SEQs

Question No.1

a) Name 5 fibrinolytic agents.

b) Write down mechanism of action of heparin.

Question No.2

Write down 5 clinically important ecosanoids along with their

indications.

Question.3

a) Name clinically useful COX2 inhibitors.

b) Write down 5 toxic effects of NSAIDs on chronic use.

Question.4

a) Define zero order kinetics.

b) Write 5 factors affecting half life of drug.

Question.5

a) Name 5 competitive neuromuscular blockers.

b) Write down mechanism of action of succinylcholine.

Question.6

a) Name 3 long acting glucocorticoids.

b) Write down 5 important indications of glucocorticoids.

Question.7

a) Name any five alpha blocking agents.

b) Write down five indications of alpha blockers.
Question.8

Define bioavailability of drugs and its therapeutics importance.

Question.9

a) Classify beta blockers according to their receptor affinity.

b) Name three agents which are relatively safer to be used clinically in
asthmatic patients.

Question.10

a) Name three cholinomimetics useful for the treatment of glaucoma.

b) Write down two drugs which are contraindicated in case of close –
angle glaucoma.

Question.11

a) Write down any five factors affecting absorption of drugs.

b) Write down any five disadvantages of oral route of drug
administration.

Question.12

a) Write down five neuromuscular blocking agents.

b) What is sequence of paralysis of muscles when competitive
neuromuscular blocking agents are injected intravenously?

Question.13

Role of lipid solubility in pharmacokinetics of a drug.

Question.14

a) Write down mechanism of action of class IV antiarrhythmic drugs.

b) Write down five side effects of amiodarone.

Question.15
 Write down three different regimes for treatment of H – Pylori
induced ulcers.

Question.16

a) Write down antiasthmatic drugs acting on leukotriene pathway.

b) Write down three names of centrally acting cough suppressants.

Question.17

a) Write down three names of tissue plasminogen activators.

b) Write down mechanism of action of Heparin.

Question.18

a) Name five competitive neuromuscular blockers.

b) Write down mechanism of action succinyl choline.

Question.19

a) Write down the major groups of drugs used for the treatment of
congestive heart failure, with one example of each group.
b) Write down mechanism of action of cardiac glycosides.

Question.20

a) Write down names of three selective serotonin norepinephrine

reuptake inhibitors.
b) Write down mechanism of action of lithium.

Question.21

Write down mechanism of action, uses and side effects of ketamine.

Question.22

a) List all clinically useful H2 – receptor blockers.

b) Write down mechanism of action of omeprazole in detail.
Question.23

a) Write down the mode of action of potassium iodide.

b) Write down three dangerous and potentially fatal side effects of
thioamides.

Question.24

a) Write down difference between the mechanism of actions of

spironolactone and amiloride.
b) Write down indication and contraindications of mannitol.

Question.25

a) Write down mechanism of action of local anesthetics.

b) Name 5 amide type of local anesthetics.

Question.26

a) Write down five clinical uses of benzodiazepines.

b) Write down mechanism of action and advantages of buspirone.

Question.27

a) Write down names of selective Cox – 2 inhibitors.

b) Write down 5 names of disease modifying antirheumatic drugs.

Question.28

a) Write down side effects of quinolones.

b) Write down clinical uses of sulphonamides.

Question.29

a) Name any 5 antiretroviral agents.

b) Write down role of interferons in treatment of chronic hepatitis C
infection.
Question.30

a) Write down names of antimicrobial drugs active against pseudomonas

infection.
b) Name anti-malarial agents effective in falciparium malaria.

Question.31

a) List 3 non – sedating anti-histamine (H1 blockers).

b) Write down 5 clinical indications of H1 blockers.

Question.32

a) Name 5 clinically useful drugs for angina pectoris.

b) Write down anti-angina mechanism of action of vasodilators.

Question.33

a) Write down components of 1st line triple therapy for H. Pylori induced
ulcers.
b) Write down side effects of cimetidine.

Question.34

a) List inhaled general anesthetics.

b) Write down 4 side effects of thiopentone sodium.

Question.35

a) Write down mechanism of action of amphotericin – B.

b) Write down 4 side effects of flucytocine.

Question.36

a) List all types of oral contraceptive pills.

b) Write down main contraindications of oral contraceptives.

Question.37
 a) Write down 3 examples of drugs blocking archidonic acid pathway at 3
different levels.
b) Write down mechanism of action of Azathioprine as DMARM.

Question.38

a) Name three short acting glucocorticoids.

b) Write down 5 clinical indications of glucocorticoids.

Question.39

a) Write down mechanism of action of meglitinides.

b) Write down 3 contraindications of metformin.

Question.40

a) Write down toxicities produced by chronic alcohol use.

b) Write down pharmacological intervention in chronic opioid analgesic
abuse.

Question.41

a) Write down mechanism of action of lithium in treatment of bipolar

disorder.
b) Write down cardiovascular side effects produced by antipsychotics.

Question.42

a) Write 3 drugs from distinct pharmacological groups that can cause

malignant hyperthermia.
b) Write down clinical uses of carbamazepine.

Question.43

Write down 5 factors which determine the movement of drugs between

body compartments.

Question.44

a) The main substances required for phase – I reactions (oxido –

reductase process).
 b) Write 5 example of phase – II reactions.

Question.45

a) Name main signaling processes related to drug receptors.

b) Describe molecular mechanism of G protein coupled receptors.

Question.46

a) Write down the location of cholinoreceptors and adrenoreceptors.

b) Write pharmacological effects produced after giving epinephrine.

Question.47

a) Classify indirectly acting cholinomimetics.

b) Write down 5 clinical uses of anti – muscarinic drugs.

Question.48

Name alpha stimulating drugs and write their clinical uses.

Question.49

Write down 5 demerits of rectal route of drug administration.

Question.50

Write down definitions of following terms.

1. Up regulation of receptors.
2. Tachyphylaxis.
3. Idiocyncracy.
4. Hyper reactivity.
5. Potentiation.

Question.51

Write down 5 factors affecting half life of a drug.

Question.52

Compare and contrast epinephrine & nor – epinephrine (5 points)

Question.53

Write down the molecular mechanism of ẞ - agonistic drugs in

producing positive ionotropic and positive chronotropic effect on heart.

Question.54

Write down 5 indirectly acting cholinomimetic drugs along with 5

clinical uses.