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108 Basic Pharmacokinetics

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Figure 6.2 Passage of drug in the gastrointestinal tract until transport across the membrane.

SCHEME:

Xa Ka (h–1) X K (h–1)
(drug in Xu
(Absorbable body or
drug at absorption Absorption Elimination
site) blood)

SETUP:

Ka K
Xa X Xu

Figure 6.3 Absorption of a one-compartment drug with first-order elimination, where Xa is the mass or amount of absorbable
drug remaining in the gut, or at the site of administration, at time t (i.e., drug available for absorption at time t); X is the mass or
amount of drug in the blood at time t; Xu is the mass or amount of drug excreted unchanged in the urine at time t; Ka is the
first-order absorption rate constant (h−1 or min−1 ); and K (or Kel ) is the first-order elimination rate constant (h−1 or min−1 ).

Sample chapter for Basic Pharmacokinetics 2nd edition