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  • HLA-DRB1 0401 (Class II MHC Gene)

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    Jackson Chen
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    The document summarizes key aspects of class II MHC molecules and HLA locus nomenclature. It notes that class II MHC molecules are heterodimers of α and β chains encoded by DP, DQ, and DR loci. The HLA-DRB1 locus encodes the DR1-17 alleles, with DRB1 having the highest diversity. HLA locus names indicate the gene (e.g. DRB1), subtype (e.g. 0401), and allele (e.g. DR4).

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    Class II MHC

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    The document summarizes key aspects of class II MHC molecules and HLA locus nomenclature. It notes that class II MHC molecules are heterodimers of α and β chains encoded by DP, DQ, and DR loci. The HLA-DRB1 locus encodes the DR1-17 alleles, with DRB1 having the highest diversity. HLA locus names indicate the gene (e.g. DRB1), subtype (e.g. 0401), and allele (e.g. DR4).

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    © All Rights Reserved
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    14 views4 pages

    HLA-DRB1 0401 (Class II MHC Gene)

    Uploaded by

    Jackson Chen
    The document summarizes key aspects of class II MHC molecules and HLA locus nomenclature. It notes that class II MHC molecules are heterodimers of α and β chains encoded by DP, DQ, and DR loci. The HLA-DRB1 locus encodes the DR1-17 alleles, with DRB1 having the highest diversity. HLA locus names indicate the gene (e.g. DRB1), subtype (e.g. 0401), and allele (e.g. DR4).

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    © All Rights Reserved
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    of 4

    Class II MHC molecule

    • Heterodimer of α and β chains


    • DP, DQ, DR loci have A or B genes:
    encode α and β chains.
    • HLA-DRB1 locus encodes DR1-17§

    HLA locus nomenclature


    (serologic and molecular methods)

    HLA-DRB1*0401 (class II MHC gene)


    • 01 subtype of the
    • DR4 allele in the
    • B1 gene

    HLA-A*201 (class I MHC gene)


    • 01 subtype of the
    • A2 gene

    § DRB1 has the highest diversity of all DR genes


    Abbas, Cellular and Molecular Immunology, 7th Edition. Saunders, 2011
    Rheumatology. Hochberg, Marc C. Sixth Edition, Mosby, an imprint of Elsevier Ltd. 2015
    Risk alleles

    Rheumatology. Hochberg, Marc C. Sixth Edition, Mosby, an imprint of Elsevier Ltd. 2015
    Bibliography
    1. Robbins Pathologic Basis of Disease. Kumar, Abbas, Fausto,
    Aster (Eds.) 8th Edition. Publ. Elsevier Saunders 2009
    2. The Autoimmune Diseases. Rose, N.R. and Mackay, I.R.
    (Eds.) 5th Edition. Publ. Academic Press 2013
    3. Rheumatoid Arthritis Smolen JS, Aletaha, D, McInnes, IB.
    (2016) Lancet DOI: 10.1016/S0140-6736(16)30173-8
    4. Rheumatology. Hochberg, Marc C. Sixth Edition, Mosby, an
    imprint of Elsevier Ltd. 2015

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