chemicalWATCH Factsheet
Boric Acid
Boric acid is a low-toxicity, non-volatile
mineral with insecticidal, fungicidal, and
herbicidal properties It has long been
embraced as a safer alternative to highly
volatile, synthetic chemical pesticides.
Boric acid is especially effective when
used as part of an ongoing integrated pest
management (IPM) program that incorpo-
rates sanitation, cultural, mechanical, and
biological practices.(3)
Boric acid and its sodium salts, all boron-
related compounds, generally refers to
seven active ingredients, including boric
acid, sodium tetraborate decahydrate
(borax decahydrate), sodium tetraborate
pentahydrate (borax pentahydrate),
sodium tetraborate (anhydrous borax),
disodium octaborate tetrahydrate, diso-
dium octaborate (anhydrous), and sodium
metaborate. No registered pesticide
products contact boric oxide as an active
ingredient.(6)
Boric acid was originally registered as a
pesticide in the U.S. in 1948; there are
currently 189 registered pesticide products
on the market containg boric acid or one of
its sodium salts as an active ingredient.(5)
While exposure to boric acid has been
linked to adverse health effects, experts
agree that careful application offers a less
hazardous, more effective alternative to
many pesticides, without the indoor air
problems commonly associated with
pesticide sprays.
Use and Mode of Action
Boric acid and its salts, borates, have been
used in medicine as a bactericide, a
fungicide, and an antiseptic since the
1860s.(3) It is used as a wettable powder,
liquid (applied as a spray or aerosol),
emulsifiable concentrate, granule, pow-
ders, dusts, pellets, tablets, paste, bait or
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crystalline rod depending upon the
circumstances and target pest.(6)
As an insecticide, boric acid acts as a
“stomach poison” for ants, cockroaches,
silverfish and termites, and is most
commonly used in a bait formulation
containing a feeding attractant or as a dry
powder. The powder can be injected into
cracks and crevices, where it forms a fine
layer of dust. Insects travel through the
powder, which adheres to their legs. When
the insects groom themselves, they ingest
the poison, which causes death due to
starvation and dehydration 3-10 days later.
Boric acid can also abrade the exoskel-
etons of insects.(5) As long as the
material is not allowed to become wet, its
continuous presence ensures that hatch-
ing insects, which sprays commonly spare,
are exposed and die as well. Many
insecticidal formulations contain a
desiccant to protect the boric acid from air-
borne moisture. These formulations can be
effective for more than a year.(3)
When used as an herbicide, boric acid
dessicates and/or interrupts photosynthe-
sis in plants, or suppresses algae in
swimming pools and sewage systems. As
a fungicide, boric acid can be used as a
wood preservative that controls decay-
producing fungi in lumber and timber
products.(5)
In agriculture, boric acid is used as an
insecticide, herbicide and fungicide in food
crops and orchards (6), and borates have
also been utilized as a nutritional supple-
ment for boron-loving crops, such as
sugar beets and cabbage.(4)
Boric Acid Toxicity
Boric acid occurs naturally in water, fruits,
vegetables and forage crops. It is an
essential nutrient for plants and an
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essential element for many organisms.(5)
The acute toxicity of boric acid in rats is
less than that of table salt.(2) It is generally
of moderate acute toxicity, and has been
placed in Toxicity Category III by the EPA
for most acute effects, including oral and
dermal toxicity, and eye and skin irrita-
tion.(5) Sodium tetraborate (anhydrous
borax) products are categorized as Toxicity
Category I because of high acute toxicity
for eye irritation effects.
There are few allergic responses from skin
applications of boric acid. Absorption
through skin is negligible unless the skin
is broken or burned. Respiratory irritation
can occur from chronic inhalation of
airborne boric acid or borates. Workers
show eye irritation, dryness of the mouth,
nose, or throat, sore throat, and cough at
mean exposures of 4.1 mg/m3.(2)
The oral LD50 in rats ranges between 3160
and 4080 mg/kg body weight depending
on the species and sex, with males being
more susceptible than females. (For
comparison, an alternative termite treat-
ment, chlorpyrifos (Dursban®), is about 20
times more acutely toxic at 163mg/kg).(2)
Large chronic daily doses of boric acid
(about 1g in 1kg food) shrink testicles in
dogs and rats, and interfere with reproduc-
tion.(2) High doses are selectively toxic to
the testes, causing histopathological
changes and even sterility in both male
rats and dogs.
Workers exposed to large amounts of boric
acid in manufacturing plants were also
found to have reduced sperm count and
motility in one study with a small sample
size.(7) EPA says the study results “are of
limited value for risk assessment due to
sparse details and small sample size.” No
effect on fertility was found in a much
larger study of U.S. borate production
workers (Whorton et al., 1994a,b, 1992),
but exposure concentrations were much
lower (approximately 2.23 mg/m3 sodium
borate or 0.31 mg B/m3) in this study.(7)
Boric acid is not mutagenic. In chronic
oncogenicity studies using mice, rats and
beagle dogs, boric acid and borax were
found not to be carcinogenic. The EPA has
classified boric acid as a “Group E”
carcinogen, indicating “evidence of
noncarcinogenicity” for humans. Repro-
ductive and developmental toxicity studies
using rats, mice and rabbits found maternal
liver and kidney effects and decreased
weight gain, as well as decreased fetal
body weights. Two studies found that no
litters were produced at the highest dose
levels. Prenatal mortality occurred at the
highest dose levels in the rabbit study.(5)
Boric acid is toxic to all living cells,
partially due to enzyme inhibition. Rats fed
complex organic salts or boric acid had
their serum cholesterol levels lowered due
to liver enzyme inhibition. Boric acid was
also found to antagonize riboflavin
metabolism in chickens.
The greatest danger of boric acid to
humans results from chronic unprotected
exposure to aerosols, or accidental acute
ingestion of large amounts. It is extremely
rare that an accidental poisoning of boric
acid is lethal.
Ecological Effects
Boric acid is practically nontoxic to birds,
fish, aquatic intertebrates, and relatively
Boric Acid chemicalWATCH Factsheet Bibliography
1. Daar, S. 1988. “Boric Acid Outper-
forms Dursban® In School District
IPM Program for Cockroaches.” The
IPM Practitioner, 10(4):5. Bio-Integral
Research Center, Berkeley, CA.
2. Quarles, W. 1992. “Borates Provide
Least-Toxic Wood Protection.”The
IPM Practioner. 14(10):1-11. Bio-
Integral Research Center, Berkeley,
CA.
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nontoxic to beneficial insects. However,
its noncrop herbicidal use along rights-of-
way may harm endangered or threatened
plants and pose a potential threat to
aquatic invertebrates, as a result of runoff
into acquatic environments.(5) EPA
concludes that boric acid’s limited outdoor
use patterns, low toxicity and natural
presence in terrestial and aquatic environ-
ments reduces concerns about its impact
on nontarget organisms.(5)
Effectiveness
An EPA assessment of a boric acid pilot
pest control program conducted at the U.S.
Army’s Aberdeen Proving Ground in
Maryland found that boric acid was both
more economical and more effective than
monthly spray treatments. (1) At least one
study has shown that the combination of
heat at 110 degree F for two hours with
boric acid will increase the speed at which
the German cockroach is killed. (1)
A study comparing crack and crevice
treatments in conjunction with a full IPM
program for cockroaches in school
cafeterias found that one crack and crevice
application of boric acid reduced roach
numbers from 40 per trap to less than three
per trap within three months. The low
average was maintained for two years by
the single boric acid treatment. The same
level of control with Dursban® required
two full applications followed by a spot
treatment. The need for multiple treatments
combined with the higher unit cost of
Dursban® made boric acid much more
3. Quarles, W. 2001. “Boric Acid, Borates
and Household Pests.”The IPM
Practioner. 23(3):1-12. Bio-Integral
Research Center, Berkeley, CA.
4. Rio Tinto Borax. 1995. “Borates for
Farm, Fire and Forest.” Borax
Pioneer. Valencia, CA.
5. U.S. EPA. 1993. “Boric acid.” R.E.D.
Facts. Office of Pesticide Programs.
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202-543-5450 (v) • 202-543-4791 (f)
cost-effective.(1)
Regulatory Information
EPA is requiring three phytotoxicity
studies to assess the risks of non-target
plants and endangered plant species.
These studies are not part of the target
database and do not affect reregistration
eligibility of boric acid and related active
ingredients. EPA has requested product-
specific data including product chemistry,
acute toxicity, and efficacy studies, revised
Confidential Statements of Formula and
revised product labeling for reregistration.
EPA has reregistered all 43 boric acid
products covered by the General Registra-
tion Standard. For these products, only
current labeling and Confidential State-
ments of Formula must be submitted to
ensure that they still meet the criteria set
forth in that document.(5)
EPA has issued a general exemption for
tolerance (acceptable residues) of boric
acid in raw agricultural commodities, but is
setting limits for the chemical in food and
feed additives in the unlikely event that is
use in food establishments results in food
residues.
Under its worker protection standard, EPA
is requiring personal protective equipment
(PPE) and a 12-hour reentry time for
nonresidential uses of boric acid and its
salts because it believes that use patterns
present a potential for dermal and inhala-
tion exposure among applicators and
people reentering treated areas.(5)
Washington, D.C.
6. U.S. EPA. 1993. “Boric Acid and Its
Sodium Salts.”Reregistration
Eligibility Document. Office of
Pesticide Programs. Washington,
D.C.
7. U.S. EPA. 2004. “IRIS: Boron and
Compounds, CASRN 7440-42-8.”
Section I.B.1. Washington, D.C.