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Antimicrobial Agents and Chemotherapy-1977-Welling-462.full PDF
Antimicrobial Agents and Chemotherapy-1977-Welling-462.full PDF
3
Copyright C 1977 American Society for Microbiology Printed in U.S.A.
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VOL. 11, 1977 COMPARISON OF TETRACYCLINE AND DOXYCYCLINE 465
sr
TREATMENT
4 O 1 CARBOHYDRATE
02, FAT
O 3 i PRITN
A 4' FASTN 25 wl
A 5FST
*W 250 ml
0 6 FASTING SOLUTION
w
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FIG. 1. Average serum levels of tetracycline.
TREATMENT
4~ O I, CARBOHYDRATE
* 2, FAT
* 3 PROTEIN
A 4 1FASTING 25 Rd
E A 5 FASTING 250 ml
0 6 sFASTING SOLUTION
8 2
cn
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FIG. 2. Average serum levels of doxycycline.
tendency for these parameter values to be reported values. Serum half-lives of doxycyc-
larger from the fasting treatments, differences line were somewhat shorter than those re-
in values between fasted and nonfasted treat- ported by some previous workers (11, 22), but
ments frequently failed to reach significant lev- were similar to those recently obtained by Ao
els. and associates in normal individuals (1). The
Serum levels, peak level values, times of accuracy of some of the reported longer doxy-
peak levels, and serum half-lives in fasted sub- cycline half-lives has been questioned by Gi-
jects in this study were similar to previously baldi (13).
466 WELLING ET AL. ANTIMICROB. AGENTS CHEMOTHER.
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VOL. 11, 1977 COMPARISON OF TETRACYCLINE AND DOXYCYCLINE 467
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468 WELLING ET AL. ANTIMICROB. AGENTS CHEMOTHER.
DISCUSSION relatively short sampling periods may be inade-
quate for accurate bioavailability testing. Barr
The results obtained in this study show that, and associates (3), however, showed that re-
although the absorption of orally dosed doxy- sults obtained from single-dose studies, using
cycline and tetracycline is impaired in the pres- 10-h serum or 48-h urine sampling periods, ac-
ence of food, the degree of impairment is far curately predicted tetracycline serum levels
greater in the case of tetracycline. The small during multiple doses of various commercial
influence of food on doxycycline absorption is products.
advantageous in view of the gastric irritation The present study utilized only single doses,
that may occur when this drug is taken on an but comparisons of data based on short and long