Pathology Practical •

Slides
 Ischemic necrosis of the myocardium. A, Normal myocardium.

B, Myocardium with coagulation necrosis, showing eosinophilic anucleate myocardial

fibers. Leukocytes in the interstitium are an early reaction to necrotic muscle.
Compare with A and with normal fibers in the lower part of the figure.
Coagulative and liquefactive necrosis. A, Kidney infarct exhibiting coagulative
necrosis, with loss of nuclei and clumping of cytoplasm but with preservation
of basic outlines of glomerular and tubular architecture. B, A focus of
liquefactive necrosis in the kidney caused by fungal infection. The focus is
filled with white cells and cellular debris, creating a renal abscess that
obliterates the normal architecture.
Kidney infarct exhibiting coagulative necrosis
liquefactive necrosis in the kidney
• A tuberculous lung
with a large area
of caseous
necrosis. The
caseous debris is
yellow-white and
cheesy.
Foci of fat necrosis with saponification in the mesentery.
The areas of white chalky deposits represent calcium soap
formation at sites of lipid breakdown.
• Keloid: Excess collagen deposition in the skin forming a raised
scar known as keloid. B, Note the thick connective tissue
deposition in the dermis.
Keloid: Excess collagen deposition in the skin
• Liver with chronic passive congestion and hemorrhagic necrosis. A,
Central areas are red and slightly depressed compared with the
surrounding tan viable parenchyma, forming the so-called "nutmeg
liver" pattern. B, Centrilobular necrosis with degenerating hepatocytes,
hemorrhage, and sparse acute inflammation.
• A, Punctate petechial hemorrhages of the colonic mucosa, seen here
as a consequence of thrombocytopenia. B, Fatal intracerebral bleed.
Even relatively inconsequential volumes of hemorrhage in a critical
location, or into a closed space (such as the cranium), can have fatal
outcomes.
Punctate petechial hemorrhages of the colonic
mucosa
• Mural thrombi. Thrombus in the left and right ventricular apices,

overlying a white fibrous scar.

• Large embolus
impacted in a
pulmonary
artery branch.
 Fat Embolism

Bone marrow embolus in the pulmonary circulation.

• Examples of infarcts. A, Hemorrhagic, roughly wedge-
shaped pulmonary infarct. B, Sharply demarcated white
infarct in the spleen.
Sharply demarcated
white infarct in the
spleen.
Hemorrhagic, roughly wedge-shaped pulmonary infarct.
Purulent -
Inflammation -
PUS

Pneumonia
 Fibrinous pericarditis
Deposits of fibrin on the pericardium.
Lung : Abscess
Lung Abscess
Fatty changes: Liver
Typical tuberculous granuloma showing an area of central
necrosis, epithelioid cells, multiple Langhans giant cells, and
lymphocytes
Fetal Anasarca
Edema
Serous Inflammation – Pericardial Effusion
Hyperemia and edema
Congestion
Petechiae &
Ecchymoses
Lines of Zahn: alternating

layers of platelets and

fibrin.
Downs Karyotype: Trisomy-21
Liver - Metastasis
Carcinoma Lung:
Fibroid uterus:
(leiomyoma)
Liver with multiple metastases
Thyroid adenoma (well-differentiated)
Rhabdmyosarcoma
Granulation tissue
Cavity lung
Tuberculosis
Ghon’s Complex: 1ry tuberculosis