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Antihrombotic Therapy
Antihrombotic Therapy
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located on the World Wide Web at:
http://www.chestjournal.org/cgi/content/full/126/3_suppl/609S
CHEST is the official journal of the American College of Chest Physicians. It has been
published monthly since 1935. Copyright 2005 by the American College of Chest Physicians,
3300 Dundee Road, Northbrook IL 60062. All rights reserved. No part of this article or PDF
may be reproduced or distributed without the prior written permission of the copyright holder.
ISSN: 0012-3692.
1.1.1–1.1.3 Chronic limb ischemia and claudication Antiplatelet therapy (clopidogrel, ticlopidine, aspirin) Survival; ischemic stroke, MI, vascular death, walking distance RCTs
1.1.4–1.1.5 Chronic limb ischemia and claudication Cilostazol, pentoxifylline Improvement in maximum walking distance, absolute RCTs
claudication distance, walking impairment questionnaire,
health-related quality of life
1.1.6 Chronic limb ischemia and claudication Prostaglandins Improvement in maximum walking distance, absolute RCTs
claudication distance, walking impairment questionnaire,
health-related quality of life
1.1.7 Chronic limb ischemia Ketanserin, suloctidil, fish oil supplementation, Survival; composite end point of ischemic stroke, MI, vascular RCTs
naftidrofuryl, picotamide, heparins, warfarin death, improvement in maximum walking distance, absolute
claudication distance, walking impairment questionnaire,
health-related quality of life
2.1–2.2 Acute limb ischemia Anticoagulation, intra-arterial thrombolytic therapy Limb salvage, survival RCTs;
observational
studies
3.1 Vascular surgery Intraoperative heparin anticoagulation Graft patency, fatal/nonfatal MI RCTs
3.2.1 Infrainguinal prosthetic bypass Aspirin, clopidogrel, ticlopidine, warfarin Graft patency, limb salvage, survival RCTs
3.2.2 Infrainguinal vein bypass Aspirin, clopidogrel, ticlopidine, warfarin Graft patency, limb salvage, survival RCTs
3.2.3 Infrainguinal bypass at high thrombotic Aspirin plus warfarin Graft patency, limb salvage RCTs
risk
4.1. Carotid endarterectomy Aspirin Stroke, MI, death RCTs
5.0 Asymptomatic and recurrent carotid Aspirin Stroke, MI, death RCTs
stenosis
2.2 Thrombolysis
5.0 Asymptomatic and Recurrent Carotid
2.2. In patients with short-term (⬍ 14 days) thrombotic Stenosis
or embolic disease with low risk of myonecrosis and
ischemic nerve damage developing during the time to 5.0. In nonoperative patients with asymptomatic or
achieve revascularization by this method, we suggest recurrent carotid stenosis, we recommend lifelong aspirin,
intra-arterial thrombolytic therapy (Grade 2B). 75 to 162 mg/d (Grade 1Cⴙ).