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    2 views3 pages

    207 PDF

    Uploaded by

    Lay Lyly

    Copyright:

    © All Rights Reserved
    Download as PDF or read online from Scribd
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    of 3
    BULeRrxSATGSERRLERBAA RARE FB bam ARR: 207 & ORR LK 4 EE (1) Assume a single dose of 100 mg of drug-A was given orally. The drag is 90% systemically available. The total amount of unchanged drug recovered in the urine is 60 ma, and the total amount of metabolite recovered in the rine is 30 mg. According to the literature, the elimination halflife for this drug is 3.3 hr and its apparent ‘volume of distribution is 1000 mi From the information given above, please find the values of (@ fe points) () total body clearance (3 points) (©) renal clearance (3 points) (@ the non-renal clearance (3 points) (2) A.rug with an elimination half-life of | hour was given to a male patient (80 kz) by intravenous infusion at arate6f'300 ma/hs. At™hours after infusion, the plasma drug concentration was 11 gine (@) What is the total body cleffance for this ting? (2 points) (bd) What is the apparent’ ‘Yolunie ak disafieition Yor this drug? (3 points) (©) Ie ihe drug is not metabolizes anaeseliirated only by renal excretion, what is the renal clearence of this dria? (& ra (©) What isthe probable mes ings or real leranve ofthis dog? (8 points) @) The bioavailability of propranolol is 26%! Proprafolol is 87% bound to plasma proteins and has an elimination halfifS06FS'9 hr, The apparent volume of

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