sont © OM dy econ - pare a - Fas eernmteth op op qws wd os't # swco | waza" V0 ony ‘widiostY quvo-s00 suro wo wee + epbeg yea ANRIO TN Sueynou8 at enouoqier) 149 10 Sytem auesina a 9ueyy onda peisens onntoed so ep moo temo eed yunbure wine ae Joep sn yy ro 9; ut ot ansseiBon syne) 539 08 juno wees pawsey 9Q:29IeN Neonatal Pharmacopoeia /sSecond Edition « Phiarfnacy Department _ The Royal Women’s Hospital Melbourne Australia ‘tig nerve. Ths wok is copyright. “aga nay use peed unde the | Copyight A 1968, no pat may be £ epreduces by any process whet sere perrsaon fe the publeoe "22005 Phovmacy Depssrent he Koya es Hosaimensive | Tatensive ome | a ca > Sa Ss te | ay} st0 340. | Phototherapy sone: Preterm babies We 150 20008, Bill Levet all Others: >70 $125 a Tt S200 she Se si TO Eechange tf tntenstve phototherapy falls: Preterm WRG | WL TS0O | WES Bili Level 20008, Bill Level, Bili Level STWTBS | 3255 _ SFOs S17: SOS, | S230 S| Sa | 5390-320 Sao TS si Z 2 months age, ep 8 sora agen negate hte rovers at Prevennr® lanrn® Sabie (Oral Poa Vaecnd) Hvar ie Corwen Provener®, if 2 months old any when the me Polio yacin pl) adinktored with routine vaccinations May 2005. eee ele to coront uihince fr delay uni DighthedkVTeanuacetule Pons Pol Poeurecoccat Paumococeal pats 8 a (7 Pedhaie @ thathan rider 32 wees gation ‘AND rot na bighorst roup lee protec Inpatients wl fave subcutaneous (al polo vaccine canbe edninsared ser 1s bce RW vaccinalion sede aso ssalmmunise eal goxaeae Ripcibhy 5 rn nay, vibe soe OS estat a th (weeks) 3st <28 Bae ang wns dmg - seme DiohiherarTemmefaceller Potwsss nae) rameep 8 Comvan “| nthe “Sine (Or Palo Vain) ipeto (SC Pao Vaccine) Prevent 5 oman Tote (Oral Polio Weelne) . RWH Contiauous infusion Chat. RW H Parenteral Nutiion Protocol [WH Endotracheal Tube Orug Schedule. 96 7 8WH Routine Immurisationsi Jt RWHCONSINUOUSINFUSIONS onwg Howto mae op ase ualet Dose Range resin gh Som inviz~ Dinknganiginin” ob Inienyatgnn ona Gniorgraly in Bonar = BOImaganginn Ow OGRelemgaignin nee a Oabanioe ete EPC” soir Vorcopankiinn So ROncayarighnn 3 Opens [ome ia som imifr= Tonierogimaginia 21 20nicoyamighnin Fenn 2obnizogamhgln Smt In ‘ie Snicepantahy Seger Suonisopanvig nn) Ee ionicegariighe ‘naka ign Ont 7 eon eoreaghr ‘Midazolam gig in Se ‘Imi¢hr = Tenicrogravegionin 0,5 30 dmicrgiamdkginin + Morphine ‘Smeg in Sm Tel = lonidogemvkgln. Se Onloggraringhe. Va 0? em tal, Dee Hale wea: g at . 2 aig, 82-32 33 diay a GD Pua ee. Pub ea LEAH a: Hily hee qc SUR ‘oan a8 anc t ruorTowas ouB Aye sogdo SA on ag OE HN ey COM Hh oye Yep apsnut Bev wnjunoaved yas mee St 7 “wnyoouaenns 00) -wouyrbas umaroae 29-4 Hapesuow uous usa uy poave soda ney) jssooy vo sueesind cui pow 3q 1A a8 AN woud 995 eg a wpeEO Byte ee ios _ no Wr z Bywezo —weonmr] qwpunfomniog, SEO TsO nweseNHOOF ‘ ee yw Safa F roar rosie wie, geo wu eee eet, ee a wopeni@ouey —. ewna —-auiION ‘pape oon) Suna’ ered iota R00) EIANETENE ETRE SEISACKNOWLEDGEMENTS - - coMnteD BY Rowena Fary Pharmacia, RWH fachel eth Pharenacist, RWH co EDITORS De Peter G Davis Constant Neonatologis, RWH (Dr Sue'facobs 25 - Constant Neonatologi, RW The ecitoyl tex would ke to thank ll those who fave kindly drated the? ime and expesize to this Ike. A special thanks to the sal ofthe pharmacy 44 weeks may requke doses up to Smaregidose 12hry. Notes Prescribe as caffeine base, {(2mg caffsine crate # m9 oatfeine base) ‘Caution ia renal and River impainent. Give oral doses with feeds. Signs of toxicity are gashic iitation, agialion, tachycardia and diuresis. Approc time to steady state is. Bia Gays. Montating of levels fs not required.VITAMIN E (D-ALPHA TOCOPHERYL ACETATE) n° Fasoloble waa Preparations’ ‘MIX 16.6 unis/.Amt (alps ocophcil eee ‘MCT Combination ‘Vitamin A = 210i. ‘Vitamin € = TO2udieer, Dose ‘Stspesnent ‘Given to all babies <1700g at bith, Commence on Oay 7 of ie and cease an discharge. ‘ORAL: O.tmL dally ‘Chron chokestacks ‘ORAL: Souriwhy/day. lcreaise in SOuritsvg/lay increments to 150 to 300unieg/éay. Notes Do not give at same time a ron preparations. -Monitor doze by measurement of serum viearin € levels, vanmnin Etotal blood lipid ratio, ander ‘measurement of red Llood cel membrane resstance to peroxidation, VITAMIN K Fotzoluble vitamievCaaguiatlon factor Preparations IS 1O-mgitent 1S) 2rg/0.2e TAB Forms 1 preparation and compatibiities Do not mi with infusion fui, Com.VITAMIN A (RETINOL) MIXT Eatibination *, Bt Viana manos Var = zur a bes i sao than ia ‘jst date acovdingo levels. Check level = tegulady in prolonged therapy ‘unit ana A = 0.3nicogram resol ‘No commercial prepiaioncoxtaning Viumin A= alone aveable me VITAMIN Dz as (ERGOCALCIFEROLICALCIFEROL) atoll vitamin |. Preparations CAP 25microgam ¥e Dose ¢ Une only até dcson with pueda: endecinoog. Chronic cholestasis ee ‘ORAL: § 20 7mkxogaveghig. Sp the glans! ‘apne arc empty eontenison fa spoon before sreneuring dove. pee fone Criin® outer enpeies contain eatin of ovine“ Sign ond my not be suse nal ereumsances ‘{Goounis=2emicogam ergecicverl + esmirogyam eholecalierh ACETAZOLAMIDE Catponic Asie tite Preparations tan 2s0mg 1m) 00m, 1 preppéation and egos ¢ ath Ot, NaC 0.5%: [Recoeute 500mg vil wih So WI ge a emerson of Gig. Sage esse reparation for other ries ‘ORAL Take tm (200m) of recs scation nl urher clue 12 Sol with G33. This ges bmg sleton, Pepa a fiesh slaion every 24 pou, Dose Giavcome CORAL: Safire 6 to By Mesbaie Alalers 1 Zsmgighdoe Bry apa bss Aco NZORAL: Sme/ldose 6 to 12hry Notes ‘May ecou aces od Moy cust ser metic ali in ck preritre fas. Monitor ‘coos and ood gases. Concer iaiterande {iam biorbonate during high dove therapy Avid ‘ravasaton. . ACICLOVIR . Ants Preparations “TAB 200mg, 600g Inj 250m, ONT 5%WV preparation and compaibites Compatible with G5%, NaCl 0.9%. possible cuusasive organisa. $eeeiate 250m wal th 1M Wo ge a : I Smghaline er og ~ comedies “ oe: ih. Give over 1 hour via syringe pump. + CA>32 00 6weeks — Tahely paar armel ee ge no wee . & ‘concentration of 20mgjma. Give required dove by Caution i patients with renal impairment, Monitor Se a era, Sete ceatatoncb sare ene cen ah en ced Use only fallowing discussion wit ‘neonatalogat 7 _rskcof hephrotoxicty. +e - SE rane Er cae ‘Merpes Simplex and Varicella Zoster LO aaa sax eerie mee wr wn : ee some CA 220 weeks 2hily “Take (eéugh level immediately before ext dase, + eowe ht Tc ci linc ee gers ‘Consider rechcing dose yuna babies over ~ ‘VITAMINS, INFANT J week of age. if renal function adequate. ‘Supplement OC: Apply Tem to the affected eye five nes. dpy Preparations BE ca capanapoh a Notes Vitamin supplementation CORAL: Give 0.45e daily with a feed ‘May need to Increase dose interval in renal ‘Commence on ta 5 or sen infant 0 fll enteral Impairment and preterm infants. Observe wine ccapun parol veo wth ober cepirotese | ~ feed. see rere equ heen. [Not required alter dichange. - ae erates dn’ ey or uth, eat ra = Notes rnin of 14 dys. Pei Forty poe for Sesernated or CNS cscate, west for 21 days. Viomin® Sonus ADENOSINE 2 > 7 gene ac datantntsic icouinmide 13am reparations # Van 85 Ghonrerogra: ind mg/2mL - 7 Fyaidonine Suumieram 1v preparation and compas ” Visas 35m . - Choleeslstero! 22.smioxogram™Take levels on 2nd dose if 36 or Atty, ane on 3rd dove it Zaha a Therapeutic Range: Trough ? 2a XE: Ing 1 drop 2 hay uit improvement seen, thea thy Notes ‘Alc patients should have boselne crentinine and urea smcesured. Caution to patients with cenal Impairment, dose adjustment wil be necessary ‘Action of pancuroniven ay be patented. Indomethacin, vancomycin and amphotericin B may inerease the rik of nephrorociciy. com. asee » i © Thyroid hormone. [TAS Somteogram, 100rricogra, 200mierog* s0xF D5microgamda. RE { Dove Che pay es ition wh pean crosetecloge Hypothyoi, OeAL 8 tosSmicogang day Aun Soe scconting to thyroid func te. Notes Monitor thyroid function. Airn to maintain serum Ahyosine i the upper half f the naa rnge ad ‘serum TSH level in the normal range. FICARCILLIN-POTASSIUM ‘CLAVULANATE Feaiclin abioticl Betalacamase intiitor ‘Preparations 1N] 3g/100mg CTimentin®) 1 preparation and compatibles ‘Compatible with C5%, NaCl 0.9%. Recoresinste 31g with 13eL WF to give 3 ‘conceniraion of 200rmgticarcilinyrt. Further dilate to 20mgficarclinyi. Give slowy cover 30eins. Dose Use only following discussion with aronatologit ‘and/or coraultation with elnical micrbiologs Doses expresed as tac 1 75mgfhgldose terval CA €37 weeks vahly 7smpfglsose CAc26 weeks a6hty €A26 10.29 weeks 2Ahty CA30w35 weeks Bhrty CAP 36 wets hy . Focbabies CA 37 weeks and >7 days age. gh ih Notes ‘Therapeutic bevel: Peak 20 t0 30mg. Tough s 10mg". “Tale levels on 2nd dose for 36 and «Bhrly doses, and on 318 dive for eiher dose fequerces. “Take tough level immediately before dove, “ake peak evel 30ruins afte infsion is iid, djs dove in renal impairment The risk of ‘pephrotoniey and ototexcty is increased when ‘sed in combination with vancomycin, fraxemide ‘andlor other aminoghycosile antibiotics, AMINOPHYLLINE * Preparations 1) 2509/10 IV preparation god computbiliies CCompatioe with C54, NaCl 0.9%. (Dilute to SmgfenL with NaCI 0.9% and give over 3& leas 20min. Dose ‘Neca! apace Leading dese rwWemakgidose Materanance dose Commencehy 2Dhay wahily High levels ay cause tachycardia therefore monitor beat rte porto administering dose. ‘Therapeutic range 40 to BOmiciomel. Levels not roulnaly taken but toxicity sunpectad ihe samp'e Consider ronitoting levels if given with ‘enthromyein, ciprolsacin, phenebatitene, pPhonytoin 0° razed AMIODARONE Aninaythec Preparations TAB 100mg. 200m IN] 150m9F3ent BV preparation and compatbiies * ‘Compatible with GSI. ‘Ace TOeg 0.20iL) 10 4.8L 5% 10 glee Cconeentetion of 1Omg/Sml. ‘Give dose lowly over 1 hour via singe pomp. INF Dilute according to 1V deg protocol ‘Use elated saltions within 12 hour. Dose Use only following discussion with pacdintic cardiologist, ‘Supeaventicula and vénecutsethyarehythents ORAL: dengg/dose Bly for} week, then 1Zhy {or 1 weeks then dally thereatee, WINE 2 fin for 4 hours, then give 5 to TSmicrogearvlghmin, tated accerding to responce, ges? days BSimphgehse —12ty ABEL Vedas Smgiptlae —12hy Ig 2M die Amgpidaxe ——12hly Notes : Doze may be adjusted according to response, adver eflecs, CA and occasionally serum levels ‘Monitor serum levee ony if ei ns of toxicity tr lick of cic eficaey.Theropeuti range $00 omicromol, ike sample imately before rest ‘de, Arpruxiate tine to Seadytale 310 6, clay: Theophyliae hr many dg erations. Naldin@ mature eonpins SOM sg 7 THIOPENTONE Anticonutisnt Preparations infos 1 preparation and compattites Compare with GSM, NAC O75, Reconsitute amour with 20m WAT 10 give 3 cconceniation of 25enpetl. Cave ever Sins. Dose hevapy 4 erat Aniiconvalsant easing dese Weapon ‘Maimanance dose WN 2g ‘Notes ‘Nenitor fr hypotension. Ainopyine may niagonise the effects of thiopentone, TV preparation conaies &.Smmdt of sodium per 1g. inhstce only by ans1V preparation and compatibiftes = ‘Adiinistes ubdihted aoconting i TV ding protocol ‘Maximum rte of infesion should not exceed AmiAgiminute. Dose Merbolic adidsts IV TenUg of 0.3M sletion for every Tmmoit. by | ‘which Rie desied to lower the base deficit 102 ‘airman of 1OMURE. oR olf covection dose:- ‘Volof 03M = OS fet gx base dei imme) «1.11 sohenld Notes Total dose should not exceed! Tommolkg/12hrs, “THAasW® should not be used for moce tien 24hrs. enmat=3.3mL of 0.3M solution. ‘Dus to rok of apnoea and respiratory depresion, ‘ventilation facies must be available, Administer ‘ih caution very lowiy in non-venated babies. ‘THEOPHYLLINE Xanthide derivative Preparations . AE 125mg MIRE BOmgASmC Date Neonatal spaces Loading dose CORAL: Grgfkytiosel sintenance dose Comunenee we pats ator ois suetght. : ‘nodarone leahesplascisee (DEH from PVC ‘containing infsion bags, vehich may affect ae reproductive vat development. Use n0r-DEH fines and ether Tersmo® oF BDO spinges. Wanster, tora therapy as soon as possible to minimise ‘expos Injection contains benzyl alechol. AMOXYCILLIN Peniciin set Preparations MAH 125me/Srt, 250Mg/SmL 184 500r8, 18 1 preparation and compatibites Compute wil 5% Nol 0.9%, econsitute 500mg ial with 4.6m WE to give a ancenvaion af 100eigfm.- Give over at east Omi. Preparation fr other routes to Recon 500mg vith 2.GmL WEI ghee 3 oncetrtion of Sobre. Do ne: ge more Gan 30g pee iM iejeaion. Cons secon eorateloge prio to prevatiog by IM route. * ORAL Rect powder with WFL according preys ea Sein eget. bose Standard infection wiht 25mposeSevere infection (meningitis, septiaens IN, Ba: SOrpgighove Intonal . cacy 7B days vahdy > 28 days hy aay 7 days rhily >7 days ahi Dosage iteral may be decreased fori 8 to Giy in suspected meningitis or septicaemia, (OPAL: 7.5 to 25myfgidose Bhly Notes Caution in cenal Impaiement, extend dose interval if neces. CContaindicated in ptr with history of- eniaiin aang, AMOXYCILLIN/CLAVULANIC ACID Feiztn aibioter ea Ice aoe Preparations MKT s00mg570g In SMLCAUE Prepacation for other routes ‘ORAL Reconatise powder wth WAH aceon 16 package inser. Stare effgeratn Dose ons tee arin concent of Duo prodsct, ORAL: 12:5 to Zasmepgzoose Vin Notes Conesincaed ia ptets wt 3 hor of pain allergy iat pron jo bet 3 fod Duea AMPHOTERICIN B (CONVENTIONAL) Anitungat Preparations INE Som Pharmacy wil pps prelandet syringes Monday tw Frag com es {be admintcred by medi autor ving sa edi San ender, BP iat. nyotlaemia and aprceh Tay OC pricy ats epested doves Areal doe tray be rete pent wih hypoalaere0¢ hypocakcaemia. ‘TEICOPLANIN Gycopentide antibiotic Preparations 1M] 360mg fincludes GOkng averaged 1 preparation and compatbilties Compatible with GS%, NaCl 0. Dilute according 2 1V drug s=saco [DO NOT SHAKE. ‘Admin over 30min by ing frequent small bolus Injections. Dose Use only folowing dicussion with neonatologst nao in cormulation th eincal mierobiotogt Treatment of kxawn or sospects hospital acquired infection where MRA or proven severe CONS) Is 2 possible eautative organiser: Loading dose I aimgfgjeoe Maintenance dose IN: ayo Biba, artng 24 hours after the: loading dose Notes ‘Caution in rat impaienvent. Monitor coral function ‘when ging in combination wih arsinoglycosides, _raphoteiin, NSAIDs or ether nophretoxte dregs.‘SURFACTANT (BERACTANT) f Pulmonary sot ‘SUSP 25th phosphoipidnl Carvants@) Does espidtay Dives Syrome Irtratrachea adminitaton by redial salt ceperienced it suaciatainraton Gr under supeniton of Few. ComsaRt os suct Inrtraches:4ighdose atts than Shy intra for a mix 2 doses ‘An additonal 2 does can be pena he Comal User upto 4d fo the it dose Notes : [DO NOT SHAKE VIAL Warm by sanding oom Aeeperatre for 20min prior to edinissaton ‘dminter only 0 Inn wo are endotracheal frtubated undergoing mechanical venladon. Marked inpreerens fn ng compliance ar ‘oxygen ray ocaut within nuts of sminisraton| Corea monitoring of verletery Fequlcements if essen sUeAeTT ons 2 Hort acting dapaloing muscle relaxant” Preparations! 7 IN) SOmgimL oy IV preparation and compotibides 5°” ‘Compatible with 5%, NaClO9%. Refer 10 IV drug protocal for adminisation. Dili wth WF oF NaCl 09% to give « onceatcation of SOmgn. ‘Gave ever 1010 30 seconde and lush ine with NaCl os. . Dose 1 preparation and complies Comrie wits 5%. Secorte 30g val wah 1Omt WH to pe encentraon of Sgn. Wiiaw Tel solution and clitute to SOmL with C5% to Fee concertabon of OmgfL, Wir dase and {Ge ove 6 hours sia ringe pune, Bo wet fice through FALLS fl awn sce pcandaceaipnnnn Conserving converanal preparation in babies CA>a0 weeks or BW >2500g 1M: 025mq/afose hey. Increase by O.25me/ig/dose 24hrly to a maximum of Vetere. (Gow increments qn be incseaced by 0.Seafglday In severe infection’ ¥ renal function is adequate and, iniosen rte lee. ote ution n real inpalment lany sdverse eed inching hypolalsenia and nephrotonsin, ‘Monitor rena function, cecrohes and F8C. CConcviten adeinitraion of ether nephrotoxic ‘hap amine ysis, vancomycin) mayrincess. fof nephvoioricty. , Dips tdety may occur secordary to rypoksloema Cased Ly amphoterin AMPHOTERICIN B (LIPOSOMAL) Astifungal Preparations in somg. Pharmacy wil prepare preloaded syinges Monday to Fiday, he 1 preparation and compatibiit Comnatthia with C2ceo 0 1 chug protocol aed gos hoor Use enly G5 for lution eo not nase through PALL fer, Dose ‘Use only following discussion with neonatoogit andjor in consitaton with cna erkrobotogst. Liposonal pepstatin shoukt always be used for ‘aibies CA 30 woes BW 12503. mefigfdowe 2atuly increasing ey tego wo ‘a macnn of Smghaydose 2st Doserof Smptaghline 2th hove-been vied and may be consideved if renal fnction adequate. Notes ‘Athough adver eftecs are repaied les leequeiy ‘han with conwetional Weatoent, the sae, precautions apy fr Bp amphoterin Eaton in en npsiment Many aderse eft nciocing ypehaavena and rsphratoney Stoitor renal fnctivn electohtes and FC, ‘Concurrent adrsngiation of ther nephrotoxic “ups laminegyeeside, vancomycin m3 rk of nephritis. ‘ DDigosin tonicity may occur scenery 0» hyposaganis caused by eemphoediiy B. ATROPINE Antichotineegciyeatc Prepatations INT a00mcy/o EEK 1¥ preparation and compstbittion Comatibes with 5%, NaCl 0.9%, Dilute Toomierograr (.25mL) to te with NEC (0.936 to gee concentration of 100micrgrardent. Give aver t minute, ‘asim nly done Cw <1s00g 2.5m, v2 1500 Smt ‘Administer dove stouy 10 foe of vogue. ‘Administer 75 to 50% of procedural dose Zins prog to panel procedure. Continue every 2mins Lunt procedure fx wee or masimam procedural dove has been reached, ‘Notes ‘Adeinstration s nr inated, tt must be prescribed by 2 doctor. Poscribe maximum procnduraland maximumday doses = Sce policy SMHO4-2-138 fr fll guidance on use of SULPHADIAZINE pasate Preparations tn] 6) td TAB 500m 7 MAT Tomy. Re 1 preparation and coimpatibiiag CConepae edh NaCl. ary a se ' (Gee sly infion pur. Dose 7 Us oly towing dass wih reonatingst ndloen conzulsion wilh nial aieabilogist, raiment of conga ropes 1X, Somphase ily ‘ORAL: Sonypigldne 12hely Motes Used in combination wth pyres to trent tore simon. ; ay incase plant le. Coder reduction and increasing dosge nena in renal Irpaiiment Can increase the kof Kener.Note ‘Monitor QT intenal dy during intiation of ‘herapy. Oo not give with medications that may prolong CI interval ‘eg. amiodarone, chioal hydrate, enyhvomayin,feconazok) For updated lit see Hypotension, badycarda and dyspnoea may oceut ‘Onl doses best adminétered on einpty omach, ‘SPIRONOLACTONE . Potassium sparing’diuretc. Preparations ‘Ta 25mg, 100mg -MOKT Senge. RW Dose Diet ORAL: 0.75 to 1.Segikgldone 12hy Notes (Caution if given together with potassium sparing _gtats, potas supplements or ACE into ‘May cavee hyponatraemia or hypetkalaemia. Usually given in comination wath other diuretics such as hydroehoretiazide. SUCROSE Analgesic Prepocations aver 3336 RE Dose ‘Analgesia far minurpaaful procedures including enapuncline ad el pricks abies wha ate Nil By Mouth Upto 6.2m. por precede [Dabies on Entel Fee CW < 15003, eve 1500, ET intubation, resuscitation JN, FF: 20micrograimssigldose. Repeat at 5 t0 10 (pate ine needed, Baysrasis WE: oe cp sir ee dap surgery ‘Apply pressure (where posible) to lcres! sae for 1 12min allowing apiaton to reduce steric absorption. Noms For Er intubation give riot to suxamethonium. Peak focrease in heart ate occurs in 2 to reins, BENZYLPENICILLIN * Penietn aniibotte Preparations 15 Song Equivalent to 1,000,00urits) WV preparation and compatibilities ‘Cormpaibie with CS, NaCLOSX. Reconsttute 600mg wih $60. WE to give ‘concentration of 1O0me/mL and give dove slay love! a last Sins, Preporation for other routes cecansitute GOmg with 1.5mL WF! to give erncenueation of 308mg, Dose Stared infection CE Boma glen [CHS meringi Re ba {2Onghgfeoe CAST wks Play 7 diy LaheyNotes CContraindicated fo pallens with a history of sericilin alery. IV preparation contains ¥.7eamol of sodium per ‘omg: CAFFEINE CITRATE Nonthine derivative Preparations IN] 2Omg/mL caeine vate. 20mg caffeine cacate= 10mg calfeine hate 1 preparation and compatibilites Compatible with C34. Give slowly over 30mins. Dose Doses expressed as caine ctuate Neonatal spnoes Loading dose 1, ORAL: 20mg Mumtemance dose (commence Zihws afer loading de) 1M, ORAL: Smgleg/daily Maintenance dave can be increased to 9 maximum fof 1p. Notes ‘Chution in renal snd fv impaleoert. Give oral eon with feeds. Sigs of toxicity ace gate iitaton, agitation, rnchyeardia del diuresis Approx time to stealy state i810 6 days. Monitoring of vale fs not required. CALCITRIOL ‘Activa form of vitamin D3 Preparations CAP O.ASmicrogaem MUST (SAS) teiceogranni ssa day quem IN 2 wo Ammodigisy ded vo itavenous is ORAL: 2tearimligldpr n 3 or 4 dived doves Notes js se cording sera tvs. Nach ose conaine Smal of soln. Natl 20% contin wrod srr. NSC 6% comaine leno sodium SODIUM-NITROPRUSSIDE : Vesodttor Preparations ee Inj 50mg 1 preparatio an comptes” Dist 100.05 o OSarfmt ad inte va senge ‘pu roe on Dose i , IV IN: tially 0 bacrgramsinte, increased "eording to respolse a maximum ol (eit Notes 2 Use with eaetion fn renal are heaticimpattehent, Convinonus blvod pressive monitoring is essential If wad over sever lays, monitor blood cyanide level fs seven lew icryyansL). Maite Blood 2 SOTALOL t nately Preparations TAB Bua, 160m Sans Se Pose Use ny elon clscusion with eeontologit andor in conaulaion with predinee excl ‘realment and prevention of supraventricular arith ORAL: tergla/done 12hly increased as adssed by eaeSIMETHICONE net ‘ncivated dimethicone Propasatfans XE AQUI Dose ‘ORAEF som 0.5m with foes PR, - SODIUM BICARBONATE » ppicnasd ” sans om Altos agen Nea. ANT Teno WH) 1v preparation aod compiles Dil tT 121 wth WL and pve slowly over 1S tw sting Dose Tococrec metabolic acidosis INe Che HALF the mel coi thes even remel deficit = Base excess x weight (hy 3 Notes . Hypenaracmia may ei rom epésed dss. + |, preparation (8.4%) contains 1 Jmimolienl socio. SODIUM CHLORIDE, . Sapper Ieon ti Prepacations SF 0.5%, 09%, 20% sob 686 1 preparation and compartiites ‘ite and itu acorn to IV dig prota Do ot exceed’ conceiraton of 154moV if given eps Dose Use only folowing corsulaion with renal physiiat cor enlocnoiegit iypocakaeris, hypepacathyoidisi rena Gllore'= ORAL O.2miciogamiagiéay. | Notes “ i : Liquid inside eapsule 0.17 rik 0.25mnicrogram (.Siicrogiam/mb “Moritor-zereralkaline phosphite-cacium, phosphate and creatinine. ° Conient of eaprule may bi remover by carctly slering the capsule at cach cid and pushing air through capsule to force Rquid out the opposite Hole ‘onto 5 spon, Ersace operon sfety ata times. CALCIUM sey se suppiemen Pesparations IN Calm guuonste 70% QOD = 0.22mi) TAB 100mg SsAdeCSIS 5mm Iv preparation nd compaiitos Compas with G5%, C10, NaC 0.9% + Dilute bolus an erection doses to 20mg (insite, two Smt, : ‘Give shy ove 30 to GOmins or by inkiion, ‘Preperation for ther routes ee ORAL Desole one SandoCot® tblacin 4S WF fo gre. eonceriraon of Sng in Zr (mmel Cth in 20. oo Prepare resvacatlon fr each 40%. Dose” : ‘Symptomatic hypocalcaemia treatment Woks: 0.11 mmol (Sim of 10% eaton)\ypoctesemiaanaatenance (VINE: irumelngyday {3-Smurglday of 10% solution ORAL: sOmglose 4106 tas aay Notes Monitor for badjeandi and anythin Aveid ‘Give ora suppernets between meats CAPTOPRIL ACEInhibitor baparsts taba Mer teh ewes Preparation fr oer rontes Dacre 225 tablet in D5 Wo ge a Concensadon el tg, Rae er peeparnion Pepa aes ston eey 24 hous Dose Tes doce Oralsacs ere, nace sty, aera response. Asntrance ORAL: 01 to Osean shy betes oactany oor of os ede done nce impsrer. eves ee wih can, BaP ontorng seen Monitor Oporto dosing ad ever Soin forte et 2 our ator Sernaraon Then rece mening ery 4 Kevus Folin tie regen foreach ee wells Sable mainteance dow reche. Then sbo Souyshon Gath exten caution tn hyponsacra and ' nese * Use on flowing dscuion wih neontologke nif conauaton wit cinta miobioeg For sezrinfecions where grits are kaown NORA: Wongigtone 2ahly [Nabari mengtis prophylaxis CORAL: Smgfigloce V2hty (or dees. acmophit intense 1p 8 props ORAL: longline Mat for day Notes . rales nid be gven.on am empty torch Indes er enzymes thereto many O28. intwacions Mayrecoce srs kee of theapinine, digo, derametesone, phenytoin, dtp and ecaaaie nortortee ‘ccoant ds reccany rovmsh ed dcluraon of boy Sis, incting tears swest, rine faces 30d sta, may SALBUTAMOL * Betas adeenoceptor agonist Preparations BS somecie it a NEB 2.5mg/2.5ml, Sg? INHSOL Seegint Z Dose ‘Beonchediltation, athena z I Ta pn crv A ya NEB Ge 2g en po eve A Notes tay eae pelle eat and cyt igh doses. Porson High or recited doses may cates worsening «2 Fypora. Approximately ooly 10% of nebute doce, inlsled. aNotes cause’ Bradijeardia or arhythias if given by ‘op neato Hay read jo end dno fries thn ipamen ay icese orig lve, An of morphine maybe enced Sp nas cho. RESONIUM A®@ |. : (SODIUM POLYSTYRENE SULFONATE) ation encange resin Preparations SACH 53 (RWHH Preparation for other routes Compatible with C5%, Gi0%, WEL, ‘Add 310 del of required uid to each yr of usin “Yo make a sixpension, Doce ‘Nom lile-threatenng yparalaeria PRs 250mgyigfdove Chay. DDosas up to Tpfgdose have been used Notes ‘Adjust dote depending upon serum electrolyte tees, igre colon betwoen doses to prevent ‘impaction of resin. Redicion in serun potassim eel ersy take hours 1 days. Use ahernatine tucatment if hyperkalvemia i He thvesteniag, RIFAMPICIN Antbiose Prepreations ny ME Oe 1 préparation and coropatibities ‘Compale with CS%, NaClO.r. Feconttote wal wits G5t and fore ete toa concertation of If. Wide dose snd nfne SE tion pumpovert how monigor setum sodium ding therapy. Correct Inypenstracmia porto inating therapy. Strongly ‘consider sopping spironolactone. Monitor potassium {evel and rena! Keon. Malnaln aoquate hydration, Administer on an empty Romsch. CARBAMAZEPINE ‘antcorwuléns Preparations TAB 100mg, 20mg, 200mg CR. A009 CR MIXT 20mg Preparation for othor routes 1s ponsble wo gle the susperaion reealy 10 teenporaily replice oral therapy. Give same tel daly de tu sna utile cas. Pilate 121 wih arn was, Mir he Leave effet, Dose t Experionce is Bieta newestes. ‘ORAL: Commence al 2.5meyhylose 12haly Increasing every 2 days to miasknum of TSeghagine ? ly Notes ‘CR tablets can be halved bat ot erushed, Suspension ta be given alone. Avid use in active Five disease. Increase cae sly lon fr enzyme induction upon inten of therapy. Serum Levels: Ram: 20-40 micron, Sample iormetatly before nent dese, Time to stectly ste approx 11a 2 weeks, CARBIMAZOLE Arcihyoil an Preparations TAS Sg MAINT Tg WEDose ‘Use only after discussion with panditic cendoerinaogi.. ORAL: O.2mpfigidose Biuly for 2to 3 wesks thos: reduce to Ocmgfg/dese 8 to 2ahily, acjusted ‘ccording to yrotd function teas. Notes Can combine with thyroxine replacement therapy {tui gokve size fs a problem). (CEFOTAXIME 2rd Generation cephalosporin Preparations Wp 28, 1v preparation and compatibiltes ~~ ‘Compatible with GS%, C10% NaCh 09%, Reconstiute 1g wih 9.5L WF to give ‘concentration of 00mg/mt. May be dilutes to ‘SOmmg/at. Give over atleast 1Omins. ‘Preparation for other routes 1M Reconstitte 1g with 3.6m, WF 0 give 8 concentration of 250mg. Dose 1 Mt SOmgfegdose foenal AiO weds $28 days 1ahely Dae days abily CAzsoweels £14 days 12h or aay Dove interval may be reioced from Bhuty to Shily in share inlectondmeningtis. oe Notes ‘May require dosage Inter w be increased In « ‘ables with severe tena aur, PYRIMETHAMINE repatations TAB 25mg SUS? Zimghnt RW) oie Use ony follwing dscusion with neonatclogit andlor in consultation with clinical microbiologist “tesiment of tooplasma infection ‘OPAL: Dmejkgfdayf0" 2 days then tengheleay Duration of weaument to be advised by 1D/CSinkal Microbiolags. Notes ‘Give in combination with subphadiazine, ‘Weekly FBC should be cared out to motion for, ~ Uheombocytopenia, ieveopenia and magoblatic lanaeara, Folni acd (5 to 10m) shoulebe given ‘heee times per weck (MAMA) coving treatment: RANITIDINE i Hs receptor antagorist Preparations ‘TAB 150mg ORT tSragfe, NI 25mgimL. 1V preparation and conpatiilites Compatible with GS%, G0% NaCl 0.9%. ‘itt with NaCl 0.34 to ge a concentration of ‘traf Give doze swiy ove at eos" Sing ouinum concenbation 6f Dmg ea be ced in uid vee parts = Dose . To reduce wast a sreion or prevent uleraton Migvine moos So : IME gg 6 to Eby» ORAL: 20 Amgfgidore 8 to 12h. 7‘Notes . ‘Check APTT 15s post dose. Hypoiension, bracycardia ae Mushingrhay occur swih,pid IV i Drotdinine has a0, aecongelan effect at hig doses Prctine Img ake neuraes ne ant thsorbin Sig fot of nnn. oy ey “i rexktve the anti-Xa fer etc. PYRIDOXINE ery ie roche Namie sppeiee Preparations INL Stig ? Tall 35mq, 100m 1 preparation and eonpotbiities {Compe with C% NNO U2 No dilation requle. Give ae emer Sains Dose 7 2 Diagnosis and teatinentafppidavine dependant regnatat seizures ‘eat dae Wve 70mg a . 4 ‘Obseave for 30mins fa defite response i seen! continue with or maintenance. os Maintenance CORAL: 50 to 100myfdove 2h. Notes 9 ee F Profound rk of hypotonia, sion anil apnoea” swith Gat tet dase, which may requle serior "appor. Iealy ve whist monitoring with bees EEG too! to monitor impaction seizures and background activity, = eee CEFTAZIDIME 3ed Generation cophalosporr Preparations WN) 1g 28 41Y preparation and compatibiltes ‘Compatibie wih G5%, G10%, NaCl 0.9%. Reconsitute with WH (1g with & Sel, 2g with 18,2) to gre a concentration of 100mg/mL. May te dilted 1 SOmpft. Give over at leas 10mins. reppin or ir vents = lua Reconanae Ig vil with 2.9m WI to give a concentration of 250mghmfttal volume Sent). Dose Use anly allowing scusion sith nevnatalogist ndlor a evesulation with clinical microbiologist. 1: somgtgidose nénal hot CAsI0 weeks £23 days why 328 days het Az soweds os 14 das Tahuly p14 day hey Notes = : ‘May requie dosage iteral to be increased in ‘abies with severe eens flor. Used for infections caysed by suscepible organs wih suspected er documented resistance to other anibitis in consation with miciobiocogy. CEFTRIAXONE {ed Generation cephateeport Preparations shag, 25 1 preparation and corapatbiiies S Compatiie G5%, G10%, NaCl 0.9%. Raconsite 1g vial wih 8.64 WE to gh aW: Somg/kgfiove 2atuly ~-Sé¥erE tnfection meningis) 1: Toompfeydove Raby oe SOmpgfdose Vly Notes : Diplaces bilbin fom serum albumin. Not recommended in neonates with unconjugated bhyperbiiubinaemia, IM route may be used only where no IV access ‘zailable and ater discussion with senior ‘neonatologi CHLORAL HYDRATE Sedative Hypnotic Preparations AIT 100mg/et, Dose Sedative ORAL: Bmgfegidove 6 to Bhuly Hypnotic i “ORAL: 25 t6 SOmghkgldose 2ahily (maximum 1g per dose) In ventilated patients, higher doses of up to Somekg/dove 6hrly may be used if required. Notes ‘May caize nausea, voting and diarhota. Dose may be cited with water or feed t reduce theé de effec. Tolerance may develop after long-exm therapy. CHLORAMPHENICOL at Preparations ~ EVERAR 0.5% ocis, Aerhythoias CORAL: 0.2 to OSmefegldose 6 to {2h Increase according 1 response 10 a maximum of ssimyfigldose Notes Respiratory depresin may occur. Masitr for Iypetencon and bradycardia, May cause Iypeglyeacraia, monitor blood sugars uni therapeutic dose esablished. Conraindicated i athena, Use wth eaution in pate with cardise -frilvee and condoction'dsorders: PROPYLTHIOURACIE Preparations TAB SOme, ‘Ant thyroid agent Dose (Use only ater décuston with paediatric endoctnologit. Neoeaatthyrotustcosts ‘ORAL: Smefkgldoce Taha. : 1 PROTAMINE . : Heparin antagonist Preparations gmng BSS Omelet. ro 1 preparation and compatibles ‘Companble with G5%, NaClOS%. No dition required. Give over 10sins. Dose = ‘Testment of hepa overdove . H- 1bout since heparin dave © = + wee STAR OSeafi00unitshepatin ~~ Subsequent doses Imgfkg (max SOrg)POTASSIUM ‘Supplement Preparations f IN) Oe Oe. (MOXT Yomenoll (RW) fe om, 1Y preporation and compattiites Compa wiih G5%, G1O%, NaCl OK. (Use G10% as the prefered infusion Quid. Always cite before slinisration: An overdose can be rapt fatal. Mix solutions thoroughly ta aveid pooling of povassiom. DBilste sccosting to ¥ dug protocol, Do net excced a se of OZemalteyhou. ‘Maximo concerttion for peviphea adintation ia0mmnell. Maximus concentration fo celta sdmiisation, ornmoWt, Dose “eatment of hypohalaent ‘Acute depletion IWINF: Ofmmollky over 3 hous, thon maintenance of 210 srmoliay. ‘ORAL: 2 fo Aenvol g/day i 3 vides doses, ‘Usual daily equtremerts WINE: 2 to Jemattegdy 36 maintenance infusion ‘ORAL: 2 te Smmolghly in 3 cnided coses Notes Patsstiam 075/10 = trol diet dose accoeding 10 serum porssivm levels ual doses ace best given ater alee. PROPRANOLOL, Beta advenocepior setagonit Preparations TAB 109, 40mg [MINT OSes RD Dove (Get Apply 05 to 130m upto iy oF ght if dope are being used during the day. EVE: Ins 1-6top, 210 Gh for 2 10 3 days ates nical symptoms have resolved, and then decrease (0304 tows a day, EAR: Ina 4 drops Gy Notes ‘reat both ey. Discard al toprol products 30 days afer opening. CIPROFLOXACIN s Qeinctone alibiotie Preparations TAS Sotheg 2 2g 1v preparation snd corpatbites Coenptiste wilh €53%, G1, NOCL OSX. Dose Use only folowing discusion with neonaslgst nin in coma with cSoical micrbicloi. ‘Standard infection 1M, ORAL: Spat 12h Severe infection IORAL: 1010 Sp gone ely Cortrovery exe ove the psbilty of cpmtorcincaiing achropay in exldren, “Muntoetcophytios levels on day 3 of eiproftoxacin ‘weaument, Deerease kas by 50% elevated, CLINDAMYCIN * rable Preparations t ANI 150mgfat CAP ASM1V preparation and compalibilies ‘Compatible with G39, NECLO.IK Dilute to 2 maximum concentration of Y2mg/mt. Give ove! at at 30min Dose * Use only following discussion with neonatologist andor In consultation veh clinical microbiologist ‘Ages 7days: V1 <20005, Smgfigldose 12hry aw > 20005, 7smplgfdom Why Age >7 days: ‘CW <12008 Smgfigldose Whey €W.1200-2000g Smgfigldose ely GW 20004" " .Smgfkgldose 610 Shy Notes Risk of hypotension and cardiopulmonary arrest if ven quiedy. Discontinue iW severe diacthoea Sevelops and invezgate cause. Increase dosage Tnveral in paents with sigaiicant liver dysfunction. CLONAZEPAM enzadtazepine/ Antconvant Preparations 19 Fong MIXT 25mg. crop =0.1mg, TOOmicrograrv, wes 1 preparation and compatibiies Compaibie wth C5, Gr0%, NaC10.9%. Dice with dent provided immaviatly before we to ge aconcenration of Img in 2. ‘Giro oer Serine Preparation for other routes ~ _ien ging str, count eps ont a spoon ‘before adminicerng” Do nat ve drecty fom ‘ate to patent a verdosng may ooo ex, Cont. PIPERACILLIN-TAZOBACTAM Peni anibici) 2 era lactamase inhibitor Preparations Inj 29/250, 49/500 1V preparation and compatbiftes Compatible with G5%, NaCl 0.9%. Reconsthute 29/250g val with 8.4mL WEI or MCT 0.9% to give a concerivation of 200mg/L. Further de to 25mg: ith NaCl 0.9%, Withdraw recquired dese and give over at last 30min. Reconetured fal may be stored in refrigerator for upto 26 hours. Dose * Use ont fllowing discussion with neonatologst and/or in conautaion with ciieal microbielois. “Treatment of serious inféetions where sensitivities known Dou selertoPiperaca content, | mM jsomekgfdose : May be increased to a maximum of 75mafigidose in sevete Infection and if renal fonction ix adaquate. Interval ‘Age 7 days ‘Tah ‘Age >7 days 60 shy Notes oe 1 ‘Use with caution fn patients wih renal impairment, extend dose intenal necessary. te Sa} ‘May cause prolongation of pancuronium effec. ‘Containdicsted i patente with a ior of penialin allergy. sie ne teh preparation contains 2Ammol ftodiurs per 1g.Dose . “realment of sieves nol conroded by phensbarbitone teasing dose : Z 14 15 9 2Ompheyfdose Miafgnance dose {coaifience 12 hours alter loading dosed ORAL: E CA37 weeks) $14 days 2mghhgtose 12hy aude anette Uy CAz37 weds £14 days Angigltos 12h wae SI" Sie Smpigtdone hy Notes (Do rot aerinit o pairs on dopamine, Rapid 1 injection say ease hypekesion, avshythias, bradycardia, eardivascuar cllnpse dd respiratory depen. : ‘Gouin ia pti th hepare impatient ‘Many deg teractions “Teepe ute range 10 fo BUmicromolA. Sampo should be taken inimadiely beloe no de. ‘Apprenimae te to steady sate i 7 Gay ‘Unpredictable pnarmacckiaticy, 2 sal imerease in dose can have disproportionate increase in elle ‘oze may need to be ncrezse er the ed week ‘life, Ort rout sno ecormerided in newhorss Ss absorption i conable and may reque ven. Fgh doses. : PHOSPHATE Preparations MIT o.Smmlmt WH) Preparation for other routes Dissolve one Phosphate Sadr tablet n 20m Wl to give concentration of. drimolin. Solution issuable for 2 ious in efageatoe oe 3 ea? days after nial monet i250 the er dass peur fr. pros ete Grey bo gre inlance de 1M, ORALS QOL gfegydese Btirly Commence mittrance se burr bg Sanaa rain oy reed oo Spa a gly Elen Din shold ie hu ik er men Rosle tna kay eel serene Sine ti 1 ict oy separ thsi, Rents sake fewer Ens cress pvr, wppe som et a te see pe Therapeutic: ranges 0 t1) 35Unancened. * CLOTRIMAZOLE Sa Say fang i Preporotions | ckE IE, 4 OP. Apply ated 00.2 : limes day and mptoms have gob. COPPER Prepseations [MIXT 20sncrogramnt. #RWH Bose (ORAL: 25micropameteyday whoa os Notes Riatore paipored by phurelscy deportesCO-TRIMOXAZOLE (TRIMETHOPRIM. AND SULFAMETHOXAZOLE) Cinyareote reductase inhi /Sulfonamide Preparations MOET Bom. Dose Dose expressed as coment of wimehoprn ; ‘Standard infection “Teatnest ORAL dergghdon ny Frophylanis ‘ORAL: Zepto at right reamacyal cae posenonta (PCP) Use oly fllowisg dsausion with nsoasologét se de nog Wom: Seo thy ae 30 oi Froppass ORAL: Sme/efdoce mix 16Omfare chee daly (on 3 daysheak (AWA, Notes ‘Do not ws ti undid neonates. | Notrecornmended before week 4 fe due tte cof kemicins, Gest gen with (ood. Mio folate satus of pallet f weanert org term o igh Jor Contraindteated ia GEPO defceney. Can cause Phekowenstty r DEXAMETHASONE Preparations INI Sirgfnt, Dilute to Tmgfrl and ge required dove over Yeieute, ma I t Long halle in agonates, however half Wie decreases with prolonged use (over 2 ween due to live encyene induction, Mary deug interastions. May decreas levels of theephline and pheny:oin. izmpicin may decrease phenabarbitooe eves Avcid in combination vith large doses of | acta as hy ees of heptotoic tables ‘may be produced. PHENOXYMETHYLPENICILLIN Peake antibiotic praparaigge= IS MIXT 125m/Sm, 250mgfSm > Preparation or other routes OAL Recoaute powder wih WR secrdng 0 package inser. Store i refigeator Dose . ORAL: tomy/gfdone Ghiy Notes ra ‘Contyindicated in patios with ahisony of [peicilin allergy. To be taken on an empty stomach, PHENYTOIN | pieces . poe : ey : sv preparation and compattlies” : ee ceeriee “concentration Bs less than 6mg/mL.. Sieraeguorn godine Sent viet ete ed ne(ral preparation may be used rectally. ‘Use for maximus 6f 48 hours before review, Doses up to S0mag/y/28 hours have been used Under medical superzio in older babies, PHENOBARBITONE Aaticorvatsont Preparations 1] 200mgfmt SUSP dmg 1 preparation and compsibiites Compatible with G5%, Nacl0.9%. unter dite 200mg ent) with Yk, WET to give concentration of 200mg/m\. Give a Lyhyinute, PArsimam ten emergency mpg). ‘Preparation for other roules na Adminter undiluted. Dose Aaticonrulant Loading dove 1, 20mp/hgldone ‘May be repeated vil a masinmum of Adm hes ‘been aeached. Maintenance dose ‘Commence 24 hous afte loading dose. 1, IM, ORAL: 310 Smpfegtlay. May be given as. single dose a night, o divided Srna owe dose. Notes Thekaperatc range 80 to 12Cmicsome_ Take sumple Immediately before next dose. Time to steady sate approx 9 days. Use with caution in hepatic o uinliepaienent, May couse respiratory depresic’ apnoea, bypotension and drowsiness ‘Mechanical venation may be ‘quired n doses Dose ‘Chron Lung Disease! Bronchopuimonary dysplasia DART Regimen ORAL: aR glen Yay fr Ses Dy 5.6 Urge 12h for 6 doses | Day 7.8 ‘.025me/agdose 1 2hly for 4 doses ~ Bay 9,30 OO1mghyfone 12hny for 4 doses ‘Cowse may be repeated once if necessary. Bay 2.23 D.5myfighlows 12hrfy for 6 doses Day 4,5, 6 Shane ey fr 6 doses Day ? and afer Decree dave by 10% evry 3 days nil se of D.Amykyay is reached. Then give on alternate ays fort week, then cease. i italy inalfective dlseontinceatter 5 cays. Yo prevent lle of FT extubation and post ‘extubation sridor 1M, ORAL: 0.25me/ky'dose Bhly for 3 does. Give lose dose 1 hour prior to extubation Notes Hypertension 2nd hyperglycaeméa may occur, [Monitor 8P and Blood glucose. Encore ll existing Infections are vested belare commencing sdexamethseare. Ora! anlungal medication (Nystatin to commence of day 1 of weatment and continue for three days after dexarethacone has ceased. See page 93 for steroid equialence,DIAZOXIDE Acthyperensive Avinypoghyeaemic et Preparations 181 15rage, CAP GAS) 100M FOxt GAS) Tori ED 1 preparation and compas ‘Or ee reer. Only we Vi or hesabr ccna. Cot pharmacy fr frther Soc Dose Use only ater diana wih pda endcrnolo Hpogieaemia second ta ypernsetnaeia ORAL: 2 to Smpfigidine Ghrly as recommended by cialis hye increta co axinu of Aor. : Notes : arto od pret 3s ater dhe. ani patel fr atin and Inpengeaem Un asain cat ith prolonged wi. ‘May hoe ania fcc, Say enone rtm DIGOXIN cade syeoside Preparations AN) 25microgran. ‘TAR 62, Smiragrar, 2508 erog-am1 Mac Somicropramdink 1 preparation and compatibitities CCemaatile with GS¥, NaCl 0.9%. te Smlerograrsin, Withdraw required dave aad give slowly over 5 0 1Omiae, Cont wo gee 2 concentation of aight Willd required dose. Administer into i fine ad us seth NACIOIK.. ed = ‘Use only following escusion with neonstologis. Paras af respiratory wscls to improve fatenary compliance fa patients with assisted eattation : 1120.05 t0 O-imglyldcse as cequited. Adjust dove according to duration of muscle relaxation. Anidote NNecetigrine SOmicrogramiydse with atropine omer Notes Ti not wee waon-ventlated patents, = Side effects include tachycardia, hypertension ard, ypothermia. . ‘Risen COE and 2 dtop in PsO2 may be seen with Fetal dove. May increste pespheral oedemss if used foc longer than 24hours, ations Fay require labieating eye drops. PARACETAMOL ‘ Analgesic /antipyrotic Prepaeations, SUSP 120my/Sal, 250mg/Sm, Dose Analgesia, antipyretic OAL, PR: ISpfkydose CARMI weeks Thy (onax 09/9/2409) CAazto 36 weeks Ohaly {nax Comglg/ 24th) A237 weeks 6 to Bly (rax 6Omgftg/? hs} Notes ~ Caution in pati inparent Coat. 6sBowe Suppression of gastric ae section “ORAL: tially O.7pg once diy nthe moring. haign nour before eed. ‘Davie dose ater 7 £018 dys if pens pes Dose gto 2amgtgtaxe hevcbeen wed. PALIVIZUMAB. - Aaonoclil antibody 1 prepscatin sad compattiltes Reconsite 100g with Fmt WAT give 3 conceniation of 100me/. Ae WET only by running dawn side of val Ole by tating vil for 30 seconds da no shake} then leave 290m temp for at least Orns wn saliton earifes {reine opalescent before withdawing dose: Use sth 3 hows of econsizsion, aes Beet 4 nippy nei ne, Atte Tomgfigldace once 4 month throughout RSV, seine ° ‘Notes ; : Give ik dene prior to REV easer, Inject into sterol epee of high ec ‘exceeds IL, we Boo fection ses == PANCURONIUM é tong ang no paing ‘rewrorusculr binckur Prepirstions IN) 2mgiL 1 preparation avd! compatbiies dose (Use ely flor season with paeditie ena, Loading dose (otal 3 doses) fr srzhylrias only CA-<37 weeks TN, ORAL: Hiniennggars by sta tbe Svicrogragidese Ube fr 2 the, A237 weeks WW ORAL: Tiers estat then Nomiermgramtghlene sly for? Sartor dees. Maintenance dose yonane A en ORAL: 3 rangone 12hely Notes esl bow i eas ingame Commie har dase i patients ging ated wih ingemetnacin or erthensyein, Hale chee if 0 sith il aon, Fypehalens aay cscs: dk gin tity toh ar thous increase! eign wel theveone sve enay-pregnO= falionts te dgpaia tonics. Ther [Fy 28 haa Serum feed mil eter a J! clay Bat nar eset ewe say be recency, > “ake simple at lst 6 hers ater doe, Sige tude inclale waiting, eFarhioea, anasines, Inayety and ath Desc must ass fe presi mera DOBUTAMINE 2. Carbine nets Preparations IN 12 Sm 1v peepacation and compatibiites Compatible wih C5%, NaCl 0.92. Diule ncontngto IV deus pretocol avd give 36. ‘continuous inotion via intusion pump. Fit mic with crenaly alkane sobions 0orm bE Improvement of carding output and BP IVINE. 5 to 20miciogamghinute Stan a Smicrogramfgiaioute and increase ater 4Oming ss neti. Notes Use wit caution Hf given through peripheral ne due 10 vasoconsiriave aaion. Correct hypowolaemia before commencing infusion. ‘Observe V site fr iflarmation, extravapation and ‘extreme vésocontiction (racking. May be used iogethecwith dopamine, May cause tachyesed, Cohrancited optic ypetopie subseic stenosis, DOPAMINE Cardiac awope Preparations NL 40mg/mL WV preparation and compatibles, Compatible with G5%, NaCl 0.9%, i Diite sacording to 1V drug pretocel and ge as a contlnvoustfusion via infason pump. De nt ic with arenfy aii slons sodumicaroonae, Dose - = Improvement of cardia outputand BP =, VINE 2 w 20micrograrvegmin +h Notes {Use wih caution ven tou piper ie ve ta xasoconetrcve action. Corset bypove 3 asocnepsric thn | cian ‘May be wea topither with dobuesrine! ~ Rann i oper th opie ie zo | ‘hypotension. Teanngerisenon-lepslrsing nevromuscnar —« beaate TN20.08 10 .35eghe. Uragoritechotloec tees wih avapne SOrscogrtg) ete Mas be gen under medical pero, Mentor forchoege sie els oan nines ening, incensed secretand. radar, chyeaa, Trpetemio,respatry depression ahd eda: or repay ane are 3g of verde, Renecaon flies held be sole. Coenen wll dingots the eect of neostigmine ix mpasnia poe NYSTATIN ” dnifargst Preparations MRF 100,000. Che 10,c0007f5 ise Props foal candiass ding se thesapy ‘ORAL Use it hry for 3 dye arr ome. Teale ot candi lens of ie moc ‘renbres sd ite tak GAL Ue nk ys andat incon ef the skin . TOP Apply 3 nes dy af nap hangs tes Ce ee 7 Spr againNEOMYCIN’ Ophtric antibiite Preparations VE neomycin S00unis pein 251g, granted 2snicoyarn Ecneomycin seOUunis,pelymixn Sg, backracin Soon me Dove EVE aly iti 1 drop inn the flected ees ‘hy or 2a hous, then ntl op Shay fe $197 Saya ater syoptons veoh. CE Appiy bo to Ter 2 to 5 ies daily for $107 Sipe ake gpl rely Notes ¢ Disa 30 days sie oping. wrotinls may bested steely veh infomed er troken skin NEOSTIGMINE 4 pavichsinestorae Preparations 18] O5mgftmb {WV preparation and compatibiltes Compatible with GSM, NACL OIE, No dirton require. Give dose owes Tein, Medical Staff meat Be a attendance. Preparation for thee routes In SC: Amines ued Dose” To test or myasthenia gravis 104, $C: O0smpegfone stat (artagpnive chotinergie elects wth atropine 2omicogyaevgidose To treat enyathonia gravis IY, 4, SC 0.07 0 D OsimggrUose every 210-4 ENOXAPARIN “eo ow molecular wel hepacn Preparations In 20mg/02mL, sOrmg.Aei, Omg. mL, Toorak ration for othe roules ‘Compatibe with NaC. 9%, « ‘Diure vo 26m ith NACE 0.0%, Wray epee dase ad sinister by St Gano ‘njction. Dose Fer exeanly ter ehscussion wth pec amas ” Syatenie antcongutaion “Trgstcot SC: Lyte 12ly ruplin ‘SCP: 12b1ly Capericnce fa nents Revd, Dose rsh Timpani Stor SEA IEA the unt werd ot hear: Foe andrea tao, tate das aoe a tet tn pe de iroument (3 0 Ton. Sra #2 eth tos edging af mumtnigdpoemd ciid Fe at we cy De dee nd he Seetironve tae . ‘rg pean compa nis Tg conned ERYTHROMYCIN Macro ani Preparations ia ae,Iv preporation ard compatties CCompatte with N9Cl 03% Reconsuce 31m vial wile Gok WPT to give a cmcenvation o 50 Farther cite tn Seg ress and ve ceguie Bowe ve 60 to Y20ms. Preparation for eter routes CORAL Reconstute powder wih WF according io pckage feet, Stor in relator Dose Standard infection I, ORAL: TOngfayHose hey Severe infection 1 ORAL: 15 to 25eglgone Bhny Notes 1 my ead to incgeadersk of hypenvophic pili senen inthe Get 2 weeks cf He, Fat recommended by Pa injection de to pan at Injection se V must be admired ore t least 1 hour due tof earavasaton ard pin at Injection she May increase teophyline and digoxin Jeb. ERYTHROPOIETIN m tettropoiede hormone Preparations 1s) 4000uei. Iv preparation and compatiiiies Compa wy NaCl 08% Deca quired doe fom pe filed singe nto appsopntely sited syringe Dose . 15:20 10 only dy fr 10 done. Notes ‘Sbetancoun doing mare fect than N Cone and chet wall igi ay occur wis raid adminisfation. al feof morphine: CASS! weeks Fem ot ladys 69h q NALOXONE a va picid antagonist Preparations tt deny : { 1 preparation and compatibitie Compal with NaCl 09%. Die eae Yo wth NCL OY. and gear Thine. : ° ration for oer routes 1%, Advmiier undined. oye (pb NOT Give TOINFANTS OF NARCOTIC DexeNDANT MOTHERS WN: O-tmafteldore ne TY INF: 0. mefkgh. Rate of Tafsion shout be. tiated to respons, as duration of action i shower ‘han most oplolss.‘Constant sedation in venilted patients IVINE: 83 to 2microgramginis Selnwees . IY INE, O.1 smigMose sat then tricropamghnin. Resptatory depression moy actus partiglry at: highé doses, Concomitant adniniaation of opiate ess may oe ac ren depression, Dose of migazolam ray need to reduced. Flumazenil should be aveiable or reversal Seeder snp pe [0 ork) MORPHINE 7 fagiyies 2.9) ad ate eT oid aie Preperation: Plan OR Ire Omg, 1S, 20m NI rg tg Iv pera and eopeties Compaiste nih CS, C108, NATO, Siu oat ea Spin. he over Se Ihe Dike acceding oT evs potacl ae lose ‘va stings pump.” . bese songs, Staton pr osimetioe (ini So tom cogent eds op {0 Omieropargyr may bene nents ater : toro ample) rt be abbr aan . ‘Sppterati reef fetes withdrawal a nants contin weg GeAL: aconngto the Neo Abtnence Scoring Stem hoes Adequate in stores ace aveessry 4 a9” Sppeopristerexponse to aatwopailin, Consider iron supplement. ° CClarance in neonates 310-4 times hit of adults, FENTANYL oot Preparations | IN} ste grarin 1¥ prepratctwand compl Compaiie wilh CB, Da wilh WL ta geo eae crv a eee he sensi : {Nt Die nad aint cig 1 ei ron . Dene “Aralgesiain ventsted patients only Ne Tt Smceensonvag de 2 to Abn a eis VINE: 1 to Smicrongarn Us four P ‘alow argh mat Be ata fn weversle ty Notes a “ee ont “lepressint, Monga ees wall igh. « Moe pation cal 6 cava sae Pree ag Teserance my devclip koosing cman fiisin, “Sgyicant withawal sympa have bee epi in patents treated with continu nfason longer than $ days." G ‘Buraton of action 30 10 ming, theefore anaes cect is brig unles given hy continaons infusion,FLUCLOXACILLIN, fas Latamae resist periclia ancibacc Peeps tre Some, 18 MIXT 125mm, 250mg/Sem, 1 preparation and compatibiiice ‘Compatinie with GX, NaCl OS. Recoratae 5COmg vial with 4. WFLt0 give concentration af 100mgfmL. Tae Tmt ofthis {olution nd father Siuteto 2ek-with WELT given cconcenteation of SOmgfml, Withdraveragived dose and give over at leas Yomies Preparation for other eoutes Im Reconsiute 500mg vil with 7.6m. WEL to give ‘concentration of 250eap/mL. CORAL Reconstute ponder with WEL according to package insert. Sore in refrigeration Dose ‘Standard bfecton IW IM ORAL: 25mghkyidoze ‘Severe infection I, IM, ORAL: Sompfkgtore tater Ages 7 days rahuly ‘Age 8 to 28 days hay Age >28 days ohiy Notes ‘Caution in patents with hepatic impairment. Oat doves best given on an empty stomach, ‘Connraiedicated i patents wih history of penielln allergy. ores ‘Mixture should be taken on an erty stomach: Predominant ute ia NEC in combination with “zmoryeilin and gentamicin. May darken cring to brow. Consider necessity for IV adminsration 2s adequate levels cn be achieved using oral emulsions duc thigh bioavatabiity. {alasion contain approx 13.Sramc of sodium per ‘00mg. : _MICONAZOLE ‘eniarga Preparations RE 2 GL wat Bose i ‘Candid ifoctions ofthe mucous membranes and ‘eterna text CORAL: Apply O25mL (quarts of the measxing spoon provided) ofl inside the mouth 4 mesa dy akerafeed. =~: “opted trealinen of fonga én afections. GRE: Apply to area of rash tice a day. Continue f6t 4 day ster specs esos. MIDAZOLAM ef ats : Benzodiazepine Preparations Np Tngh, Smo oe IW preparation and compatbiies © > ‘Compatible with G5%, GIOK, NaCl 0.9%. ‘Give Inet, dry ver at eat Sins. INF Dibge aconding to V rg protocot and ii vin singe pup. lige = Sedation fe intensive Care >” 0.05 to O.2mevkyldove wp to a toa ofNoles Dosage interval should be increased if evidence of ‘renal allure apd estment cassed in ares, IV pteparatcn contas 3.92mi of sodium per 1g. _ METHYLENE BLUE 2 Thinzine dye Preparstions IN 4¥ preparation snd ‘Compatible with G52, NaCI 0.9% ‘Give undluted over at leas 15a, Doe ° “Treatment of methaernoglobinatnla eV to 2mgflyfese. Repeat ate Thr i sequted Notes ‘may dicoluur facees, urine and skin blue. CContineieated in GBPD dsfiseney. Overdore may produce hoernolyts and methacmylobioaena. METRONIDAZOLE anibisne Preparations : AN} Seg MIXt 200m. 1V preparation and compatibilites Compatisie with G5%, NaCl as. ‘Ghee uncut! over # how ORAL: Tsmafhgttone Natnenance dose IN. GRAL: 7-Smgigldone several ‘Age $28 days satel ‘Age >28.days any Commence maintenance dove A257 weeks 2s afi osding dora FLUCONAZOLE * Anise Preparations 9 Img MT TOmgiat, WV preparation and compatibiltce Acimiistr uelutd over at feast 6Dmins, Dose ‘Use anlyfllowing eacusion with nent” eeoe in consult Guth dikeal microbiota, ‘Systemic ifeeion andlor meningiis Lraaingelose INC ORAL: T2mpegidose ‘ainienance dine 1 ORAL: bmgigtione {Cetancous infections, candidiasis Lansing dose sod Te ORAL: Gmgtghlne ‘aintenaace dose ORAL: Sngiyetne Avera Ages 14 cays P2inty ‘age 1S W286 dys alady ‘Age >28 days 2ahly Notes onto Hive fonction teas and scot nue i ee sree dowel, Condes dane et in cna impiemen. Da ot use Io teal C Kreo © Ciabeata, Stay increase keel! phgnytuin, theophylline an tealiine. Consider monitoring ewes, 1 prepivation cnnains tSemmol sodium pee 10. FLUCYTOSINE antcng ProportionsW preparation and compatibiiies ‘altar undittcd Give Tome over a feast 308 Store batweon 1S anal 25°C in original container as Dreepilation oceus at proionged storage under $5°C ond comersion to SRuoroutac! occurs if sored above 25°C. Flacycsine shouldbe considered 3 potential ‘carcinogen in humas and must be handled 253 ‘qnotoxic dug. ‘The pharmacy deporerent wl supaly preloaded dores a8 VOre/e solutions Monday to Fiday- Dose ‘Use ony fetlowing discussion vith neonatologist andlor in consltaon wit clinical mnirobiologs. Use in combination wit amphotericin B for syteenic atecions not responding 19 conventional antiongal berapy Standaed infection Iv: 25mg Shy Severe lafectin INE SOmgfkg/cove shely Notes ‘Do nat use alone, Morite levels to avaid marrow tonic, Measure peak The after start of iniysion and trough imnediately prior to next dose. ‘Therapeutic ange impsiement ad when wed in combination with cuher nephrotoxic deugs. ‘Monitor liver Furcton tests. Invasion solution contains 34.4rmmat of sodium por 250ml. ope Preparation for other routes : WM Dike to 6.Bormolent. Dose Hyporpagnesaemia MMe 0.2 to Odmmollgidese 1abely ypocalezemn Inte OAcnmaltgidose 12h fox ? doses Notes ‘Noemal range: 0.75 to 1.2memotA. “Feat seru levels <0.7mmol. ‘Neuromuscular blackace of pancaronium may be potertieted. Monitor BP when ging IV inusion. Pay cause hypotension and CNS depression. Oral ‘therapy not recommended due to puxgatve action. MEROPENEM . CCarbaponera anubiotc Preparations INI 500mg, - WV preparation and compatibiities Compattle with 05%, GiOK, NACI OS. Reconatute 500mg val with 10m WEL give 3 concentration of Somgfa according to Veg protec ° Gre as.an infusion via singe pump over 30min. Dose Use orl following diceusion with neonatologit Sailor in congulation svt ciel ricrobiologt. Standard tnfetion vs 2omgfegldose Inteeval , Ages days at Ape > dns aiely Severe infection . ‘Dose may be increased to 4Grg/he/dove mening iafecions cased by Pseudomonas =, GonDose * entries TV. teofedase tony ver ates 5 ies, follow hin 1Smins wih an infson of 1019 Sornograr vgn, tating ote sccding to rege Noted” Symptoms of tc ince Iypeiterion and Contsindiated io Well Perinson ite sjndrorme- * Soria Coasting preserve shoal nat be” Bren LOPERAMIDE : Aniidsithoos! Peepatations ‘ car 2mg Preparation for olher eotes ‘ORAL Disperet content of cape in a WEI 10 fives concession of Omg Prepare 2 fesh {elton foreach dose 2 Dose Short get syndrome dinhoes ‘ORAL: Up tn 1 25mggay nto 3 died hasbeen wed.” “ Notes ‘Conalndicata in children th gastroenteritis: MAGNESIUM SULPHATE ‘Supplement Preparations tne] 49:38 Comin. *% 1 preparation and compuliiles Compatible wily G5it, GIO%, Nach OX. * Dilute to O-Arrao¥il. Ge slowly over 20mine. FOLIC ACID Supper Preparations 1h) 15mgind, Tag 05mg, Sm 1¥ preparation and compatiiltes 4 Compile with G5%, CHS, NaCl 0.9%. Administer ever mininuim of 1 minute, Deticeney _ in IV, ORAL: Somicayyaen once daily Notes Con be given IM ar SCH neeessry FGLINIC ACID Cava teucowerin / Cacia font Préparations 181 SOS, 1Smy/2mL Tan Tm aXT 10mg : 1 preparation and compotibilfes ‘ Compatible with GBM, NaCl. Dove ‘In ceenbination with pyrimethamine for toxoplasmosis CORAL Ong thee times a week MINED ‘Biesming newotrancmitter defects ORAL: 75mg once daly Notes, Antidote to folic aid antagonias. Ujed in ‘combination for toxoplesmess therapy.FRUSEMIDE Lanp eet pecporations 3 10mm TAG dom MIKE Togo, " 1 prepacatin and compatibiites Compas with NaCl 05%, Drag may predate tlw pH. ‘ ‘namiister no tse ran O.OSimgts. Dose = \V.ORAL: 0. to 2mgfegldove ‘atonal CAc3? vaele — 24hey CAbwweele ST days 2th 37 days 12hty IV INE: 0.110 tegfafhour High dove therapy may be wscesay in pie with feral impairment. Ancrioliuric renal flare nay tequice doze of Sng ose or higher to eabich tine autpe Oe dere can be nena eto Egos n resktant cases. Notes Hypotalacina, hpovolaemia and hypotension may Fisk of ototoxic is increased wath ronal impsiment, high doses, epi JV administration and # the ese of other ootexic drugs. Indomathacin, may reduce disretic response, I usec long-term, monitor ‘pola and consider potsium supplements oF the addon of potassum-sparng diuretics, GANCICLOVIR, Preparations 1] S00, ‘ORAL: TOmptyfdore 2atly vp to mee 2Ong/hgldose 300m 24h fr severe infetions. Notes ‘Monitor theaphytine and phenytoin eves used together with sociaid, Should be given on 3” fempty stomach a+ feed and antacids reduce bloaatabty, ISOPRENALINE # ~ Non selective-betareceptoe agonist Prepaeations 1N) 2000mierogrardint 1V preparation and compatibiiies ‘Compatible with G5%, G1O%, NaCl 0.9%. Dilute according to 1V drug protocol Arfuse via syringe parmp. Dose” ‘Teealment of severe hypotension and beadyearcha VINE: 0.1 to O-ricrogamiigin Notes ‘Mainiy chronotropic alecs with zome inotropic ‘ctions. Simultaneoss admiristation of adrenaline may cause severe anhythias Tadhyestdia, | * arrhythmias and skin fusing way occur Covfect hypovolaemia before commencing ioprenaline. LIGNOCAINE . Local arsestheil Asiartythmic Preparations . 1N11%, 2%, 10% a 1 preparation and commpaibies °° Cemmpatle with COX, Ne Die to apropteYlme arin Haig pumpypedalsamis!© + VINE: 0.02 to D.Teniaghh using Gracose 25% 28 ‘the Infusion sclution. Notes (Overdose wil be indicated by hypogycaemis achycardi, pale, Mogtor Blood glucose levels 30 mins after sant of infusion, repeat in 30mins then ‘monite hourly un infsion ceased, IRON . Hemopiletc agers Preparations = Ferrous Sulphate tio Liguid) MOT 130mg/SiL Brg eam Dore Prophyt Albabies <2.5kg at bith Commence om day 21 Hf feds ze ely exabtsed. (ORAL: Gere 0.5m Grmg fermentation) datly with feed. Teeatment Dose may need tobe increased in deficiency sates Up to aSmUkg once dilly may be given according toseverty Notes Feeds ae (lly eablahed ven the infant hos tolerated tl arength, fll volume feeds for 1 weet. Separate form Vainin € dose. Continue for 6 onthe afr dischar ISONIAZID at eonfSe) Anivtuberculass agent Preparations TAS 1000 Dose Use only following discussion with neonatoogit andl in cmnsuation with dinieal micrebilogs. aes JV praparstion ard compatibitiies ‘Compatible with G5%, MaCl 0.9%, ‘Canciclair should be eensileed 3 potentnt carcinogen i humans and mut be handled 95 9 eytotore drag. ‘The phermacy department will spy prfoncled doses as Syn Soltions Monday 40 Frid, - inte via syringe urap over The andor in consuliion with clinical mirabiohgt ‘Teealment of Kile threstening CMY disease IR: Sree 12h Notes ‘Neuvopenis ad dheumboeytonwnid muy ostur requitng case reduction. Wie bow cl sd pelt counts shal be taken every 2a fo the Fit 1 das, Do ne use in comitoaton wil CAVISCON fpeaerveiettin Aiginate Preparations SACH Caviscom inari® fuaigen ginare 225014 ‘nd magnesion aliaahi 67. Sm) Preperation for othee routes Compare sith WF, maasny fine feel ABA Contes 4 om’ Casco aun sachet ter Wail WE Shake wai unt ponte caper seal Cavitera ulation sbane may he mtjyeitedd for upto 12 fours Dose Refer tn guidelines for exnet values of Canscin {olution lo be given per exact volumes of fei, For infos <-shy Full sens: Vsacher fet 120ant of fed+ Hal sree: | Waa sicheliper 120m ol feed | Suet ‘Wh ol a sect per 120m of feed Consult pharmacy forces for infnts over 45h, wows tin doe ith feed immadtsy before ving se. 6 1 not us for sy Saved fora. GENTAMICIN z 2 ‘ ‘Aminasycosie anibio « _ Prepari. INI omy, Aoi breosx ~ Iv preparaion and compattites ‘Compatble with C5, C1OK, NaCl 0.8% For reconetiution and dilation tefer to W drug Wh, : ‘Give slowly-dyer at least 30mins, Doe ings Smengtoe easel ; . wi <1300¢ C Ne 87 cays dondy * Ape Bt 30 days 36huly ie 30 days Bandy: Bw 2 12003 . ge s7 days 36hrly © ee ge >7 eae aay Notes a nnd doe intel in poten wh oa! 4 leeponmant Rik of mephr oki may increase i ned togithec with ether potentially nephrotoxic ~ ‘devs such a¢ indomethacin, vancomycin and amphotericin, Acton of pancutonium may’be potentiated by gentamicin, Take telson 2d dose for 36 and 4Bhly dose, . Com. Dove “relent of Patent Detar Arersus in he neceate Leng dose ay ow gag 2 GWE Omg Maintanacy dae ay 2166 “Ogee ely stati 24s ater acing se. Noes ~ Oka rabtire is avaible but de to erratic ion IV route is prefered. Disielc effect of rusemide may be reduced. CContraidicated i eardizc defess where patency of the cuctus is nacésry fot pulmonary blood how, Gt ‘leg NEC or osibonope patents Check ple pat coercing ndometo, Caution in rena impairment Tansient impairment of vena! Ganction may result i olguria with emia and fyperkaleea, Monitor rine oulpul vad electives at leas oice daily, ‘Amioglyceida, elgenin and vancornycin clearance maybe reduced, INSULIN’, Pancreatic hormone. Preparations i IN) 100k Op se neta ns or toonates Acs of Hila RO. WW areparation and compatoiives ‘Compatible with CS¥, NaCi0.9%. ~Reler dug roca fox propraon ard ‘admisiseation.” >Physiological Replacement RAL: G2mpfkgdowe Bly Acute Adeenal lasuficieacy Loacinese Ne to.zmytgldose Mointomnnce dose TY OPAL: 3 to 2mgfegidese Ghul anges Adrenal types tary Neonata! Hygatension IV: 2rapldase sa hen Tmyiylase 6 4012p Notes ‘Gintion in presence of ster fom infections, ‘Caution in patient with hypurersion Iyperhrenemia, Monitor OP blood glucose stam, potassium levat aad bane bliods. Do not cease Suddenly given in high doses for Langer than ro ‘weeks, Finger pressure applied wo lnerimal sc ater tye drops wil educe systemic absorption. INDOMETHACIN : : Prostaglandin tehibior FNonitroidl antiinflammatory Preparations INLImg eo ‘CaP 25mg ARF gin 1 preparation 3d compatibities Compe wth NAC1 09%. Reconitute al ity 2a Wt ge a Concenation of Sng, Add raged dow Gsm of sa 09% Gir oy gver te co ante and on 3rd dos fr Dah dos Therapeuticlevels ‘tough: + © Rey Peat 5:0 fOmeft “Tough levels token invmesaney before dose Peak i taken-30mins after érd of infusion, GLUCAGON Aatirypogincaertc “Preparations W104 id 1¥ prpirstion ad compas: Com pattle with CIO. Dina niet provi Use hin isis agent Pancreatic hormone Treatment of hypoglycarmis Int SC. Ne 30thcrogsanvgdove x mio peated in Tins if necessary. S10 1oniogreihow Notes Note Tagis eqavaiento nk. Rebound « hypoglctennia may oceut auton CR. monitor blasd gcese. Mare than one IM ste may ‘Ge required i ne dose ist be given. GLUCOSE. 4 . 3 ¥ taesion id Prepacations| 4 INF 5%, 108%, 50% i % 1 preparation and compatibilites + Prepare non-standard concentrations aezording to V deus protocol. ‘Adige ata saximum of 0 SghgfhrNave ‘larch sully ‘Glucose conceneations hss than or equal 19 12.54% funy bp adiaistered via peripheral ne. ‘Glucore concentrations geste than 12.5% must be Administered though eenteal or umbifcalfine only. HEPARINSODIUM = * ‘Amtioagulant Preparation: N10, SPDs 2e. SOOCuRLAL 1 preparation and compatities Conpatbe with C5%, NaCl O.9%. Give over a last one mine. ite ro appropriate volume and inise via singe pap. i Dose “Tomaintin patency af 1A lines Sein inf or Ch 45%, rg 05 to 1.0abhic ‘Systeme anticoagulation Use only flowing discussion with paediatitc Iaematcogia. tow doge treatment IY INF: Upading dose 7Simifigldose then 5 td apg At dee aceon ting ns, SC: Pbunigdose hy Fall dor teatment [INF Losdirg dose 50 10 200uriig, then 15 to Onishi. Adjust sccordiog to ting tine Notes Incompatible with many drugs. Fash ine th siting before ging other digs. Prociaine Img ecralbes ‘apprximattly 1004 of hepa. ent HYDROCHIOROTHIAZIDE Thiazie divetic Prepataions Tab 2509, MIXT Spf WED ‘Dove (ORAL: 1 40 2eng/tldcne they, Notes: Use wis caution allergic tqullonamides. Adit ol doce with feed © enhance * seasiptlnt HYDROCORTISONE * - Preparations In 100mg e TAO deg, 20 MT Sink AWAD EYE 05, 1% OC 08%; 1% REDS, 1% ONT OS%, 1% 1¥ prepication and compatibiltes ‘Compote with GSMs, NaCI UK, senate ‘vent prodded or 2m. of WEI to A chettationof SOmg. Grebe loner dlstad to tng wits compatible’ (id eee. ‘Give over atleast Sins. Dose ‘AnGtamealocy Iv, IM: 2 Sighigtdoe Ghaly ORAL: 1 to BigfhgHlace 6 t' Tr tenrstabye ced to mes dilly EVE- (Atte oplths mology review! chop 2 toAtny cor when needed. (OC: Aooly 2 10 4 times dally rast