AQUALANCE

FACE BODY
TM

rovides a dynamic moisturising effect complementary to

the skin’s natural water gradient.

Homarine and erythritol

Function:
Osmoprotectant skin moisturiser. Keratinocytes
Definition:
Osmotic module composed of size +37%
homarine and erythritol. DRY REHYDRATED
Properties:
Protects against hyper- and hypotonic
stress, desiccation and UV dehydration
stress. Ensures aquahomeostasis of the Skin surface
skin cells and progressively rehydrates the
different layers of the skin. moisture +34%*
Characteristics: * after 24 hours
Erythritol exhibits permeation properties
and improves the water holding capacity
of the cell.
Homarine, a cyclic zwitterion, counteracts
the ion disequilibrium of the cell.
Aqualance™ ensures cell viability against
the damaging environment by maintaining the
water level and volume of the skin cells.
Points of interest:
Aqualance™ mimics the
osmoprotectant system that enables
Platymonas subcordiformis, an estuarine
microalgae, to survive the alternating
salinity of the estuaries.
INCI name:
Water – Erythritol – Homarine HCl
Applications:
All moisturising products.
Formulation:
Water soluble
Recommended use level:
3-5%
Patents:
FR 2 927 801 - WO 2009/104118
- EP 2 252 375 - US 8,368,939 -
JP 5350402 - CN 104203210

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E-mail: sederma@sederma.fr
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Member of Croda International Plc
 CLAIM SUBSTANTIATION 08 - 2014
In vitro tests on keratinocytes
Hypertonic stress: +200 mosmolar, NaCl, at day 2

Number of cells +36%* Number of cells +81%*

Cell size +37%* Cell size +91%*

Normal Stressed Aqualance™ 3% Aqualance™ 5%

Hypotonic stress: -150 mosmolar, water, at day 6 *Significant/control: p<0.01

Number of cells +195%* Number of cells +223%*

Cell size -14%* Cell size -22%*

Normal Stressed Aqualance™ 3% Aqualance™ 5%

Synergistic effect & comparison to betaine Resistance to drying

Hypertonic stress: +300 mosmolar, NaCl, at day 5 and 7 Drying by aspiration of all culture medium
160
Erytrithol+betaine
Before
Variation of the cell number /

140
Aqualance™ 3%
120
Control
Erythritol
control (%)

100

80 Homarine
Aqualance™ 3% +16%
60
After desiccation
40
Aqualance™ 5% +43%
20

0
Day 5 Day 7 0 1 2 3 4 5 6 7

This study demonstrates the enhanced efficacy of time (minutes)

Aqualance™ compared to the individual molecules and other

combinations. Aqualance™ is 1.7 times greater than the Aqualance™ improves the skin water holding capacity and
individual components. provides the cells with a strong resistance to desiccation.

In vivo tests
20 women (23-67 years old) applied twice-daily on the legs a gel containing 3% Aqualance™ or a placebo.
Measurements of skin moisture after 1h to 7h, 24h and 8 days with Corneometer® (Courage&Khazaka), MoistureMeter-D™ (Delfin), near infra-red.
Evaluation of squames by image analysis.
Hydration kinetics Squames
T0 T 6h T 24h
Corneometer® MoistureMeter™ Infra-red

T 1h +29% T 1h +31% T 24h +13%

T 7h +36% T 6h +40% (p=0.13/placebo)
T 24h +34% T 24h +36% T 8 days +11%
(p<0.02/placebo
T 8 days +38% T 8 days +32%
-44%/T0* -12%/T0*
*Significant/T0: p<0.05

The hydration kinetics of Aqualance™ in the different layers

of the skin is complementary to the skin’s water gradient.
The water level stabilises in the stratum corneum after
1h, in the epidermis after 2h and in the deeper layers after
24h. Aqualance™ can replenish the skin’s pool of water and
maintain the optimal level of water in the cells.
Each result is significant/Placebo: p<0.01
v. 151130
Non-warranty: The information in this publication is believed to be accurate and is given in good faith, but no representation or warranty as to its completeness or accuracy is made. Suggestions for uses or applications are only opinions. Users are responsible for determining the suitability of these
products for their own particular purpose. No representation or warranty, expressed or implied, is made with respect to information or products including, without limitation, warranties of merchantability, fitness for a particular purpose, non-infringement of any third party patent or other intellectual
property rights including, without limit, copyright, trademark and designs. Any trademarks identified herein, unless otherwise noted, are trademarks of the Croda group of companies. ©2015 Sederma 11/15 PCS PO 030 V1 EN
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