SR & MA training group

Systematic Review & Meta-analysis Training Group,

Overview

Sebastien Kenmoe, PhD

Centre Pasteur of Cameroon
 Outline
• Disease epidemiology
• Overview on Systematic Reviews
• SR & MA Training Group Objective
• SR & MA Training Group Members
• SR & MA Training Group Organisation
• SR & MA Training Group Work Plan
• SR & MA Training Group Previous Activities
• My presentation
• Overview on Research collaboration

S R & M A Tra i n i n g G r o u p
 • all ages

• Global distribution of
Lower respiratory
infection mortality in • < 5 years
2016

• > 70 years

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S R & M A Tra i n i n g G r o u p
 Coronavirus
research before
Covid-19
Pandemic

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S R & M A Tra i n i n g G r o u p
 Biomedical
research
funding in 2016

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 Biomedical
research funding
in Africa by
Region in 2017

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 Systematic Reviews – Overview

S R & M A Tra i n i n g G r o u p
 Systematic Reviews – Overview

S R & M A Tra i n i n g G r o u p https://wiki.jbi.global/display/MANUAL/JBI+Manual+for+Evidence+Synthesis

 Systematic Reviews – Overview
• Search Question (PICO, CoCoPop, PEO…)
• Search strategy
• Protocol registration (PROSPERO)
• Study selection (Rayyan review, Covidence…)
• Data extraction (Google forms)
• Risk of bias assessment
• Data curation
• Data analysis
• Manuscript drafting & submission

S R & M A Tra i n i n g G r o u p
 Objective
• Objective: To establish a sustainable multidisciplinary African research network for the
synthesis of existing data and the identification of information gaps.

• Facilitators :
Arnol Bowo Ngandji, The University of Yaounde I
Cynthia Paola Demeni Emoh, The University of Yaounde I
Cyprien Kengne Nde, National AIDS Control Committee
Donatien Serge Mbaga, The University of Yaounde I
Gadji Mahamat, The University of Yaounde I
Hervé Raoul Tazokong, The University of Yaounde I
Jean Thierry Ebogo belobo, Ministry of Scientific Research and Innovation
Sebastien Kenmoe, Centre Pasteur of Cameroon

S R & M A Tra i n i n g G r o u p
 SR & MA Training Group
Governance
• Facilitators
• PhD Graduates
• Trainees
• External Collaborators

S R & M A Tra i n i n g G r o u p
 SR & MA Training Group
Governance
• Facilitators
• PhDs Graduates
• Trainees
• External Collaborators

S R & M A Tra i n i n g G r o u p
 SR & MA Training Group
Governance
Facilitators :
Arnol Bowo Ngandji, The University of Yaounde I
Cynthia Paola Demeni Emoh, The University of Yaounde I
Cyprien Kengne Nde, National AIDS Control Committee
Donatien Serge Mbaga, The University of Yaounde I
Gadji Mahamat, The University of Yaounde I
Hervé Raoul Tazokong, The University of Yaounde I
Jean Thierry Ebogo belobo, Ministry of Scientific Research and Innovation

S R & M A Tra i n i n g G r o u p
 SR & MA Training Group
Governance
PhD Graduates :
Aristid Ekollo Mbange, University of Yaounde I
Chavely Gwladys Monamele, epse Fodja, Centre Pasteur of Cameroon
Dimitri Ngongang Tchami, University of Yaounde I
Elisée Libert Embolo Enyegue, Free Lance
Elodie Teclaire Ngo Malabo, Centre Pasteur of Cameroon
Kengne Gounmadje Landry, University of Yaounde I
Magellan Guewo Fokeng, University of Yaounde I
Marie Amougou Atsama, Ministry of Scientific Research and Innovation
Sebastien Kenmoe, Centre Pasteur of Cameroon
Serges Tchatchouang, Centre Pasteur of Cameroon
S R & M A Tra i n i n g G r o u p
 SR & MA Training Group
Governance
Trainees :
More than 30 registered trainees

S R & M A Tra i n i n g G r o u p
 SR & MA Training Group
Governance
External collaborators :
Pr Harish Nair, Centre for Global Health, UK
Pr Harry Campbell, Centre for Global Health, UK
Pr Igor Rudan, Centre for Global Health, UK

S R & M A Tra i n i n g G r o u p
 SR & MA Training Group
Organization
• To be done…

S R & M A Tra i n i n g G r o u p
 Project structure

Work plan

WP3: Training in WP4: Training in

WP1: Systematic WP2: Training in
article peer grant proposal
review writing systematic review
reviewing writing

Publons Academy
All members (1 All members All members
(Online, 3
SR/ 2 Weeks) (weekly meeting) (weekly meeting)
months)

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S R & M A Tra i n i n g G r o u p
 WP1: Systematic review and Meta-analysis writing
• SR & MA Training Group’s vision is to integrate and exploit existing knowledge and data to provide greater
insights into the impact of Neglected Tropical Diseases on health systems and societies throughout Africa, and
to actively engage stakeholders in order to improve strategic planning and decision-making.

WP2: Training and Capacity Building

• builds on longstanding training and capacity building efforts by SR & MA Training Group partners and thereby
leveraging the successful methods, available materials, schemes, processes and strong working relationships,
to ensure the training in the writing of articles and more particularly the systematic reviews and meta-analysis.

WP3: Learn to peer review with confidence

• Gain practical experience in peer review with the Publons Academy, a free peer review training course. Write
real reviews with one-to-one guidance from a mentor, and gain exclusive access to the Publons Academy
Review Template and examples. Upon graduation from the course, be a certified peer reviewer, ready to
connect with top journal editors in your field.

WP4: Training in grant proposal writing

• To understand the process and requirements for applying for a grant; to writing our own grant application;
design our own strategy for attracting funding and moving forward in our research career.

S R & M A Tra i n i n g G r o u p
 Proposed schedule for 2021

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 WP1. Overview
Objective

• To conduct systematic reviews to inform Neglected Tropical Diseases burden in

Africa including prevalence, incidence and case fatality rate.
• To determine overall and high-risk group specific to Neglected Tropical Diseases
in Africa.
• To provide high-quality, sustainable, robust data that link closely with public
health/regulatory bodies/health care providers for informing policy and
regulatory processes in Africa.
• To promote the dissemination of knowledge to a wide range of stakeholders,
raise awareness, foster connectivity and promote informed action in Africa.

S R & M A Tra i n i n g G r o u p
 WP1. Overview
Participants

• Lead: First author (Member that proposed research question)

• Co-leads: Facilitators & PhD Graduates

S R & M A Tra i n i n g G r o u p
 WP1. Overview
Governance
WP1: Evidence-
based synthesis

Task 1: Prospero Task 2: Task 3:

protocol manuscript Manuscript
submission writing submission

First author & First author &

Sebastien All authors Sebastien
SR & MA
Kenmoe
Tra i n i n g G r o u p
Kenmoe
 WP1. Overview
2021 Agenda

S R & M A Tra i n i n g G r o u p
 WP1. Task 1 (Prospero protocol submission)
Objective - Participants

• Objective: Study protocol registration in PROSPERO involves the

submission and publication of key information about the design
and conduct of the systematic review. Applications are assessed to
ensure that they fall within scope and that the required data have
been provided. Records are published on an open access
electronic database.

• Lead: First author

• Co-leads: Sebastien Kenmoe, (CPC)

S R & M A Tra i n i n g G r o u p
 WP1. Task 2 (manuscript writing)
Objective - Participants

• Objective: Study protocol registration in PROSPERO involves the

submission and publication of key information about the design
and conduct of the systematic review. Applications are assessed to
ensure that they fall within scope and that the required data have
been provided. Records are published on an open access
electronic database.

• Lead: First author

• Co-leads: All PhD Graduates; All Facilitators.

S R & M A Tra i n i n g G r o u p
 WP1. Task 2 (manuscript writing)
Objective - Participants

• Main activities
• 2.1. Article search (Sebastien Kenmoe)
• 2.2. Study selection (Sebastien Kenmoe & Jean Thierry Ebogo Belobo
• 2.3. Data extraction (All PhD Graduates & All Facilitators)
• 2.4. Data curation & analysis (Sebastien Kenmoe & Cyprien Kengne Nde)
• 2.5. Methodology & Results writing (Sebastien Kenmoe)
• 2.6. First draft writing (All PhD Graduates)
• 2.7. Manuscrit revision (All Facilitators & PhD Graduates)
• 2.8. Manuscrit submission (First author & Sebastien Kenmoe)

S R & M A Tra i n i n g G r o u p
 WP1. Task 3 (manuscript submission)
Objective - Participants

• Main activities
• 3.1. Authorship (All facilitators, All PhD Graduates & Active Trainees)
• 3.2. Manuscrit submission (First author & Sebastien Kenmoe)

S R & M A Tra i n i n g G r o u p
 WP2
Objective - Participants

• Objective: Training in evidence-based synthesis

• Lead: Sebastien Kenmoe, (CPC)

• Co-leads: All facilitators
• Participants: Trainees & PhD Graduates (Optional)

S R & M A Tra i n i n g G r o u p
 WP2. Overview
Activities

S R & M A Tra i n i n g G r o u p
 WP3
Objective - Participants

• Objective: Training in article peer reviewing

• Participants: All members

S R & M A Tra i n i n g G r o u p
 WP3. Overview
Activities

S R & M A Tra i n i n g G r o u p
 WP4
Objective - Participants

• Objective: Training in grant proposal writing & grant proposal

writing

• Participants: All members & external collaborators

S R & M A Tra i n i n g G r o u p
 WP4. Task 1 (Training in grant proposal writing)
Participants

• Lead: Harish Nair, Centre for Global Health (UK)

• Co-leads: Sebastien Kenmoe (CPC)
• Participants: All members

S R & M A Tra i n i n g G r o u p
 WP4. Task 2 (Grant proposal writing)
Participants

• Lead: Sebastien Kenmoe (CPC); Harish Nair, Centre for Global Health (UK)
• Co-leads: All facilitators & All PhD Graduates

S R & M A Tra i n i n g G r o u p
 WP4. Overview
Activities

S R & M A Tra i n i n g G r o u p
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S R & M A Tra i n i n g G r o u p
 Our training activities

• Design of the data input mask in Epi Info

• Article search strategy
• Management of article references in database (Zotero and Endnotes)
• Statistical analysis of data using SPSS or R softwares
• Critical article reading
• Article writing particularly Systematic reviews
• Training in article peer reviewing
• Training in grant proposal writing
• Advanced use of Excel, Word and PowerPoint

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 Primary Outputs

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 Primary Outputs

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S R & M A Tra i n i n g G r o u p
 Incidence and seroprevalence of Rabies virus in humans, dogs and other
animal species in Africa, a systematic review and meta-analysis.

• To determine the incidence and seroprevalence of Rabies virus

(RABV) in humans, dogs, and other animal species in Africa
• These estimates could be essential in the implementation of a global
strategic plan to eliminate the RABV by 2030 as adopted by the WHO,
OIE, and FAO.

Manuscript under review, One Health 42

S R & M A Tra i n i n g G r o u p
 Manuscript under review, One Health 43
S R & M A Tra i n i n g G r o u p
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S R & M A Tra i n i n g G r o u p Manuscript under review, One Health
 Worldwide epidemiology of Crimean-Congo Hemorrhagic Fever Virus in
humans, ticks and other animal species, a systematic review and meta-
analysis.

• We estimated the global case fatality rate (CFR) of CCHFV infections

and the prevalence of CCHFV in humans, ticks and other animal
species.
• We also explored the socio-demographic and clinical factors that
influence these estimates.

Manuscript under review, PLOS Neglected Tropical Diseases 45

S R & M A Tra i n i n g G r o u p
 Manuscript under review, PLOS Neglected Tropical Diseases 46
S R & M A Tra i n i n g G r o u p
 Manuscript under review, PLOS
Neglected Tropical Diseases
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S R & M A Tra i n i n g G r o u p
 Influence of confounding factors on the association between early viral
LRTI and subsequent wheezing development, a systematic review and
meta-analysis.

• We performed a meta-analysis to determine the influence of

confounding factors on the association between LRTI at ≤ 5 years and
the development of wheezing in adolescence or adulthood.

Manuscript under review, PLOS One 48

S R & M A Tra i n i n g G r o u p
 Manuscript under review, PLOS One 49
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S R & M A Tra i n i n g G r o u p Manuscript under review, PLOS One
 Workshops on “Scientific communication and policy brief“, IFYAR - International
Fair for Young African Researchers, Yaounde, Cameroon, December, 01-05, 2020

S R & M A Tra i n i n g G r o u p
 Summary
• SR & MA Training group has made substantial progress in the last 10 months
• Reported first African burden estimates for Lassa in humans, rodents, and other
animals species
• Invited trainers for “Scientific communication and policy brief” Workshop during
the “IFYAR - International Fair for Young African Researchers”, Yaounde, Cameroon,
December, 01-05, 2020.
• In the next months several FIRST AND EXCITING RESULTS expected
• Global burden of crimean congo hemorrhagic fever virus (Partially accepted, to revise)
• LRTI & wheezing association (Partially accepted, to revise)
• Rabies virus epidemiology in Africa (Under review)
• Global burden of Hepatitis B virus in healthcare workers
• Viral hepatitis & Hepatocellular carcinoma
• Global burden of Burili ulcer
• Association between Diabetes mellitus & tuberculosis
• Global Epidemiology of Enterovirus 68

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 Kenmoe Sebastien, 35 articles
14
13
12
12

10

8
7
6
5 5
4
4

2
2
1 1 1 1 1 1 1
0 0
0

2013 2014 2015 2016 2017 2018 2019 2020

Total First author
S R & M A Tra i n i n g G r o u p
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S R & M A Tra i n i n g G r o u p
 AREF/EDCTP Preparatory Fellowships – 2019
VARIAFRICA

S R & M A Tra i n i n g G r o u p
 AREF/EDCTP Preparatory Fellowships – 2019
Abstract
VARIAFRICA

The overarching goal of VARIAFRICA (Viral Acute Respiratory Infections in AFRICA) is to build an investigator network on
Acute Lower Respiratory Infections (ALRI) in Africa. There are substantial gaps in data on the burden of ALRI in sub-
Saharan Africa. The ALRI burden attributed to the sub-Saharan Africa is thus associated with an increased uncertainty and
is a likely under-estimate of the true burden. We believe that synergistic work by experts from Africa could contribute to
the production of relevant data on ALRI and thus reduce the existing uncertainty. The fellowship aims at gaining training
and expertise in evidence synthesis specifically through systematic reviews and use these to estimate ALRI burden in
Africa. The fellowship will also provide for training and skills development in writing grants and manuscripts and public
communication of science. Finally, one of the key deliverables of this fellowship would be the development of an ALRI
investigator group in Africa.
Therefore we propose the following specific aims:
Aim 1: To train in evidence synthesis using systematic reviews to estimate disease burden at national and regional levels.
Aim 2: to develop skills in writing successful grant proposals and manuscripts and in public dissemination of scientific
results. Aim 3: to build a newtwork of African investigators working on ALRI .
Significance: The research networks have proved their relevance in the progress of research work throughout the world
and more particularly in the industrialized countries. Systematic reviews have also proven their relevance in most fields
for the synthesis of existing data and the identification of information gaps.

S R & M A Tra i n i n g G r o u p
S R & M A Tra i n i n g G r o u p
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S R & M A Tra i n i n g G r o u p
 Kengne Andre Pascal, 509 articles (Pubmed)
90
85
80
74
70

60
59
53 54
50 51
50

41
40
36
30
26 28
20 20 22
20 18 17 16
14 12
10 9 11 10 11
8
10
5 7
4 3 32 42 4
100 100 000 100 210 0 0 0 0 1 0 0 1 2 1 0
0
2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020

Total First author Last author

S R & M A Tra i n i n g G r o u p
 What motivates
collaboration?
• Exponential increase of researchers and costs of conducting research
• Substantial reduction in the cost of communication and of travel
• Science is a social institution where advances depend crucially on interactions
with other scientists
• No single individual can perform all specialist tasks associated with modern
research that combine many fileds such as Bioinformatic
• Political factors encouraging greater levels of collaboration among
researchers
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 Benefits of research collaboration
• High number of published output
• High credit given to published articles by the scientific community
• High impact of a paper with high number of citations
• can enhance the potential visibility of the work
• Sharing of knowledge, skills and techniques
• Fairly formal division of labour and thus ensures a more effective use of their
talents
• A source of stimulation and creativity
• Provides intellectual companionship that may lead also to personal
relationships
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 Networking on Human Respiratory
Syncytial Virus

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 Networking on Human Respiratory
Syncytial Virus

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S R & M A Tra i n i n g G r o u p
 Next steps

• HBV in HCWs (To be attributed to 2 PhD Graduates)

• Viral hepatitis & HCC (To be attributed to 2 PhD Graduates)
• Antiplasmodial Limonoids (To be attributed to 2 PhD Graduates)
• EV-D68 (Data Extraction to be initiated from Sunday 10/01/2021)

• Recruting New PhD Graduates as much as possible!!!

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S R & M A Tra i n i n g G r o u p
Merci