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  • Calculos de Farmacocinetica

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    Diego Padilla Santos
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    The document contains data from a pharmacokinetic study measuring the concentration (Cp) of a drug in plasma over time. It shows Cp decreasing over 12 hours from an initial value of 17.52 mg/mL to 0.06 mg/mL. Graphs of Cp, log(Cp), and ln(Cp) versus time are provided along with linear regression equations and calculations of elimination rate constant (KE) and half-life (t1/2).

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    calculos de farmacocinetica.xlsx

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    The document contains data from a pharmacokinetic study measuring the concentration (Cp) of a drug in plasma over time. It shows Cp decreasing over 12 hours from an initial value of 17.52 mg/mL to 0.06 mg/mL. Graphs of Cp, log(Cp), and ln(Cp) versus time are provided along with linear regression equations and calculations of elimination rate constant (KE) and half-life (t1/2).

    Copyright:

    © All Rights Reserved
    Download as XLSX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    6 views5 pages

    Calculos de Farmacocinetica

    Uploaded by

    Diego Padilla Santos
    The document contains data from a pharmacokinetic study measuring the concentration (Cp) of a drug in plasma over time. It shows Cp decreasing over 12 hours from an initial value of 17.52 mg/mL to 0.06 mg/mL. Graphs of Cp, log(Cp), and ln(Cp) versus time are provided along with linear regression equations and calculations of elimination rate constant (KE) and half-life (t1/2).

    Copyright:

    © All Rights Reserved
    Download as XLSX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 5

    tiempo (horas) Cp (mg/mL)

    1 0.5 17.52
    2 1 13.65
    3 2 8.28
    4 4 3.05
    5 6 1.12
    6 8 0.41
    7 12 0.06

    Cp - Normal
    20

    18 17.52

    16

    14 13.65

    12 f(x) = − 1.42108236895848 x + 13.0994656228727


    R² = 0.718658325909201
    10
    8.28
    8

    4 3.05

    2 1.12
    0.41 0.06
    0
    0 2 4 6 8 10 12 14
    0.06
    12 14
    tiempo (horas) Log (Cp)
    1 0.5 1.24
    2 1 1.14
    3 2 0.92 KE = 0.22
    4 4 0.48 b= 1.34
    5 6 0.05
    6 8 -0.39 Co = 10b 21.88
    7 12 -1.22

    Log (Cp)
    1.50
    1.24
    1.14
    f(x) = − 0.215043772480455 x + 1.34644520531562
    1.00 0.92

    0.48
    0.50

    0.05
    0.00
    0 2 4 6 8 10 12 14
    -0.39
    -0.50

    -1.00
    -1.22

    -1.50
    tiempo (horasLn (Cp)
    1 0.5 2.86
    2 1 2.61 KE = 0.49
    3 2 2.11 b= 3.1
    4 4 1.12
    5 6 0.11 Co = eb 22.20 mg/ mL
    6 8 -0.89
    7 12 -2.81

    Ln (Cp)
    4.00

    3.00 2.862.61
    f(x) = −2.11
    0.495156584854699 x + 3.10030465829304
    2.00
    1.12
    1.00
    0.11
    0.00
    0 2 4 6 8 10 12 14
    -0.89
    -1.00

    -2.00
    -2.81
    -3.00

    -4.00

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