Comparison Between Hyaluronic Acid (Hyalone®) and

Platelet Rich Plasma for Knee Osteoarthritis Intra-

articular Injection
Handoyo HR1, Bakri AH2, Suryaningrat KAI3, Tahalele P4
1. Orthopedic surgeon of Surabaya Orthopedic and
Traumatology Hospital, Indonesia
2. General practitioner of Surabaya Orthopedic and
Traumatology Hospital, Indonesia
3. Orthopedic surgeon of Surabaya Orthopedic and
Traumatology Hospital, Indonesia
4. Chief of surgery department, Widya Mandala Catholic
University, Surabaya, Indonesia

Abstract

Introduction: Osteoarthritis is a worldwide burden which

demands prompt treatment. Both intra-articular injection with
platelet rich plasma (PRP) and hyaluronic acid (HA) seem to
give promising result. Our study intended to seek the efficacy
of both agents in managing knee osteoarthritis patients.
Methods: This retrospective cohort study was done during the
period from January 1st, 2017 to December 31st, 2018.
Registered patients in Surabaya Orthopedic and Traumatology
Hospital with grade I-III knee osteoarthritis receiving intra-
articular PRP and Hyalone® as HA injection were evaluated by
using the Western Ontario and McMaster University’s Arthritis
Index (WOMAC) and pain score.
Results: Analytical result from 18 and 20 patients receiving
Hyalone® and PRP respectively revealed that mean improvement
of total WOMAC was 12.94 ± 13.83 (P = 0.001) in Hyalone®
group, and 7.10 ± 9.49 (P = 0.003) in PRP group. Meanwhile,
mean of total pain score decreased 2.06 ± 2.46 (P=0.002) and
1.25 ± 1.71 (P=0.004) consecutively in Hyalone® and PRP group.
Conclusion: Both agents resulted in improvement of knee
osteoarthritis. Albeit, further studies are recommended to
compare the effectiveness of both agents.

Key words: knee, osteoarthritis, platelet rich plasma,

hyaluronic acid,intra-articular injection.