mucous membrane due to qualitative & quantitative deficiency of Hb or
RBC in the blood in respect to age & sex.
Iron Deficiency Anemia (IDA): Anemia due to iron deficiency is termed as IDA.
Inflammatory bowel disease (IBD): It is an umbrella term used to describe disorders that involve chronic inflammation of
the digestive tract.
Chronic kidney disease (CKD): It is also called chronic kidney failure, describes the gradual loss of kidney function. Our
kidneys filter wastes and excess fluids from our blood, which are then excreted in urine. When chronic kidney disease
reaches an advanced stage, dangerous levels of fluid, electrolytes and wastes can build up in our body.

Model Detailing
Dear Sir/Madam,
There are several treatment options available for Iron Deficiency Anemia (IDA). But conventional treatments have some
drawbacks whereas Ferric Carboxymaltose is a novel IV iron preparation to rule out all these drawbacks. So, for the
management of iron deficiency anemia ACME offers intravenous iron preparation, Hemojet (Ferric Carboxymaltose).
Hemojet is the best choice of iron product to increase hemoglobin level effectively, rapidly & safely. Because, highly
Stable carbohydrate shell ensures safety to administer of high dose of Hemojet in a very short time to ensure rapid
increase of Hemoglobin as well as reload iron storage.

Moreover, we are the only company to offer type-1 plus glass vial, latex free infusion set with ‘Y’ injection port,
complementary pouch pack & ampoule breaker for personal safety & hazardless infusion.

Sir, considering all these benefits, I am requesting you to prescribe (# 2 prescription) in favor of Hemojet for your next
available patients of Ferric Carboxymaltose. It is available in almost all chemist shop to honor your prescription. Thank
you.

Competitor’s Analysis (IMS- 2Q, 20)

Total generic market of Ferric Carboxymaltose: Tk. 50.08 Cr. with 14.85% growth.
Sale Value (Cr. Tk.)
Rank Brand Name Company Growth (%) IMS
IMS
1 Maltofer Incepta 27.24 -0.37
2 Ferisen Healthcare 11.46 19.73
3 Maxfer SKF 3.23 999.00
4 Xefer Ziska 3.03 61.71
5 Fematos General 3.03 -31.98
6 Ferintus Beximco 1.74 999.00
7 Ferinject Unimed Unihealth 0.20 -5.54
8 Enrifer Beacon 0.15 999.00

FAQ
1. What is Hemoglobin and it’s normal level?
Hemoglobin is a complex compound composed of heme & globin. Hemoglobin level varies depending on age & sex.
Hemoglobin carry out oxyzen throughout the body from lung & Carbon dioxide from throughout the body to lung.
Normal Hb level in gm/dL in adult male: 13.5-17.5 & female: 12.5-15.5, Children: 11-13, Pregnancy: 12-16

2. What is the difference between Non anemic Iron deficiency & iron deficiency anemia?
Non anemic Iron deficiency: The level of serum iron or ferritin iron is less than the normal level but Hb is within the
limit.
 Iron deficiency anemia: When Hb level is less than the normal level due to iron deficiency.

3. What is ferritin, transferrin, transferrin saturation & hepcidin?

Ferritin: Ferritin is a protein that stores iron and releases it in a controlled fashion.
Transferrin: It is a plasma protein that transports iron through the blood to the liver, spleen and bone marrow.
Transferrin saturation: It is the value of serum iron divided by the total iron binding capacity on the
available transferrin.
Hepcidin: Hepcidin, a liver enzyme controls the release of iron from ferritin. If hepcidin level increases the release of
iron from ferritin is decreased.

4. What is the normal level of ferritin & transferrin saturation?

Ferritin normal level in male is 12-300 ng/ml & female 12-150 ng/ml & transferrin saturation normal level is 20-50%.

5. What are the risk factors of IDA & why?

Pregnancy: The body iron requirement for an average pregnancy is approximately 1,000 mg. 350 mg of iron is lost to
the fetus and the placenta and 250 mg is lost in blood at delivery, about 450 mg of iron is required for the large
increase in maternal RBC mass. Lastly, basal losses of iron from the body continue during pregnancy and amount to
about 240 mg. Iron losses during pregnancy excluding blood loss at delivery is 1040 mg.
Heavy Menstruation: The average menstrual blood loss is 35 ml. Heavy menstrual bleeding (HMB) may be defined
as menstrual blood loss >80 ml. Up to 30% of women of reproductive age are afflicted by HMB.
Postpartum hemorrhage: The median blood loss during vaginal delivery is around 500 ml. Blood loss more than 500
ml causes anemia. But blood loss in excess of 1000 ml occurs in more than 5% of deliveries which increase the risk
of postpartum anemia 74-fold. The prevalence of IDA in the postpartum period is about 20%.
Children & adolescent: Children & adolescent are at increased risk to develop IDA as high iron amount is required for
rapid growth of children & adolescent. Teen girls need additional iron to replace what they lose monthly when they
begin menstruating.

6. What are the benefits of IV iron preparation over oral iron?

Oral Iron IV Iron
1. 90% of oral iron is not absorbed 1. No limitation as it is parenteral preparation
2. Slow increase of Hemoglobin 2. Rapid increase of Hemoglobin
3. Ineffective to reload iron storage 3. Effective to reload iron storage
4. Inconvenient dosing schedule
5000 mg iron should be taken to ensure 500 mg 4. Convenient dosing schedule
iron to form Hemoglobin.
5. It may require several months with daily multiple
5. Large amount of iron can be taken at a time
medication for the correction anemia
6. Usually 5000 mg iron in more than 1 month with
6. 500 mg IV iron at a time may raise 2 g/dl
daily multiple medication may raise 2 g/dl
Hemoglobin within 1-3 weeks
Hemoglobin
7. Dose dependent Gastrointestinal side effects like
7. No GI side effects
constipation, nausea, vomiting, diarrhea

7. What are the benefits of Ferric Carboxymaltose (Hemojet) over Iron Sucrose?
Parameters Ferric Carboxymalose Iron sucrose
1. Complex stability Highly stable type-1 complex Moderately stable type-2 complex
2. Release pattern More controlled release Less controlled release
3. PH Neutral PH (5-7) Very high PH (10.5-11.11)
4. Hemoglobin correction Rapid Slow
5. Dosing schedule Convenient Inconvenient
 6. Maximum administration 200 mg
1000 mg
at a time
7. Maximum dosage 1000 mg/week 300 mg/week
8. Infusion time 1000 mg/15 minutes 100 mg/15 minutes
9. Test dose Not required Required
10.Adverse events Less More

8. Is Hemojet safe to use in pregnant women?

Yes, Hemojet is considered as safe to use in second & third trimester of pregnancy as prophylactic of iron deficiency
anemia.

9. Is Hemojet safe to use in lactating mothers & neonates?

Yes, Hemojet is safe for both lactating mothers & their newborn babies. Only <1 % iron can be excreted through
breastfeeding milk.

10. Is Hemojet safe to use in children?

Yes, USFDA recommends to use it after 14 years of age due to lack of proper clinical safety data but there are some
renowned journals which suggest it can be used to children from 9 months of age.

11. Can Hemojet be given through both as IV injection & IV infusion?

Yes it can be given through both as IV injection & IV infusion but IV infusion is more convenient & acceptable.

12. What is the guideline to preparatiom & administration of Hemojet?

Maximum amount of sterile 0.9%
Volume of Hemojet Required Equivalent iron Administration time
dose w/v sodium chloride solution

2 ml 100 mg 50 ml 6 minutes

10 ml 500 mg 100 ml 6-15 minutes

20 ml 1000 mg 250 ml 15-30 minutes

13. Why doctor should prescribe Hemojet?

We are the only company to offer…
Type-1 plus glass vial
Latex free infusion set with ‘Y’ injection port
Complementary pouch pack &
Ampoule breaker
.. for personal safety & hazardless infusion.

Website link
www.ferinject.co.uk