5/30/2020 Human Genetic Disease | Practice Final Exam | 7.

00x Courseware | edX

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Human Genetic Disease

Human Genetic Disease
Consider the pedigree below. This pedigree represents a family with a
rare genetic disease. Note two very important assumptions:

Individuals who marry into the family may carry a disease allele.

The disease is completely penetrant. That is, any individual with a

genotype corresponding to a disease phenotype will show the
disease.

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5/30/2020 Human Genetic Disease | Practice Final Exam | 7.00x Courseware | edX

Human Genetic Disease, Part A

1.0/1.0 point (graded)
i) Is this pedigree consistent with autosomal recessive inheritance?

No 

ii) Is this pedigree consistent with autosomal dominant inheritance?

Yes 

iii) Is this pedigree consistent with X-linked recessive inheritance?

No 

iv) Is this pedigree consistent with X-linked dominant inheritance?

No 

Submit

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5/30/2020 Human Genetic Disease | Practice Final Exam | 7.00x Courseware | edX

Human Genetic Disease, Part B

1.0/1.0 point (graded)
What technique could scientists use to determine the location of the
disease gene in the human genome?

RNAi

use microarray to compare mRNA levels in normal and diseased

individuals

use microarray to compare SNP pro les of family members from

the pedigree

cloning by complementation

cloning by protein expression

Submit

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