Professional Documents
Culture Documents
Acknowledgments
• The Palliative Care Nurse Practitioner Symptom Assessment
Guide has been adapted from IPM Pocket Guide for Palliative
Care c/o The Institute for Palliative Medicine, San Diego USA.
For further information and purchase of IPM Pocket Guide for
Palliative Care see website: http://www.palliativemed.org/
Disclaimer
The information contained in the Symptom Assessment Guide is
intended to provide recommendations to Nurse Practitioners and
candidates for assessing symptoms common to patients with
advanced disease. The information within the guide should not be
considered to be complete but will be complemented by the clinical
experience and skill of the individual nurse.
Appendices
Physical examinationination
Causes
Vital signs. Record weight. Examinationine mouth for
The anorexia/cachexia syndrome is multi-faceted. The signs of mucositis. Check skin for pallor.
association between contributing factors is not clearly
Diagnostic tests (if consistent with goals of care)
understood. Chronic inflammation has been identified
as a core mechanism. Lipolysis, muscle protein Specific biochemical markers of the anorexia/ cachexia
catabolism, increases in acute phase proteins (including syndrome are not available, but less specific markers
C-reactive protein) and a rise in pro-inflammatory may be helpful. Patients usually exhibit low serum
cytokines are associated with the syndrome. albumin and high C-reactive protein.
Malignancies produce chemicals that contribute
to cachexia in some patients. Some tumors also References
directly produce inflammatory cytokines. Raised
• EPEC-O Jan. 2006.
basal metabolism, alterations in hormone production,
eg. reduced testosterone levels are often observed. • Blum D, Omlin A, Fearon K, Baracos V, Radbruch
The interaction between chronic inflammation, L, Kaasa S, Strasser F. (2010). European Palliative
tumor cachectic products, and other associated Care Research Collaborative. Evolving classification
pathophysiologic features is unclear. Anorexia may be systems for cancer cachexia: ready for clinical
due to the effects of inflammatory cytokines on the practice?
hypothalamus with consequent changes in the balance • Supportive Care Cancer. 18(3):273-9.
of neuro-transmitters stimulating or inhibiting food intake.
Important points
1. Calories alone cannot reverse cachexia.
2. Total Parenteral Nutrition (TPN)/enteral nutrition are
incapable of reversing cachexia.
3. Exercise is an important treatment recommendation.
4. Effective treatment of cachexia will require a
multipronged approach (appetite stimulation +
anabolic agent + exercise prescription).
5. Do not wait until the patient has lost greater than
10% of pre illness weight to intervene.
6. Corticosteroids stimulate appetite but will cause
proximal muscle wasting if treatment is prolonged.
Maladaptive or excessive response to stress primarily • Hospital Anxiety and Depression Scale
involving the neurotransmitters norepinephrone, • Distress Thermometer (Appendix 6)
serotonin, and gamma-aminobutyric acid (GABA).
• K10 (Appendix 7)
Anxiety can be associated with physical conditions
such as hypoxia, hyperthyroidism, sepsis, poorly Physical examination
controlled pain and adverse medication reactions
or withdrawal. Vital signs. Observe for signs of nervousness.
Examine heart and lungs. Check thyroid if necessary.
Stools that are decreased in frequency and may be • Absent bowel sounds: listen for hyperactive or
difficult to evacuate. absent bowel sounds. If none are heard, continue
to listen for five minutes before establishing the
Constipation is a symptom, not a diagnosis. In all cases absence of bowel sounds.
the underlying cause must be sought, as many causes
are correctable (http://pallipedia.org/). • Hypoactive/increased bowel sounds: may indicate
paralytic ileus, peritonitis, bowel obstruction,
electrolyte imbalance (e.g. altered potassium).
Causes
• Hyperactive/increase bowel sounds: may indicate
• Medications: opioids, calcium channel blockers, impending diarrhea or early bowel obstruction.
anticholinergic
2. Percussion
• Decreased mobility
• Ilieus • Assess general density of abdominal contents
Symptoms may include the following: abdominal • EPEC-O Education in Palliative and End-of Life Care
distention/bloating, flatulence or absence of, less – Oncology, Chicago, Il, 2007.
frequent bowel movements, oozing liquid stools, rectal
fullness or pressure, rectal pain at bowel movement,
small volume of stool.
Physical examination
Physical Assessment to include abdomen. Determine
abdominal contour from rib to pubic bone. Assess
for bloating, distention, bulges, visible masses or
asymmetric abdominal shape.
Important points
Table 2. Medications that can cause delirium
1. While delirium presents with psychiatric symptoms,
it is important to remember that these symptoms Analgesics Clonidine
are manifestations of medical abnormalities and not
primary psychiatric illness. Anesthetics Corticosteroids
Antiparkinsonian Ranitidine
References
• Holland J, Alici Y. (2010). Management of distress in
cancer patients The Journal of Supportive Oncology
8: 14–12.
• National Breast Cancer Centre and National Cancer
Control Initiative. 2003. Clinical practice guidelines
for the psychosocial care of adults with cancer.
National Breast Cancer Centre, Camperdown,NSW.
• Pessin H, Olden M, Jacobson C. (2005). Clinical
assessment of depression in terminally ill cancer
patients: a practical guide. Palliative and Supportive
Care 3: 319–324.
• Food borne pathogen or irritant (parasites), infections Look for signs of dehydration such as tachycardia,
(viral or bacterial), Irritable bowel or colitis hypotension, rapid weight loss.
• Hormonal (thyroid, carcinoid) Examine abdomen for bowel sounds, tenderness,
and percussion for dullness/fullness. Consider rectal
Important points examination to rule out impaction.
1. Diarrhoea can be a serious symptom. Diagnostic tests (if consistent with goals of care)
2. Consider infection risk and use appropriate contact • Stool for ova and parasites and or C. difficile if
precautions. indicated by history, occult blood testing
3. It is an expected adverse effect of fluorouracil and • FBE (Full Blood Estimation), CRP (C-reactive protein)
irinotecan chemotherapy. • Abdominal X-ray if impaction or obstruction is
4. Consider bowel obstruction. suspected
Assessment Reference
History • Wrete-Seaman, Linda. Symptom Management
Algorithms: A handbook for Palliative Care.
• Establish the patients’ normal bowel habit
Intellicard, Yakima Washington, 2005.
• Elicit a description of the stool that is different from
normal (i.e. consistency or frequency, urgency, fecal
soiling, greasy stools that float, presence of blood,
color, volume, etc)
• Duration of diarrhoea
• Nature of onset (sudden or gradual)
• Relationship to food intake
• Travel history
The uncomfortable sensation or awareness of breathing Auscultation of the heart and lungs. May include
or needing to breathe; shortness of breath. pulmonary dullness, crackles, inability to clear
secretions, stridor, wheezing, cyanosis and tachypnoea.
Examine for oedema.
Causes
Diagnostic studies (if consistent with goals of care)
Physical causes may include airway obstruction,
bronchospasm, hypoxemia, pleural effusion, Pulse Oximetry, FBE (Full Blood Estimation),
pneumonia, pulmonary oedema, pulmonary embolism, electrolytes, arterial blood gas, chest X-ray may clarify
thick secretions, anaemia and metabolic derangement. pathophysiology. Goals of care need to be established
Psychological, social, and spiritual issues may cause before ordering diagnostic tests. Serum bicarb may be
dyspnoea. Anxiety may play a factor. used as a crude measure for hypercapnia.
Assessment
History
Dyspnoea is diagnosed by subjective reporting.
There are no reliable objective measures of dyspnoea.
Respiratory rate, oxygen saturation, and arterial blood
gas determinations do not always correlate with nor
measure dyspnoea. A severity scale 0–10 may be used
to assess dyspnoea.
Causes include the following: underlying disease, • Treatable, contributing factors, e.g. pain, depression,
effects of treatment (chemotherapy, radiotherapy), insomnia, anaemia, malnutrition
systemic disorders such as anaemia, infection, • Deconditioning and comorbidities, e.g. infection,
medications such as opioids or beta blockers, cardiac, pulmonary, renal, hepatic, neurological or
insomnia, sleep disorders, metabolic disorders, endocrine dysfunction
hypoxia, psychiatric disorders such as depression.
Physical examination
Important points Vital signs. Weight. Examine heart, lungs, and skin for
pallor. Focus on signs of infection, anaemia, respiratory
1. Fatigue is the symptom with the greatest impact distress or other organ failure.
on every day life.
2. The pattern of the treatment related fatigue varies Diagnostic tests (if consistent with goals of care)
with the type of treatment. Consider laboratory tests including FBE (Full Blood
3. Anaemia, though an important cause of fatigue, may Examination), Electrolytes, TFT’s (Thyroid Function
not be the therapy-resistant etiology of fatigue in Tests), CRP (C-reactive protein) and/or X-rays as
many patients with cancer. needed to rule out infection, or anaemia.
4. Anaemia is the most common cause of reversible
fatigue. Increases in quality of life appear greatest References
when the haemoglobin is in the range of 11–13 gm/dl. • EPEC-O, 2005.
5. Try something – this is a major debilitating symptom. • Textbook of Palliative Medicine, 2006.
6. Too much ‘rest’ may lead to progressive muscle • National Cancer Institute. Fatigue PDQ Cited
wasting and further reduction of energy level. 28/06/2010.
7. Encourage patients to exercise as tolerated.
The elevation of core body temperature above normal. Consider Full Blood Examination, CRP (C-reactive
Normal average adult core body temperature is protein), blood cultures, urinalysis, urine culture
37 degrees (98.6F) and displays a circadian rhythm. &sensitivity, chest X-ray to locate cause. (If not
conclusive, consult collaborating doctor to consider
other testing as appropriate such as lumbar puncture,
Causes paracentesis, ultrasound, CT (Computised Tomography)
T, MRI).
Often multi-factorial. Infections, malignancies,
thrombosis, Central Nervous System metastasis,
radiation, blood transfusion reactions, biological Reference
response to some drugs (such as antibiotics,
• Textbook of Palliative Care Medicine, 2006.
cardiovascular drugs, anticonvulsants, cytotoxics
and growth factors).
Assessment
History
Careful history of symptom to include disease-related
history. Medication review.
Diary of temperatures. Initial evaluation may not identify
focus of infection in some neutropaenic patients.
Physical examination
Vital signs. Physical examination of all major body
systems including evaluation of the skin, mouth, nose,
throat, ears, lungs, heart, abdomen, venipuncture and/
or IV sites, lymph nodes, catheters (urinary, suprapubic,
renal), implanted devices.
Causes Assessment
Tiring easily with decreased capacity to maintain History
adequate performance.
Detailed history: Description, temporal profile, severity
Conditions associated with hiccups can be grouped 0–10, effect of treatments.
into three main categories:
Assessment of: medications, disease status, sleep
1. Physical causes within the anatomical distribution disturbances, mood.
of the phrenic and vagus nerve: gastritis, bowel
obstruction, GORD, hepatic disease, foreign body Physical examination
in ear, pleural effusion, lateral MI, mediastinal
Chest assessment: Evaluate respiratory rate, effort,
disease, thoracic aortic aneurysm, recent thoracic
distress, percussion to evaluate for dullness, lung
or abdominal procedures.
sounds for crackles.
2. Neurological conditions thought to interfere with the
Abdomen: Observe, auscultate, palpate for
central control mechanisms: brainstem infarction,
hepatosplenomegaly, ascites, masses.
multiple sclerosis, brainstem tumors, CNS infection
(tuberculoma, toxoplasmosis), sarcoidosis. Diagnostic tests (if consistent with goals of care)
3. Metabolic/toxic and drug-induced causes: steroids Review current laboratory results: especially metabolic
in particular have been linked with the onset of panel for signs of hepatic, renal disease, electrolyte
hiccups and are thought to lower the threshold for imbalance, calcium level.
synaptic transmission in the midbrain: hyponatremia,
uraemia, Addison’s disease, hypocapnia, alcohol, Review recent X-rays for signs of mediastinal masses.
corticosteroids, midazolam.
Reference
• Textbook of Palliative Medicine, 2006.
5. Caffeine.
6. Depression/anxiety.
Important points
1. Patients and families may be disturbed by insomnia,
particularly day-night reversal.
2. Assess and recommend good sleep hygiene.
3. Antihistamines or benzodiazepines frequently
manage insomnia effectively. However,
anticholinergic effects of antihistamines and
amnestic effects of benzodiazepines may cause
frail elderly patients to fall.
4. Low doses of a sedating neuroleptic may be
required to manage day-night reversal.
Musositis is a complex problem for patients resulting Examine mouth for oral erythema, ulceration,
from damage to the epithelium. The initial insult can or desquamated epithelium of the oral mucosa.
be caused by a virus, chemotherapy or radiation. The
insult produces inflammation, as well as cytokine and References
enzyme release. The tissue injury is amplified and leads
• Education in Palliative and End of Life Care
to ulceration. Oral bacteria then colonise the wound,
– Oncology (EPEC-O). Module 30: Symptoms-
and produce additional immune response increasing
Mucositis, 2005.
inflammation. Healing eventually occurs spontaneously,
and relies on epithelial cell migration and differentiation. • Potting C, Mistiaen P, Poot E, Blijlevens N, Donnelly
P, van Achterberg T. (2009). A review of quality
assessment of the methodology used in guidelines
Important points
and systematic reviews on oral mucositis. J Clin
1. Viral ulcers are localised and while treatment- Nurs. Jan; 18(1): 3-12.
induced musositis is generalised.
2. Treatment focuses on good oral hygiene and
comfort measures.
3. Certain positions may ease symptoms. • Naughney, Anee. Nausea and Vomiting in End-Stage
Cancer, AJN, November 2004, Vol. 104, No. 11.
• http://www.cks.nhs.uk/palliative_cancer_care_
nausea_vomiting#
Physical examination
Vital signs to include blood pressure. Note changes
in behaviour such as not moving, or guarding. Note
changes in mood withdrawn, anxious, or depressed
appearing. Feel for masses, tenderness in guarded
areas. Pay attention to the specific area of complaint.
References
• Adam: ABC of Palliative Care: The Last 48 hours.
BMJ 1997;315:1600-1603 (13 December).
• EPEC-O, 2005.
2. Secretions from GORD (Gastro Oesophageal Reflux • Wrede-Seaman, Linda. Symptom Management
Disease), Pneumonia are generally unaffected by Algorithms: A handbook for Palliative Care.
anticholenergic medications. Intellicard. Yakima, Washington (2005).
2. Don’t let the wound dry out because dry nerve Stage 1 Intact skin with non-blanchable redness
endings exposed to air = pain. of a localised area usually over a bony
3. Low albumin increases risk of pressure ulceration. prominence. Darkly pigmented skin may
not have visible blanching; its color may
4. With inflammation, opioid receptors migrate to the differ from the surrounding area.
periphery; therefore, receptors are increased in the
Stage 2 Partial thickness loss of dermis presenting
wound bed.
as a shallow open ulcer with a red pink
5. If the wound is not painful, it is less likely to be wound bed, without slough. May also
infected. present as an intact or open/ruptured
serum-filled blister.
6. Nociceptive pain is due to inflammation from
infection. Stage 3 Full thickness tissue loss. Subcutaneous
fat may be visible but bone, tendon or
7. Neuropathic pain is due to partially destroyed nerve
muscle are not exposed. Slough may be
endings. present but does not obscure the depth of
8. Ensure adequate blood supply. tissue loss. May include undermining and
tunneling.
9. Dressing orders should start with dressing nearest
wound surface. Stage 4 Full thickness tissue loss with exposed
bone, tendon or muscle. Slough or eschar
10. Honey is bactericidal (but can cause clostridia if may be present on some parts of the
not irradiated). wound bed. Often include undermining
11. Topical antibiotics penetrate approximately 4 mm. and tunneling.
Unstageable Full thickness tissue loss in which the base
of the ulcer is covered by slough (yellow,
tan, gray, green or brown) and/or eschar
(tan, brown or black) in the wound bed.
References
1. Anderson F, Downing GM, Hill J. Palliative Performance Scale (PPS): a new tool. J Palliat Care.
1996; 12(1): 5–11.
2. Morita T, Tsunoda J, Inoue S, et al. Validity of the Palliative Performance Scale from a survival perspective.
J Pain Symp Manage. 1999; 18(1): 2–3.
3. Virik K, Glare P. Validation of the Palliative Performance Scale for inpatients admitted to a palliative care unit
in Sydney, Australia. J Pain Symp Manage. 2002; 23(6): 455–7
Appetite problems
Nausea
Bowel problems
Breathing problems
Fatigue
Pain
Completed by:
N = Nurse, D = Doctor, F = Family, P = Patient
References
1. Abernethy, A. P., Shelby-James, T., Fazekas, B. S., Woods, D., & Currow, D. C. (2005). The Australia-modified
Karnofsky Performance Status (AKPS) scale: a revised scale for contemporary palliative care clinical practice
[Electronic Version]. BioMed Central Palliative Care, 4, 1–12.
2. Grbich, C., Maddocks, I., Parker, D., Brown, M., Willis, E., Piller, N., et al. (2005). Identification of patients with
noncancer diseases for palliative care services. Palliative & Supportive Care, 3(1), 5–14.
3. Nikoletti, S., Porock, D., Kristjanson, L. J., Medigovich, K., Pedler, P., & Smith, M. (2000). Performance
status assessment in home hospice patients using a modified form of the Karnofsky Performance Status scale.
Journal of Palliative Medicine, 3(3), 301–311.
Anger None 0
Some 1
Moderate 2
Severe 3
Scores: High risk = 19 or higher • Medium risk = 13–18 • Low risk = 12 or lower
Reference
Parkes CM. 1991. ‘Evaluation of bereavement service’, Journal of Preventive Psychiatry, 1(2), pp. 179–88.
Definitions
PHASE
0 Absent
1 Mild
2 Moderate
3 Severe
RUG-ADL
Reported RUG-ADL is combined score from each domain (Eating + Bed + Toileting + Transfer)
References
1. Kristjanson, L. J. Pickstock, S., Yuen, K., Davis, S., Blight, J., Cummins, A., et al. (1999). Development and
testing of the revised Symptom Assessment Scale. Perth: Edith Cowan University.
2. Nightingale, E., Yuen, K., Firns, P., Duggan, G., Cummins, A., Kristjanson, L. J., et al. (2000). Evaluation of a goal
specific care model. Perth: The Cancer Foundation Centre for Palliative Care.
3. Toye, C., Walker, H., Kristjanson, L. J., Popescu, A., & Nightingale, E. (2005). Measuring symptom distress
among frail elders capable of providing self reports. Nursing & Health Sciences, 7(3), 184–191.
Ref: Abbey J, De Bellis A, Piller N, Esterman A, Giles L, Parker D, Lowcay B. Funded by the
JH & HD Gunn Medical Research Foundation 1998-2002.
Negative vocalisation: none is characterised • Knees pulled up: flexing the legs and drawing the
by speech or vocalisation that has a neutral or knees up toward the chest. An overall troubled
pleasant quality appearance (exclude any contractures).
• Pulling or pushing away: Resists attempts of others
• Occasional moan or groan: Moaning is mournful or to help. Tries to escape by yanking or wrenching free
murmuring sounds, wails or laments. Groaning is or shoving helpers away.
louder than usual inarticulate involuntary sounds,
often abruptly beginning and ending. • Striking out: hitting, kicking, grabbing, punching,
biting, or other form of personal assault.
• Low level speech: negative or disapproving quality:
muttering, whining, or swearing in a low volume. Consolability: no need to console: a sense of well
Complaining, sarcastic or caustic. being – the person appears content
• Repeated troubled calling out: phrases or words • Distracted or reassured by voice or touch: behaviour
being used over and over in a tone that suggests suggestive of distress stops when the person is
anxiety, uneasiness, or distress. spoken to or touched.
• Loud moaning or groaning: mournful or murmuring • Unable to console, distract or reassure: the inability
sounds, wails or laments in much louder than usual to sooth the person or stop a behaviour with words
volume. Loud groaning is characterised by louder or actions. No amount of comforting, verbal or
than usual inarticulate involuntary sounds, often physical, will alleviate the behaviour suggestive
abruptly beginning and ending. of distress.
• Crying: an utterance of emotion accompanied by
tears. There may be sobbing or quiet weeping.