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17:42:39
>> Hey, come on in.
17:42:42 Yeah, have a seat. Excited?
17:42:46 Yeah, you did really well on your interview last week. We're
17:42:49 excited to have you join the group. Do you want to see what we
17:42:52 did with our social anxiety research program last week?
17:42:55 Check it out. This is a video of the
17:42:58 social interaction test that we used in most of our studies.
17:43:01 Here's a mouse in this cage here. And you can see our
17:43:04 test mouse is really interested in it. See how she's
17:43:07 getting right up close to the cage? This is very
17:43:11 typical in mice. They come across the thing they don't
17:43:14 know and want to check it out. Look at this mouse. See
17:43:17 how she's staying back? She's not approaching the cage, but she's
17:43:20 paying attention to it at the same time. We measure
17:43:23 how much time the mouse is sort of watching the cage and we
17:43:26 call that social vigilance. This behavior is interesting
17:43:29 , because developmental psychologists see a very similar
17:43:32 combination of avoidance and vigilance sometimes in
17:43:35 children. They call it behavioral inhibition and that's one of the
biggest
17:43:39 risk factor for developing anxiety problems
17:43:42 later in life. So humans, we can take
17:43:45 a brain scan and see what parts of the brain are active when the
17:43:48 person is feeling anxious, but we can't see what individual
17:43:51 selves are doing. We can do that in mice. Today you're going
17:43:54 to see why that's important. Let's go up
17:43:58 .
17:44:04 Hey, Emily. Remember our new lab
17:44:07 member?
>> Yeah. So, welcome.
17:44:10 Today, we're looking at brain tissue that has been stained for
17:44:13 individual neuron associated with social vigilance behavior
17:44:16 . But before we can have you start helping out,
17:44:19 we have to make sure you're wearing all your personal
17:44:22 protective equipment. So the first thing you're going to nide
17:44:27 need is a lab coat. Pair of
17:44:30 gloves.
17:44:33 Can't forget the eye protection.
17:44:37 And a bike helmet.
17:44:40 I'm just kidding about that one. So come on in.
17:44:48 We're going to be looking at brain tissue that has
17:44:51 been stained for os toes
17:44:54 sin
17:44:58 Oxytocin neuron. And this is associated with
17:45:01 good feeling like love, social
17:45:04 interaction and parenting behavior. And
17:45:08 oxygen tones to
17:45:11 Son
17:45:14 Oxytocin is working in some regions of the brain to
17:45:17 help promote the feel good feeling and working
17:45:20 in other regions of the brain to actually promote anxiety