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    25 views1 page

    Shwabs Grab Technology

    Uploaded by

    TWGASc
    MIT

    Copyright:

    © All Rights Reserved
    Download as PDF or read online from Scribd
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    USPTO PATENT FULLTEXT AND IMAGE DATABASE Unites Sates Patnt soausr60 Set-actuating chemomachanical devices for detvery and extended release of therapeutc agents inthe gastontestnal act Aetract, ‘The present closed dalury syste uz mito sto eer sa oragrgprs to devs aug oer herapoute aga o egeed ese, Move patty the dus dary jem nd matods prove aaslvety atm hats capale ol enchorng oa sue ean ten destetng a uo erapete agent othe sue dec} oo be sly a teat over ah exenood od otane Any urbe cl hetapppas maybe Gepoyed as destad to Glve Meant dase of eared du or erepeuc agent. The eager ao Gon be Modegrcabl such ta fey Fomainin place eran extended porad a imo anaton ogred witout aavesoy afocing the sureunn est, Inventors: Salar; Florin (Caton, MO), Gracias: David H (Gairoro MO) Brager Joyee (Bator, MD) opine: Name iy State County Type {THE JOHNS HOPKINS UNIVERSITY Bstinore MD US Assignee: THE JOHNS HOPKINS UNIVERSITY (Slimate, KD) Famiyio: — st4zi302 ApplNo: —— 1st95446 Fes Maron 3, 2014 ‘Bosumant snr USanraoadacaoat ‘Sep, 2014 Related U.S. Patent Documents ‘pplication Number ng Date Patent Munber Issue Date Ccurene Us. class 4 Gunent€PC Clare: ‘aot sone 20130108), Curent inernatona lass: ‘ABI 310020080101), References Cited (Referenced By] U.S, Patnt Documents owossaars ‘August 2004 WiaeDste zouwouzs091 ay 2018 ‘tere TAT shay 2014 elon ot 2o0aisi797 wo 2oransasit wo otter References Morishita, Mota, "ithe oral rout posse or apie and profi ru deliver”, Dro Discov. Toby, 2006, pp. 905910, 1. toby appcant. Basak. N etal. "Enzymatealytggered acuaton of mrlahiraed to" JAm Chem, Sos, 2070p. 1634-16817. vol. 152 No 46. tad by appt Colombo, Pet a, Novel ators for fl uy davon” Pharm, Res 2008 pp 01-11 ol 20 No.3. cls by apoteat. Shgel Ro a, "Overview of convertase macharene In Fundsrantals and hopin of Conaled Release Og Daley”, 2012, Controle Release Society. ed by appear Best AW, “Advncodi clone eg dle" 2008, res, vo 65 cle by aplant Litene Data "Ueeatve colts cue nd fare Ueabrat sages, igetve Diseases, 2013, pp. 1.0, vol 31. ced by spent Chott AS "Management lacie Cehnsscose euro io Arai Medel Assocation, 2013p. 2150215, vl 309, cad by spptcant tbe: Pretal, Probing tbe nachanams of rug flsace om hyroges, Juma! of Confolod Releoe, 100, pp. 220238, vo 16 cle by apc. ‘ao, SL etal. "Misolgbedto au dala store: om pats to ores Advancad Drug Delo Revions, 2003. pp 316-28, vol 86 ted by appleant LLamprect otal, Apttsensv miosphee sysom erie coin devery of erie cortanngnaneparces™. Jounal of Contolies Resa, 200, pp. 337-46, vo. 108 ‘edb spleant ‘Gua, tl, Fabieaton of chars mirparles er rug delay by so ography’ Biomater, 2006, pp 4034-404, vl 27, i by applicant De Lees LGl otal, Rao-contod etal uy dlr in man wha hyregs praparator, Jura of Gorvad Relees, 180, op, 17-24, vl 4 ced by applicant Gia, ation opr revenge, an esa pole mater vet ps2 > clsy raze CS atl, Pula oa evar of tremely nd antitrmbotc agents using paN-snropiacremiecomatacryle aid) hyioge Jounsl of Contre Release, 1096, gp. 57-64, wl 30 cted by soplesht ‘ao, tot “Gastortsstral patch estome fo orl dug delay" rug Decovr Today, 2008 pp.000-015, v.10. td by appoet He HY sal "a rl devory doves baced on cating arog, dural of Cortotes Release, 2006, p. 330848, vl 10. oa by appcant Dadetan. i etal. stratesponevtyctgol for dorm delve’ lamas 2010, p. 051-8082. vol 3, cod by appteat ‘Chita, HO st a. "iutresowor beadhesws miredoveos for Indaperdenretsconealles calvary of MuRDs drugs’, Sal 2012p. 3830-846, vo 8 ced by aplcant. Bomaras,OAstal,"Naneshueures hn im poner devices or contantsato poten daltey” Nelo 2012 pp 8356-536, ol. 12. fwd by appar ‘Ginn Pot, "jogo om contaledrseara to pceeponcve sug doer" Orog Decor Today, 2002. pp 380379 ol 7 ned by appar ‘hrs, HO ots, "raging merstchnclogs fhe Gevloprent fora Sug delvrydovoes”Atvancod Drug Davey 2012, pp. 100-1978. vl 6, cod by appican ‘Su, Jl. “Salidng a ee cmeniaal hate! mitoabustures” The Joral of Physical Choravy B, 2005 pp. 25134-25157, vl 100. td by apzcan Bent N ela Phatahograopicall aterned amet hyena bates bier ature" Palmar, 2010, pp 095-605, vl Sted 0) spaleet temo Ls Soft monn seolang pole Sat Mata. 207. pp. 7BOe78, vl. 7 ted apacat Si, TS etl. "Cenotes caer tog of opt ayers wh aunaed ean reba meet: Atewan Chm, 201.6, HZOSEP. oS. by Sioyooy, 6. tal, “shape pogranmedfong of stimuesponsve poymar bilayer", ACS Nano 2012, pp. 326-9834, vol 6. ted by applet ‘Gracas, OM, “simul fospanave stoking usta fn peer fn Curent Opeion in Chemical Engeeatng, 2013, 0p 12-710 vel 2c by appear WU, 2 tal, “Thoo-Smensina shape Wansformatiosofhyeogo sheets née by salscale medulton of mal stssox” Nahr Commuieabons, 201, 9.156, vl ‘chee by appcant Loong. TS etal, Tihs thomobicharicaly atsted microgiper,Procnsngs of he Nana Acacomy Sciences, 2009, 703-708, vl 16, sed by applicant ‘Gutope ER oa, “Bopey wt horns vosponie unetered mirtoo,ASrance Matra, 2013, pp, 51-578 wl 25. ct by appican SGitoge,E etl "Snagc tutus semping mth unatared mrogpper” Castoaieogy 20/3 pp 8s-885 va tek. cle by epoca (Gh KS sal. Hydrogastbses rug deivery stem wn msec maxing. Smee! Appstone of Hyrogle Handbeak, 2010, Spring ted by pplcant Palme and a dalveryeylome”. Curt Dug Delvry.20°2 pp. 367-94 vo. © eed by appear. Larger RS ol a, Prevent nd ue appcatone of bemateals contol drug very syst" omer, 195, pp. 207-214, we. 2 elle by aptean. ‘Gum, Rt, "Madeang of suslaned rotease of ala solecugs Hom porous, rphabiepoynte Slmalal Y82, pp. 27.32. vol 3. ted by Soper ‘Shak Real, "Mucoodhosv ug delvory eysame™ 1 Pham, eaiod. Ss, 207, pp. 8010, vl 3. Sod by applcat Kromser Ct," viodatarminaten ote ta and eaten of muccedheev du Seve stom srtagron n tho gastrtstal tac”, Magnet Resonane naga. 2008, po. 68-645, vl 26, toa by appear Forands atl, "Sotoking poymre cntiner for encapeulstion and evry of drugs. Adv Or Dev Re. Now 201264(14)1570-8, Mar 6, 2012 cted by apleant Fanwal tal, "30 hographcaly fara nolo conainas for ou dobry Advanco DroqDalvery Reviews 0, 1647-186, 2007 ted by apart. mary Examiner Hayman nan 8 ‘Ateay, Agu or Fm Came lone, Chie erey W. FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT ‘This invrtion wae made in par with Unt Siales Government suport under ODODE awarded by tha Natonal neti of Heat (MB), The US. Goverment hee cra gin he invention. Parent Case Text ‘This appcatn aime he bani of US. Provisional Appin No 617788, fed Mar 1, 2013, hich iincooaed hori by ttecence init ent ‘aime 4. Acystom fr delivering one o more horapoute agents to eeu sto Ina eubact he sstom comprising) an uttered mechan! ping modus having a renion renang rom about 10 Icon abet Iran corprsing a pura of gas compris a pray cf sary tapered tps, wheran be ingers compris amet. pamar having modulus ares’ han sett InPa. or combinatons tarot, wharon the mechanical arging meale compres at was seclusion ayer ana eco aye eperatey connected th actuator aye when he aca yer fompreee a eos lye and a noua! yer rd confgured fo ow treana nary an wher fo coral laye manta the acluton tye subaral af confguraten maa! ‘mvronmenaconditon and sisal reepond a change fhe aca onaronmentlSoston fom ona amare simu hry raleseng the sre oman egy of he Stason ayer assing ‘Thangs he schuston ayer oa secondcoguraton, whch th ectania popping ad aap lo coe by cutang ote resp co tous tte tau she wan a scan layer change the second canigutetn ad (2) a chanical module sonar & Win im pareus male capsule, eset ptemes onthe mechanical oping mol, waren the i i, poousmaai capi, uororcorarzes he one orate Werapeue agent, share Ie cherie! Module pared ele Heorporaadn te corel ayer 2. Tn ys of a 1, warn th i fit pyar a ge bak 83.Thooytom clan 1, whoo the mechanical greping mle compris polymer, @ mea or combination thao 4. Te sso of cal 1, whorin the syst alpha. 5. Tho eytom of claim 4, whaoin tho gytom comprises Hsopopyacamise (NIA and polypropylene fanaa) PPF). The yam of clin 1, wherein te aye is degradable, 7-The yam of clan 1, wnersin te aye hat a shape alc om he owe coniting ot sao a apace having play of ges mg sylem of clam 7, wnersin fhe pursly of ngs Nas 8 ange rom box we To abut 1000 tages, Tho eyeom of clam 1, whos the ono or more sbmul sles fom he group conelsing ofa angen tempor, «chang in pH. an sl. ocho, enzyme soluble poten er furoce Bomar 10. The eytom of cam 9, whan the change in tampersture comprises charging he trperatr above about 37. depo ©, “1. The salem flan 10, where he change in rpeatre capris charging Ie lrpetre above sboul 52 depee. 12.The system ola 1, nore the sytem futher compress mais. ote, ctowallconpisn the ane or more Metapete agents 18.The system lam 1, ner the sytem compass on exgefling syste. “Tho ejtom olor 1, whore tho sytem compress at fldng andor ufing sytem, 18. The stom of clam 1, whore tho unistored mechanical rpping made compisas a metal andthe systom further coms on or mee magnets elements abowng Magnet etal fhe Uninares mechani grbping male ome sinor Beserption Mien detvry of arapeuc agi, uch at ug to a ube n need of erp stent can be prfoundy cd bythe charac ofthe Gey veil, Aide tom act vo ‘oa toropouo eon canbe dolirod tease accooatg win a csoaco, conan, dsrae or sympom Saou, whee nasa curaton af cso pray ong compares tata ‘Sraton ofthe dsoeso cordton, dsr or cymgio. One fhe met changing tsk fein the Werepeeweebrant of Mucoslgestonstna (GI) Sead, and oer non eases, eneltone, ardor, or symptoms that canbe eet eugh eects 1 to Get how to elechay end clely eens terepeut agers eh eal oft Youle Dt felts hen- invoswo and acceptable te patois. Metta ané Peppa (206) Recent rogers th choncal compotion ane characteris of every vel fr oral orca administration aos er he sirtsne oleae of herapouts agents om poker maces an ‘horrentold every om ebjet over he core of ever! aye (opto moth) nthe crenata he a fol modes owev, herapmite eget, soo a ge are eneapusis = [as or capes tnd rove sang hel tat na mateo ous ai anrng ebay. Te al erate aga wll be taken ences would ove ais oa er systemic eves he ‘ve agent rhe duran cf acts, conton, dora, symptom terete cer atin of sucha rug deer para ae eek ofa ys ta canbe enced tthe cased aera tne ein to provi esis tetany ano eat xpuion by melo tar pyle melt Se. Iron espe he prosonty laced subject met prove ystom fr dlveng ono or mor hrepauc agents suo sto in cbf. the yt compra a) mutsingaod mechanical ‘pain modula camprung sual el share lapsed tps. wherein te fngerscanpise e mela, if yee cominsions steel te machanealguppng modu having fat canraon Epic cing acute oat scond coniguaton a rsponaeto ane or more sul ete te mechani groping md adapted wo gasp tate athe tas stwhen he seat cand conguratn: end (2) atanicl nogus comeing atin fm, pecus ator capuia, of erereepatemod on he ochanclgrpping mel, whore he fi, porous mali apeu, ecb compre tha ane o mae therapeu gon Inner aspects, the present soso subject mater provides a maths or dvecng one or mare therapeutic agents to a ssue st na subject. he method comping nosing tthe ‘bjt a laity of lve systems compris () al. tngerod machen rpg mostiacomprng spray f sharp or tapered ps, wera te Rrgers compre a etl, af rs, oF fombabone there the mechanical groping module hag are conigraton capa of bong aad to tae acon eonfguatn ih rexpene fo ore ora cr wherein ‘mecha gippingmosule adap grep fave m he hee sto whon tho a lest coco conguatan and (i). Stren mosleconpraing nf pou ratra cape, oF ‘coavaptared on fhe nacho rpg mad wherein etn im, porase msteral, cape a asa compres te a mate arapaute ages) ane be pratt Sebery ‘ata fhe sue sc) atering «conguean o he purty of regppers tom a a conagiaton t= second conigraicn when conactwih fa tzsun, he second cturton ‘tapiod such tate mechanical modu reps the euea cts ost a()feaing one or mare horapele agent hom he paral of devery sates. Inseme aspects, the delnering one of more heapeute agents os sue sine subject compos eating subset or Seas, conan, sod or symptom. Carta aspacts of he rasnty closed injec mtr having been salad heanatov, which ta addressed n whole or ipa bythe paar aeloed subject mater, cher epee wi come feo athe descr proceeds when akon conecon nt he secompanying Eramples and FaUiee se Dest dotbos hero el. BRIEF DESCRIPTION OF THE FIGURES Having tha dace the presenti caoned subject matin gon FIG. 1Aand FIG, 18 show vis the preteny coced dover aysom, eared le hetan ata Aheragreper nan epen slate andin a led sae respect: FIG.2A FIG. 28, 4 FIG.2© show ter views othe preseilydssosed tarps uy open sae a pata dosed eae ana losed sal, respi. and eatecbety dept Procite et oosn, FIG 3 shows vs compnsng steps of an exampe tan ectuston sequence fhe present soso neegriper upon hetng or cing (ingers opan an lose heppoe decors) FIG 4A, FIG, 48, nd FIG, 4 show plan vous ot (A) mut-ngeres eragppars that can incl, fr example, Boxe andlor ri porns andor (C sutace medication: FIG. SA and FIG, 58 chow lan vows of mul-ingored heraprepes tat epic acl ehaped an mete desis: FIG 6 shows examples of the presentycecsed eragrippar obicaled wah rug of sain riot, FIG. 7 shows plan vow ofan example ofa mulstgeted Neoprppe that hes mulfple gs patemed hereon abe eased Hom the same therapies FIG 8A and FIG, 85 chow an oxampl cf a representative process for absinthe presntydscosed tharerppers ung hograpie postion and ovapratontachniqus: FIG. 9 shows a perspective vow fan example of a theragpprstucturs formed using the fbristin process shown in FIG. Aan FIG. 86: FIG. 0A and 16,108 show images oti ito dye aviation on chicken brass wih an ula (A) fuerescance of hodaine BS: and) rescence of horesom FG. 11 anowsenimage of ors eons rm te presently dactosed egrinpr acd FIG 12 shows tmelapso photography scuence icing tame A 8, C.D. E.F.6,H. and | damenealing Be int eu lating capac the preseny deoead Weare ‘Tho prsonty closed cutoet mater now wl be described moro ful Nrenatr wi erence oho accompanying Figur. n which come, but tal emtedimens of he nventons ae shown, ie rumeers ear tothe semeristeughaut. Tho rent dled sxbject mater maybe sriodiesin any afer forms and oud wo be consad assed to he embodiments fh hero rater. these embodiments are proves o ati lsu wl sats appaollgalraqurrers néaed, many meditations anc ahs midline ofthe prsany closed sino "ata at fri fren wal come fo min oe klein he a to which he procnty rlowed suet mater ora having te bane fo tachinge preven he oogang acento a the atsovale Figures. Thraera, so be understood that tho prosonydecosod subject rater ele belnod lo spac embodiments discoved ara at macabre ane ther ‘rca ee intended bef win te scape oe oppendad ans Hye Macanial-Chamical Systems for Detvring Therapaute Agen Tage Titus ‘Tho prsonty closed cuboet mater provioe 2 elabaly non-svasve and nonoxs, hyd mechnica-chemical devo ota hat alows forth sustained eoase of horpoutagorts wen of Inthe pouty of rgeted or doaodocaton oaea a ube boy Tho precntydecosod hod mechanical chamal alvey stom capioe a mechan! comporont capa of bang Sette to arasptesve na erga’ o esta ara of @ subjcte boy and achencalcemponetcapale ef aavrng one mers tarapeubs gars, sich sea ug tote targete cached ‘ea, The presrty closed hyo mechan choral dlvery sytem is rama eferred herein as @mrte a mcrogrpar @harapauc grpper” anor @ergnper” ‘Ther are soar! ahartagous features of he preconty closed heragrpoes which alow fo delving alot oe therapeutc azn! iret t an afeced ara of th body. For example, the ‘ovoos sn be fcaid and acho annsaa wa coabalcive and ica anor Nao, he devices coe fagpanaa © a change macal enero, sa a oy tips ay “ithe fe miuts which enable ctson ia witless a letheres manne Further he secs ae level toinet andor bedogfaddia te revi edd k franonaly unten) Ie teins. Further the cece a sel enough to be cploved wih stand sulcal eather of ug every devese Known the at fx sample ene-felense cpsu ral. he “Sevens same omboament, may ossast Magnet erent sowing meget taal ain st acing ‘The praenty closed therapippere can be daigned larga tinal 1 dese are oe ncatn ins subjects ody tat aici wih adeese, canton deed. of 8 yma ‘roto Further te proven cose theragrppers can be sploed ina subjects body turbos suet to impree De atiscal hanced of delve to ltgted dead sea, aio ‘Savoy of otequate doses ofa arepeute agent te fgeted Got see ‘Tho prsonty closed theropinpcs ao wills and can bo sl aeuaod by avr f smu ncaing physical simu. such 2 change in tampsrature adler oH, ander no or mete Helos _rphysingeal cues, such se aes, enzymes, sible retain or sac loners. The present coved subject mater le grove methods for Uo ofthe Gu dear sje and Westmont ‘ta tnje or aeacecondsonSaardr oeconbiation ere Because ta presently decosed heragipprs are feostndng and unter, hy can b ingest bythe cibjoct ag. via a sstanadselnae capede, dopoyed oa ieazed aia an invasive ‘ape, sich sn anstope or eparecope,or arias ecpiilared te siecl e.g, va supposhay, ever arejecton, Ar beng sdrinres othe aie the etapppes canbe Seta in response fo pyseal or Bologie cue earch the micrgppa lament of he traprope targeted or desre ue for example, isasad tue In ned of rape ape. ‘ener such theregippare preterasy mimic bolgtalepsencager, suche aa, ann ame embers have foul jars betwee ig elon. The heagrpere may be ay shape tat hay acta raping stargate asic ore para, he proce dosed hybrid mechenca-

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