CAVENDISH UNIVERSITY ZAMBIA

SCHOOL OF MEDICINE

OCM 202 tutorial(amines)

Question 1

In the following reaction, identify the major organic product(s) formed and indicate the
stereochemistry where required.

(f)
Question 2
Provide the detailed mechanism for the following reactions using the given reagents. Explain
the flow of electrons and identify all the intermediates formed.

Question 3
Pure secondary amines can be synthesized from primary amines using of the following three
step process (i) reaction of sulphonamide of a primary amine with hydroxide, (ii) reaction
with an alkyl halide and (iii) hydrolysis. Illustrate the mechanism for preparing N-
methylaniline from aniline using this approach.

Question 4
Identify a reagent or series of reagents that will bring about the following conversion.

Question 5
Give the reaction mechanism for the reaction below used to synthesize 4-nitoaniline. This
chemical is commonly used as an intermediate in the synthesis of dyes, antioxidants,
pharmaceuticals, gasoline, gum inhibitors, poultry medicines and as a corrosion inhibitor.

Question 6
In the following sequence of reactions to synthesize α-amino acids, outline the mechanism
for Steps II and III.