Generic Trade Classification Dose/Dosage Mechanism of Action Side effects Nursing Considerations

Name Name
Peramivir Rapivab Antiviral 10 mg/mL Peramivir belongs to the - Cloudy urine - Explain purpose of
neuraminidase inhibitor - Fever peramivir to patient
drugs that shares a - Chills - Advise patient to
common mechanism of - Diarrhea notify health care
action. Peramivir, a - Dizziness professional if signs
cyclopentane analogue, - Fast heartbeat and symptoms of
selectively inhibits the - Hives, skin anaphylaxis or rash,
influenza virus or neuropsychiatric
rash
neuraminidase enzyme, symptoms occur
preventing the release - Advise female
of viral particles from patient to notify
infected cells. health care
professional if
pregnancy is
planned or
suspected or if
breastfeeding
Baloxavir Xofluza Antiviral 20 mg; 40 mg Baloxavir marboxil is - Headache - Patients should be
Marboxil an oral prodrug that is - Sore throat treated with a single
converted to baloxavir, - Runny nose dose of baloxavir
an inhibitor of the - Diarrhea within 48 hours of
endonuclease activity of - Dizziness symptom onset
a selective polymerase - Fast heartbeat - Baloxavir may be
acidic (PA) protein, - Hives, skin administered with
which is required for or without food, but
rash
viral gene transcription, advise patients to
resulting in inhibition of avoid
influenza virus coadministration
replication. with antacids,
laxatives, dairy
products, calcium-
fortified beverages,
and supplements
containing calcium,
 iron, magnesium,
selenium, or zinc.
Oseltamivir Tamiflu Antiviral capsule Inhibits influenza A and - dizziness - No evidence
Phosphate - 30mg B virus enzyme - insomnia supports drugs used
- 45mg Neuraminidase which is - headache to treat viral
- 75mg thought to play a role in - vertigo infections other
powder for oral viral aggregation and - fatigue than influenza virus
suspension release from the host - abdominal type A and B
- 6mg/mL cell. Neuraminidase pain - Drugs must be
inhibition, therefore, - diarrhea given within 2 days
appears to interfere with of onset of
- nausea
viral replication. symptoms
- vomiting
- A drug isn’t a
- bronchitis
replacement for the
- cough
annual influenza
vaccination.
Patients for whom
vaccine is indicated
should continue to
receive the vaccine
each fall
- Drug may be given
with meals to
decrease
gastrointestinal
adverse effects
- Store at controlled
room temperature
(59º to 86ºF [15º to
30ºC])
Zanamivir Relenza Antiviral inhalation Relenza belongs to a - diarrhea - Start within 48 h of
powder new class of compounds - nausea onset of flu-like
- 5mg (20 units called neuraminidase - vomiting symptoms for most
per Rotadisk) inhibitors. - headache effective response.
Neuraminidase is an - nasal - Use any scheduled
enzyme, which breaks irritation inhaled
the bond holding new - ear, nose, and bronchodilator first;
virus particles to the throat then use zanamivir.
infected cell. Once infections - Do not breast feed
broken, the new viruses while taking this
are free to infect other drug.
cells, spreading the
infection. Relenza is
thought to work by
inhibiting breakage of
the bond and preventing
release of the new
viruses, therefore
interrupting the spread
of infection within the
respiratory tract.