‘a sth 20 >= ‘ >= Chemistry Conference for Young Scientists Blankenberge, Belgium =o F ERR UARY 2 t= 23 BOOK OF ABSTRACTS Attp://www.chemcys.be Attp:// www.kvev.beContents Introduction Location .. Committees. Programme Jury ... Keynote Speakers. Broaden your view : Analytical and Environmental Chemistry Oral communications ,, Posters Life Sciences Oral communications Posters. Inorganic Chemistry. Oral communications Posters... Organic and Organometallic Chem stry Oral communications Posters. Macromolecular and Materials Chemistry Oral communications ceseeenneeeeeens Posters. Physical and Theoretical Chemistry . Oral communications Posters... Page 1Chemoy> Life Sciences: Posters Session 1 (21/02/2018 - 16:10) hael Russelle Alvarez - University of the Philippines Los Bafos - LS-P-1A Purification and Characterization of E. coli B-glucuronidase inhibitors from Plectranthus amboinicus (Spreng. Lavinia Berta - University of Medicine and Pharmacy Tirgu Mures - LS-P-1B Synthesis, Characterization and Antibacterial Activity of Novel Pt Complex with Na 7[NaAs,Wao0z40]-xHz0, a Polyoxotungstate Cryptand Mohammad Ghattas - Al Ain University of Science and Technology - LS-P-1C Studying the molecular basis of promiscuity via conducting Molecular dynamics simulation of aggregate-enzyme complex in solutions Geert-Jan Graulus - Hasselt University - LS-P-1D Site-specific modification of nanobodies targeting ovarian cancer and innovative bioconjugation methods for the efficient detection of cancer at early stage Nataliia Harna - National University of Pharmacy - LS-P-1E synthesis and anticonvulsant activity of 6-methyl-2-thioxo-2,3 dihydropyrimidin-4(1H)-one derivatives Olesya Koloskova - NRC Institute of Immunology FMBA of Russia - LS-P-1F Synthesis of hydrophobic peg derivatives for new generation liposomes design Kinga Szilvia Merczel - Budapest University of Technology and Economics - LS-P-1G Oral pyrophosphate inhibits connective tissue calcification in mice Alona Oberemko - Vytautas Magnus University - LS-P-1H Chitin extraction and characterization from cell wall of two mushroom species (Boletus bovinus and Laccaria laccata) Krisztina Olah - Budapest University of Technology and Economics - LS-P-11 Examination of probiotic Bifidobacteria via impedimetric method Fanni Turéczi - Budapest University of Technology and Economics - LS-P-1J Gluten free flour development: Investigation of pentosan and enzyme addition in case of buckwheat flours Page 89Synthesis, Characterization and Antibacterial Acti of Novel Pt* Complex with Na27[NaAsqW4oO140]-XH20, a Polyoxotungstate Cryptand L. Berta’, A. Mare’, A. Curticapean* 1. General and Inorganic Chemistry Department, University of Medicine and Pharmacy, 38 Gh. Marinescu street, 540139, Tirgu Mures, Romania 2. Microbiology Department, University of Medicine and Pharmacy, 38 Gh. Marinescu street, 540139, Tirgu Mures, Romania Objectives: The aim of this work was to synthesize a new Pt** complex Nayo[NaAs,WeoOrgoPtz"*}:xXH20 (AS4WaoPt) of Nap 7[NaAsqWqa140]+xH20 cryptand (As,Wgo) and to assess the antibacterial activity. Both compounds are polyoxotungstate (POW), inorganic componds with a broad range of pharmacological properties (antiviral, antibacterial, antitumoral activities), even that their molecular mechanism of action Is poorly understood. Methods: The As;Wio cryptand was synthsized following methods described in the literature (Na,WO., NaAsO,. The complex was obtained by direct addition of cation salt solution, KPtCl, to As;W4o sodium salt solution at pH=4 keeping the temperature between 70-80°C. The ratio of the reagents was calculated according to the reaction molar ratio(2:1). After purification the complex was identified and characterized using UV, IR, TGA, conductometry, X-ray methods. The biological activity was studied in vitro on Gram positive (Staphylococcus aureus ATCC 29213) and Gram negative (Escherichia coli ATCC 25922) bacterial strains by successive dilution method, with identification of minimum inhibitory and bactericidal concentrations. Results: The As,W.oPt complex structure is a Leyrie assembly which consist of 4 identical trilacunar Keggin anion structures ([AsW.033]”) joined together by 4 WOs octahedra in a ring-like form with high symmetry. Oxygen atoms delimit the structure, The pt** cation is central coordinated inside the structure, in active positions formed in the lacunar places with high electron density. The results obtained by successive dilution method are the following (MIC,MBC=mg/ml): As,WaoPt - for Staph.aureus MIC=1.33, MBC=1.33; for E.coli MIC=2.66, MBC=10.65; AscWio - for Staph.aureus MIC=2.00, MBC=2.00; for E.coli MIC=4.00, MBC=32.00, Conclusions: A new complex was synthesized, NaelNaAs,WeoQrgoPt>’*]-xH,0. Both compounds exhibit antibacterial activity. The complex has shown a bigger antimicrobial activity than the cryptand. Staph. aureus have proved to be more sensitive than E. coli. Keywords:polyoxotungstate, platinum complex, antibacterial.&a Page 92