Ger

nal
pat
hol
ogyAl
lpastpaperbyDr
saj
j
adYousufz
ardar
i

1.Ascenar
ioofamy
loi
dosi
s.Onaut
opsyoft
hepat
ienthear
twaswei
ghed540gms.Thi
s
changei
sdueto

A.
Hyper
trophyb.Hy
per
plasi
a

2.Br
eastat
rophyi
nyoungf
emal
eisduet
o:A.Est
rogenB.Est
rogenand

Pr
ogest
eroneC.Pr
ogest
erone

3.Apat
ienthasnodul
eonv
ocal
cor
d.Themostl
i
kel
ymechani
sm?A.Hy
per
plasi
aB.At
rophy

4.WomenwhohasLei omyomaandepi t
heli
um coveri
ngendometr
ium showsabundantst
roma
wit
hlessnumberofendometr
ial
glands,whatshappeningi
nEndometri
um:

A.Hy
per
plasi
a

B.Dy
spl
asi
a

C.Met
apl
asi
a

D.Neopl
asi
a

5.Caseinwhi
ch2y
earhi
str
oywi
thHPVi
nfect
ioni
nfemal
ecer
vix+nucl
euspr
omi
nentand
enl
arged??

A.
Hyper
plasi
aB.car
cinoma

C.met
apl
asi
aD.dy
spl
asi
a

6.pr
emal
i
gnantl
esi
ona.dy
spl
asi
ab.condy
lomat
ac.cy
sti
chy
per
plasi
aofendomet
ri
um

07.Regar
dingdy
spl
asi
a

A.Notal
lcel
l
spr
esentonsamesur
faceB.I
rr
egul
arl
yshapedcel
l
sC.I
rr
ever
sibl
e

8.femalepresentedwi
thsomeepithel
ial
changesndhpv+v
e.Agai
npr
esent
sandpapsmear
showslargecell
swithl
argenucl
eus.Di
agnosi
s

A-
met
ast
asi
s

B-dy
spl
asi
a

C-car
cinoma

9.Met
apl
asi
a

A.I
ncr
easenumberandsi
zeofcel
l

B.Funct
ional
changeofEpi
thel
i
um
10.er
vical
met
apl
asi
amostl
i
kel
ycausea.
highmul
ti
par
it
yb.HPVi
nfect
ionc.I
UCD

11.Epi
thei
alchangesi
nendocer
vixi
nsquamoust
issueduet
o

A.
met
apl
asi
ab.
dyspl
asi
a

12.Pol
yar
thr
it
isnodosaa.
fi
bri
noi
dnecr
osi
sb.
renal
fai
l
ure

13.Mostappr
opri
ateTBHist
ologi
cal
pict
ure:
a.Aci
d-f
astal
cohol
bact
eri
ab.Caseousnecr
osi
s
c.
Giantcel
l
sd.Epi
thel
i
alcel
ls

14.Ptcameinwit
habdominal
pain,
hisamy
lasewashigh,hewasdiagnosedwit
hPancr
eati
ti
s.
Whatishisoment
um goi
ngtoshow?A.Caseousnecr
osisb.Fat
tynecrosi
sc.Li
quef
act
ive
necr
osis

15.Deat
hofGasgangr
enei
s,
,,

A.
Toxemi
cshockb.
excessi
venecr
osi
s

16.Thespeci
fi
cfeat
ureofApopt
osi
s

A.cel
lshr
inki
ng

B.kar
yol
ysi
s

C.hy
per
chr
omasi
a

D.cel
lswel
l
ing

17.Hostdef
enceagai
nstneopl
asm

A.
apopt
osi
s

B.
goodheal
th

C.
nof
ami
l
yhi
stor

18.apopt
osi
sa.
Prev
entov
erpopul
ati
onb.
Mut
antcel
l
s

19.Regar
dingapopt
osi
s,cor
recti
s

A.Dest
roymut
antcel
l
s

B.Pr
eventov
ercr
owdi
ngofcel
l
s

C.Membr
anesbr
eak

D.Cont
ent
sleak

20.Apopt
osi
sini
ti
ateswhen…a.Bcl
-2act
ivat
ionb.Phagocy
tosi
sc.
Act
ivat
ionofcaspases
21.Councel
manbodi
esi
na.Apopt
osi
sb.Necr
osi
s

22.Nat
ural
def
enceagai
nstneopl
asm a.Necr
osi
sb.Apopt
osi
s

23.I
nAcut
eInf
lammat
ionFl
uid

presenti
sA.Speci
fi
cGr
avi
tyofFl
uidi
s1010B.i
sknownasTr
ansudat
eC.Pr
otei
nmor
ethan
3gram

24.1str
eapnonseagai
nstacut
einf
lammat
ioni
nti
ssuea.Neut
ophi
lb.
macr
ophage

25.Mostpot
entchemot
act
icf
act
ora.C3bb.C5a

26.I
nit
ial
stageofapopt
osi
sa.DNAl
ader
ri
ngb.Act
ivat
ionofcaspases

27.I
rr
ever
sibl
eInj
uryA.Massi
veCaI
nfl
ux b.Massi
vecaef
fl
ux

28.Apat
ienthav
ingvegetat
ionsonheartval
vesduet
oStaph.Aur
eusdied.Onautopsyatan-
whit
ewedgeshapedlesionof1.5xp3cm isseenwit
hit
sbaseoncapsule.Lesi
onont he
spl
eencanbeexplai
nedas?A)Coagul ati
venecr
osi
s?B)caseousnecr
osisC)Liquefect
ive
necr
osi

29.Li
quef
act
ivenecr
osi
soccuri
na.Br
ainb.Pancr
eat
it
is

30.I
stl
i
necel
li
ninf
lammat
iona.Macr
ophagesb.Neut
rophi
l

31.Coi
nlesi
ononchestxr
ayofawoman,
howt
odi
ff
erbt
wngr
anul
oma&neopl
asi
a?b.
Rapi
d
i
nreasei
nsize

32.8mnt
hBabyboywithrepeat
edr
hinit
is2epi
sodesofpneumoni
ainl
esst
hen2mnt
h.l
ow
pl
asmaBcel
l
sndecreasedimmunoglobuli
ns:

A.SCI
D

B.I
gAdef
icencyC.I
gGdef
ici
ency

33.whi
chonei
sspeci
fi
cfordi
agnosi
sofSLE

A.ANA

Bant
idoubl
est
randedDNA

34.Lowcompl
ementseeni
na.Sj
ogr
enb.
Sle

35.Xer
oat
emi
a,ker
ati
ti
s,pai
nful
joi
ntsa.Sl
eb.Sj
ogr
en

36.Sj
ogr
enr
elat
edwi
tha.R.
Ab.SLE

37.Local
causeofdel
ayedwoundheal
i
nga.I
nfect
ionb.Zi
nc
38.Col
l
agent
hatgi
vesst
renghtdur
ingwoundheal
i
nga.
Type1b.
type3

39.Scenar
ioofsur
gical
l
ymassr
enal
whi
chwi
l
lindi
cat
emal
i
gnant

nat
ure:

A.Necr
osi
sB.I
nvasi
on

C.hi
ghnucl
eart
ocy
topl
asm r
ati
o

40.whi
choft
hef
oll
owi
ngi
sbeni
gn

t
umour
:a.wi
l
m'st
umor
,B.
war
thi
ntumor

41.whi
choft
hef
oll
owi
ngi
sbeni
gn:
A-hepat
omaB-
adenoma

:42.whi
choft
hef
oll
owi
ngenv
ironment
alf
act
orscausemut
ati
onofpr
otooncogenes:
A.Vi
rus
B.Radi
ati
on

43.
Freer
adi
cal
sfor
medbyr
adi
ati
ont
heywi
l
ldamageA.
DNA

B.
cel
lmembr
aneC.
mit
ochondr
ia

44.Pr
otoncogenconv
ert
edi
nto

Oncogencausi
ngCancerduet
o

A.GeneAmpl
i
ficat
ionB.Poi
ntMut
ati
on

45.Radi
other
apycausescanceraf
ter
:A.mor
ethan10y
ear
sB.5y
ear
s

C.5-
10y
ear
s

46.Cancercel
l
spr
edomi
nant
lyhav
eIncr
easedconc.of:
a.v
iment
in,

B.Desmi
nc.Ker
ati
n

[47.Regar
dingmali
gnantmel
anomacel
li
nchr
onol
i
gical
orderwhi
chwi
lpr
esentear
li
erA.T
cell
sB.NKcel l
sC.Monocyt
es

48.APer
sonwi
dmal
i
gnantmel
anoma.Ri
sk

f
act
or:
A.Xer
oder
mapi
gment
osum B.Pr
olongedsunl
i
ght

49.whi
chi
sasmal
lbl
uecel
ltumoura-neur
obl
ast
omab-wi
l
mst
umour

50.Ci
rcul
ati
ngt
umourcel
lmostwi
del
ydi
agnosedbyA.Tumor

mar
ker
s

B.PCR
C.Per
ipher
albl
oodf
il
m D.ELI
SAE.Bl
oodcul
tur

51.Nat
ural
def
enceagai
nstt
umoura.Apopt
osi
sb.Necr
osi
s

52.Mostcommont
umourofchi
l
dinepi
phy
sisi
s?A.
Evi
ngsar
comaB.

Ost
eobl
ast
omac.
Chondr
osar
comad.ost
eochndr
oma

53.Semi
nomai
sat
umouri
nmal
e,

i
tsequiv
alentwhenoccur
si novar
ytheni
tscal
l
eda.
yol
ksact
umorb.
embr
ynal
tumor
c.
dysgerminomad.Hydat
iform mol
e

54.Tumorsuppr
essorgenea.Rasb.P53

55.Lossofp53cel
lsur
viv
al

56.pat
einthasswel
l
ingi
nri
ghtt
high,
whi
chi
sincr
easi
ngi
nsi
ze,
xrayshownoconnect
ionwt
h
bone,
bestmarker

Acy
toker
ati
neBv
ement
in

57.Thy
roi
dCAoper
ated3cm mass

whi
chhascongost
ain.Mar
kerused:

A.Cal
cit
oni
nB.AFP

58.Thelif
est y
lepatt
ernofheal
thyper sonsf r
om 20to30y ear
sofagearestudied.Asubsetof
thesepersonshav eal
if
estyl
echaracterizedbyconsumptionofalotofpi
zzaandv eryli
tt
le
physical
activ
ity.Whi
chofthefol
lowingt issuechangesi
smostl i
kel
ytodevelopinthesesubset
ofpersonsasaconsequenceoft hi
slifest y
le.

a.Fat
tyMet amor
phosi
sofl
iv
erb.
Pancr
eat
icf
atNecr
osi
sc.Fat
tydegener
ati
onofmy
ocar
dium
d.Hyper
trophyofSt
eat
ocy

59.Medi
ator
sofpai
ninacut
einf
lamat
iona.Br
ady
kini
nandPGs b.I
L1andTNFal
phac.I
L6

60.Par
athy
roi
dhy
per
plasi
ainv
olv
es

A.Oxy
nti
ccel
l

B.Chi
efcel
l
s

C.Oxy
nti
c+chi
efchi
ef

61.Ladyf
eedi
ngherbabyf
oray
earnopr
obl
em.
..
.whathappeneddur
ingpr
egnancy
..
..

A.l
obul
arhy
per
plasi
a
B.Duct
almet
apl
asi
a

C.St
romal
hyper
trophy

62.Apersont
ranspl
ant
edapar
tofli
vert
oot
heper
sonhav
inghepat
icf
ail
ureAf
tersomet
ime
l
iversi
zeincr
easedinbot
hdueto

A.
Dyspl
asi
a

B.
Met
apl
asi
a

C.
Hyper
plasi
aD.
Tumor

E.
Hyper
trophy

63.Exampl
eofhy
perhy
per
plasi
a+hy
per
trophy

A.
Uter
usi
npr
egnancy

B.
Breasti
npuber
ty

C.
Skel
etal
muscl
egr
owt
hinat
hlet
e

64.dy
spl
asi
aisr
ecogni
sedbyA.
dysker
atosi
sB.
Lossofpol
ari
ty

65.Chemot
herapygivenandt
umorsi
zebecomesmal
lthi
smechani
sm i
sbyA.at
rophyB,
necr
osi
sC.apoptosi
s

66.P53i
stumorsuppr
essorgene,
Wheni
tisabsentormut
atedi
tindi
cat
e

A.apopt
osi
s

B.Cel
lsur
viv
al

C.DNAr
epai
r

D.Mi
tosi
s

67.A28y
earol
dmal
ewi
th

hi
stor
yofj
aundi
ceandr
aisedALT.Thel
i
verhi
stol
ogyshows

counci
l
manbodi
es.Thesear
emostl
i
kel
ytobe

pr
ocessof

A.coagul
ati
onnecr
osi
s
B.Apopt
osi
s

68.Theedemaf
lui
dinacut
einf
lammat
ion

A.i
sknownast
ransudat
e

B.hasspeci
fi
cgr
avi
ty1010

C.haspr
otei
nmor
ethan3gm /
dl

D.doesnotcont
ainf
ibr
ongen

69.cel
l
sofchr
oni
cinf
lammat
iona.macr
ophagesb.l
ymphocy
tes

70.l
i
quef
act
ivenecr
osi
sinbr
aini
nfar
cti
nvol
vest
hef
oll
owi
ngpr
ocesses

A-
denat
urat
ionofpr
otei
n

B-
digest
ionbypr
oteol
yti
cenzy
me

C-
put
ri
fact
ion

D-
all
oft
heabov
e

E-
bot
ha&b

71.Fi
bri
noi
dnecr
osi
soccuri
nal
lexcepta.
SLE

B.Pol
yar
ter
it
isnodosa.

C.
Mal
i
gnanthy
per
tensi
on

D.
Rheumat
icf
ever

E.Essent
ial
hyper
tensi
on

72.f
oll
owi
ngar
eexampl
esofapopt
osi
sexcept
:

a.menst
rual
cycl
e

b.
ather
oscl
erosi
s

c.gr
aftv
/shostr
esponse

d.f
ormat
ionofcounci
l
manbody
.

e.neut
rophi
l
sinacut
einf
lammat
oryr
esponse

73.Al
loft
hef
oll
owi
ngar
efeat
ureofapopt
osi
sexcept

A.
Cel
l
ularswel
l
ing
B.
Int
actcel
lmembr
ane

C.
Nucl
earcompact
ion

D.
Cyt
opl
asmi
ceosi
nophi
l
ia

74.Rar
esi
tef
ort
umourmet
ast
asi
s??
??

A, l
i
ver

B,
,skel
etal
muscl
e

C,
,spl
een

D,
,br
ain

75.
Causeofdeat
hingasgangr
ene:

A.Sept
icemi
a

B.Bact
eremi
a

C.Toxemi
a

:
76.Dy
str
ophi
ccal
cif
icat
ioni
spr
esenti
nwhi
choft
hef
oll
owi
ng

A.Acut
epancr
eat
it
is

B.Mal
ari
a

C.Tuber
cul
osi
s

D.Ki
dney

77.Al
lar
efeat
uresofi
rr
ever
sibl
ecel
li
njur
yexcept

A.Kar
yol
ysi
s

B.Kar
yor
hexi
s

C.Aut
oly
sis

D.Shr
inkageofmi
tochondr
ia

E.Appear
anceofmy
eli
nfi
gur
es

78.Atwhatr
ect
alt
emper
atur
e.per
manentcel
li
njur
yoccur
s.i
fthatt
empr
emai
nconst
anta.
99

B.
101c.103d.
106

79.Themostcommoncauseofcel
li
njur
yinourcount
ry?
?
A.
Alcohol

B.
Mal
nut
ri
ti
on

CHy
poxi
a

D.
Ischemi
a

E.
Ioni
zi
ngr
adi
ati
on

:
80.
Whi
chf
indi
ngonel
ect
ronmi
croscopyi
ndi
cat
esi
rr
ever
sibl
ecel
li
njur
y

A.Di
l
atat
ionofER

B.Di
ssoci
ati
onofr
ibosomesf
rom r
oughER

C.Fl
occul
entdensi
ti
esi
nmi
tochondr
ia

D.My
eli
nfi
gur
es

81.Aboywdornit
hinetr
anscar
boxyl
asedef
ici
ency,
li
verfail
urehadl
i
vert
ranspl
antaf
terone
yearbot
hdonorndrecepi
entpr
esent
edwdenlargedli
ver
--cause

a:
hyper
plasi
a

B:
met
apl
asi
a

C:
neopl
asi
a

D:
atr
ophy

82.
Whi
choft
hef
oll
owi
ngf
act
ordoesn'
tef
fectwoundheal
i
ng?
??

a.
..
VitCdef
ici
ency

b.
.l
ocal
inf
ect
ion

c.
.vi
tDdef
ici
ency

d.
.zi
ncdef
ici
ency

e.
.t
ype1col
l
agendef
ici
ency

83.Themostcommoncompl i
cat
ionofwoundheal
i
ng(
1)gr
anul
ati
ont
issue(
2)pai
nful
scar(
3)
wounddehi
scence(
4)i
nfect
ion

84.I
L-1pr
oduces

AT-
ly
mphocy
teact
ivat
ion

B.Del
ayedwoundheal
i
ng
C.I
ncr
easedpai
nper
cept
ion

D.decr
easedPMNr
eleasef
rom bonemar
row

85.I
Nbl
ackwoundheal
i
ngwasasked,
heal
i
ngwi
l

A:
KELOI
D

B:
PREMALI
GNANTLESI
ON

C:
PREMALI
GNANTCHANGE

86.Apr
efor
medmedi
atorofi
nfl
ammat
ioni
s:

a.Pr
ost
agl
andi
n

b.Hi
stami
ne

c.Leukot
ri
ene

d.Ni
tr
icoxi
de

e.Pl
atel
etact
ivat
ingf
act
or

87.l
astmedi
atorofendot
oxi
cshocka)
IL1b)
IL6c)
TNFal
phad)
li
popol
ysachar
ide

88.
Whati
sthemedi
atorofal
l
ergy?A.5hy
droxyt
rypt
ami
neB.Br
ady
kini
nC.Adr
enal
i
ne

89.Secondar
ymedi
atorofshocki
ncl
ude

A.
myocar
dial
fact
or

B.
hypot
ensi
on

C.
Moder
atedegr
eeofAnemi
a

D.
nor
mogl
ycemi
a

E.
hist
ami
ne

:
90.Ci
rcul
ati
ngphagocy
tei
s

A.Neut
rophi
l

B.Monocy
te

C.Macr
ophage

91.Puscont
aina.Deadbact
eri
ab.Deadneut
rophi
l

92.Mostcommongenepr
oduci
ngt
umor
???
??
A.
..
..WT

B.
..
..RB

C.
..
..p53

D.
..
HNPCC

93.Aboywdorni
thi
netranscar
boxyl
asedef
ici
ency,l
i
verfai
lur
ehadl
i
vert
ranspl
antaf
terone
y
earbot
hdonorndrecepientpr
esent
edwdenlargedl
iver
--
cause

a:
hyper
plasi
a

B:
met
apl
asi
a

C:
neopl
asi
a

D:
atr
ophy

94.
Whi
chofdf
oll
owi
ngi
snotneopl
asi
a?

achor
ist
oma

bmeni
ngi
oma

cl
ymphoma

dl
eiomy
oma

95.Al
lcel
l
scont
aint
elomer
aseexcept

A.Somat
ic

B.Ger
minal

C.Haemopot
ic

D.Tumour