collagen metabolism is considered as the main factor in premature rupture of

membranes.
Vitamin C usage during pregnancy can modulate the collagen metabolism and
cause the strength of amniochorionmembranes

Vitamin C is involved in collagen synthesis, secretion, and collagenolysis

processes.
Some studies have shown that there were lower levels of vitamin C in serum
and amniotic fluid of cases with PPROM.

3 cicumstances where in Cervical cerclage may be of benefit

1. women who have history of recurrent midtrimester losses and
diagnose with cervical insufficiency
2.women eho have short cervix <25 mm (identified thru sonographic examination)
3.Rescue cerclage - done emergently when cervical incompetence is reconized in
women
with threatened labor

Progesterone clearly plays a role in the maintenance of pregnancy.

Circulating levels of progesterone rise during pregnancy
One of the major mechanisms of progesterone action in maintaining pregnancy is
inhibition of the contractions of the myometrium

It is recommended for women who has history of prior preterm or no history of prior
preterm but has sonographically identified short cervix