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Heart Failure

⇣ SV & CO

Activation of
Neurohormonal
Response

⇣ Blood Pressure ⇣ Renal Perfusion

Carotid Baroreceptor Juxtaglomerular


Response Apparatus Response

Angiotensin
Activation of SNS Activation of RAAS

⇡ HR ⇡ Contractility Vasoconstriction ⇡ Renin Angiotensin I

Angiotensin II

⇡ Aldosterone ⇡ ADH

Na & Fluid
⇡ Blood Pressure Myocardial Fibrosis Fluid Retention
Retention

⇡ Preload, ⇡ Afterload, Negative Remodeling of the heart and worsening Heart Failure

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