Records identified through

database searching
(n = 170)
Identification
170 from PUBMED

Records after duplicates removed

(n = 170)

Screening

Records screened Records excluded

(n = 170) (n = 139)

Eligibility
Full-text articles assessed Full-text articles excluded,
for eligibility with reasons
(n = 21) (n = 15 )

Studies included in
Included quantitative synthesis
(meta-analysis)
(n = 6)

From: Moher D, Liberati A, Tetzlaff J, Altman DG, The PRISMA Group (2009). Preferred Reporting Items for Systematic Reviews and Meta-
Analyses: The PRISMA Statement. PLoS Med 6(7): e1000097. doi:10.1371/journal.pmed1000097

For more information, visit www.prisma-statement.org.