PDE Example: Nerve Cable |GSBmE + Consider the following! D distributed parameter model of a nerve cable: Re intracellular resistance (cm) transmembrane capacitance (Fim?) log: Membrane lon currant (Am?) ——— + To derive the underlying PDE of this system, we represent it first as a lumped parameter model voy —W nTR Ne A — tracer domain le = . extracellular domain axNerve Cable (continued) IGSBmE + For any given node k, we can write a current conservation relationship Using R=pL/A length (2) A: cross sectional area (a)Nerve Cable (continued) + The LHS of this equation is simply the finite difference approximation to the 2" spatial derivative of V. + In the limit as Ax + 0, the equation may be written as the PDE: P, :Mosolic resistivity (om 1 axon rads (m) For the Hodgkin-Huxley formulation of ign, we have (recall from last lecture)+ This cable equation can be solved using the method of lines. + Re-arranging, we have » [z ex and discretising in x ave 1 ve aC,Hodgkin-Huxley Cable Equations [eyiiis HO Tg) Ben Te) eel 1), ah Fah Be lth) in Bea l-nh ar 20000,8en? 36000 cu 0006MOem 10 Seat? 0.0025 euxMatlab Implementation |GSBmEMatlab Implementation HH. cable_prime.m:Matlab Implementation (esti HHL cable_prime.m (continuedMatlab Implementation Pg