Active Beauty

Actisculpt
Fight against cellulite
Crafted by green technology
Unique composition

Actisculpt is a blend of two plant extracts known for

their abilities to decrease fat levels.
Coleus Forskohlii root extract:
• contains 0.1% of forskolin working to elicit cAMP
dependent responses.

Commiphora Mukul resin extract:

• is the gum resin from the mukul myrrh tree,
a small, thorny tree found in Arabia and India.
• used in Ayurveda herbal medicine, as a treatment
of obesity and lipid disorders.
• known to lower serum triglycerides and cholesterol
especially bad ones (LDL and VLDL).

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Process

Comiphora
Dipropylene
Gycol Mukul Mixture
paste
& Forskolin cooled & Actisculpt
added & filtered
heated &
stirred until
dissolved
homogeneity

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Mechanism of action
Forskolin and Gugglesterones

Forskolin
• Stimulates adrenergic receptors
• Induces cAMP synthesis
• Induces fat lipolysis

Gugglesterone
• Eliminates fatty acid and sterols
released in the blood by lipolysis

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In vitro evaluation

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Effect on human adipocyte formation

Protocol:
Adipocytes were obtained from cAMP cell concentration

processed pre-adipocyte cells

per mg cell protein

and treated with Actiscult at 335

pmol cAMP
0.002% and 0.001%.
256
• The positive control consists of
differentiated cells treated with
isoproterenol, a cAMP booster.
• The negative control are 83
pre-adipocytes not capable of
lipolysis. 14

Control Positive Control: 0.001% Actisculpt 0.002% Actisculpt

Isoproterenol
Dose dependent increase of
cAMP level in adipocytes is
observed using Actisculpt.

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Clinical evaluation

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Slimming and anti-fat nodes
effect

Protocol:
A gel containing Actisculpt, or a
placebo cream is applied twice-daily
on 10 obese women during 56 days.

The volunteers agreed not to change

their eating and exercise habits during
the study period.

2 measurement are realized on:

• thigh perimeter,
• the fat nodes.

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Slimming and anti-fat nodes effect

Thigh perimeter Thigh girth average reduction

Thigh measurement was carried

out with a tape measure. 0.1

A mobile board was placed at a

defined position, and the 4 weeks 8 weeks
circumference of the thigh was
marked using a ruler and pen.

cm
Results:
After 4 & 8 weeks of treatment,
the average perimeter of the -0.5 -0.5

thighs decreased (up to 0.6 cm

less than the placebo).
Placebo
-0.7
After 8 week, this variation was Actisculpt®
observed on 80% of the
volunteers.
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Slimming and anti-fat nodes effect

Fat nodes
Silicone polymer skin
prints were taken on the
thigh zones before the
start of the study (day
zero) and at day 56.
The determination of the
geometric parameters of
the fat nodes is carried
out using Laser
Profilometry.

Result:
Actisculpt clearly reduced
the amount of fat storage.

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Technical information
Actisculpt

Dipropylene Glycol (and) Commiphora

INCI Mukul Resin Extract (and) Coleus
Forskohlii Root Extract

Origin Green technology

Preservation Preservative free

Appearance

Solubility Liposoluble

Dosage 0.2% to 1%

Temperature < 80°C

Oily phase
Processing
Stirring under high shear mixer or
gentle stirring such as anchor

Compliance

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Thank you

Givaudan Active Beauty

global.cosmetic@givaudan.com

Confidential business and proprietary information of Givaudan, may not be copied or distributed to anyone without the express written permission of Givaudan
Givaudan Active Beauty Sales offices
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17-23 rue de la Voie des Bans 1 Pioneer Turn
FR-95100 Argenteuil (France) 627576 Singapore (Singapore)

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Magna House 298 Li Shi Zhen Road
76-80 Church Street Pudong Zhang Jiang High Tech Park
Staines, TW18 4XR (United Kingdom) 201203 Shanghai (China)

North America Latin America

Givaudan Fragrances Corp. Givaudan do Brasil Ltda
40 W – 57th Street - Floor 17 Av. Engº Billings - 2185, Edificio 31, 1ºAndar - Jaguaré
NY 10019 - New York (United States) 05321-010 São Paulo - SP (Brazil)

global.cosmetic@givaudan.com

Confidential business and proprietary information of Givaudan. May not be copied or distributed without the express written permission of Givaudan. 13