Morphine moa: bind 40 opiod qecpiors, nomucte M Meepses CRCR coupled \ g i \plook NOCicePtive *raNsMission © primary argerens nocicenro’s to docsatl horn Odrenyt ceycsase a Tanivid pain Vansmisson open K* channel modity central perception o€ r\c © opsring 2 1” Ayns: Anaigesia, Sedaten, Vanxiety. Cough, 94 motlity | ] \ndioation : Severe Pain, Raate Cumonary LACMA [ Poss -operatve pain, tpidural Anesth, Neuropathic Fain Wt -assoc pain, Cancer Pain Cremedication » Surgery tory Depression, Obstructive airway ds. epare ds, alcoholism, head in \unes, ence ss toronchial Secrefions /asth diseas? CL: Wypecsensitivity , Respir Paralyc Neus, acuie Wi R inttaccanial Pressure , Heart Failure 2? 40 onconic (ung) Verayea Gastic emptying, GL Ovid , Ravere eftects * : KONG aeprescion, octhostatic hypotension, Seve | Constipation , /v, Bieryete Drowsy . Diaay 4 Torerance, Dependance, withdrawal Monitor: palo control, VS,reep 2 mental Sx of hypogonadism / HYPO Scanned with CamScannerLows CUruleMs Aigowe ran ye 4 Prostagjardn Graay bri & ‘a NN Roars Woucerhve Cond Rain af ferent erne Sern Raa our Hosen. | Oe Scanned with CamScanner2 Muttecatever, (4200m9 /alL) aan wrens aoe a Down PYRENC (300-2460 aera MOR: NON-SELECIVE Cox INHIBITOR (IRREVERSIBLE ) | INHIBIT TXA, PCI, PLE, Cp, E ‘ *Hromboxaneprod, 4 plateler agg reqqon (3-l0days) NV hyperatgesia, Lacodilation 4 Pronchoconssnction, A myomeltial Conrackion Abs : rapid) variable 4 \z2hrs (nonentene) Rane 0 route, dosage ; Peak plasma : SNe pamee aed) N JO: wider to body Hssues; placenta, breast milk 170 mL/kg | Plasma inaing : $0- 407. (alloumin) Metap : @ Uiver 5 soticytic acid glucoroniae, salioyuric aad EXCH + Fenal (1g 7. calioyluric), 1/2: 15-20 mins [os Inflamm disod« CRE, Kawasaki, 1 a) Woke ower, mifi-mod pain, prophylaxicte CY events sito! MT wgacchion, WB , CL: Renal /Repatic Impairment Hypecensittuty to othes NEGUS, children {lb yes old serve Ang b-vival RUD, rag aise, Qours Preqnancyl® dnd) Ladahon asiperations T beeding : Ween, ateohel, Tage DVOID: Ayo (RMe's ANOROME) Side errecs * #= Salioylate censifwity, Hanus + Fatal: Dyspnea, Loma , CN collapse, Reye's syndrome, “ GL: dyspepsia, cromaon Weed, uleesS - Sour + Nepnniencity Dmg Take axns % 61 Vieed,wloers : wo) coricostercids ANH COaguiants , NSALDs | oddosis, TONS foxicry: V{ carbone Anhydrase { T hypoalycoma . w) Sulgonylureas Food \necoxns AGL Vieeding %&) alcolno| Food : ¥ G4 icritaton AOKI POSE ( \Pmg /kg) - TP-drive — Hypervenniabon, ‘exp. alkalosis LETHAL (00mg /'g) - untoupling oxidabve PhespHoryralen Anil = Fomaernire maak lorie ci do sis ; ion f bap Weta Acid Scanned with CamScanneree » anne alelet MOA : irreversivie inhibition ef ADP to receptor AXNS: : ae oo © AOC- mediated proreiet acrivation Da pol aoe v X activate of Ciycoprowin b/ ila Abe : fe Fapid, incomplete (507) , PLAK Plasma : 4Fmin 98% (parent drug) Metow: @ ver hydiolysis by esterases —> inactive carvaxule acid derivative Oxidation, by CHP2C\G —> GoKVe Yhicl Metabolite Exc: renad (S07) , Cecat (46) T% = Uns (paren), 0.5 ms (Aniodd, Bhs (Carpoxytic aid) Indication: grewent/ts of Wt = vasoular aveides Cahromooonneue) | ww] 05 pein Kok cotonany cyndrome, hoyle ST ase @ CL: svive patho weed (P0D, intracanial hemorthage) Sewere Neparc impairment Hdverce GRCCAS: OFoss reackine drug wuypersensinvity (rach) Orolonged bieeaing Ame Gir distomgort thaused, Dyspepsia Int cranial/ cerroperitoneal Wemarthege, purpura Monitor + Hgb, Het, signe of bleeding ( Ast ks) Drug tnteraxns 1 weeding W/ aspirin, anticoagulants, ankiplateres, NSAID . SSRI Food Inttaxn » Fatal; orapetrui YL anhplareter eCcect Scanned with CamScannerScanned with CamScannerEmoxaparn’ cindired) MOR : pings to Antithrombin T) —s accelerate aorivity —? © cag Xa, Na | dicakea Ao: 1007, peak plasma: + Shr VJO: 4.9L + dows NOT vind to heparin-winding Pforins Metolo: DESULFATION POLYMERIZATION @ Uver Elim: renal (40% unchanged, 4077, ahve) Uh: q-Shig Prophylaxis of venous +h Puimeémbo 4 Colting in Extracorporeal RNR ‘ «dihs, CL? Hypexsensitiviry, ACnve wayor bwediag , noure vee ge recent hemorrnagic Stroke, ACbVE PUP. *hrombocytopen Precavtion : S645kg , oF Brko, diabenc remnopathy, GS uleess hx Hepatic (Renal Imparment Adverse 2 Hemorrhage @ ‘Any, UR ? se Runs Perigreal Gert , ogtenp ovo sis Anemia, Hemarudd, Gocaymosts, FLUE, Congusion, N Faral ; Hemorrhagic tomplic { reno peritenea ,jntexct ania!) Monitor : Meuolgial impairment Sx -» Lumbar Quncture, spinal/epidural anesth. COC ( Plater, Stool Occult) Nasoulor ciceess sites Prug rnveraxns: © Vieeding | ANwaguants, Rlaiees aBgregahon intibitors Cxcann,) * bleeding wl vit & OVydose 2 Tx Ww] erstomine sulgate Scanned with CamScannercm 2 MOA: gqmpetitive inhivitor of HANG cof reductase > FRFECIS ' 4 © upregulation of LOL X conversion to mevalonate A eipression of LDL recephvts A. : + hepahe uptake COL ~Y vlesterot syntnesis feduee YLPL-C, TAG, ¢ Abs: GIT, DW. | peck plasma 1-2hr's Np 480 L } prowin vinding? 48% ‘bh Metab: oyegso,shy (@ liver ¢nt)—9 ACTIVE = onthe» por hydroxyatqvacte Flim: Wile wjo eieronepatic teciroul, 2iMACnve: B - oxi dation vecHeel _ pn (47) VeT 4 As Ties nis, 30 hrs (metabolites) * Heasonee 6.2SmUYmia Slutoreni ‘Andications : Wyperoholesteratemia (Familial NONFawiilia’) Prophylaxis O CV events Podimin> wf of wo fred > qvord 21L/4ay Concump: Of : active liver disease, Preqnany » Lao omunmittant wt w) Golesporin unexplained % Rdverse Exwots Scanned with CamScanner‘LaCTULOSE mon : form FA metabolites @ gut Vv +H, 1 meahane Intratu minal é AciA Lormahon gas Foi mahon peristathe ’ is 3 an aos of aMMionia 2 TOXIG N comp, osmotic a \ , Freer @ Sut lumen A Frequency Lammonsa cone. v OF Stool (for tx 0€ Pst #120 content @ st00| ~ SOFTEN Stoo} Mis: poorly abs @sr (437) VID, PB « NeQiaigie amounts Merob + @ Wien by cgccharolye ae (Lactobacillus, &.coli, Clostridium) v TReWLose — Acetic hades Formo beds Lace Aad Wim, AZ stool, $7. reMial vsjin all hes ication: loxahve €oi Ohronic constip,adjuncr to dick for ** Of emceplnald CL: gataciosemia, GE dvstrustion, subocoiusive Syndrome, UC, CD Special Precaution: lactose imoleranice, DM, ingants, Adery, gasto~card Advece Run: Elecrrolyke Lmloalance NIN, Diarrhea, Flatulence, Cow Pregnancy B Monitor. BP, Sr. edecktalytes, Sr. WHy, Fluid status, owed mwwt Px: Drink 15-2 doy Drug Lnitronne TK loss ; w/ Aniaride, Stereos, ampnolenan B® * eRcen ae cording alywcides Scanned with CamScannerPERI POPRIL ACE - INHIBITOR . MoA* comper w/ M1, tor binding to ACE \ : YD _nzymatic proteolysis of AT, to ATI a One 7 Hyperen sion ‘ 4, 7 Heard Failure \ pl VBP by Oeressor egcec Stavle Conan renin Aemvity (toss OF foednacty Ortery Os \ Vascpansttiokon, aldosterone sec Ros: capidly ave Awe agiec oral admin , pioavall : W598 7 , reduced «0/ food N]D + O.2ts Kg, PB? Go7, (perindopril) Mets: @ ete : hydrolysis by €slerases > perindoprilat (Oxive), Pee Exc. renal (157 , 4-127 unchanged) TWr + 26-305 (perindoprilad) CL: bx % angioedema to ACK-1, Mok Nereditary/idiopathic angio bilateral /unilarsal renal srenosis DU J renal mpaitmens {GFR <4OmL] min |.73 mn’) many 0 haverse Rans * Onoiesiatic “jaundice, hygorenson, SyMcope, hypert emia, Gua) Fora: Angicedema, acthythinia Monitor: Bf, BUN, Stk, Creativine, renal fa, C&C WI dikter enha) bnagived ema signs Counsel = impair aldility + Ate Joperate Inachinery Drug Indecaxns + hypotension W] Aiuretias, Mates, Anti- HTN agen 4 Wypectaleino ya} SHONDACNE, supplements * jypogly cemia wo] insult of ther drugs Fangjoedtma w) yoioh Yanik . NSAIDS Cax2) 2 yen Sen dereriovahon 6r ahsterin Scanned with CamScannerRepuce ¢: DECREASE | ACTIONS/EFFECKS + UT: Ist or 2nd Ischemic tleart Ds Crome Hear} Failure - Diaverc Nephropathy Cfor diabetics) cnronic Kidney & -Lprmieinuna SIOE EFFECTS 1) HYPOTENSION : Lov, etp.@ Fit dose then Hapeee : ’ 2) PERSISTENT DRY Covey : accumulation of kining Howitt to ALB @ wigs . 3) HYPERKALEMIA : retain b+ (monitor) : 4» HEADACHES , OIZZINESS, FATI6UE, NAUSEA: 6) Aniclogpenna Cuasoditation), CAUTION : if taken w/ K* supplement / k* spari divnteg ‘px w/ renal impairmens (Renal any cenalicd Chronic kidney Ds = lower dose , mowitor : [PREthaNcy D\- wrisk * Lena Fai i : ailure Risk ence 4 taken Scanned with CamScanner