45 /os/a0x Intlarmatfon =—_~_>> >,esr rss o s, || de ¥ Toflammation, |tferally encantng busietingy 3a he commonest of Fathojente phenomena. Defietton: ~ Taflammection s degtined a the local sesponge of Ang mammealfan disse to Zqjasy f3t0m. any agent. ~Th fs « body defense Steaction 2a osdes to elininede on Lest lhe govead. Of Sj ewSous agent ‘followed by semovab of adhe nectosed cells and. Rasctes , Causes: 1. Tnfective agents She baclesifa. v2sseg ond. thefse toxths, fang? poscstts . % Tissue necros% caudal. by Vowutug agents Such OS Sschaemfa, PhyStealL agends eg, heed, cotel, Stacdtedbion anc mecharfal t3auma) 3. Fenm unclasioal. agends Jkt coll-medliaded ancl ondigen, aatbody steaclfons. 4: These meatesfals such a8 fosen bodied 1 deeds, sutuses ete. # Fnflammedion kovolves @ besfo Process with Some ovadape Wier easly gnetarmection Segponse sock lakes follooel by supose : fe. ‘Seanned with CamSeanner_* Signs of Znflarnm ion. codenal. stins of Soglarmmedion og “DRubose (stedmes§) TD Tamas. Core Lb ‘) Wealosec head) wD clolose Grek) ~ £564 stan of Sof lammedion ts furdio Lace (loss of functias) Basic concepts Tojesy J Reaponse of body i changes 29 changes 2a cells blood “vessels Connective S8ssua) ~ Response $8 osually protective, but some Lines heomfeL Classiffe ation Me. type of aplarornadion —) CATARRHAL Tolar adie sab hype Orpendtog upon the slefense caparly off athe hast and duseion Of Sesponse » Sngtammadion can be. olsse? #iedas Preade Soplammedion chronic Enflamm ebioni) Acute inflammation: xh ts of showt ckwation Class tng las than gweeks) - and. Stepsesents the easy ody Steaction « Stesalves gusekly amd Ys osucdhy followed. by healteg, Aeude goflernmakion —s short dusadion Neubophils © crafn feeds: D accumulation of plutd and plasma. ad the affected. ste. Dandsavascdase activation of plateleds . ere : 8) Poly masephonuclease nealsiopttls 08 Sinflarmacory cells. 2) chronte Saflammation: chronic Snflammodion — long dustedion mone nualeax WREs (Lymphocytes enc monocyia) ~ Td 8 of longer. dusection and occusig after. delay 5 etthese ashen the caudtlive agent of acute. fnplammetion Pesetels fas. atong Afme as. the sifmulug % such hed, Sacluces chronte SnPlammedion. fromm the foegSovting, chonactesiistic fecdusres: ~Paesence of chrosfe gnflammedory edls uch =3 Jeraphocytes floama. colis and. macwojphages ~ gqranuLedtion 42soue. formation ~ Spectfta stluakons as granslomsdous Snflammestion, Scanned wih Camseanneraitacion of nflernrmedion: D Recong ction syste of sectors S Recap tor fox secogattion of micwolocs © Beeeplas on leucocytes OReeplors far stecogaFtion of necsotic coll gy ctoenbeding prokeins ; Aicale inf. Vasculas evens celular evens. Vasculan eveals See en #'abdesradion fo the microvosculadune ts the eosdhiess Stegpons 40 athe issue Sqjusry. TH Sncludes haemodynamic changes @atlered vascwlas. penenta helity @Heemodynamte changes ~The easltead feoksed of Roflammedory sesponse seul Frm charge? Bn dhe vasculas flow and. coltlre of small tolood. vessels gq the Saisie Ressae @ taonstert vasoconstaiction of aschestfoles @ Vaso dodion SSE A, = romek SS Geclnas Fabs P temper adtine) clos @ local hydroly tte pressuse, @ shouting aK Stogie. prascdos 1 > 4 Hemoconcenhotion —) | plooel Flow) Stade Permeadsl BR OOE——EE Scanned wih CamSeanner© Autered vascuak PEAMEABILITY Ah —_accumuladion of edema, flute So She Jokes Plt compasitenend wich comes fiom blood cane 4 ks escape sImough the endothelial wall. of POEM yageulos.. bcd | a4 eaplafned basis on Slastbing's hypothass: ~ fuluzd bahance % mafalainel by to r0cas J forces that cause oukeocend. movernend of furl. Fororn ertoroctrculalion. Dforceg that case Invocad movement of Intasotitiolk hurd ato circuledion. =a. . f 3S _— a fuse i eaudade —5.dlig | een Fron) Protas Plechanisen: 4. endotieltal, cells codsitchion 7 Fmmediode toangien} gesponse~— Thon piel Dorvect erdothelfal coll Igoory ITenmelede SustoSred steaponse—) Severe busin | Sepicern®a. Derdatheltal. call sebsaction—3 ddayed. Jaansient 9@ponse—) eoofergal LF ectior Perot. amg —s bagel! prelonged leakages ebesin br + Celladase changes BD Iota. vesculase cellulase changes B) exdsie. vaseulos. cellar changey X)Ioba sie eliled chong @® moaginesion : @ Rolfing» patoher moginaded. endl prremanted. aes ~phil cll aie she’ endo theta calls JBitag che vasel. 7 | Scanned wih CamSeaner2. @pchestor os = 0 0g Bocendiven | Bees thas, Senn -sohacelatan adhesion males vent) Vesculea ¢ adhesion) rrolecwal afeneinsj made of Fab ose Brows 95 con ofA G Toanerigeadion: After reucacyle endothelium adhesion 0 | +8 mow along dhe anclothelzal Surface Ell % swlobectte belwer fhe endofhaBtal cells fourk eshere Phe neatiophils. Hom cxpteplosetc poeuclopo Erhacednbar changes, a4 3 enovernent of Aeucooyts 49 chengoal meleculed 05 factors cond the Jad cheeno @ chernolne’s « daxection of aljnctaals 6 Leakoale activation Re o nition of forget el ; : a a ee e gosmadion- = opsorisafion 7 Baclenita, becomes foster pseporensiel aig ~ anbody gonmnation @Hilifeg of brclessta.t the enjoy function of Pras oct oS ao cell? &5 Erllng and deqeadadion miferobe fo lspase of St sniling of becfeaFo ree essenakion fos iting an enechanism. B extracellular mechoufians: Reach sory eee Dactiveted Leucocyted 7 a NPO~ Iedepernlent Dale — @Dthtc cxtde : i vjsosorls ae ks, a Trmane mechanisms Scanned with CamSeannerPoeforrned chersteak, medgelows eal med8etors a Vo Ceoltatase plasma eee L5kftata system Ly coag uledory preformed faeshly nee ote: ae Ls comple mardoxy Ly serotonin Lyattsic ode athe by Lysosomal, enryeg —— Lycytohins Loasachidoric ciel met aboorltties ‘Chsionic Safar elea ~chronie anflammetion % defined, oS Jorg Lostig, flan “madory Sesponse 2q whch #sauc clahuction and Anflammation cecus at same b%me. Gehonie Lnflammation foltoakyg acute Saf larrmeufion ® Recasinent ablacks of acede an tarmtion © dmonie SnfLammation sdassbioy, cle neve. SySlemic feakoes: Dfeven DAnaeriq Dleacocy tes QB ESR | arnyloidosts. Tye! chroig non- Specific Saflammediont then the LoePtant substance produced a non-specific dnonte Inflammatoy seackion aifth formakion of granulation H3ssue and s8ssae sepa by flowosts A ts called ag chronic non spedific Loflammedion. Sd chronic asteomyel is Scanned wih CamseannerChronic ep anulomedoug wy: fame ahoo ~an J athe eltelegis ay ere Ceudes oF chariqofovielic meciphologte Mone, esponse by founrtion og cgrambucrn, eg tabreatasis, Leprosy sy phils Q Peed: SH masqphology PecitheLl cellgs these ane go called. becande ¢ thet epsthelial cell. Uke appearance. © Nott nucleate anh ces thae ane fowned by fusine of Saljacent pidheltatl edly ond. may hae 20 on tnie md nucle @ lymphotel eds ~ 68 a cells enedlfoled. teameoe. sxe tino to antigens the host steyponse, by Symphosstes 25 2ndegeoh 46 Composition of graneborma. ' SNecwSis: wecrasis may be pealue of somes anuleraasos condthow ‘ey. contsed coscction necsosts 2a fubencubasis O@fibwsts: fPhrosts 2 a feeduse of heady by prokifencsiog Fbvoblasis at the patpheny of granuloma. Causes! A) Tojectous congas: mycobacterfa» bacterka, epesroctertes , fungal. Snfections , Poscattes, B noninfeckoug canses These nelle exogenous agands cach Formnune causes, Scanned wih Camseanner“gen yume! Ceperta__ Sv¥Yacrotnguh _.49t a — aod 2541@9™ | Defimadion —— sivextna? 4 fed * | The Gueek Licrd. Lo wlorbion ol! “free fluid” Excessive ac { sion tha ontevat tial “Hisar Apace Onad Sexotes Cavitied» IP Body Cavities. —> Commonaly Calted ak lon * fee fluid Ta fhe L Tntexstitial Aboce —? Cenmnmennly term oA_oedemo Depen i Acumulabea if 14 Corscapandingli, Kviolon 4 = +f tm_the pexitoneat Couiky - Aacites e im the “pluscal County Plewrol: Etpusion se le AL tn tho. becicosdual cauiy ~ Pericardial.» e Be mo fluid Lbtes foe tothe linterst bal Shore pbolween the Coll " and Con be aa plasedd from one. 4n the Cohe of cedoma. tm subcutaneous Haul momentary brewuve of finger prduct 0 debyetion Knoun Ob “putting ee fhe othex uatiekeStyhes ——_____—— i, to als finding = | (Pitkin _Liver. _diseast | ee stray “eg=—tysndema | {Depending orn Lace ian = (w_Localred = eg=_Lymbhatt oP Qo feneval eg - Heng d x Deb whi tipo fluid Comm pos ition one foot. Ie i =n (ose af oedema of Cor focthogenesis Ot Oedema edema wi Coed y-amnechont si thet ae moxmol fluid. balers of blatmo, entevanbas fluid lymph. Floto | Une 4. oy on Comabimeth dure GBedoma. Decreased plasma (ncatic. bresture- . i mevense d Cop lorry Pyluottabic hyesture. Po}. ‘Lymphatic Obstruction a pe Tisul foctorA _C éneseased_oncohe pressuxe of tnler _—__——=stittal fluid ond tre timue ineseced. Capillary permeability = ~~ ¢g-[ Sodium ond tsater Retention —T- Jenaion J. _ * (The plasma Oncehic_ Presure erected Juy the tofal | ——jOneuirt_s|_plaima. protien dends to dain lui Ldn_cto Veisel, osmallys k + Fa Ds Totar flasma Peorien. Level + Lowereng Of plosma Gneahe peestuve +N tong : es pressure of bloods wall ¢ dicreare Penvorey movement of fluid from intershhal Space Wace enol Dea Ascitesatic PRESSURE Coppilloxy ts thi _foxce cit flirt dhyound ae —Cappillory oul win to he sntesshtial st ee. by feuniesachany the fo ce. ct plosma omcotic t presaure . | mimimal or no veobsorhtion 0 fiurd at the / 1} 7 enw wently Leading to _bedema._ 3. Lympxatic OBSTRUCTION AL 2 ihot Lluitd in the Hae | chncosse The uny of Lumbhad ; i paceha. 4 Lady OF gna poh che — | ——_4] ribet tote of these channels causes Incalited. edema Knoan oA Lymbhoedana- a | ji 4- | Tissue FAacrors : \ L a7, i Wome sie decom ll 2 L aie These +i : meagre cont ty Comtexatt the effect of plosnan.MeShbechvely. T t Hay rover in ame Situiohmns the +iatne factor, on loose Aub it al oy du ecm pst _ CEneneasen CaPeiceary FeameaBiurry set Lopillony endothe ita. cemipeamie ef t Qs OTE VLA > si euty kthen Hat (opillo-ry en {ethelinaa Sodium and Water Retention 4 Metenton. AN a Blood. remure Bedema NA wart : - ed ae syive Rot AV HU) jes v oe = may 12191 ott -