Colágeno y MEC

Odontología

2020
Figure 19-53 Molecular Biology of the Cell (© Garland Science 2008)
Figure 19-59 Molecular Biology of the Cell (© Garland Science 2008)
Figure 19-60b Molecular Biology of the Cell (© Garland Science 2008)
 Fibras

Figure 19-54 Molecular Biology of the Cell (© Garland Science 2008)

Clásicamente se
describen tres tipos de
fibras que integran la
matriz extracelular
fibrilar: colágenas,
reticulares, y elásticas.
 Colágeno

Tres hélices dextrógiras

• Secuencia G-X-Y
X e Y suelen ser Pro e hidroxi-Pro
En Y también abunda hidroxi-Lys
 Colágenos I, II, III, y V/XI:
Ensamblados supramoleculares

Figure 19-65 Molecular Biology of the Cell (© Garland Science 2008)

Figure 19-63 Molecular Biology of the Cell (© Garland Science 2008)
Figure 19-68a Molecular Biology of the Cell (© Garland Science 2008)
 Según la organización

•Colágenos Fibrilares: fibras con bandas, incluye los

colágenos I, II, III, V, XI

•FACIT: Asociados a fibrillas con hélices triples

interrumpidas, se unen a la superficie de otras fibras.
Incluye los colágenos IX, XII, XIV, XVI, XIX, XX, XXI.

•Formadores de redes hexagonales: VIII, X

•Trasmembrana: XIII, XVII, XXIII, XXV

•Formadores de membranas basales: IV, VII (fibras de

anclaje)
Page 237
90% Colágeno tipo I
Fibras reticulares
Figure 19-71 Molecular Biology of the Cell (© Garland Science 2008)
Collagen Biosynthesis
 Modified in Golgi
 Cleavage of
propeptides by N-
proteinase and C-
proteinase
 Self-assembly due to
hydrophobic,
electrostatic and cross-
linking interactions
 5 collagen molecules
form a fibril, which
associate into fibers
End up with this after crosslinking…
 Figure 8-32 Banded appearance of collagen fibrils.
Page 237
 Figure 8-30c X-Ray structure of the triple helical collagen
model peptide (Pro-Hyp-Gly)10 in which the fifth Gly is replaced
by Ala. (c) A schematic diagram.
Page 236