The relation between polycystic ovarian

syndrome and BMI in females at age (15-30) y in

Baghdad medical city from 2015 to 2017
-Supervisor:

‫ جامعة بغداد‬/ ‫ كلية الطب‬/‫ فرع الكيمياء الحياتية‬- ‫د منال كمال‬.‫م‬.‫ا‬

-Students:
‫مريم قيس هاتف سعيد‬
‫مالك علي جالل عبد الغفور‬
‫ميس محمود شاكر حمودي‬
Background:
 Importance:
Polycystic ovary syndrome (PCOS) is one of the most common
(1)
endocrinopathies among women at reproductive age and its prevalence
i s up to 12% of women at reproductive age(2) meaning it affects 1 in 15
(3)
women worldwide . The impact of PCOS on growth is reflected by its
widespread detrimental effects on the physiology and metabolism of the
(4)
body and their resulting long-term consequences and since both obesity
and overweight are increasing worldwide and have detrimental influences
on several human body functions including the reproductive health (5) .

 Current efforts:
Multiple trials are being done to find easy methods and criteria for diagnosing of
Polycystic ovary syndrome as it remains a syndrome and no single diagnostic
criteria is sufficient for clinical diagnosis and the presentation of the patient
varies in different literature (6) .

 Justification:
It was thought that obesity was associated with PCOS, but later on it was found
that lean females could also develop PCOS

Goals:
To approve that polycystic ovary syndrome has no correlation with BMI.

1
Objective:
We aimed to study whether polycystic ovary syndrome among females from
the population is associated with BMI or not.

Proposed method:
 Study population:
Patients who attended Baghdad medical city, Iraq and were diagnosed with
PCOS, according to Rotterdam criteria.
Those included in the study are:
-post pubertal Females aged up to 30
-Females who fulfilled the revised Rotterdam criteria for PCOS diagnosis,
which are presence of two of the following three features (1) Oligomenorrhea,
(2) Clinical and/or biochemical hyperandrogenism, and (3) Polycystic Ovaries
on Ultrasound
While excluded patients are those with:
-Other disorders that may mimic the clinical features of PCOS, such as thyroid
dysfunction, hyperprolactinaemia, non-classic congenital adrenal hyperplasia
(CAH), and Cushing’s syndrome.
-Females with renal failure, heart failure, confirmed malignancy and taking
steroids therapy.

 Study design:
Analytic studies / observational studies (Cross-sectional).

2
 Operational definition:

-Polycystic ovary syndrome: heterogeneous, multifactorial, complex genetic

and endocrine disorder, characterized by menstrual disturbances, clinical and
biochemical manifestations of hyperandrogenism (1).
-BMI: is a person's weight in kilograms (kg) divided by his or her height in
meters squared, according to the World Health Organization (WHO), if BMI is
equal or greater than 25 kg/m 2, it is considered overweight, whereas the BMI
higher than 30 kg/m 2 defines obesity (7) .
-Menarche: first menstrual cycle occur at puberty (8) .
-Reproductive life: is the period between menarche and menopause (8) .

 Sampling procedure:

Cluster sample:
The selection here will be of groups of units rather than individual unit.

Sample size:
We took 180 females patients at the age of (15-30), on the assumption that
we have three groups (BMI) and one outcome variable (PCOS) we used
Anova.
 Data collection:
180 females’ data’s (age, BMI and medical condition) collected from
medical records according to the questionnaire we used which includes
questions.
 Analysis plan:
-The type of analysis we used is
analytical.
-No laboratory analysis was used.

3
 Human subject protection:
The Ethics Committee of the Baghdad university college of medicine approved
the study design.

Expected benefits:
-We expect that PCOS has more prevalence in obese females than normal
weight females.

4
References :
1. Katulski K, Czyzyk A, Podkowa N, Podfigurna-Stopa A, Ignaszak N, Paczkowska K et al.
Clinical and hormonal features of women with polycystic ovary syndrome living in rural and
urban areas. Annals of Agricultural and Environmental Medicine [Internet]. 2016;:1.
Available from: http://www.aaem.pl/Clinical-and-hormonal-features-of-women-with-
polycystic-ovary-syndrome-living-in,72547,0,2.html

2. March W, Moore V, Willson K, Phillips D, Norman R, Davies M. The prevalence of

polycystic ovary syndrome in a community sample assessed under contrasting diagnostic
criteria. Human Reproduction [Internet]. 2009;25(2):1. Available from:
https://academic.oup.com/humrep/article/25/2/544/673002

3- Polycystic Ovary Syndrome: 1 In 15 Women Affected Worldwide And Burden Likely To

Increase [Internet]. ScienceDaily. 2018 [cited 17 April 2018]. Available from:
https://www.sciencedaily.com/releases/2007/08/070831204314.htm

4- Allahbadia G, Merchant R. Polycystic ovary syndrome and impact on health. Middle East
Fertility Society Journal [Internet]. 2011 [cited 17 April 2018];16(1):1. Available from:
https://www.sciencedirect.com/science/article/pii/S111056901000141X

5- Silvestris E, de Pergola G, Rosania R, Loverro G. Obesity as disruptor of the female

fertility. Reproductive Biology and Endocrinology [Internet]. 2018 [cited 17 April
2018];16(1):1. Available from: https://rbej.biomedcentral.com/articles/10.1186/s12958-018-
0336-z

6- Revised 2003 consensus on diagnostic criteria and long-term health risks related to
polycystic ovary syndrome. Fertility and Sterility. 2004;81(1):19-25.

7- Definition of Body mass index [Internet]. MedicineNet. 2018 [cited 17 April 2018].
Available from: https://www.medicinenet.com/script/main/art.asp?articlekey=16125
8- Menarche [Internet]. En.wikipedia.org. 2018 [cited 17 April 2018]. Available from:
https://en.wikipedia.org/wiki/Menarche