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IDENTIFY ABSTRACT Farida Wulandari
IDENTIFY ABSTRACT Farida Wulandari
Disusun dalam rangka untuk memenuhi salah satu tugas mata kuliah
English 3
Dosen Pembimbing: Lia Febriani,M. Pd
Disusun oleh :
Farida Wulandari (108118037)
2020
1. Identify Abstract
Internasional journal
Title :
Risk factors for distant metastasis of patients with primary triple-negative breast cancer
Background :
Objective :
Triple-negative breast cancer (TNBC) involves higher rates of recurrence and distant
metastasis. The present study sought to characterize the risk factors for distant metastasis
of TNBC.
Methods :
The Surveillance, Epidemiology, and End Results (SEER) database was exploited to
enroll patients diagnosed with TNBC from 2010 to 2015. The eligible patients were
dichotomized into locoregional and distant metastasis at the time of diagnosis. Patients’
demographics and tumor features, and treatment were evaluated to identify the risk
factors for distant metastasis of primary TNBC. The categorical variables were examined
by chi-square tests. Univariate and multivariate logistic regression analyses were used to
determine the risk factors for distant metastasis. Breast cancer-specific survival (BCSS)
and overall survival (OS) were estimated by Kaplan–Meier plots with log-rank tests.
Results :
We collected 26863 patients with primary TNBC, 1330 (5.0%) of them presented with
distant metastasis. In the univariate analysis, all the variables indicated statistical
significance. The significant variables were subsequently enlisted into the multivariate
logistic regression analysis. Age > 50, higher clinical stage T and N, and tumor size > 5
cm were independent risk factors for distant metastasis of primary TNBC. Moreover,
higher clinical stage T and stage N were independent risk factors for bone metastasis of
the patients. TNBC patients with either bone or visceral metastasis have poor survival,
with brain metastasis worst of all, though the OS difference was not statistically
significant.
Conclusions :
:TNBC patients with larger age, higher clinical stage, larger tumor size were more
predisposed to have distant metastasis. Great attention should be paid to the prognosis of
these patients with distant metastasis.
2. Jurnal Indonesia
Title :
Faktor risiko terjadinya metasis jauh pada pasien kanker payudara
Background of study :
Objective :
Mengetahui faktor risiko yang berpengaruh dan lokasi tersering metastasis jauh pada
pasien kanker payudara (KPD).
Methods :
Total 1.289 pasien kanker dari periode bulan Januari 2001 sampai Desember 2010 diteliti
secara retrospektif. Dari 913 pasien yang memenuhi kriteria inklusi dikelompokan
menjadi tiga kelompok. Faktor risiko dengan uji Chisquare pada kelompok dengan
metastasis (Kelompok I+II) dibandingkan dengan kelompok bebas-metastasis (Kelompok
III); dan uji Cox-regression untuk mengidentifikasi kesintasan bebas metastasis (DMFS)
Results :
Total 1.289 pasien kanker dari periode bulan Januari 2001 sampai Desember 2010 diteliti
secara retrospektif. Dari 913 pasien yang memenuhi kriteria inklusi dikelompokan
menjadi tiga kelompok. Faktor risiko dengan uji Chisquare pada kelompok dengan
metastasis (Kelompok I+II) dibandingkan dengan kelompok bebas-metastasis (Kelompok
III); dan uji Cox-regression untuk mengidentifikasi kesintasan bebas metastasis (DMFS)
Conclusion:
Status T3 – T4, status pN positif, dan subtipe triple-negative yang bermakna secara
statistik pada metastasis jauh (p<0.05). Lokasi tersering metasis adalah tulang.
The Surveillance, Epidemiology, and End Results (SEER) database was exploited to
enroll patients diagnosed with TNBC from 2010 to 2015.
S + To Be + V2
Breast cancer-specific survival (BCSS) and overall survival (OS) were estimated by
Kaplan–Meier plots with log-rank tests
S + To Be + V2
Moreover, higher clinical stage T and stage N were independent risk factors for bone
metastasis of the patients. TNBC patients with either bone or visceral metastasis have
poor survival, with brain metastasis worst of all, though the OS difference was not
statistically significant.
S + To Be + V2
Indonesia – English
Title :
RISK FACTORS FOR REMOTE METASTASIS IN CANCER PATIENTSBREAST
Objective :
To identify the risk factors and common sites of distant metastasis in breast cancer
patients (BC).
Methods :
1.289 breast cancer patients from January 2001-December 2010 are retrospectively
assesed. Of 913 patients that met the inclusion criteria; were grouped into three group .
Risk factors were assessed using Chi-square on Metastasis group (Group I+II) vs
Metastasis-free group (Group III); and Cox-regression analysis was used to identify 5-
year and 10-year Distant Metastasis-Free Survival (DMFS)
Results :
T3-T4, pN positive and triplenegative subtype were significantly related to distant
metastasis occurences in Metastasis group compares to Metastasis-free group (p<0.05).
The pN-positive (HR: 2.51; 95%CI: 1.65 to 3.83) and histopathologic grade-3 (HR: 1, 67;
95%CI: 1.06 to 2.64) were significantly associated to and could predict the 5-year and
10-year DMFS in Metastasis-free-on-admittance group. Common locations of metastasis
in Group I were: bone (n = 73; 64.6%), lung (n = 33; 29.2%), liver (n = 24; 21.2%), brain
(n = 1; 0.8%) and contralateral breast (n = 5; 0.8%); while the common location of
metastasis in Group II were: bone (n = 76; 62.3%), lung (n = 34; 27.9%), contralateral
breast (n = 26; 21.3%), liver (n = 22; 18%), and brain (n = 13; 10.7%).
Conclusion :
The T3-T4 status, pN-positive and triple-negative subtype were statistically significant
risk factors for distant metastasis (p<0.05). Most common sites for distant metastasis was
bone.